scholarly journals Role of Prophylactic Antibiotics in the Management of Postoperative Endodontic Pain

2015 ◽  
Vol 16 (12) ◽  
pp. 939-943 ◽  
Author(s):  
Leena Alsomadi ◽  
Riyad Al Habahbeh
Keyword(s):  
Pain Scale ◽  
Prophylactic Antibiotics ◽  
Post Treatment ◽  
Endodontic Treatment ◽  
Significant Difference ◽  
Group A ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Group B

ABSTRACT Aim To investigate the efficacy of using antibiotics in post endodontic treatment as a method to alleviate post-treatment pain. Materials and methods After completion of endodontic treatment 129 patients were randomly divided into two groups: Group A (65 patients) received Ibuprofen 400 mg one tablet before procedure and one tablet every 8 hours for the first day, then one tablet once indicated by pain. Group B (64 patients) received the same regimen as group A in addition to amoxicillin, clavulanic acid tablets (one tablet before the procedure, and then one tablet twice daily for a total of 3 days). Intensity of pain at 8 hours interval using visual analog scale (VAS) and total number of Ibuprofen tablets used was recorded by patients. Results Peak postoperative pain occurred at 16 hours posttreatment in both groups, there was a significant difference in the pain scale between the two groups in favor for group B over group A (3.8 vs 2.1 respectively). Pain scale was significantly lower in group B at 24, 32, 40, and 48 hours post-treatment with a p-value of < 0.05. The pain scale at 56, 64 and 72 hours were also less in group B, although could not show up as statistical difference. Patients in group A used statistically significant more Ibuprofen than patients in group B (486 vs 402). Conclusion Antibiotic prescription to manage post endodontic treatment pain results in less pain with less consumption of Ibuprofens. Clinical significance Pain management in endodontics is a real challenge, nonsteroidal anti-inflammatory drugs (NSAIDS) are used effectively in many patients to alleviate post endodontic pain. Nonsteroidal anti-inflammatory drugs may have adverse reactions or may be contraindicated. Short-term use of antibiotics to alleviate pain can be of clinical benefits in these patients. How to cite this article Alsomadi L, Al Habahbeh R. Role of Prophylactic Antibiotics in the Management of Postoperative Endodontic Pain. J Contemp Dent Pract 2015;16(12):939-943.

The role of tolvaptan in prevention of hyponatremia in patients undergoing transurethral resection of prostate surgery- A randomized double blind study

2021 ◽  
Vol 8 (2) ◽  
pp. 321-325
Author(s):  
Dinesh Kumar Singh ◽  
B B Baj ◽  
Vipin Goyal
Keyword(s):  
Transurethral Resection ◽  
Blind Study ◽  
Transurethral Resection Of Prostate ◽  
Double Blind Study ◽  
Double Blind ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B

The aim of our study to determine the role of tolvaptan in prevention of hyponatremia in transurethral resection of prostate surgery. This is randomized double-blind study conducted in 60 ASA grade status 1 and 2 patients age group between 45-80 yrs undergoing TURP under spinal anaesthesia in urology operation theatre in Mahatma Gandhi hospital Jaipur after receiving permission from hospital ethical committee. A detailed history, complete physical examination and routine investigation were done for all patients followed by informed written consent was obtained. Patients are randomly divided into 2 groups. In group A -30 patients who received orally tab tolvaptan 15 mg and group B-30 patients who received orally tab multivitamin 2 hrs before surgery after doing electrolytes of the patients in the morning. In both groups age (in yrs), wt (in kg), ASA grade, volume of irrigating fluid (in litres), volume of prostate resected (in gm) and duration of surgery (in minutes) all demographic and surgical details data were compared. Electrolytes were compared in both groups pre and post-operatively and statistical analysis was done.There was significant difference in post-operative sodium level between the two groups (A and B). The mean level of sodium significantly reduced post-operatively in group –B (control grp). The mean level of sodium significantly increased post-operatively in group –A (tolvaptan grp). We conclude single dose of tolvaptan -15 mg found to effective in prevention of hyponatremia in patients undergoing TURP.

