LITARARY REVIEW OF KARNINI YONIVYAPAD

In classical Ayurveda texts almost all the gynecological disorders come under the term 'Yonivyapad’. Kar-nini Yonivyapad is one among these twenty Yonivyapadas. Although the cardinal symptom of the disease is excessive vaginal discharge, but often the long-term sequel of the disease like lower dyspareunia, ab-dominal pain, low backache, sickness feeling, fatigue etc. become too much troublesome to the patients and start affecting their daily routine. All Though it is not fatal, yet the long-term association with the dis-ease and a number of symptoms both related to the genitourinary system as well as psychological imbal-ance in the patients need attention. The treatment modalities described in modern science have their own disadvantages and side effects. Moreover, they are not cost effective and being carried at higher medical centers only. Owing to the com-plexities in the modern management, it is the basic need of time to develop a dependable and easily availa-ble therapeutic intervention cost effective, safe and devoid of complications or side effects. With this background this research project entitled.

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A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210413 ◽

2021 ◽

Vol 11 (4) ◽

pp. 102-105

Author(s):

Lalita Sharma ◽

Sudama Singh Yadav

Keyword(s):

Fungal Infection ◽

Health Problem ◽

Skin Diseases ◽

Modern Science ◽

Treatment Modalities ◽

Major Health Problem ◽

Psychological Burden ◽

Major Health ◽

Almost All ◽

Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

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A ROLE OF JALUAKAAVCHARANAAND NIMBA HARIDRACHOORNA LEPA IN TREATMENT OF INDRALUPTA - A CASE STUDY

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2409062021 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1299-1302

Author(s):

Sejalgamit Sejalgamit

Keyword(s):

Side Effects ◽

Female Patient ◽

Hair Loss ◽

Medical Science ◽

Modern Science ◽

Human Being ◽

Contemporary Science

Hair is crowning glory and mark of identity of human being. Indralupata in modern science correlate with alopecia aereata. It is characterized by localised areas of non-scarring hair loss which can be co-related with indralupta. Due to side effects and limitation of contemporary science, some harmless and effective medicines are expected from alternative medical science. indralupta disease is described under heading of kshudraroga by sushruta, vagbhata etc.in modern science its main treatment is corticosteroids which is having harmful side effects and not advisable for long term use.so it is necessary to find better remedies .it can be easily fulfilled by Ayurveda. Here, a case of female patient suffering from indralupta was successfully treated with jaluaka and haridra and nimbalepa. Keywords: kshudraroga, indralupta, jaluaka, haridra and nimbalepa

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Problems and Benefits Associated With Restorative Materials: Side-Effects and Long-Term Cost

Advances in Dental Research ◽

10.1177/08959374920060012001 ◽

1992 ◽

Vol 6 (1) ◽

pp. 7-16 ◽

Cited By ~ 27

Author(s):

Ivar A. Mjör

Keyword(s):

Side Effects ◽

Dental Materials ◽

Cost Effective ◽

Oral Mucous Membrane ◽

Restorative Materials ◽

Restorative Therapy ◽

Lichenoid Reactions ◽

The Cost ◽

Amalgam Restorations

The paper reviews data on biological side-effects of dental materials on patients and also on personnel who routinely handle the materials. The incidence of adverse effects is low-in one study indicated to be 1:700 for all types of treatments. For individual types of materials, it will be significantly lower, and for restorative materials, probably in the 1 : 10,000 to 1:20,000 range. Allergic reactions are the most common type of adverse effect of dental materials. Lichenoid reactions on the oral mucous membrane adjacent to amalgam restorations are the most frequently encountered side-effects for a specific group of restorative materials. Cost analyses were based on reports of longevity of different restorations and the cost of restorations at the time of placement. Amalgam restorative therapy was more cost-effective than composite restorations and gold castings.

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Evidence Based Herbal Medicine for Modern Dentistry

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2431 ◽

2020 ◽

Vol 11 (3) ◽

pp. 3171-3176

Author(s):

Chinmayee Dahihandekar ◽

Sweta Kale Pisulkar ◽

Rohit Mistry ◽

Hetal Purohit

Keyword(s):

