scholarly journals Illness concepts among patients with benign and malignant mammary tumors

2020 ◽  
Vol 1 (3) ◽  
pp. 49-52
Author(s):  
Lali M. Kogoniya ◽  
◽  
Anna S. Nelubina ◽  
Ekaterina V. Markarova ◽  
Ekaterina E. Tuntsova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Disease Prevention ◽  
Illness Perception ◽  
Mammary Tumors ◽  
Illness Behavior ◽  
Regional Research ◽  
Primary And Secondary Prevention ◽  
Compliant Behavior ◽  
Illness Concept ◽  
Illness Concepts

The paper reports variants of subjective illness perception in patients with benign and malignant mammary tumors. The study included 100 patients followed-up in the Vladimirsky Moscow Regional Research Cinical Institute (MONIKI) (50 patients with stage II–III breast cancer and 50 patients with fibrocystic breast changes). The study provided data on subjective illness concept variants for patients of both groups which defined the illness behavior of patients, including the non-compliant behavior. The results obtained may be used for development of disease prevention programs (primary and secondary prevention).

scholarly journals Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells SurvivalIn Vitro

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Giovanni Vanni Frajese ◽  
Monica Benvenuto ◽  
Rosanna Mattera ◽  
Saverio Giampaoli ◽  
Elena Ambrosin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mammary Tumors ◽  
Experimental Models ◽  
Breast Cancer Cell Lines ◽  
Beneficial Effects ◽  
Significant Prolongation ◽  
Reduced Water

Electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H2and the presence of platinum nanoparticles with antioxidant effects. Many studies have demonstrated that ERW scavenging properties are able to reduce the damage caused by oxidative stress in different experimental models. Although fewin vivostudies have been reported, it has been demonstrated that ERW may display anticancer effects by induction of tumor cells apoptosis and reduction of both angiogenesis and inflammation. In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion. ERW decreased ErbB2/neuexpression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells. In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors. Ourin vivoresults showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control. In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in tumor multiplicity. Overall, these results suggest a potential beneficial role of ERW in inhibiting cancer cells growth.

scholarly journals Evaluation of Platelet Indices and Complete Blood Count in Canine Mammary Tumors

2021 ◽  
Vol 49 ◽  
Author(s):  
Zeynep Günay Uçmak ◽  
Lora Koenhemsi ◽  
Melih Uçmak ◽  
Mehmet Erman Or ◽  
Özge Erdoğan Bamaç ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Tumor ◽  
Blood Count ◽  
Complete Blood Count ◽  
Mammary Tumors ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Platelet Indices ◽  
Grade 3 ◽  
Tumor Types

