scholarly journals Precancerous Lesions of Oral Cavity

2010 ◽  
Vol 2 (1) ◽  
pp. 7-14
Author(s):  
Uday Pawar ◽  
Chris de Souza
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Precancerous Lesions ◽  
Precancerous Lesion ◽  
Malignant Lesion ◽  
Invasive Squamous Cell Carcinoma ◽  
Betel Nut ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Malignant Condition

Abstract The term premalignant (precancerous) lesion has been replaced by the term potentially malignant lesion. Such lesions have as their cause, tobacco use, exposure to the human papilloma virus and the chewing of the betel nut. These substances contain carcinogens. The mucosa of the oral cavity is normally quite robust. Exposure to these substances can cause it to undergo change. These changes are usually initiated as a leukoplakic patch. While some leucoplakic patches recover and resolve, some progress into invasive squamous cell carcinoma. Oral submucus fibrosis is another such potentially malignant condition caused by the abuse of betel nut.

scholarly journals Exemplary Delineation of Osmf Turning Malicious

2017 ◽  
Vol 05 (02) ◽  
pp. 104-109
Author(s):  
Anjali Narwal ◽  
Mala Kamboj ◽  
Shruti Gupta ◽  
Esha Singh ◽  
Pooja Sharma
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Malignant Condition

AbstractOral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral cavity that can affect any part of the oral mucosa. It is strongly associated with a risk of oral cancer, although the biology underlying this association is still unresolved. The purpose of this paper is to show the histopathological prototypical illustration of OSMF turning into oral squamous cell carcinoma.

Expression of Interleukin-17 in Potentially Malignant Disorders and Squamous Cell Carcinoma of the Oral Cavity

2018 ◽  
Vol 126 (3) ◽  
pp. e167
Author(s):  
Ricardo Natã Fonseca Silva ◽  
Laís Bueno Dallarmi ◽  
Tarcília Aparecida Silva ◽  
Elismauro Francisco Mendonça ◽  
Aline Carvalho Batista ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interleukin 17 ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Clinical characteristics of precancerous lesions and early squamous cell carcinoma in the oral cavity.

1999 ◽  
Vol 11 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Teruo Amagasa ◽  
Eiji Fujii ◽  
Tetsuo Suzuki ◽  
Masashi Yamashiro ◽  
Ichiro Ogura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Characteristics ◽  
Precancerous Lesions ◽  
Early Squamous Cell Carcinoma

scholarly journals Human Papilloma Virus 18 Detection in Oral Squamous Cell Carcinoma and Potentially Malignant Lesions Using Saliva Samples

2012 ◽  
Vol 13 (12) ◽  
pp. 6109-6113 ◽  
Author(s):  
Khor Goot-Heah ◽  
Thong Kwai-Lin ◽  
Gabriele Ruth Anisah Froemming ◽  
Mannil Thomas Abraham ◽  
Nik Mohd Mazuan Nik Mohd Rosdy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Malignant Lesions

scholarly journals Detection of Human Papilloma Virus in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

2021 ◽  
Vol 17 (3) ◽  
pp. 279-285
Author(s):  
Snehashish Ghosh ◽  
Sartaj Singh Wazir ◽  
Rajesh Shah ◽  
Manoj Kumar Upadhyay ◽  
Rahul Gupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Potentially Malignant Disorders ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Human Papilloma Virus 16

Introduction: Human Papilloma Virus 16 and 18 affects the keratinocytes of oral mucosa and skin and can lead to the development of dysplastic lesions and ultimately into invasive oral squamous cell carcinoma. The objective of the present study was to evaluate the presence of human Papilloma virus 16 and 18 DNA in already diagnosed oral potentially malignant disorders and oral squamous cell carcinoma. Methods: 200 biopsy specimens (50 each) of already diagnosed leukoplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF) and oral squamous cell carcinoma was included for the study. A total 50 control tissue sections, which were obtained during removal of impacted teeth were also included in the study. All 250 specimens were subjected to polymerase chain reaction (PCR) for the identification of HPV 16 and 18. The results are analyzed using Statistical Package of Social Sciences (SPSS) version 16 software and Pearson’s chi square test was used for statistical analysis. Results: HPV 16 and 18 was noted in all the OPMDS and oral cancer specimens but the results were not statistically significant. However, not even a single case of control tissue showed the presence of HPV 16 and 18. Conclusions: The results of the present study shows HPV 16 and 18 is present in oral cancer as well as OPMDS, therefore it could be implicated in the pathogenesis of the above mentioned conditions.

scholarly journals Human papillomavirus-associated oropharyngeal carcinoma: trends in epidemiology and methods for detecting the virus in tumors

2018 ◽  
Vol 8 (3) ◽  
pp. 77-83
Author(s):  
A. I. Stukan' ◽  
O. Yu. Chukhray ◽  
V. A. Porkhanov ◽  
R. A. Murashko ◽  
V. N. Bodnya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
White Men ◽  
Hpv Infection ◽  
Heavy Smoker ◽  
Oropharyngeal Carcinoma ◽  
Papilloma Virus ◽  
Former Smokers

Oropharyngeal squamous cell carcinoma has been traditionally associated with tobacco and alcohol consumption. Nevertheless, latter 30 years have shown squamous cell carcinoma (OPSCC) incidence stagnation and increasing, despite the decrease in smoking prevalence. The incidence was recognized among white men of middle age, often non-smokers or former smokers in the investigations with smoking cessation data. It differs from traditional patient with OPSCC, older men, heavy smoker or alcohol drinker. The incidence of OPSCC is increased due human papilloma virus (HPV) infection. The infection transition is associated with sex and oro-genital contact may lead to HPV-infection of oropharynx and oral cavity. There are multiple types of HPV, but the majority of OPSCC is associated with HPV 16 type. Epidemiology of HPV-associated OPSCC, HPV-infection of oral cavity and/or oropharynx and HPV detection are discussed in the review.

