System of fluorescence spectroscopy in the evaluation of surgical margins for squamous cell carcinoma of the oral cavity in moments in situ and ex vivo

2013 ◽  
Author(s):  
Ana Lucia Noronha Francisco
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Fluorescence Spectroscopy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ex Vivo ◽  
Surgical Margins

scholarly journals MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma

RSC Advances ◽  
2019 ◽  
Vol 9 (54) ◽  
pp. 31264-31273 ◽  
Author(s):  
Wei Li ◽  
Cheng Tao ◽  
Jiexin Wang ◽  
Yuan Le ◽  
Jianjun Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Squamous Cell ◽  
Local Chemotherapy ◽  
In Situ Forming ◽  
Complex Construction

The complex construction within the oral cavity causes incomplete surgical resection of oral squamous cell carcinoma (OSCC) that may enhance the risk of recurrence and metastasis in the treatment.

scholarly journals Independent Predictors of Prognosis Based on Oral Cavity Squamous Cell Carcinoma Surgical Margins

2018 ◽  
Vol 159 (4) ◽  
pp. 675-682 ◽  
Author(s):  
Marisa R. Buchakjian ◽  
Timothy Ginader ◽  
Kendall K. Tasche ◽  
Nitin A. Pagedar ◽  
Brian J. Smith ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins

scholarly journals Surgical Margins Status and Prognosis after Resection of Oral Cavity Squamous Cell Carcinoma: Results from a Taiwanese Nationwide Registry-Based Study

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 15
Author(s):  
Chung-Jan Kang ◽  
Yu-Wen Wen ◽  
Shu-Ru Lee ◽  
Li-Yu Lee ◽  
Chuen Hsueh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Local Control ◽  
Squamous Cell ◽  
Survival Rates ◽  
Surgical Margins ◽  
Control Disease ◽  
Disease Specific ◽  
Overall Survival Rates

(1) Background: The optimal cutoff value that maximizes the prognostic value of surgical margins in patients with resected oral cavity squamous cell carcinoma has not yet been identified. (2) Methods: Data for this study were retrieved from the Taiwan Cancer Registry Database. A total of 13,768 Taiwanese patients with oral cavity squamous cell carcinoma were identified and stratified according to different margin statuses (0, 0.1–4 and > 4 mm). The five-year local control, disease-specific survival and overall survival rates were the main outcome measures. (3) Results: The 5-year local control, disease-specific survival and overall survival rates of patients with close margins (0 and 0.1–4 mm) were significantly lower than those observed in patients with clear margins (> 4 mm; all p values < 0.001). In multivariate analysis, margin status, depth of invasion and extra-nodal extension were identified as independent adverse prognostic factors for 5-year local control. (4) Conclusions: A thorough assessment of surgical margins can provide a reliable prognostic prediction in patients with OCSCC. This has potential implications for treatment approaches tailored to the individual level. The achievement of clear margins (>4 mm) should be considered a key surgical goal to improve outcomes in this patient group.

Prognostic Role of Porphyromonas Gingivalis in Oral Cavity Squamous Cell Carcinoma Patients

2020 ◽  
Author(s):  
Qingli Chen ◽  
Zhe Shao ◽  
Ke Liu ◽  
Xiaocheng Zhou ◽  
Lin Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Porphyromonas Gingivalis ◽  
Squamous Cell ◽  
Systemic Disease ◽  
Prognostic Indicator ◽  
Chi Square ◽  
Genotype I

