scholarly journals Improving Medication Adherence with Two-way Short Message Service Reminders in Sickle Cell Disease and Asthma

2017 ◽  
Vol 08 (02) ◽  
pp. 541-559 ◽  
Author(s):  
Brandi Pernell ◽  
Michael DeBaun ◽  
Kathleen Becker ◽  
Mark Rodeghier ◽  
Valencia Bryant ◽  
...  
Keyword(s):  
Medication Adherence ◽  
African Americans ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Short Message Service ◽  
Intervention Group ◽  
Short Message ◽  
Cell Disease ◽  
Act Scores ◽  
Message Service

SummaryIntroduction: Sickle cell disease (SCD) is a childhood and adult disease that primarily affects African Americans, characterized by life threatening sequelae mitigated by medications. One-way and two-way short message service (SMS) medication reminders have differing efficacy in chronic diseases. There is limited literature about SMS medication reminders in SCD.Objective: The goal of this study was to test the feasibility, defined by recruitment/acceptance, retention/attrition, and technology utilization, of two-way SMS medication reminders in individuals with SCD with and without asthma.Materials and Methods: Participants were randomly allocated to standard care or reminders. Two-way SMS reminders were automated using Research Electronic Data Capture (REDCap) for hydroxyurea, fluticasone, budesonide and montelukast. Adherence was measured using the Morisky Medication Adherence Scale-8 (MMAS-8). Asthma control was assessed using the Childhood and Adult-Asthma Control Tests (ACT). Participants were enrolled 28 to 60 days with a common termination date.Results: The recruitment rate was 95% (47/49) and 82.9% completed the study. Among the 47 study participants enrolled, 51.1% were male, 61.7% were adults, median age was 20 (range: 3 to 59), and 98% were African Americans. Of the 26 participants receiving messages, 20% responded on over 95% of the days and usage varied with an average response rate of 33%, ranging from 21% to 46%. Medication adherence scores improved significantly in the intervention group (3.42 before, 5.46 after; p=0.002), but not in the control group (3.90 before, 4.75 after; p=0.080). Childhood-ACT scores improved in the intervention group (19.20 before, 24.25 after). Adult-ACT scores within the intervention arm were unchanged (21.0 before, 22.0 after. ACT scores did not improve significantly.Conclusion: This study demonstrated the feasibility for two-way SMS medication reminders to improve medication adherence in a high-risk population where daily medication adherence is critical to health outcomes and quality of life.Citation: Pernell BM, DeBaun MR, Becker K, Rodeghier M, Bryant V, Cronin RM. Improving medication adherence with two-way short message service reminders in sickle cell disease and asthma: A feasibility randomized controlled trial. Appl Clin Inform 2017; 8: 541–559 https://doi.org/10.4338/ACI-2016-12-RA-0203

scholarly journals The Feasibility of a Using a Smart Button Mobile Health System to Self-Track Medication Adherence and Deliver Tailored Short Message Service Text Message Feedback

10.2196/13558 ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. e13558
Author(s):  
Rebecca J Bartlett Ellis ◽  
James H Hill ◽  
K Denise Kerley ◽  
Arjun Sinha ◽  
Aaron Ganci ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Health System ◽  
Mobile Health ◽  
Short Message Service ◽  
Text Message ◽  
Short Message ◽  
Message Service

scholarly journals THE EFFECT OF SHORT MESSAGE SERVICE (SMS) TEXTING ON MEDICATION ADHERENCE AMONG TUBERCULOSIS PATIENTS

2019 ◽  
Vol 13 (1) ◽  
pp. 49
Author(s):  
Yunus Adhy Prasetyo
Keyword(s):  
Medication Adherence ◽  
Short Message Service ◽  
T Test ◽  
Control Group ◽  
Short Message ◽  
Tuberculosis Patients ◽  
The Public ◽  
Significant Difference ◽  
Message Service ◽  
Experimental Group

The study was conducted to examine the effect of Short Message Service (SMS) Texting on medication adherence among tuberculosis patients. 68 persons diagnosed with tuberculosis and registered in the public health center in Klari, Karawang, West Java, Indonesia, were randomly appointed to an experimental or control group; 34 persons assigned to each group. Participants in the experimental group received routine SMS Texting, while those in the control group receive none. Data were analyzed using Dependent t-test and Independent t-test. The results indicated that after participating by receiving SMS texting, there was a significant improvement in medication adherence in TB patients in the experimental group, which was shown by significant difference in mean score of medication adherence. In addition, after participating in the program, there was a meaningful difference in mean scores of medication adherence between the experimental group (X=6.38, SD=0.85) and the control group (X=3.64, SD=1.04), p<0.01. The SMS Texting method appears to be effective in improving medication adherence among TB patients.

