Low Serum Albumin is A Significant Prognostic Factor in Burn Mortality; A Retrospective Study from January 2016 – November 2020 in Buth Jos Nigeria

Introduction: Albumin is a single polypeptide chain of 585 amino acids synthesized by the liver which accounts for 75-80% Osmotic pressure. Hypo albuminemia in burns occurs due to loss from damage tissues, reduction in hepatic blood and due to inhibitory tissue factor such as Necrotic tissue factor, interleukin 1 and 6 released at burn sites. Method: The information about the 73 patients in our study was from our unit records and the hospital records. We Used the Cobas C III system, colorimetric assay method to carry out the serum albumin and total protein investigations. Result: We had 11 burn mortality out of the 73 patients, and based on the serum albumin at the time of death, those with serum albumin of < 25g/L have burn mortality sensitivity of 90.9% and specificity of 83.3%. Discussion: Amongst all the prognostic factors we evaluated such as type, size of burns, age of patients, inhalational injury, co-morbid factors, we found that serum albumin of < 25g/L to be a more useful prognostic factor in burn mortality. Conclusion: We used serum albumin of < 25g/L in our patients to prognosticate burn mortality and to use this knowledge to optimize their serum albumin to avert death.

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Interaction of dinitrophenyl groups bound to bovine serum albumin with univalent fragments of anti-dinitrophenyl antibody

Biochemical Journal ◽

10.1042/bj1770225 ◽

1979 ◽

Vol 177 (1) ◽

pp. 225-236 ◽

Cited By ~ 4

Author(s):

C. Graham Knight ◽

N. Michael Green

Keyword(s):

Bovine Serum Albumin ◽

Fluorescence Quenching ◽

Serum Albumin ◽

Bovine Serum ◽

Deae Cellulose ◽

Serum Albumins ◽

Single Polypeptide Chain ◽

Quenching Efficiency ◽

Lysine Residues ◽

Single Polypeptide

Two lysine residues of bovine serum albumin reacted with 1-fluoro-2,4-dinitrobenzene with apparent second-order rate constants approx. 500-times greater than those observed in similar reactions with low-molecular-weight lysine derivatives. A series of dinitrophenyl (Dnp)-bovine serum albumins were prepared and their ability to bind univalent fragments of anti-Dnp antibody was measured by fluorescence-quenching titrations. Compared with the Dnp group of the free hapten, 6-N-Dnp-aminohexanoate, the majority of the protein-bound Dnp groups were unavailable to the antibody at pH8.0. When the same Dnp-albumins were titrated at pH3.0 the availability of the Dnp groups increased approx. 3-fold. Dnp-albumins were treated with pepsin at pH3.0 and Dnp-containing fragments isolated by chromatography on DE-52 DEAE-cellulose. Fluorescence-quenching titrations showed that the Dnp groups on the fragments behaved like the free hapten with respect to quenching efficiency, although with an increased dissociation constant. The association between the Dnp-albumins and the antibody was measured also by difference-spectral titrations at high protein concentrations. Antibody binding was increased under these conditions, but the Dnp group of mono-Dnp-albumin remained unavailable to antibody. We propose that the reactive lysine residues are located in clefts between the globular sub-domains of the single polypeptide chain. Dnp groups attached to these lysine residues are fully exposed to the solvent, but binding of the macromolecular probe, anti-Dnp antibody, is sterically hindered by the adjacent surface of the albumin molecule.

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Serum Albumin as a Significant Prognostic Factor for Patients with Gastric Carcinoma

Annals of Surgical Oncology ◽

10.1245/s10434-006-9093-x ◽

2006 ◽

Vol 14 (2) ◽

pp. 381-389 ◽

Cited By ~ 94

Author(s):

Luis F. Oñate-Ocaña ◽

Vincenzo Aiello-Crocifoglio ◽

Dolores Gallardo-Rincón ◽

Roberto Herrera-Goepfert ◽

Rocío Brom-Valladares ◽

...

Keyword(s):

Prognostic Factor ◽

Gastric Carcinoma ◽

Serum Albumin ◽

Significant Prognostic Factor

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Serum albumin as a significant prognostic factor in patients with malignant pleural mesothelioma

Tumor Biology ◽

10.1007/s13277-014-1938-5 ◽

2014 ◽

Vol 35 (7) ◽

pp. 6839-6845 ◽

Cited By ~ 15

Author(s):

Zhou-Hong Yao ◽

Guang-Yan Tian ◽

Shao-Xiang Yang ◽

Yun-Yan Wan ◽

Yan-Meng Kang ◽

...

