Although well-being studies started in the psychological field (1961) when well-being was discussed in terms of “the good life,” the concept dates back to ancient times from Aristotle's idea of eudaimonia to the human-centered understanding of the Renaissance. During the last decades, different studies focused on social, physiological, and psychological impacts of the dwelling and the neighborhood, and some even applied neurosciences to architecture. The contribution of studies carried in healthcare contexts has been crucial, as well as experimental results in workplaces, but also biologists, psychologists, and sociologists supported theory and practice, starting from the 1960s. Nevertheless, the specific role of architecture and interior space has been quite under-evaluated. This chapter aims to discuss the foundations of the concept of living well evaluating the understanding of “space for human well-being” in different cultural contexts at different times.