Background: Malignant mammary tumors in humans and bitches cause hematological disorders such as anemia, erythrocytosis, thrombocytosis, hyperproteinemia, and leucopenia. Novel studies have been conducted on the predictive and prognostic values of platelet (PLT) indices in human breast cancer (HBC). However, there is little information about the alterations in hematological parameters in canine mammary tumors (CMTs). The aims of this study were to evaluate the platelet indices and complete blood count (CBC) parameters in bitches with and without mammary tumor and to assess the above mentioned parameters with regard to histological tumor types and grades.Materials, Methods & Results: A total of 71 bitches were enrolled in this study. The bitches in the study group were divided into 2 groups which consisted of malignant epithelial mammary tumors (group EMT; n = 43) and malignant mixed mammary tumors (group MMT; n = 12). Control group (group C) consisted of clinically and gynaecologically healthy 16 bitches. Blood samples were obtained to perform the CBC and PLT indices analysis. Histopathological examinations were carried out under a light microscope. Histological tumor types and malignancy grades were classified. The bitches with mammary tumor showed significantly increased PLT values and decreased hematocrit (HCT), hemoglobin (HGB) and mean corpuscular hemoglobin (MCH) values versus the healthy ones, regardless of the tumor type. However, in comparisons with the group C, mean platelet volume (MPV) and mean corpuscular hemoglobin concentration (MCHC) values were different only in the group MMT, while plateletcrit (PCT) and mean corpuscular volume (MCV) values were different only in the group EMT. Also white blood cell (WBC), PLT and PCT values were higher than the referenced laboratory ranges in grade 3 tumors. In the presented study, MPV was considerably correlated with PLT, platelet distribution width (PDW) and PCT. Also, PCT and PLT had high sensitivity and specificity to distinct EMT and MMT from the healthy bitches.Discussion: Microcytic and hypochromic anemia occurs due to the decrease in the amount of HGB. Levels of MCV, MCH, and MCHC in the HBC group were reported to be significantly lower than in humans without breast cancer. Although anemia did not occur in EMT and MMT groups, obtained significances in the HCT, HGB, MCV, MCH, and MCHC levels between the bitches with and without mammary tumor were in line with the previous reports. In this study, WBC levels in grade 3 tumors were significantly higher than grade1 tumors (P < 0.05). Whereas levels of WBC in grade 1 and grade 2 tumors were in referenced laboratory ranges, it was higher in grade 3. Increased level of WBC in grade 3 was supposed to be due to the rise in malignancy as previously reported. Thrombocytosis was detected in 48.83% and 41.66% of the bitches in EMT and MMT groups, respectively. The higher percentage of CMTs with thrombocytosis in this study might be due to the difference in referenced upper limit of PLT in previous studies. The elapsed time between tumor formation and clinical presentation could be another influencing factor. Although PLT and PCT values were not significant according to the histological grading in this study, both parameters were found to be higher in grade 3 than the normal reference values. Further studies conducted with higher populations may lead the differences in these parameters to significance. With the support of further studies, alterations in the above mentioned parameters in bitches may contribute in the diagnosis process, management of treatment and may constitute an easy way to have an idea about the prognosis of mammary tumors.

scholarly journals Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

2007 ◽  
Vol 104 (29) ◽  
pp. 12117-12122 ◽  
Author(s):  
S. Rottenberg ◽  
A. O. H. Nygren ◽  
M. Pajic ◽  
F. W. B. van Leeuwen ◽  
I. van der Heijden ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Hereditary Breast Cancer ◽  
Chemotherapy Resistance ◽  
Mammary Tumors ◽  
Conditional Mouse Model

scholarly journals Illness perception and sense of well-being in breast cancer patients

2019 ◽  
Vol Volume 13 ◽  
pp. 1557-1567 ◽  
Author(s):  
Yaelim Lee ◽  
Jong-Min Baek ◽  
Ye-Won Jeon ◽  
Eun-Ok Im
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Illness Perception ◽  
Well Being ◽  
Breast Cancer Patients

scholarly journals Breast cancer prevention: what women think about the illness, its risks and self-care

Psico ◽  
2018 ◽  
Vol 49 (3) ◽  
pp. 266
Author(s):  
Carolina Ribeiro Seabra ◽  
Maria Júlia Armiliato ◽  
Luisa Vital ◽  
Paola Otaran ◽  
Ana Carolina Peuker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Perception ◽  
Illness Perception ◽  
Self Care ◽  
Personal History ◽  
Cáncer De Mama ◽  
Healthy Women ◽  
History Of ◽  
The Relationship ◽  
Illness Coherence