scholarly journals Role of Immediate Release and Delayed Release Omeprazole in Patients with Gastro Esophageal Reflux Disease

2017 ◽  
Vol 11 (2) ◽  
pp. 67-73
Author(s):  
Mahabub Rahman ◽  
Dewan Saifuddin Ahmed ◽  
Syeda Nur E Jannat ◽  
MM Shahin Ul Islam ◽  
Abu Ahmed Abdullah
Keyword(s):  
Reflux Disease ◽  
Immediate Release ◽  
Esophageal Reflux ◽  
Double Blind ◽  
Delayed Release ◽  
End Of Treatment ◽  
Significant Difference ◽  
Group A ◽  
Group B

Proton pump inhibitors are widely used for Gastro Esophageal Reflux Disease (GERD) treatment. This prospective double blind randomized cross over study was carried out in the Department of Gastroenterology, BSMMU from June 2007 to May 2008 to assess the efficacy of Immediate-release omeprazole (IR-OMEP) & Delayed-release Omeprazole (DR-OMEP) in relieving symptoms & healing of oesophagitis in GERD. All patients who fulfilled the inclusion criteria underwent upper gastrointestinal (UGI) endoscopy to be lebelled as nonerosive and erosive GERD. Among total 69 patients, 43 (62.3 %) had nonerosive and 26 (37.7 %) had erosive GERD. Patients were divided into group A (35) and group B (34) who received group A drugs (20 mg IR-OMEP bd) and group B drugs (20 mg DROMEP bd) from day 1-14 respectively. Then drugs were crossed over (group A: 20mg DR-OMEP bd; group B: 20 mg IR-OMEP bd) from day 15-28. Improvement of heartburn, regurgitation in each group were assessed in every week, during drug cross over and at the end and then compared between two groups. There was no significant difference in relieving heartburn and regurgitation between IR-OMEP and DR-OMEP either in erosive or nonerosive GERD (P>0.50). Patients with erosive GERD underwent UGI endoscopy at the end of treatment to see healing of esophagitis. Study showed significant healing of oesophagitis in group A after 4 weeks than group B (14%) (P<0.05) but there is no superiority of IR-OMEP over DR-OMEP in relieving symptoms of GERD.Faridpur Med. Coll. J. Jul 2016;11(2): 67-73

scholarly journals To assess the role of lingual flap for the removal of lower wisdom tooth.

2020 ◽  
Vol 27 (08) ◽  
pp. 1656-1663
Author(s):  
Noman Ahmed ◽  
Almas Rahoojo ◽  
Syed Zafar Abbas ◽  
Syed Ghazanfar Hassan ◽  
Zunair Memon
Keyword(s):  
Nerve Injury ◽  
Maxillofacial Surgery ◽  
Sensory Nerve ◽  
Lingual Nerve ◽  
Control Group ◽  
Wisdom Tooth ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objectives: To assess the role of lingual flap in encountering lingual nerve injury during the surgical elimination of lower wisdom tooth. Study Design: Cross Sectional Case Control study. Setting: Department of Oral & Maxillofacial Surgery, Institute of Dentistry, Liaquat University of Medical & Health Sciences Jamshoro / Hyderabad. Period: January 2016 to September 2016. Material & Methods: Subjects were categorized into two categories: Group-A (lingual flap) & group-B (control group) each having 52 patients by Lottery method. In group A an envelope mucoperiosteal flap followed by lingual flap elevation carried out and in group B only envelope flap was carried out. All patients were reviewed on the first postoperative day and again 1 and 3rd week after surgery. At each postoperative visit, patient was examined for sensory nerve impairment of the lingual nerve by same observer. Results: Total 104 cases were studied, all the cases categorized among two groups 52 in each group. In group-A 34 were males and 18 were females, while in group-B 44 were male and 8 were females. There was no significant difference among both groups according to the pre-operative assessment. According to objective findings, lingual nerve paresthesia was found among 2 cases of group A on 1st visit, while no any case was found with nerve injury in group B. Out of 2 cases, one case was improved and only one had presented with complain at 2nd visit and 3rd visit, no significant difference among both groups, p-values were quite insignificant. Conclusion: It was concluded that lingual nerve injury (LNI) occurred among few cases of lingual flap group which was insignificantly higher as compare to control group, but the nature of injury was temporary.