LAYANAN PESAN SINGKAT PENGINGAT MENINGKATKAN KEPATUHAN MINUM OBATPASIEN DIABETES MELITUS DI RSUD ULIN BANJARMASIN

2017 ◽  
Vol 1 (1) ◽  
pp. 57
Author(s):  
Riza Alfian
Keyword(s):  
Blood Glucose ◽  
Medication Adherence ◽  
Short Message Service ◽  
Patient Adherence ◽  
Fasting Blood Glucose ◽  
Short Message ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Message Service ◽  
Diabetes Melitus

Diabetes melitus is one ofthe metabolic disorders with characteristic hyperglycemia that occurs due to abnormal insulin secretion, insulin resistance or both. The non adherence patients of taking antidiabetic drugs are the main factors that could cause high blood glucose levels, so it is necessary an intervention to achievedoutcome therapy desired. Giving of short message service reminder intervention in diabetes mellitus patients was expected to improved the medication adherence and achieved normal blood glucose levels.This study was conducted to determine the effect of a short message service reminder on medication adherence of ambulatory diabetes melitus patients in Ulin General Hospital Banjarmasin.This study was conducted with quasi-experimental design,the data were taken prospectively during May to June, 2014. The subjects were ambulatory diabetes melitus patients in Ulin General Hospital Banjarmasin who had received oral antidiabetic drugs. Subject who met the inclusion and exclusion criteria were 39 patients and had given an intervention for seven days. The data collected by interviews and pill counting on filling sheet. The blood glucose levels data was taken from their medical records.The result showed that giving of a short message service reminder intervention improve patient adherence (p<0,05). Fasting blood glucose level and blood glucose level two hours post prandial have decreased significantly (p<0,05). There were correlation between the patient adherence and the decreasing in fasting blood glucose levels (p=0,050; r=0,316) and blood glucose two hours post prandial levels (p=0,010; r=0,040).Based on these result, it can be concluded that the giving of short message service reminder in diabetes melitus patientshas been improved patient adherence.

scholarly journals Acceptability and feasibility of short message service to improve ART medication adherence among people living with HIV/AIDS receiving antiretroviral treatment at Adama hospital medical college, Central Ethiopia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tamrat Endebu ◽  
Alem Deksisa ◽  
Warku Dugasa ◽  
Ermiyas Mulu ◽  
Tilahun Bogale
Keyword(s):  
Medication Adherence ◽  
Antiretroviral Therapy ◽  
Antiretroviral Treatment ◽  
Short Message Service ◽  
People Living With Hiv ◽  
Short Message ◽  
Central Ethiopia ◽  
Message Service ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background People living with HIV/AIDS are facing sub-optimal adherence to antiretroviral therapy. Short message service innovative strategies have been recommended by the national strategy to support medication adherence among HIV positive people. Thus, this study was conducted to examine the feasibility and acceptability of a short message service to improve medication adherence among people living with HIV/AIDS receiving Antiretroviral Treatment. Methods We conducted a cross-sectional survey, from February 5 to 30, 2018, among 422 randomly selected adults living with HIV/AIDS receiving antiretroviral treatment at Adama Hospital. Interviewer administered structured questionnaire was used to collect quantitative data on the feasibility and acceptability of short message services, socio-demographic and clinical characteristics of participants. Qualitative data were also collected from two focus groups to supplement the quantitative findings. Logistic regression analysis was performed to identify factors associated with the feasibility and acceptability of short message services. Results Of 420 participants responded to our questionnaire, about nine of ten patients (93.8%) possessed had a mobile phone. Most of the patients (90.9%) were willing to accept SMS to improve their medication adherence. Patients who were in young age, early adult, disclosed their HIV status, having cell phone always and believe short message service aid adherence were more likely to accept short messages on adherence. On the other hand, frequent ART Clinic visit and perceived low confidentiality of short message service were negatively associated with acceptability of short message service. Conclusion The acceptability of short message service on adherence to antiretroviral therapy was high among people living with HIV/AIDS central Ethiopia. Authors recommend further studies, piloting or experimenting, that validate the acceptability, feasibility, effectiveness, and scalability of the intervention.

