scholarly journals Risk of neurally mediated syncope in hypothyroidism and obesity

2021 ◽  
Vol 129 (3) ◽  
Author(s):  
José Ramón Lanz-Luces ◽  
José Manuel Lanz-Luces ◽  
Luis Fernando Escobar Guzmán ◽  
José Daniel Lanz-Souquett ◽  
Héctor Aceituno ◽  
...  
Keyword(s):  
Weight Gain ◽  
Thyroid Hormones ◽  
Cardiac Function ◽  
Autonomic Dysfunction ◽  
Neurally Mediated Syncope

Introduction and rationale: Thyroid hormones participate in several known mechanisms of cardiac function, being compromised in hypothyroidism (HPT), when uncontrolled, is associated with weight gain. HPT and Obesity participate in autonomic dysfunction.

scholarly journals Association Between Weight Gain, Blood Parameters, and Thyroid Hormones and the Development of Ascites Syndrome in Broiler Chickens

2001 ◽  
Vol 80 (7) ◽  
pp. 965-971 ◽  
Author(s):  
D. Luger ◽  
D. Shinder ◽  
V. Rzepakovsky ◽  
M. Rusal ◽  
S. Yahav
Keyword(s):  
Weight Gain ◽  
Thyroid Hormones ◽  
Broiler Chickens ◽  
Blood Parameters ◽  
Ascites Syndrome

Thyroid hormones improve cardiac function and decrease expression of pro-apoptotic proteins in the heart of rats 14 days after infarction

APOPTOSIS ◽  
2015 ◽  
Vol 21 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Alexandre Luz de Castro ◽  
Rafael Oliveira Fernandes ◽  
Vanessa D. Ortiz ◽  
Cristina Campos ◽  
Jéssica H. P. Bonetto ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cardiac Function ◽  
Apoptotic Proteins

scholarly journals Thyroid Hormones within the Normal Range and Cardiac Function in the General Population: The EPIPorto Study

2020 ◽  
pp. 1-11
Author(s):  
João Sérgio Neves ◽  
Ricardo Fontes-Carvalho ◽  
Marta Borges-Canha ◽  
Ana Rita Leite ◽  
Sandra Martins ◽  
...  
Keyword(s):  
General Population ◽  
Thyroid Hormones ◽  
Cardiac Function ◽  
Normal Range

scholarly journals Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

2021 ◽  
Vol 12 ◽  
Author(s):  
Hiroyuki Yamakawa ◽  
Tomoko S. Kato ◽  
Jaeduk Yoshimura Noh ◽  
Shinsuke Yuasa ◽  
Akio Kawamura ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Cardiac Function ◽  
Cardiovascular System ◽  
Antiarrhythmic Agent ◽  
Current Knowledge ◽  
Cardiac Contractility ◽  
The Body ◽  
The Past ◽  
Systolic And Diastolic Function

Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system. It is well known that THs raise the heart rate and cardiac contractility, improve the systolic and diastolic function of the heart, and decrease systemic vascular resistance. In the past 30 years, some researchers have studied the molecular pathways that mediate the role of TH in the cardiovascular system, to better understand its mechanisms of action. Two types of mechanisms, which are genomic and non-genomic pathways, underlie the effects of THs on cardiomyocytes. In this review, we summarize the current knowledge of the action of THs in the cardiac function, the clinical manifestation and parameters of their hemodynamics, and treatment principles for patients with hyperthyroid- or hypothyroid-associated heart disease. We also describe the cardiovascular drugs that induce thyroid dysfunction and explain the mechanism underlying the thyroid toxicity of amiodarone, which is considered the most effective antiarrhythmic agent. Finally, we discuss the recent reports on the involvement of thyroid hormones in the regulation of myocardial regeneration and metabolism in the adult heart.