Keyword(s):

Prognostic Factor ◽

Serum Albumin ◽

Malignant Pleural Mesothelioma ◽

Pleural Mesothelioma ◽

Significant Prognostic Factor

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Relationship between Pretreatment Serum Albumin Levels with the Risk of Malignant Pleural Mesothelioma

International Journal of Statistics in Medical Research ◽

10.6000/1929-6029.2020.09.08 ◽

2021 ◽

Vol 9 ◽

pp. 69-82

Author(s):

Sabyasachi Mukherjee ◽

Keyword(s):

Prognostic Factor ◽

Serum Albumin ◽

Malignant Pleural Mesothelioma ◽

Asbestos Exposure ◽

Disease Diagnosis ◽

Parametric Estimation ◽

Pleural Mesothelioma ◽

Significant Prognostic Factor ◽

Continuous Variables ◽

Pretreatment Serum

Background: Malignant Pleural Mesothelioma (MPM) is a very rare and aggressive form of cancer. Recently it was found that pretreatment Serum Albumin (SA), the main circulating protein in blood is a significant prognostic factor for MPM patients. The objective of this present article is to show the relationship between pretreatment Serum albumin (SA) levels with the risk of MPM. Methods: Generalized additive model (GAM), an advanced regression analysis method has been introduced here to find this mathematical relationship between the response variable (SA) and the cofactors. Results: The main determinates of SA are identified - asbestos exposure, hemoglobin, disease diagnosis status (patients having MPM) are the factors having significant association with SA, whereas duration of asbestos exposure, duration of disease symptoms, total protein (TP), Pleural lactic dehydrogenise (PLD), pleural protein (PP), pleural glucose (PG) and C-reactive protein (CRP) are the significant continuous variables for SA. The non-parametric estimation part of this model shows Lactate dehydrogenase (LDH) and Glucose level are the significant smoothing terms. Additionally it is also found that, second and third order interactions between cofactors are highly significant for SA. Conclusions: The findings of this present work can conclude that - serum albumin may play the role of a very significant prognostic factor for MPM disease and it has been established here through mathematical modeling. Few of the findings are already been exist in MPM research literature whereas some of the findings are completely new in the literature.

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Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myeloma

Annals of Hematology ◽

10.1007/s00277-009-0841-4 ◽

2009 ◽

Vol 89 (4) ◽

pp. 391-397 ◽

Cited By ~ 25

Author(s):

Jeong Eun Kim ◽

Changhoon Yoo ◽

Dae Ho Lee ◽

Sang-We Kim ◽

Jung-Shin Lee ◽

...

Keyword(s):

Multiple Myeloma ◽

Prognostic Factor ◽

Serum Albumin ◽

Disease Severity ◽

Serum Albumin Level ◽

Albumin Level ◽

Significant Prognostic Factor

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Kinetics of Factor X Activation Catalyzed by Factor VII.

10.1055/s-0039-1682801 ◽

1977 ◽

Author(s):

Yale Nemerson

Keyword(s):

Tissue Factor ◽

Factor Viia ◽

Normal Population ◽

Fold Increase ◽

Factor Vii ◽

Factor X ◽

Single Polypeptide Chain ◽

Upward Deflection ◽

Single Polypeptide ◽

Factor X Activation

Factor X activation is the point at which the intrinsic and extrinsic pathways of coagulation converge. Accordingly, events which control the rate of activation of Factor X might be central to the overall control of coagulation. We have therefore attempted to extract the kinetic parameters which govern this reaction. We have also devised and utilized a new assay for this reaction based on the release of radiolabeled activation peptide from Factor X. Utilizing Factor VIIa (2-chain VII) in the presence of saturating amounts of tissue factor, the KM was found to be 0.34 μ M and the Kcat 32 sec-1. The value for the KM is about twice the concentration of Tactor X in plasma. This means that rather small variations in Factor X concentration, such as those encountered in the normal population, would have significant effects on the rate at which Factor X is activated. We have also found that the effect of tissue factor on this reaction is mainly on the catalytic activity of Factor VII although in the absence of tissue factor there is also a 10-fold increase in the KM. Factor VII is predominantly present in plasma as a single polypeptide chain. Utilizing similar techniques we have also examined the reaction catalyzed by this form of Factor VII. All progress curves showed a prolonged lag followed by a sharp upward deflection. The mechanism underlying this phenomenon is now being investigated and will be discussed.