scholarly journals Role of Prophylactic Antibiotics in Open Mesh Inguinal Hernia Repair

2019 ◽  
Vol 13 (2) ◽  
pp. 18-21
Author(s):  
Md Ataur Rahman Siddiqui ◽  
Mohammad Abdul Aleem ◽  
Md Shahinur Rahman ◽  
Farzana Zafreen
Keyword(s):  
Inguinal Hernia ◽  
Hernia Repair ◽  
Prophylactic Antibiotic ◽  
Prophylactic Antibiotics ◽  
Hernia Surgery ◽  
Inguinal Hernia Surgery ◽  
Group A ◽  
Group B ◽  
Open Mesh

Introduction: The role of prophylactic antibiotics in open mesh repair of inguinal hernia is still controversial. The dogmatic hernia specialists are always in favour of no use of antibiotic in case of inguinal hernia repair on contrary, many others favour the use of prophylactic antibiotic. Objective: To determine the role of prophylactic antibiotic in case of open mesh inguinal hernia surgery by a prospective randomized study. Materials and Methods: This prospective randomized interventional and observational study was conducted from March to December 2017 at Combined Military Hospital, Chattogram. Total 40 patients selected for open inguinal hernia surgery were grouped as Group-A and Group-B containing 20 in each group on the basis of systematic random sampling. The Group-A and Group-B patients were treated with a single dose of prophylactic antibiotic (1.5gm Cefuroxime) and a similar quantity of normal saline respectively. Data were recorded, compiled, edited and analyzed by SPSS version 23. Results: The mean age of Group-A and B respondents were 53.16±7.76 and 52.39±5.69 years respectively. Mean duration of surgery was 59.76±2.1 and 54.56±18.3 minutes in Group-A and B respectively. Surgical site infection (SSI) was present in 2(10%) cases of Group-A and 5(25%) of Group-B. Though it was little higher in Group-B, the difference was not statistically significant (p>0.05). Staphylococcus was most prevalent in Group-A and multiple organisms in Group-B. Conclusion: Prophylactic antibiotic is not able to significantly decrease the rate of SSI. Journal of Armed Forces Medical College Bangladesh Vol.13(2) 2017: 18-21

scholarly journals Protective Role of Different Local Spices on Lambda Cyhalothrin Induced Nephrotoxicity in Male Mice

2021 ◽  
pp. 61-70
Author(s):  
Eme Efioanwan Orlu ◽  
Adetutu Olubunmi Obulor
Keyword(s):  
Experimental Design ◽  
Total Protein ◽  
Protective Role ◽  
Male Mice ◽  
Lambda Cyhalothrin ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Animal House

Aim: This study was aimed at evaluating the protective role of different local spices on lambda cyhalothrin induced nephrotoxicity in male mice Experimental Design: A completely randomized experimental design using standard methods for analysis. Place and Duration of Study: This study was carried out in the Animal house, Department of Animal and Environmental Biology of Rivers State University, Nkpolu-Oroworukwo Port Harcourt, Nigeria. GPS 4o47'50''N 6o58'49''E. This study lasted for 35days. Methodology: The experimental animals were separated into 6 groups (A-F) of seven mice each. Group A served as the control and Group B – F served as the test groups. At the end of the 35 day treatment period, feed was withdrawn from the mice 24 hours before termination of the experiment. Blood samples for analysis of kidney function test were collected from each mouse by ocular puncture into plain tubes. The blood was allowed to clot and centrifuged at 2500g to separate the serum from the cells. Total protein was analyzed using the spectrophotometric method of biuret, Bradford and erythrosine – b, albumin was estimated, creatinine and urea was done using enzymatic method. Vital organs were removed and weighed for organosomatic indices. Histological sections of the kidney were mounted on slides, stained with hematoxylin and eosin (H&E). Photomicrographs were generated. Results: There is no significant difference (P=0.05) between the organ weight and bodyweight in group A compared with the treatment groups. The values of Albumin, total protein, urea, creatinine and total bilirubin increased significantly in group B administered lambda cyhalothrin alone but decreased in groups administered the local spices. Histopathological analysis of the kidney shows the regular structure of the kidney architecture in group A, tubular degeneration and several vacuolations were observed in group B. However, less degeneration of the epithelial cells, regeneration of renal tubular epithelium were observed in groups C- F. Conclusion: Based on the results from liver biomarkers and histological micrographs from this study, pronounced degeneration was observed in the kidney cells exposed to lambda-cyhalothrin only. Moreover, all spices used had a regenerating ability on the kidney tubules. It is advocated therefore that consumption of this spices either singly or in combination should be encouraged especially for those exposed to insecticides poisoning