Changes in Cardiac Function Following Administration of Thyroid Hormones in Thyroidectomised Rats

1985 ◽  
Vol 7 (2) ◽  
pp. 290-296 ◽  
Author(s):  
I. Brooks ◽  
S. B. Flynn ◽  
D. A. A. Owen ◽  
A. H. Underwood
Keyword(s):  
Thyroid Hormones ◽  
Cardiac Function

Seasonal changes in weight gain, growth hormone, and thyroid hormones in male red deer (Cervus elaphus atlanticus)

1982 ◽  
Vol 60 (11) ◽  
pp. 2577-2581 ◽  
Author(s):  
Morten Ryg ◽  
Rolf Langvatn
Keyword(s):  
Growth Hormone ◽  
Weight Gain ◽  
Food Intake ◽  
Thyroid Hormones ◽  
Cervus Elaphus ◽  
Seasonal Changes ◽  
Red Deer ◽  
Antler Growth ◽  
Gain Peak

To elucidate possible endocrine mechanisms in the control of the weight cycle of red deer, we recorded seasonal changes in the concentrations of growth hormone (GH), thyroxine (T4), and triiodothyronine (T3) in serum. T3 and T4 were analyzed with specific radioimmunoassays, GH was analyzed with a hetereologous radioimmunoassay. Changes in the levels of these hormones were compared with changes in weight gain. T3 levels were high in summer and low in winter, corresponding to changes in weight gain. Peak values (1.75–4.82 nmol/L) were found in May or June, nadirs occurred in April (0.22–1.78 nmol/L) or October–November (0–1.19 nmol/L). GH levels increased to peak values, 20–53 ng/mL, in April to June, but were low during most of the period of fast weight gain. There were no consistent changes in T4 levels corresponding to the weight cycle. We conclude that the GH peaks following the casting of old antlers may be related to the onset of antler growth. Seasonal changes in T3 levels may be secondary to changes in food intake.

Obesity, energy regulation and thyroid function

2008 ◽  
Vol 47 (05) ◽  
pp. 181-187 ◽  
Author(s):  
G. Kahaly ◽  
C. Kobe ◽  
M. Schmidt ◽  
K.-M. Derwahl ◽  
H. Schicha ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Thyroid Hormones ◽  
Weight Reduction ◽  
Body Weight Gain ◽  
Definitive Treatment ◽  
Reference Level ◽  
Rest Energy ◽  
Body Weight Reduction ◽  
Tsh Levels

SummarySeveral population-based studies have shown a significant association between TSH-level and BMI (body mass index). About 30% of the rest energy expenditure are regulated by thyroid hormones, which generated the hypothesis that thyroid hormone substitution with TSH-titration into the lower reference levels may prevent body weight gain. The opposite effect of thyroid hormones is appetite stimulation, which may be responsible for body weight gain in case of substitutive medication.The association between TSH and BMI has become a complex topic in the light of the endocrine activity of adipocytes. Adipocytes are not a silent fat mass, but increase the hormone level of leptin, which influences neurones in the hypothalamus, the thyreotropic axis and TSH secretion. BMI is positively correlated with serum leptin. Elevated leptin levels, endogenous in individuals with high BMI or exogenous after leptin injection for treatment of hypothalamic amenorrhoea, shift TSH in the upper reference level. Borderline elevated TSH levels are reversible in case of body weight reduction in obese persons. It remains unclear whether high TSH levels or high leptin level are responsible for obesity or represent secondary phenomenon. Recommendation for daily practice: Borderline elevated TSH-levels in obese patients will decrease in case of body weight reduction without hormone medication. After definitive treatment of hyperthyroidism patient's history for use of carbohydrates (increased during hyperthyroidism) should be noticed and substitution with thyroid hormones aims at TSH in the lower reference level. As body weight gain is observed in all TSH groups, a special concept for prevention and therapy of obesity (diet, daily exercise, behaviour training) should be initiated early and additionally to medication.

Seasonal changes in weight gain, growth hormone, and thyroid hormones in intact and castrated male moose (Alces alces alces)

1982 ◽  
Vol 60 (11) ◽  
pp. 2941-2946 ◽  
Author(s):  
Morten Ryg
Keyword(s):  
Growth Hormone ◽  
Weight Gain ◽  
Thyroid Hormone ◽  
Food Intake ◽  
Thyroid Hormones ◽  
Seasonal Changes ◽  
Alces Alces ◽  
Serum Concentrations ◽  
Rapid Weight Gain ◽  
Thyroid Hormone Levels

To elucidate possible endocrine mechanisms in the control of cyclic weight gain in moose, serum concentrations of growth hormone (GH), thyroxine (T4), and triiodothyronine (T3) were recorded during the year in two intact and one castrated male moose. Changes in the levels of these hormones were compared with changes in weight gain. Growth hormone often increased to peak values in April or May, but was generally low throughout the period of greatest weight gain. Thyroid hormone levels increased in spring and decreased in autumn, corresponding to onset and cessation of rapid weight gain. Changes in triiodothyronine levels may have been secondary to changes in food intake.

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