Pharmacotherapeutic Considerations in the Management of Hypertensive and Diabetic COVID-19 Patients

2021 ◽  
Vol 3 (4) ◽  
Author(s):  
Samra Bashir ◽  
Nitasha Gohar

The COVID-19 disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 has emerged as a pandemic inflicting more than 229 million people over the globe. Preexisting illnesses including diabetes, hypertension, and cardiovascular diseases are known to increase the risk of developing severe disease course and mortality. Likewise, COVID-19 potentiates the risk of acute cardiovascular events, multiorgan damages and, poor glycemic control among the patients. Special pharmacotherapeutic considerations are, therefore, essential for optimal treatment of COVID-19 patients with chronic comorbidities. In this editorial, we have summarized and interpreted the current information and guidelines about the need for pharmacotherapy adjustment in COVID-19 patients with hypertension and type II diabetes. Diabetic and hypertensive patients with mild to moderate COVID-19 disease should be encouraged to continue their usual medications with frequent monitoring. However, the choice of antidiabetic drugs needs to be reviewed in severe diseases.

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sajel Nuwamanya ◽  
Alex Lea ◽  
Paul Abraham ◽  
Rubin Varghese ◽  
Jennifer Kendall

2001 ◽  
Vol 16 (3) ◽  
pp. 186-190 ◽  
Author(s):  
K.N. Roy Chengappa ◽  
J. Levine ◽  
D. Rathore ◽  
H. Parepally ◽  
R. Atzert

SummaryTopiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.


2011 ◽  
Vol 106 ◽  
pp. S85
Author(s):  
Roger Gibb ◽  
David Ramsey ◽  
Hing Tse ◽  
David McCauley-Myers ◽  
John McRorie

2019 ◽  
Vol 28 (6) ◽  
pp. 533-538
Author(s):  
Selen Nihal Sisli

Objective: This study aimed to investigate the prevalence of apical periodontitis (AP) in patients with type II diabetes mellitus (DM) with either optimal glycemic control (OGC) or poor glycemic control (PGC) compared with nondiabetics using cone beam computed tomography (CBCT). Subjects and Methods: The periapical status of 75 teeth with adequate root canal treatment performed at least 1 year ago that could be visualized in the field of view of CBCT images of 43 DM patients (29 females, 14 males) was compared with a control group consisting of 162 teeth of 86 nondiabetics (56 females, 30 males). In addition, the DM group was divided into subgroups according to the patients’ mean glycated hemoglobin level as either having OGC or PGC. The periapical status of the teeth was evaluated using the CBCT periapical index (CBCTPAI), and AP was diagnosed as a CBCTPAI ≥1. χ2, Fisher’s exact test, and independent-samples t tests were used for the statistical analysis, and p < 0.05 was considered significant. Results: Significant differences between the DM group and the control group were observed (p< 0.05) in terms of AP (the frequencies of both CBCTPAI ≥1 and CBCTPAI ≥3) and the frequency of cardiovascular disease, while there were no significant differences between the DM subgroups (p > 0.05). Conclusion: The prevalence of AP and severe bone destruction in periapical tissues was significantly higher in the DM patients compared with the nondiabetic patients.


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