Juvenile Aggressive Cemento-ossifying Fibroma of the Maxilla

ABSTRACT Fibro-osseous lesions of the face and paranasal sinuses are relatively uncommon. The biological characteristics of fibroosseous lesions range from indolent to aggressive and from inflammatory to neoplastic. Cemento-ossifying fibroma is a rare, benign fibro-osseous lesion composed of lamellar bone, fibrous tissue and cementum. It is usually found in the jaw bone and presents in several variant pathological subtypes. The overlapping clinical, radiologic and histomorphologic features of these subtypes have led to diagnostic dilemma for the clinician, radiologist and the histopathologist. Clinically, the lesions are usually asymptomatic, slow-growing and wellcircumscribed. However, in very few cases, these tumors have demonstrated an aggressive course of development. Lesions that involve the midface and paranasal sinuses and presenting in earlier age tend to demonstrate aggressive behavior and rapid growth. We describe a case of a 13 years old young boy with aggressively behaving cemento-ossifying fibroma of the maxilla presenting acutely as right cheek swelling with gingival growth. How to cite this article Bist SS, Varshney S, Bhagat S, Mishra S, Aggarwal V. Juvenile Aggressive Cemento-ossifying Fibroma of the Maxilla. Int J Otorhinolaryngol Clin 2012;4(3):156-159.

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Massive Juvenile Ossifying Fibroma of the Frontal Bone

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1190 ◽

2014 ◽

Vol 7 (1) ◽

pp. 36-39

Author(s):

SS Bist ◽

Sarita Mishra ◽

Vinish Agrawal ◽

Bhartandu Bharti ◽

Himanshual Kala

Keyword(s):

Lateral Displacement ◽

Fibrous Tissue ◽

Frontal Bone ◽

Ossifying Fibroma ◽

Lamellar Bone ◽

Craniofacial Skeleton ◽

Younger Patients ◽

Osseous Lesion ◽

Juvenile Ossifying Fibroma ◽

Slow Growing

ABSTRACT Ossifying fibroma is a rare, benign fibro-osseous lesion composed of lamellar bone and fibrous tissue. It occurs as an osseous lesion in the craniofacial skeleton. Clinically, lesions are usually asymptomatic, slow-growing and well-circumscribed. However, in very few cases, particularly in younger patients these tumors have demonstrated an aggressive course of development. Surgical management via a wide local excision is a necessity since it is notorious for recurrence, especially paranasal sinuses lesions. Here, we describe a case of a 9-year- old male child who had left forehead swelling with painless, progressive proptosis and downward lateral displacement of the globe for approximately 8 months. Computed tomography showed a massive expansile lesion involving the left frontal bone. The mass was excised surgically via a Lynch Howarth approach and proved histopathologically to be a juvenile ossifying fibroma. The radiological interpretation will be discussed which is helpful for diagnosis and selecting appropriate surgical approach in growing child. How to cite this article Bist SS, Mishra S, Bharti B, Agrawal V, Kala H. Massive Juvenile Ossifying Fibroma of the Frontal Bone. Clin Rhinol An Int J 2014;7(1):36-39.

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A Huge Cemento-Ossifying Fibroma of Paranasal Sinus: A Case Report

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2015.54 ◽

2012 ◽

Vol 55 (3) ◽

pp. 146-149

Author(s):

Ibrahim Erdim ◽

Zahide Mine Yazici ◽

Rasim Yilmazer ◽

Nurten Sever ◽

Fatma Tulin Kayhan

Keyword(s):

Case Report ◽

Paranasal Sinus ◽

Male Patient ◽

Paranasal Sinuses ◽

Surgical Excision ◽

Ossifying Fibroma ◽

Radiological Appearance ◽

Close Observation ◽

Slow Growing

Cemento-ossifying fibroma is a well-bordered, slow-growing, benign fibro-osseous disease. Although its localization is generally in the mandible, it can be seen in any area of the craniofacial region. Radiology and histopathology help to diagnose the condition. Treatment is based on close observation and/or surgical excision. In this case, we report the case of a 62-year-old male patient who had a large radiological appearance, cemento-ossifying fibroma in the paranasal sinuses.