Abstract Background: Oral microbial species play direct and/or indirect role in carcinogenesis of oral cavity squamous cell carcinoma (OSCC). Porphyromonas gingivalis (Pg) has been identified a correlation with OSCC. Fimbriae play a vital role for its attribution of initial attachment and adhesion of Pg. Six genotypes (types I-V, Ib) of fimA were identified based on sequence variations and the genotype was suggested a relationship to pathogenicity of Pg.Objective: To investigate the abundance of Pg in OSCC as well as the frequency of Pg fimA genotypes in OSCC patients.Methods: Ninety-five OSCC patients and thirty-nine gender- and age-matched non-OSCC subjects were investigated abundance of Pg in saliva. Presence of Pg was compared in OSCC tissue and para-cancerous tissue from patient as well. Clinical data were extracted and patients followed up for a mean period of 13 months. Presence of Pg and fimA genotypes were investigated in OSCC tissue and in saliva, then PCR products were sequencing and compared.Results: OSCC patients showed high abundance of Pg in saliva (Chi-square=14.531, P=0.001). OSCC tissue showed strong in situ expression of Pg by in situ hybridization compared with normal tissue adjacent to OSCC. Patients with overabundance of Pg in saliva are associated with systemic disease (Chi-square=10.328, P=0.029), longer disease-free time (Z=-2.988, P=0.003), and lower recurrence rate (Chi-square=5.670, P=0.017). The abundance of Pg was an independent favorable prognostic factor (HR: 0.124, 95%CI: 0.016 to 0.941). There was dominant distribution of Pg with genotype I+Ib (21.1%), II (31.6%) and IV (21.1%) in OSCC patients. The fimA genotypes detected in saliva were in accordance with those in OSCC tissue, and there was significantly correlation in amplified Pg fragments similarity between in saliva and in OSCC tissue. Conclusions: This study indicated that Pg might involve in the pathogenesis of OSCC, and Pg might consider as a potential prognostic indicator in OSCC. There was a dominant distribution of Pg with genotypes I, Ib, II and IV in OSCC patients. The presence of Pg in tumor might be saliva in provenance.

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

2019 ◽  
Vol 130 (1) ◽  
pp. 128-138 ◽  
Author(s):  
Joshua J. Kain ◽  
Andrew C. Birkeland ◽  
Neha Udayakumar ◽  
Anthony B. Morlandt ◽  
Todd M. Stevens ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Future Directions ◽  
Current Practices

p53 Immunostaining of Surgical Margins as a Predictor of Local Recurrence in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

1997 ◽  
Vol 76 (11) ◽  
pp. 818-823 ◽  
Author(s):  
Valerie A. Ball ◽  
Paul D. Righi ◽  
Eduardo Tejada ◽  
Shokri Radpour ◽  
Zlatko P. Pavelic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Positive Surgical Margin ◽  
Ratio Test

Local and regional recurrence is the principal reason for treatment failure in squamous cell carcinoma (SCC) of the head and neck. The conventional method of evaluating surgical margins for cellular atypia does not always predict risk of local recurrence accurately. Immunostaining of surgical margins for tumor markers may provide a more precise evaluation of risk of local recurrence. Paraffin-embedded tissue blocks of surgical margins from 24 patients with oral cavity and oropharyngeal squamous cell carcinoma were immunostained for p53 protein. Fifty-eight percent of the patients had at least one margin stain positive for p53, including eight often patients whose SCC recurred locally. The sample odds ratio test predicted a 5.333 times higher chance of local recurrence with at least one p53 positive surgical margin. The implications of these results for patient management and further investigations will be discussed.

scholarly journals Correlation between clinical and pathological data and surgical margins in patients with squamous cell carcinoma of the oral cavity

2013 ◽  
Vol 79 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Fábio Muradás Girardi ◽  
Virgílio Gonzales Zanella ◽  
Ricardo Galicchio Kroef
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins

Fluorescence Spectroscopy for Evaluation of Safety Margins in Individuals With Surgically Treated Squamous Cell Carcinoma of the Oral Cavity

2014 ◽  
Vol 117 (2) ◽  
pp. e208
Author(s):  
ANA LUCIA NORONHA FRANCISCO ◽  
WAGNER RAFAEL CORRER ◽  
THIAGO CELESTINO CHULAM ◽  
JOÃO GONÇALVES FILHO ◽  
NATALIE KELNER ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Fluorescence Spectroscopy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Safety Margins
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