“Silent scream”—work with a traumatized immigrant mother and her infant with a severe neurological disorder

2018 ◽  
pp. 109-123
Author(s):  
Sheila Levi
Keyword(s):  
Neurological Disorder ◽  
Immigrant Mother

Jansky-Bielschowsky syndrome, a lysosomal disease: First diagnosed cash in Oman

1992 ◽  
Vol 50 (1) ◽  
pp. 632-633
Author(s):  
Line Buhl ◽  
David Muirhead
Keyword(s):  
Mental Retardation ◽  
Clinical Picture ◽  
Neurological Disorder ◽  
Clinical Presentation ◽  
Neuronal Ceroid Lipofuscinosis ◽  
Infantile Form ◽  
Lysosomal Disease ◽  
Juvenile Form ◽  
Progressive Encephalopathy ◽  
Lysosomal Diseases

There are four lysosomal diseases of which the neuronal ceroid lipofuscinosis is the rarest. The clinical presentation and their characteric abnormal ultrastructure subdivide them into four types. These are known as the Infantile form (Santavuori-Haltia), Late infantile form (Jansky-Bielschowsky), Juvenile form (Batten-Spielmeyer-Voght) and the Adult form (Kuph's).An 8 year old Omani girl presented wth myclonic jerks since the age of 4 years, with progressive encephalopathy, mental retardation, ataxia and loss of vision. An ophthalmoscopy was performed followed by rectal suction biopsies (fig. 1). A previous sibling had died of an undiagnosed neurological disorder with a similar clinical picture.

Nanopharmaceutical-based regenerative medicine: Promising therapeutic strategy for spinal cord injury

2021 ◽  
Author(s):  
Chen Zhao ◽  
Zheng Xing ◽  
Chunchen Zhang ◽  
Yubo Fan ◽  
Haifeng Liu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Regenerative Medicine ◽  
Neurological Disorder ◽  
Therapeutic Strategy ◽  
Severe Injury ◽  
Cord Injury

Spinal cord injury (SCI) is a neurological disorder that can lead to loss of perceptive and athletic function due to the severe injury of nerve. Nowadays, evidences detailing the precise...

On the Abolition of Belonging as Property: Toward Justice for Immigrant Children of Color

2021 ◽  
pp. 004208592110179
Author(s):  
Mariana Souto-Manning
Keyword(s):  
Early Childhood ◽  
Lived Experiences ◽  
Immigrant Children ◽  
Critical Race ◽  
Children Of Color ◽  
Immigrant Mother ◽  
The Us ◽  
Feminist Perspectives

Belonging matters in early childhood. Despite its importance, the majoritarian conceptualization of belonging is seldom problematized. In the US, the politics of belonging draws racialized lines of inclusion and exclusion, (re)inscribing longstanding racialized systems of inequity and injustice. Through critical race and Latina feminist perspectives and methodologies, an immigrant mother and son of Color examined their lived experiences. Findings unveil the urgency of upending formal racialized notions of belonging—for example, citizenship, co-naturalized with whiteness. Attending to the palpable consequences of ideological and relational borders that exclude and subjugate immigrants of Color, implications call for abolishing belonging as property and cultivating collective healing.

scholarly journals Spermatorrhea in a Chinese patient with temporal lobe epilepsy: a case report

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098281
Author(s):  
Liang Zhang ◽  
Hao Yu ◽  
Dan Li ◽  
Hui Qian ◽  
Yuchao Chen
Keyword(s):  
Erectile Dysfunction ◽  
Case Report ◽  
Sexual Dysfunction ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neurological Disorder ◽  
Premature Ejaculation ◽  
Chinese Patient ◽  
Left Temporal Lobe ◽  
Rare Manifestation

Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile dysfunction and premature ejaculation in men. In this study, we report the case of a 65-year-old Chinese man with frequent spermatorrhea. Electroencephalography suggested local epilepsy in the left temporal lobe. After treatment with anti-epilepsy drugs, the symptoms disappeared and did not recur. To the best of our knowledge, this is the first reported case of epilepsy-induced spermatorrhea. The symptoms of spermatorrhea are probably a rare manifestation of seizure. When repetitive stereotyped symptoms occur, seizure should be considered, and tentative anti-epileptic treatment may be a good option.

scholarly journals Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?