Reflections of Healthcare Experiences of African Americans With Sickle Cell Disease or Cancer

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Brenda W. Dyal ◽  
Khulud Abudawood ◽  
Tasha M. Schoppee ◽  
Stacy Jean ◽  
Valandrea M. Smith ◽  
...  
Keyword(s):  
African Americans ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Healthcare Experiences

scholarly journals Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease

2015 ◽  
Vol 41 (4) ◽  
pp. 406-418 ◽  
Author(s):  
Kristin Loiselle ◽  
Jennifer L. Lee ◽  
Lauren Szulczewski ◽  
Sarah Drake ◽  
Lori E. Crosby ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Pediatric Patients ◽  
Cell Disease ◽  
Analytic Review

Sickle Cell Disease

2013 ◽  
Author(s):  
Alexandra Szabova ◽  
Kenneth R Goldschneider
Keyword(s):  
African Americans ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Sickle Cell Trait ◽  
Anesthetic Management ◽  
Cell Disease

0.2% of African-Americans have sickle cell anemia while, with 8% to 10% have sickle cell trait. This chapter provides an overiew of the etiology, pathophysiology, and treatment of sickle cell anemia as they affect anesthetic management—before, during, and after surgery.

Genetic Variation In MYH9 Is Associated with Sickle Cell Disease Nephropathy

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1648-1648
Author(s):  
Emmanuel Okocha ◽  
Melanie Garrett ◽  
Karen Soldano ◽  
Laura M. De Castro ◽  
Jude Jonassaint ◽  
...  
Keyword(s):  
High Risk ◽  
African Americans ◽  
Sickle Cell Disease ◽  
Renal Dysfunction ◽  
Sickle Cell ◽  
Heavy Chain ◽  
Multiple Testing ◽  
Risk Haplotype ◽  
Cell Disease ◽  
Data Set

Abstract Abstract 1648 Background: Renal failure occurs in 5–18% of sickle cell disease (SCD) patients and is a major risk factor for early mortality. However, there is no established method of identifying SCD patients that are at high risk of developing this outcome prior to the appearance of proteinuria, and its pathobiology is not well understood. The non-muscle myosin heavy chain ll-A (MYH9) gene, which encodes the heavy chain of myosin II-A in the podocyte cytoskeleton, has been identified as driving the high risk of focal segmental glomerulosclerosis (FSGS) and end-stage renal disease in African Americans. Methods: We genotyped 26 single nucleotide polymorphisms (SNPs) in the MYH9 gene in 521 unrelated adult (18 – 83 years) SCD patients who had been screened for proteinuria. Logistic regression was used to determine if the SNPs predicted risk for proteinuria among the patients. Results: Of 521 adult SCD patients studied, 140 had proteinuria, while 381 did not. On average, subjects with proteinuria were 6 years older than subjects without proteinuria (p<0.0001). The odds of having proteinuria increased by 1.04 (4.2%) for every one year increase in age, starting at age 18. We found association with proteinuria for 8 SNPs in MYH9, with nominal p values ranging from 0.025 to 0.0001. Two of these SNPs (rs5756129 and rs1005570) had been previously associated with FSGS in African-Americans without SCD (Kopp et al., 2008). Five SNPs remained significant after correcting for multiple testing (p < 0.003) using the method described by Li and Ji (2005), and a risk haplotype significantly associated with proteinuria (p=0.001) was identified. The frequency of proteinuria among individuals who were homozygous for the risk genotype ranged from 40–50% for each of the five SNPs remaining significant after adjusting for multiple testing, while the risk of proteinuria for individuals who did not have that genotype ranged from 20–30%. Glomerular filtration rate was negatively correlated with proteinuria (r = -0.25, p < 0.0001) but was not itself associated with MYH9 SNPs. Although we tested for association of proteinuria with the two most significant BMPR1B SNPs found by Nolan et al. (2007), neither were associated with proteinuria or GFR in age-adjusted analysis of our cohort, although we did observe nominal evidence for association of a different BMPR1B SNP with proteinuria in our data set (rs1434536, p=0.004, age adjusted). To further investigate a possible connection between BMPR1B and MYH9, we performed regression analyses including BMPR1B SNPs (rs1434536, rs2240036 and rs4145993) and the MYH9 haplotype in the models and controlled for age. In these analyses, the MYH9 risk haplotype remained a significant predictor of proteinuria and was only borderline associated with GFR. None of the BMPR1B SNPs were associated with proteinuria or GFR when the MYH9 haplotype was included in the model, suggesting that MYH9 is likely the more important contributor to these processes in our data set. Conclusion: Our data provide additional support for the role of MYH9 in renal dysfunction among African Americans. A specific haplotype appears to be associated with increased risk for proteinuria among patients with SCD. The association of MYH9 with renal dysfunction in SCD provides insight into the pathophysiology of this process and may lead to early identification of patients at risk and, ultimately, to new modes of therapeutic intervention. Disclosures: De Castro: GlycoMimetics: . Telen:GlycoMimetics: Consultancy, clinical trial sponsorship.

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