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Association between preoperative serum albumin and prognosis in patients with adrenocortical carcinoma after primary resection: a retrospective study

BMC Cancer ◽

10.1186/s12885-021-08689-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Fuxun Zhang ◽

Zhihong Liu ◽

Jiayu Liang ◽

Shengzhuo Liu ◽

Kan Wu ◽

...

Keyword(s):

Multivariate Analysis ◽

Prognostic Factor ◽

Serum Albumin ◽

Adrenocortical Carcinoma ◽

Statistical Significance ◽

Univariate Analysis ◽

Primary Resection ◽

Rank Test ◽

Significant Prognostic Factor ◽

Preoperative Serum

Abstract Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a poor prognosis. Given the limited treatment options, prognostic assessment of ACC is increasingly crucial. In this study, we aim to assess the correlation between preoperative serum albumin and prognosis in patients with ACC after primary resection. Methods We retrospectively collected and reviewed medical information about 71 ACC patients who underwent primary resection. Survival analysis was performed by Kaplan–Meier analysis with log-rank test or Breslow test. Receiver operating characteristic (ROC) curve and Jordan index was generated to explore optimal cut-off value of albumin. Univariate and multivariate analysis was conducted using Cox’s hazards model. Statistical significance was defined as P < 0.05. Results Among included patients, 33 patients (46.5%) relapsed at the end of follow-up, while 39 patients (54.9%) died. The median overall survival (OS) of included patients was 17 (range 1–104) months, and median recurrence-free survival (RFS) was 10 (range 0–104) months. In univariate analysis, the albumin was significantly associated with OS (HR:0.491, 95% CI: 0.260–0.930, P = 0.029) and RFS (HR: 0.383, 95% CI: 0.192–0.766, P = 0.007). In multivariate analysis, serum albumin as an independent prognostic factor of OS was confirmed (HR: 0.351, 95% CI: 0.126–0.982, P = 0.046). Conclusions Preoperative albumin might be a significant prognostic factor for ACC patients after primary resection. This result may be useful for risk stratification and management of this rare malignancy.

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Blood serum albumin as prognostic factor in patients with colorectal carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.4_suppl.740 ◽

2016 ◽

Vol 34 (4_suppl) ◽

pp. 740-740

Author(s):

Luis F. Onate-Ocana ◽

Sagrario Gonzalez-Trejo ◽

Gloria Nunez ◽

Roberto Herrera-Goepfert ◽

Jose F. Carrillo ◽

...

Keyword(s):

Prognostic Factor ◽

Colorectal Carcinoma ◽

Serum Albumin ◽

Blood Serum ◽

Cox Model ◽

Laboratory Data ◽

Prognostic Index ◽

Prognostic Models ◽

Significant Prognostic Factor ◽

Dismal Prognosis

740 Background: During the las decades, Colorectal carcinoma (CRC) has become the commonest gastrointestinal neoplasm in Mexico, being stages III and IV the most frequent, reaching thus,, diagnosed by colonoscopy and biopsyand a dismal prognosis. Basal blood serum albumin has been reported as significant prognostic factor in several diseases and in several cancers. Therefore, our aim is to define the role of the basal measurement of blood serum albumin at diagnosis as prognostic factor. Methods: Consecutive cases with CRC diagnosed by colonoscopy and biopsy and treated at a single cancer center in Mexico City from January 2010 to December 2014, were included in this cohort. Clinical history and laboratory data were registered, and patients were treated according to standard guidelines. Follow-up continued until September 2015; the Kaplan-Meier method and the Cox model were used to analyze the association of prognostic factors and overall survival (OS). Results: There were 567 patients with CRC: 258 women (45.5%) and 309 males (55.5%); mean age was 60.04 years (SD 15.6). Fifty-seven, 155, 113 and 242 were stages I, II, III and IV, respectively; 132 were located in right colon, 33 in transverse, 35 in left, 114 in sigmoid, 239 in rectum and 14 in anal canal. Neither gender, age, blood hemoglobin, lymphocyte count, albumin-lymphocyte interaction, nor Nutritional prognostic index were significantly associated with OS. Serum albumin was associated to OS, by bivariate and by multivariate analysis. This association remainded significant after adjustment for TNM stages, locations, and other clinically relevant factors. Conclusions: Serum albumin at diagnosis is an independent, significant, simple, cheap and widely available prognostic factor in patients with CRC in Mexico, adding significant prognostic information to TNM classification. Feasibly, it can be used to develop multivariate prognostic models with clinical impact.

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