2021 ◽  
Author(s):  
Jenna C. Carpenter ◽  
Gabriele Lignani
Keyword(s):  
Precision Medicine ◽  
Neurological Disorder ◽  
Gene Editing ◽  
Therapeutic Strategy ◽  
Therapeutic Potential ◽  
Single Gene ◽  
Drug Resistant ◽  
Holy Grail ◽  
Effective Therapeutic Strategy ◽  
Genetic Epilepsies

AbstractEpilepsy is a complex neurological disorder for which there are a large number of monogenic subtypes. Monogenic epilepsies are often severe and disabling, featuring drug-resistant seizures and significant developmental comorbidities. These disorders are potentially amenable to a precision medicine approach, of which genome editing using CRISPR/Cas represents the holy grail. Here we consider mutations in some of the most ‘common’ rare epilepsy genes and discuss the different CRISPR/Cas approaches that could be taken to cure these disorders. We consider scenarios where CRISPR-mediated gene modulation could serve as an effective therapeutic strategy and discuss whether a single gene corrective approach could hold therapeutic potential in the context of homeostatic compensation in the developing, highly dynamic brain. Despite an incomplete understanding of the mechanisms of the genetic epilepsies and current limitations of gene editing tools, CRISPR-mediated approaches have game-changing potential in the treatment of genetic epilepsy over the next decade.

scholarly journals Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

2021 ◽  
Vol 22 (7) ◽  
pp. 3330
Author(s):  
Mehdi Eshraghi ◽  
Aida Adlimoghaddam ◽  
Amir Mahmoodzadeh ◽  
Farzaneh Sharifzad ◽  
Hamed Yasavoli-Sharahi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Target ◽  
Neurological Disorder ◽  
Inflammatory Cells ◽  
Disease Pathogenesis ◽  
Current Review ◽  
The Brain ◽  
Comprehensive Discussion

Alzheimer’s disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including am-yloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Unfortunately, all the efforts targeting these pathologies have failed to show the desired efficacy in AD patients so far. Neuroinflammation and impaired autophagy are two other main known pathologies in AD. It has been reported that these pathologies exist in AD brain long before the emergence of any clinical manifestation of AD. Microglia are the main inflammatory cells in the brain and are considered by many researchers as the next hope for finding a viable therapeutic target in AD. Interestingly, it appears that the autophagy and mitophagy are also changed in these cells in AD. Inside the cells, autophagy and inflammation interact in a bidirectional manner. In the current review, we briefly discussed an overview on autophagy and mitophagy in AD and then provided a comprehensive discussion on the role of these pathways in microglia and their involvement in AD pathogenesis.

The relationship between psychosocial trauma type and conversion (functional neurological) disorder symptoms: a cross-sectional study

2021 ◽  
pp. 103985622110092
Author(s):  
Shimaa K. Morsy ◽  
Daniela Huepe-Artigas ◽  
Ahmed M. Kamal ◽  
Maha Ali Hassan ◽  
Nashaat Adel Abdel-Fadeel ◽  
...  
Keyword(s):  
Neurological Disorder ◽  
Conversion Disorder ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Trauma Symptom ◽  
Functional Symptoms ◽  
Neurology Clinic ◽  
The Relationship ◽  
Trauma Type ◽  
Functional Neurological Disorder

Objective: Psychosocial trauma was associated with developing conversion disorder (also known as functional neurological disorder) before Freud, though why a particular symptom should arise is unknown. We aimed to determine if there was a relationship between trauma type and symptom. Methods: We retrospectively reviewed the medical records of patients attending Australia’s first functional neurology clinic, including referral, clinic letters and a clinic questionnaire. Results: There were 106 females, 43 males and five transgender patients. Sensory (51%), motor (47%) and seizures (39%) were the commonest functional symptoms. Most patients (92%) reported stressors associated with symptom onset. Multiple trauma/symptom type associations were found: patients with in-law problems experienced more cognitive symptoms ( p = .036), for example, while expressive speech problems more commonly followed relationship difficulties ( p = .021). Conclusion: Associations were found between type of traumatic events and type of symptoms in conversion disorder. This will require verification in a larger sample.

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