scholarly journals The role of glucomannan fiber in childhood functional constipation

2016 ◽  
Vol 56 (2) ◽  
pp. 95
Author(s):  
Indiana Aulia ◽  
Supriatmo Supriatmo ◽  
Emil Azlin ◽  
Atan Baas Sinuhaji
Keyword(s):  
Controlled Trial ◽  
Functional Constipation ◽  
Boarding School ◽  
Chi Square ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Rome Iii ◽  
Group A ◽  
Group B

its most common type is functional constipation. The dietary fiber may be useful in childhood functional constipation management, but unfortunately the role of fiber in functional constipation is still less developed.Objective To determine the role of glucomannan in treatment of childhood functional constipation.Methods A crossover randomized controlled trial (RCT) was done from May until July 2012 in a boarding school in Medan, North Sumatera. The subjects were children with functional constipation aged 7 to 12 years. Subjects were randomised into two group receiving glucomannan fiber as polysaccharide gel (group A) and maltodextrin as placebo (group B) with each dose of 100 mg/kg/day (maximum of 5 g/day) diluted in 50 ml water/500 mg for 4 weeks, then after a wash out period we did the crossover of the two groups. Frequency and consistency of stools were recorded into diary sheet for 4 and 8 weeks of treatment. Functional constipation has been diagnosed based on Rome III criteria. Data was analyzed using independent T-test and Chi-square test.Results A total of 36 subjects were eligible with each group consisting of 18 subjects and mean of weight of 25 kg. We found significant difference in stool frequency, treated on glucomannan with P= 0.002 before and P = 0.0001 after the wash out period. For stool consistency, we found difference while treated on glucomannan 9/18 (P= 0.034) in 4 weeks before and 11/18 (P = 0.008) in 4 weeks after the wash out period.Conclusion Glucomannan has significant effect to improve functional constipation especially in 4 weeks treatment.

scholarly journals ANTIBIOTIC PROPHYLACTICS ON CURETTAGE FOR PREVENTING PELVIC INFLAMMATORY DISEASE EVENTS: IS IT NECESSARY?

2018 ◽  
Vol 11 (11) ◽  
pp. 267
Author(s):  
Fauna Herawati ◽  
Abdul Rahem ◽  
Dwi Handayani ◽  
Rika Yulia
Keyword(s):  
Antibiotic Prophylaxis ◽  
Pelvic Inflammatory Disease ◽  
Sedimentation Rate ◽  
Inflammatory Disease ◽  
Vaginal Discharge ◽  
Pain Scale ◽  
Prophylactic Antibiotics ◽  
Erythrocyte Sedimentation ◽  
Group A ◽  
Group B

Objective: This study aimed to compare pelvic inflammatory disease (PID) symptoms in curettage procedure with three antibiotic prophylaxis strategies.Methods: The patients were allocated to three Groups (A, B, and C). Group A was patients receiving prophylactic antibiotics and post-curettage antibiotics, Group B received prophylactic antibiotics without post-curettage antibiotics, and Group C did not receive prophylactic antibiotics but received post-curettage antibiotics. The outcomes measured to identify the occurrence of PID symptoms included leukocytes, erythrocyte sedimentation rate, temperature, pain, vaginal discharge, and bleeding.Results: This study shows that there were no significant differences in any PID symptoms between antibiotic strategies except for pain scale (p=0.03).Conclusion: The PID symptoms between the three strategies of antibiotic prophylaxis were similar.

scholarly journals Comparison of topical non-steroidal anti-inflammatory drugs and oil of evening primrose in management of mastalgias; A randomized controlled trial.