scholarly journals Verrucopapillary Lesions of the Oral Cavity: A Review

2020 ◽  
Vol 4 (7) ◽  
pp. RV1-RV7
Author(s):  
Sana Khaled ◽  
Santosh R. Bharadwaj ◽  
Bushra Anjum ◽  
Satyanarayana D.
Keyword(s):  
Oral Cavity ◽  
Human Papilloma Virus ◽  
Oral Mucosa ◽  
Diagnostic Approach ◽  
Diagnostic Challenge ◽  
Papilloma Virus ◽  
Histopathological Features ◽  
Potentially Malignant ◽  
Malignant Lesions

Verrucopapillary lesions are a spectrum of benign, potentially malignant and malignant lesions of the oral mucosa which usually are misdiagnosed. They pose a great diagnostic challenge mainly due to confusing terminology and also due to similar clinical and histopathological features which often makes these lesions indistinguishable from one another. The human papilloma virus (HPV) plays a important role in the pathogenesis of majority of these lesions. This review aims to summarize and highlight the key clinical and histopathological features of these lesions, and also provides a diagnostic approach to these entities.

scholarly journals A clinical study on precancerous lesions of oral cavity in patients attending dental hospital, Telangana

2019 ◽  
Vol 6 (11) ◽  
pp. 4739
Author(s):  
Soundarya Hanumakonda ◽  
Marri Swetha ◽  
Mallela Bhashitha ◽  
Harsha Mudigonda
Keyword(s):  
Oral Cavity ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Age Distribution ◽  
Precancerous Lesion ◽  
Number Of Patients ◽  
Dental Hospital ◽  
Submucous Fibrosis ◽  
Oral Lichen

Background: Aim of the retrospective study is to determine the type and frequency of the precancerous lesions of the oral cavity and to assess their sex, age distribution among the patients.Methods: Study was conducted based on year-wise data collected during 2015 to 2018 of all the patients with precancerous lesions of oral cavity.Results: The total number of patients was 1247, out of which 803 (64.39%) were males and 444 (35.60%) were females. Most common precancerous lesion is oral submucous fibrosis (70.24%) followed by oral lichen planus (19.08%), leukoplakia (8.98%), erythroplakia (1.68%).Conclusions: We observed marked geographical variation in the incidences of various precancerous lesions. Mostly males are affected by precancerous lesions than females.

scholarly journals Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

2021 ◽  
pp. 53-62
Author(s):  
R. Vijay David Raj ◽  
S. Marylilly
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Malignant Neoplasm ◽  
Premalignant Lesions ◽  
Group I ◽  
Malignant Lesions

Squamous cell carcinoma is the summits malignant neoplasm of the oral cavity. Tobacco and alcohol is identified as risk factors, but squamous cell carcinoma can occur in patients with no known risk factors. Oral cancer is the sixth most common malignancy and is one of the major causes of cancer morbidity and mortality worldwide. Cancer is caused due to a series of alteration in genetic and epigenetic factors that occur in multiple steps and is influenced by the genetic predisposition of the individual and by exogenous environmental factors. These factors result in a series of molecular alteration, including inactivation of tumor suppressor genes expression of p16 has been proposed as a marker for malignant transformation. The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer’s exact test. This study concluded that p16 was increasingly expressed in premalignant lesions and less expressed in malignant lesion. In the present study 9 of the control cases were p16 negative and one case showed sporadic staining. The study group I showed 1 case of sporadic staining, 6 cases of focal staining and 8 cases of diffuse staining. The study II showed 14 cases of sporadic staining, 6 cases of focal staining and 5 cases of diffuse staining. Hence variations cannot be accurately assessed, but it plays a crucial role in assessing pre-malignant lesions progressing to malignancy. To confirm this, a larger sample study is required. As advances in research have leads to greater understanding of potentially malignant lesions in the oral cavity.

scholarly journals Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1937 ◽  
Author(s):  
Omar Kujan ◽  
Bede van Schaijik ◽  
Camile S. Farah
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Rates ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). The emerging treatment modality of immunotherapy targets immune checkpoint molecules including PD-1 and its ligand PD-L1, CTLA-4, LAG-3, and TIM-3 to enhance the host immune response against tumours, and to limit the growth and progression of cancer cells. In this systematic review, we searched five databases for keywords pertaining to oral cancers and OPMDs, along with immune checkpoint inhibitors, in order to summarize the current status of their use and efficacy in these diseases. A total of 644 different articles were identified between 2004 and 2019, with 76 deemed suitable for inclusion in the study, providing a total of 8826 samples. Combined results show expression of PD-1 and PD-L1 in the majority of OPMD and OSCC samples, with expression correlating with increased progression and decreased survival rates. Immunotherapy agents pembrolizumab and nivolumab target PD-1 and have been shown to prolong survival rates and improve disease outcomes, especially in combination with chemotherapy or radiotherapy. Despite the equivocal nature of current evidence, there is support for the prognostic and predictive value of immune checkpoint molecules, especially PD-L1, and many studies provide support for the effective use of immune checkpoint inhibitors in the management of OSCC. Limited data is available for OPMD, therefore this should be the focus of future research.

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