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Cemento-ossifying Fibroma Involving Mandible

International Journal of Experimental Dental Science ◽

10.5005/jp-journals-10029-1054 ◽

2013 ◽

Vol 2 (2) ◽

pp. 127-129

Author(s):

Kamran Bokhari ◽

Mustafa Abdel Bagi ◽

Mutasim Al Nager ◽

Sulphi Abdul Basheer ◽

Mohammed Abdullah M Assiri

Keyword(s):

Male Patient ◽

Growth Pattern ◽

Fibrous Tissue ◽

Ossifying Fibroma ◽

Rare Neoplasm ◽

Degree Of Mineralization ◽

Odontogenic Lesion ◽

Slow Growing

ABSTRACT Cemento-ossifying fibroma (COF) is a rare neoplasm representing one of the benign fibro-osseous lesions of the jaw. This benign mesenchymal odontogenic lesion occurs more frequently in women than in men. Clinically, these tumors are slow growing with a centrifugal growth pattern. Radiologically, COFs present a number of patterns depending on the degree of mineralization. Histologically, these lesions are characterized by fibrous tissue with islands of bone or cementiform calcifications. We present a case of COF involving mandible in a 35-year-old male patient treated by excision. How to cite this article Bagi MA, Bokhari K, Al Nager M, Basheer SA, Assiri MAM. Cemento-ossifying Fibroma Involving Mandible. Int J Experiment Dent Sci 2013;2(2):127-129.

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A path less travelled — Short review on ossifying fibroma and osseous dysplasia

Archives of Dental Research ◽

10.18231/j.adr.2021.014 ◽

2021 ◽

Vol 11 (2) ◽

pp. 90-95

Author(s):

Deepali P Mohite ◽

Devendra H Palve ◽

Snehal R Udapure ◽

Vinanti V Bodele ◽

Mrunali D Jambhulkar ◽

...

Keyword(s):

Fibrous Tissue ◽

Short Review ◽

World Health ◽

Ossifying Fibroma ◽

Osseous Lesion ◽

Osseous Dysplasia ◽

Cementifying Fibroma ◽

Calcified Tissue ◽

Health Organization ◽

Slow Growing

Fibro-osseous lesions (FOL) are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. The mineralized product may be ossification (sometimes cementum formation) or calcification of fibrous tissue by metaplasia. These lesions have similar radiographic and histopathologic features hence the term fibre- osseous lesion is not a diagnosis, rather a description of the presence of fibrous and calcified tissue. They may be developmental (fibrous dysplasia), reactive (cemento-osseous dysplasia) or neoplastic (ossifying/cementifying fibroma). This article presents the commonly used classification for fibro-osseous lesions and an insight into a few changes that have been introduced in the recent past with emphasis on Ossifying Fibroma and Osseous Dysplasia.Ossifying fibromas are considered as benign fibro-osseous neoplasms which are principally encountered within the jawbones. Cemento-osseous dysplasias are non-neoplastic fibro- osseous lesion. Since 1971, the World Health Organization classified cemental lesions into 4 distinct entities, as follows: Periapical Cemental Dysplasia, Benign Cementoblastoma (true cementoma), Cementifying Fibroma and Gigantiform Cementoma (GC). The term, gigantiform cementoma, may imply a solitary process but it is misleading because the condition typically presents as slow-growing, multifocal/multiquadrant and expansile lesions involving both jaws. WHO classified it in Osseous dysplasia and El-Mofty et al. under Ossifying fibroma.

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Fibro-osseous lesions of the paranasal sinuses and the skull base

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20184345 ◽

2018 ◽

Vol 4 (6) ◽

pp. 1324

Author(s):

Sajedh M. Alturaiki ◽

Ali Almomen ◽

Ghaleb Al Azzeh ◽

Abdulrahman Al Khatib ◽

Nada Alshaikh

Keyword(s):