Side Effects ◽

Herbal Medicine ◽

Antifungal Agent ◽

Cost Effective ◽

Treatment Modalities ◽

Evidence Based ◽

Traditional Medicines ◽

Inflammatory Agent ◽

Naturally Occurring ◽

Permanent Cure

Ayurveda is a branch of medicine pertaining with the treatment modalities utilizing the natural ways . Traditional medicine has several benefits including being economically beneficial and having lesser toxic effects also proven to be a permanent cure when compared with its allopathic counterparts . The benefits of several such naturally occurring medicines is still not clear . They are used as anti-inflammatory agent , antifungal agent and can also be used as antioxidants and analgesics . Introducing Herbal Medicine into Dentistry will be beneficial in several aspects like relieving pain , inflammation , being cost effective and readily available etc. Apart from all the uses , the belief that ‘The herbal medicine is devoid of side effects is not true . Despite of all these advantages of traditional medicines , the amount of their usage is comparatively less owing to the lack of its awareness. Hence the objective of the article is to mention the uses and toxicities of most commonly used herbs and their usage in dentistry

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Incorporating patient preferences into osteoarthritis treatment

Archives of Rheumatology ◽

10.46497/archrheumatol.2022.8291 ◽

2021 ◽

Vol 36 (4) ◽

pp. 577-586

Author(s):

Yeşim Gökçe Kutsal ◽

Sibel Eyigör ◽

Sevilay Karahan ◽

Rezzan Günaydın ◽

Jale İrdesel ◽

...

Keyword(s):

Physical Therapy ◽

Side Effects ◽

Physical Therapy Modalities ◽

Treatment Modalities ◽

Easy Access ◽

Oral Drugs ◽

Therapy Program ◽

Home Based ◽

Physical Therapy Program

Objectives: This study aims to identify the relationship between treatment modalities and the patients’ preferences in osteoarthritis (OA) treatment and identify the related factors. Patients and methods: This multi-center, cross-sectional study included a total of 305 patients with OA (66 males, 239 females; mean age: 66.4±9.7 years; range, 38 to 90 years) between July 2019 and January 2020. Data including demographic and clinical characteristics of the patients were recorded using a structured questionnaire. Results: The mostly common involvement sites were knee joints, lumbar, and cervical regions, respectively. Prior to the study, the treatment modalities which were prescribed to patients were oral drugs (79.7%), topical drugs (73.8%), home-based exercise program (62.6%), and physical therapy (outpatient) (61.3%). Of the recommended remedy, 89.2% were prescribed by physiatrists, 24.6% by orthopedists, 5.6% by family practitioners, 2.6% by neurosurgeons, and 1.6% by algologists. The most beneficial treatments (to whom) were inpatient physical therapy program (47%), oral drugs (41%), home-based exercise programs (24.9%) according to patients’ perspective. According to patient preferences, nearly half of the patients preferred outpatient physical therapy program (45.9%), oral drugs (33.1%), inpatient physical therapy (20%), and home-based exercises (18%). The most common reasons for their preferences were previous benefits from treatment (54.4%), long-term effects (38%), easy access to treatment (33.1%) and concerns about side effects (28.9%). The mostly common reasons for their preferences were previous benefits from the treatment (54.4%), long-term positive effects of physical therapy (38%), easy access to the treatment (33.1%) and concerns about side effects of drugs (28.9%). Conclusion: Besides medical regimen, the results of this study showed that the patients preferred outpatient and inpatient physical therapy modalities, and home-based exercises programs. In the light of these findings, initiation of a new prescription (e.g., drugs or physical therapy modalities) in OA patients, previous treatment modalities, and approaches are suggested to be carefully reviewed by the clinician to anticipate and improve the adherence behavior to the new treatment.

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Side Effects and Cancer-Related Stress Determine Quality of Life in Long-Term Survivors of Testicular Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2005.08.048 ◽

2005 ◽

Vol 23 (13) ◽

pp. 3061-3068 ◽

Cited By ~ 89

Author(s):

Arnstein Mykletun ◽

Alv A. Dahl ◽

Carl Fredrik Haaland ◽

Roy Bremnes ◽

Olav Dahl ◽

...

Keyword(s):