Background: Early detection of breast cancer (BC) is important to reduce mortality rates. To prevent BC, women should adopt self-care behaviors. This study aimed at examining risk and illness perception and self-care of healthy women regarding breast cancer. Methods: Participants were 211 women (M = 59.11 years, SD = 8.54) and with no personal history of the illness, selected by convenience. Measures were a sociodemographic, clinical and health behavior questionnaire, illness perception and risk perception questionnaires. Nonparametric statistics (Spearman) was employed to analyze the relationship between illness perception, risk perception and sociodemographic variables. The open answers to the causes of the illness were classified according to the content analysis. Results: We found a relationship between risk and illness perception and self-care in healthy women regarding BC. It was identified that women had reasonable illness coherence (M = 3.18) and considered the illness more timeline chronic than timeline acute (M = 3.22), reasonable timeline cyclical (M = 3.56), with severe consequences for health (M = 4.22), and reasonably threatening (M = 3.15). Conclusions: BC and risk perception and self-care are interrelated variables among healthy women. ***Prevenção do cancer de mama: o que as mulheres pensam sobre a doença, seus riscos e autocuidado***Introdução: A detecção precoce do câncer de mama (CM) é importante para reduzir as taxas de mortalidade. Para preveni-lo, a mulher deve adotar comportamentos de autocuidado em saúde. Esse estudo objetiva examinar a percepção de risco, a percepção da doença e o autocuidado de mulheres saudáveis com relação ao CM. Método: Participaram 211 mulheres (M = 59,11 anos; DP = 8,54) sem histórico de CM selecionados por conveniência. Os instrumentos foram questionário de dados sociodemográficos, clínicos e decomportamento em saúde, questionários de percepção da doença e percepção de risco. Estatística não paramétrica (Spearman) foi utilizada para analisar a relação entre percepção da doença, percepção de risco e variáveis sociodemográficas. As respostas abertas sobre as causas da doença foram classificadas segundo análise de conteúdo. Resultados: Observou-se que existe relação entre a percepção de risco e da doença, e autocuidado em mulheres saudáveis. Identificou-se que as mulheres têm razoável percepção de entendimento da doença (M = 3.18), a consideravam mais crônica que aguda (M = 3.22), razoavelmente cíclica (M = 3,56), com consequências graves à saúde (M = 4,22), e relativamente ameaçadora (M = 3,15). Conclusões: A percepção do CM, a percepção de risco e o autocuidado são variáveis inter-relacionadas em mulheres saudáveis.Palavras-chave: Neoplasias; Autorregulação; Câncer de mama; Autocuidado.

Serial Transplants of DMBA-Induced Mammary Tumors in Fischer Rats as Model System for Human Breast Cancer

Oncology ◽  
1995 ◽  
Vol 52 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Christian Bartsch ◽  
Hella Bartsch ◽  
Anita Buchberger ◽  
Hartmut Rokos ◽  
Dieter Mecke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Mammary Tumors ◽  
Model System ◽  
Human Breast ◽  
Fischer Rats

scholarly journals Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013–14) trial

2020 ◽  
Author(s):  
Rieneke T. Lugtenberg ◽  
◽  
Stefanie de Groot ◽  
Ad A. Kaptein ◽  
Maarten J. Fischer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Neoadjuvant Chemotherapy ◽  
Illness Perceptions ◽  
Illness Perception ◽  
Regular Diet ◽  
Illness Perception Questionnaire ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Abstract Purpose In the phase II DIRECT study a fasting mimicking diet (FMD) improved the clinical response to neoadjuvant chemotherapy as compared to a regular diet. Quality of Life (QoL) and illness perceptions regarding the possible side effects of chemotherapy and the FMD were secondary outcomes of the trial. Methods 131 patients with HER2-negative stage II/III breast cancer were recruited, of whom 129 were randomly assigned (1:1) to receive either a fasting mimicking diet (FMD) or their regular diet for 3 days prior to and the day of neoadjuvant chemotherapy. The European Organisation for Research and Treatment of Cancer (EORTC) questionnaires EORTC-QLQ-C30 and EORTC-QLQ-BR23; the Brief Illness Perception Questionnaire (BIPQ) and the Distress Thermometer were used to assess these outcomes at baseline, halfway chemotherapy, before the last cycle of chemotherapy and 6 months after surgery. Results Overall QoL and distress scores declined during treatment in both arms and returned to baseline values 6 months after surgery. However, patients’ perceptions differed slightly over time. In particular, patients receiving the FMD were less concerned and had better understanding of the possible adverse effects of their treatment in comparison with patients on a regular diet. Per-protocol analyses yielded better emotional, physical, role, cognitive and social functioning scores as well as lower fatigue, nausea and insomnia symptom scores for patients adherent to the FMD in comparison with non-adherent patients and patients on their regular diet. Conclusions FMD as an adjunct to neoadjuvant chemotherapy appears to improve certain QoL and illness perception domains in patients with HER2-negative breast cancer. Trialregister ClinicalTrials.gov Identifier: NCT02126449.

Sign in / Sign up

Export Citation Format

Share Document