Skull Base ◽

Fibrous Dysplasia ◽

Paranasal Sinuses ◽

Correct Diagnosis ◽

Computer Assisted Surgery ◽

Ossifying Fibroma ◽

Computer Assisted ◽

Open Approach ◽

Diagnostic Dilemma ◽

Treatment Prognosis

Background: Osteomas, ossifying fibromas, and fibrous dysplasia comprise a set of benign neoplasms known as fibro-osseous lesions (FO), which can arise in the paranasal sinuses. The vast majority of benign FO lesions (BFOL) are incidental findings on radiographs. They tend to be slow-growing tumors, and are infrequently symptomatic. The management strategy can vary significantly for theses lesions. This can range from serial, observations to aggressive surgical resection, based on symptomatology, size, and location of the lesion.Methods: Retrospective analysis of all the data of different symptomatic FO of the paranasal sinuses and the skull base was performed at King Fahad specialist hospital, Dammam, KSA (2006 to 2017). Results: A total of 21 patients were identified; 10 (46.7%) patients were diagnosed with osteoma, 8 (38.1%) with ﬁbrous dysplasia, 2 (9.5%) with ossifying fibroma and one (4.8%) with juvenile active ossifying (JAOF), 17 were adults and 4 were children, the range of f/u (3-60) months. 19 patients were managed by the endonasal endoscopic approach. They continue to be followed with no evidence of recurrence. Two cases required the revision combined endoscopic open approach to ensure adequate removal of the disease (residual and recurrence).Conclusions: Diagnostic dilemma of BFOL can be overcome with a combination of clinical, radiological and pathological criteria. Correct diagnosis of fibro-osseous tumors is crucial for adequate therapy as their treatment, prognosis, clinical aggressiveness and long term complications of individual entities vary significantly. Endoscopic computer-assisted surgery is the treatment of choice. Endoscopic resection remains a technical challenge.

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Juvenile ossifying fibroma: case report and literature review. Management and differential diagnosis

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2017023 ◽

2018 ◽

Vol 24 (2) ◽

pp. 67-71

Author(s):

Sarah Lemoine ◽

Elisabeth Cassagnau ◽

Hélios Bertin ◽

Maria Poisson ◽

Pierre Corre ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Rapid Growth ◽

Benign Tumor ◽

Early Stage ◽

Bone Matrix ◽

Fibrous Tissue ◽

Ossifying Fibroma ◽

Juvenile Ossifying Fibroma ◽

Review Management

Introduction: Juvenile ossifying fibroma (JOF) is a rare neoplasm characterized by the replacement of the normal bone matrix with osteo-fibrous tissue. It has the tendency to be locally aggressive despite its benign character and to have a strong tendency for recurrence. Observation: In this case report, the patient is a young man, aged 16, with rapidly advancing maxillary swelling. We describe the diagnostic procedure, the surgical procedure and the differential diagnosis to be eliminated. Discussion: The clinical presentation of JOF, and its rapid growth, can cause fear of other pathologies such as osteosarcoma. The radiological characteristics should reassure the practitioner and a histological examination confirmed the diagnosis. Conclusion: JOF is a benign tumor. It should be operated on at an early stage because of its rapid growth. In its clinical and histological presentation, its trabecular form may mimic an osteosarcoma.

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Ossifying Fibroma of the Maxilla: A Case Report and Literature Update

Surgical Case Reports ◽

10.31487/j.scr.2021.09.08 ◽

2021 ◽

pp. 1-4

Author(s):

Abdouldaim Ukwas ◽

Mohammed Magdy ◽

Mahmoud Elshik

Keyword(s):

Case Report ◽

Female Patient ◽

Bone Grafting ◽

Fibrous Tissue ◽

Definitive Diagnosis ◽

Ossifying Fibroma ◽

Normal Bone ◽

Calcified Tissues ◽

Slow Growing ◽

Normal Bone Tissue

Ossifying fibroma is a rare benign fibro-osseous neoplasm of the jaw characterized by the replacement of normal bone tissue by a combination of fibrous tissue and newly formed calcified tissues of bone and/or cementum-like material. Lesions often manifest at the 2nd to 4th decades of life with a predominant female predilection. The tumor is usually slow-growing and asymptomatic but can cause notable expansion of the jawbones. Definitive diagnosis of OF can be challenging and usually requires careful clinical, radiographic and histologic assessments. Treatment commonly depends on the size, location and aggressiveness of tumor and can accordingly vary from enucleation and curettage to resection and bone grafting. The prognosis is generally good when the lesion is completely removed, but recurrence is possible in some circumstances. The aim of this article is to present a case report of a recurrent ossifying fibroma in a 28-year-old female patient and to provide an update of the literature.

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Central ossifying fibroma of mandible

BMJ Case Reports ◽

10.1136/bcr-2020-239286 ◽

2020 ◽

Vol 13 (12) ◽

pp. e239286

Author(s):

Kumar Nilesh ◽

Prashant Punde ◽

Nitin Shivajirao Patil ◽

Amol Gautam

Keyword(s):

Fibrous Tissue ◽

Three Dimensional ◽

Facial Asymmetry ◽

Ossifying Fibroma ◽

Mandible Reconstruction ◽

Three Dimensional Printing ◽

Osseous Lesion ◽

Large Size ◽

Dimensional Printing

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

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