Quality Of Life ◽

Side Effects ◽

Testicular Cancer ◽

Treatment Modality ◽

Treatment Modalities ◽

Sf 36 ◽

Related Stress ◽

Long Term Survivors

Purpose The prevalence of long-term survivors after treatment for testicular cancer (TC) is increasing, and most studies display normal or only slightly reduced quality of life (QOL) in TC survivors (TCSs). Impaired QOL is claimed to be associated with treatment modality and its side effects, although most studies in this field can be criticized for various methodologic shortcomings. We wanted to examine variation in long-term QOL in TCSs in relation to TC treatment modality, side effects, and TC-related stress in a large population. Patients and Methods QOL, side effects, and TC-related stress were self-rated by a questionnaire at a mean of 11 years of follow-up in 1,409 TCSs treated from 1980 to 1994. Norm data was obtained from 2,678 males who were representative of the general population. QOL was measured with the Short Form-36 (SF-36), and TC-related stress was measured with the Impact of Event Scale. Results There were no clinically relevant differences in QOL between TCSs and age-adjusted norm data, although there was a slightly lowered SF-36 Physical Component Summary Score in TCSs. Variation of QOL in TCSs was related to self-reported side effects and TC-related stress but not to TC treatment modality. A significant association was found between side effects and TC-related stress. Conclusion TCSs do not suffer long term from reduced QOL, and only minor differences in QOL were found between different treatment modalities. TCSs who report more side effects or TC-related stress have increased risk for reduced QOL, but these associations are not explained by TC treatment modalities. Further QOL research in this area should explore vulnerability factors for side effects and TC-related stress.

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Effect in antipsychotic-induced hyperprolactinemia after switching to long-acting injectable aripiprazole: A 1-year study

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1585 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s815-s816

Author(s):

M. Juncal Ruiz ◽

B. Fernández-Abascal Puente ◽

O. Porta Olivares ◽

M. Gómez Revuelta ◽

R. Landera Rodríguez ◽

...

Keyword(s):

Side Effects ◽

Sexual Dysfunction ◽

Clinical Improvement ◽

Drug Induced ◽

Oral Olanzapine ◽

Competing Interest ◽

One Year ◽

Long Acting ◽

Almost All

IntroductionAntipsychotic-induced hyperprolactinemia is associated with relevant side effects: short-term as hypogonadism, gynecomastia, amenorrhoea, sexual dysfunction and galactorrhoea; long-term as cardiovascular disease, bone demineralization and breast and prostate tumors.AimsTo evaluate the effect of switching to long-acting injectable aripiprazole on long-lasting antypsychotic-induced hyperprolactinemia.MethodsThis was a prospective observational 1-year study carried out in 125 outpatients with schizophrenia who were clinically stabilized but a switching to another antipsychotic was indicated. We measured the basal prolactine at the start of the study and 1 year after switching to long acting injecatable (LAI) aripiprazole.ResultsIn basal analytic, 48% had hyperprolactinemia (21.8–306.2 ng/mL) and 66.5% of them described side effects: 78% sexual dysfunction (72% men), 11% galactorrhoea (100% women), 5.5% amenorrhoea and 5.5% bone pain (100% women). In 48% of patients with hyperprolactinemia, the previous antipsychotics comprised: LAI-paliperidone (65,7%), oral-risperidone (7%), oral-olanzapine (6.1%), oral-paliperidone (5.2%), LAI-risperidone (4%) and others (12%). One year after switching to LAI-aripiprazole, prolactine levels were lower in all patients and in 85% prolactine levels were normalized. Overall, 72% described a clinical improvement, especially in terms of sexual dysfunction.ConclusionsSeveral studies have described an improvement of drug-induced hyperprolactinemia after switching to or adding oral aripiprazole. In our study, we observed that levels of prolactine were normalized in 85% of patients with a clinical improvement in almost all of cases. These findings suggest that switching to LAI aripiprazole may be an effective alternative for managing antipsychotic-induced hyperprolactinemia due to its partial agonism in D2 brain receptors, especially in tuberoinfundibular pathway.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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MANAGEMENT OF VITILIGO (SHVITRA) ACCORDING TO AYURVEDA: A CASE STUDY

AYUSHDHARA ◽

10.47070/ayushdhara.v6i1.436 ◽

2019 ◽

pp. 2040-2044

Author(s):

Rupali R. Patil

Keyword(s):

Side Effects ◽

Clinical Features ◽

Skin Diseases ◽

Autoimmune Disorders ◽

Medical System ◽

Lymphocytic Infiltrate ◽

Treatment Modalities ◽

Affected Area

The color of the skin is important biologically, cosmetically and socially. Vitiligo is an acquired condition where melanocytes are absent in affected area. The worldwide prevalence of Vitiligo is lesser than 1%. Though the condition is rare and non communicable, patients who are suffering from Vitiligo may experience cosmetically disfiguring and psychological problems like depression. It is not clear why the melanocytes disappear from the skin. Theories regarding the Vitiligo include an autoimmune cause because of association with other autoimmune disorders, presence of antimelanin antibodies and lymphocytic infiltrate in early lesions. In Ayurveda, all the skin diseases are described under the heading of ‘Kushta’, which are further divided in to two namely ‘Mahakushta’ and ‘Kshudra Kushta’. Shvitra has been mentioned separately. Based upon clinical features of Shvitra, it can be correlated with Vitiligo. Aacharya Charak has mentioned Shvitra under the ‘Rakta Pradoshaj Vikara’. Considering the limitations of modern medical system and side effects associated with long term use of medicines, Ayurveda has much more convincing treatment modalities for Vitiligo. In present study emphasis has been made to study efficacy of Shvitrahara Vati and Shitrahara Lepa in Shvitra (Vitiligo).

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Comparative study of the efficacy of oral caroverine versus oral Gingko biloba in the treatment of cochlear synaptic tinnitus

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20195694 ◽

2019 ◽

Vol 6 (1) ◽

pp. 82

Author(s):

Sachin Jain ◽

Kinshuk Chatterjee ◽

M. Aftab ◽

Dinesh Kumar ◽

Ramsiya Singh ◽

...

Keyword(s):

Side Effects ◽

Ampa Receptors ◽

Glutamate Release ◽

Cost Effective ◽

Oral Formulation ◽

Gingko Biloba ◽

Effective Treatment Modality ◽

Co Morbidity ◽

Term Basis

Background: Cochlear synaptic tinnitus (CST), also referred to as sensorineural type III tinnitus, is a type of transformation tinnitus, resulting due to aberrant signal transduction between Inner hair cells and afferent nerve fibres owing to excessive and pathologic glutamate release and subsequent spontaneous receptor depolarization (NMDA and AMPA receptors). Of the various pharmacologic agents used for treatment for CST, Gingko biloba and Caroverine have stood the test of time.Methods: A total 48 selected patients of CST, otherwise free from any medical or surgical co-morbidity, were included in the study and divided randomly in two groups, one group receiving oral formulation of Caroverine and the other group receiving oral Gingko biloba in appropriate doses. Both the groups were followed up for 12 weeks. Treatment outcomes were measured in terms of improvement in subjective symptoms (tinnitus grading) and psycho-acoustic measure (tinnitus matching).Results: Although oral caroverine yielded promising results in the initial month of treatment in terms of improved tinnitus matching, long term effect was found to be dissatisfying. Oral Gingko biloba, at the completion of 12 weeks of therapy was found to be more effective in terms of improvement of mean tinnitus grading and matching (p<0.05). Side effects of the test drugs were not noted in either group.Conclusions: Gingko biloba is thus found to be more effective treatment modality for CST for long term basis and is also readily available in the market, cost effective and free of side effects as well.

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Induced Lactation for Adoptive Breastfeeding Dyads

Clinical Lactation ◽

10.1891/2158-0782.10.3.127 ◽

2019 ◽

Vol 10 (3) ◽

pp. 127-135

Author(s):

Asti Praborini ◽

Dyah Febriyanti ◽

Ria Subekti

Keyword(s):

Side Effects ◽

Breast Milk ◽

Medical Care ◽

Prospective Studies ◽

Working Mothers ◽

Breastfeeding Duration ◽

Inclusion Criteria ◽

Women And Children ◽

Almost All

IntroductionBreastfeeding has many benefits for both mother and baby, but not all mothers can have their own babies. Here we used an induced lactation protocol to breastfeed adopted babies.Materials and MethodWe implement and describe an induced lactation protocol for adoptive breastfeeding dyads at Kemang Medical Care (KMC) Women and Children Hospital and Permata Depok Hospital, Greater Jakarta, Indonesia. Participants included 32 of 48 breastfeeding dyads or subjects undergoing induced lactation protocols and fulfilling the inclusion criteria. The induced lactation protocol included the Praborini Method (hospitalization for nipple confusion) to promote latching, pharmacologically induced lactation, and at-breast supplementation.ResultsNineteen babies (59.4%) were aged <1 month and nine (28.1%) were aged 1–3 months at protocol initiation. Almost all (31 babies, 96.8%) were adopted after birth. At first examination, 20 babies (62.5%) could not latch, but all dyads could breastfeed after hospitalization for <1–2 days. Breast milk was induced after one cycle of Yasmin in 24 cases (75%). All mothers took domperidone and no side-effects were reported. Average breastfeeding duration was 8.5 months, with weaning at 2–25 months of age, with working mothers weaning at ≤4 months. At-breast supplementation was used until weaning.ConclusionsAdopted babies can achieve long-term breastfeeding through this multimodal protocol. Further prospective studies are warranted.

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