2020 ◽  
Vol 27 (10) ◽  
pp. 2062-2066
Author(s):  
Nausheen Hasham ◽  
Ahmed Raza ◽  
Tahira Hameed ◽  
Naveed Arshad ◽  
Syed Tatheer Abbas ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Chi Square ◽  
Evening Primrose ◽  
Patients Âgés ◽  
Randomized Controlled ◽  
Group A ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Group B ◽  
Topical Nsaids

Objectives: To compare the effects of topical non-steroidal anti-inflammatory drugs over oil of evening primrose in mastalgias in terms of frequency of pain. Study Design: Randomized Controlled Trail. Setting: Department of Surgical at Holy Family Hospital, Rawalpindi. Period: January 2016 to June 2016. Material & Methods: A total of 160 consecutive female patients, ages 17-45 years with history of breast pain for last 2-3 months (cyclic and noncyclic), were presenting in surgical OPD with symptoms of mastalgias between January 2016 to June 2016 included in the study. Patients allocated in two groups, Group A received topical NSAID in 0.5% Piroxicam gel for local application to affected area twice daily for three months and Group B was given oil of evening primrose (OEP) capsules (Efamol) 500mg twice daily for three months. Patients mastalgia pain was recorded by using VAS scale at baseline (1st day) and at end of treatment (3rd month). Pain calculated by compared in terms of mean, standard deviation between groups and independent sample T test was used. Percentage compare the efficacy of response of two therapies among group A and group B chi-square distribution was used. Results: One hundred and sixty (160) patients were recruited in this study. The mean ages of the patients were 27.54±7.53 years with minimum 17 and maximum 45 years. Out of 160 patients, 115 (71.9%) were younger than 30 years of age and 45 (28.1%) were between 30 and 45 years of age. Results showed significantly lower pain in patients using topical NSAIDs as compared to OEP capsules (p=0.000). Conclusion: Topical NSAIDs are more significant and show more improvement in reduction of pain in both cyclic and noncyclic mastalgia patients as compared to oil of evening primrose.

scholarly journals Single-Dose Ibuprofen-Arginine as a Preventive for Pain, Edema, and Trismus After Impacted Lower Third Molar Surgery: A Randomized Split-Mouth Clinical Trial

2021 ◽  
Author(s):  
Edith Umasi Ramos ◽  
Luan Pier Benetti ◽  
Júlio César Silva Oliveira ◽  
Ana Paula Farnezi Bassi
Keyword(s):  
Statistical Significance ◽  
Third Molar ◽  
Wilcoxon Test ◽  
Total N ◽  
Study Results ◽  
Significant Difference ◽  
Group A ◽  
Facial Edema ◽  
Anti Inflammatory ◽  
Group B

Abstract Objective We examined if the association of ibuprofen with arginine has a better anti-inflammatory effect on pain, edema, and trismus after surgery of the impacted mandibular third molar than ibuprofen alone. Materials and Methods The study included 21 patients, 18 to 30 years of age, each with an impacted, and bilateral and symmetric third molar (total n = 21) that required transalveolar extraction. Patients were randomly assigned numbers from 1 to 21. Group A received ibuprofen-arginine as preoperative medication, while Group B received only ibuprofen. Both groups received the same postoperative medications: amoxicillin + acetaminophen. All patients were evaluated for pain at 6, 12, and 24 hours. They were evaluated for edema and trismus before surgery; immediately after surgery; and at 24, 48, and 72 hours postoperatively. Postoperative pain scores used the visual analog scale (BS-11). For facial edema and trismus, linear measurements used the method modified by Gabka and Matsumura. Statistical Analysis For the evaluation of data between Group A and Group B, we used the statistical software SPSS version 22. The Shapiro-Wilk, analysis of variance, the Bonferroni comparisons, and the Wilcoxon test were used. All tests were based on a significance level of 0.05. Results The study results reveal that the facial edema scores of Group A and Group B presented statistically significant differences (p < 0.05), while for postoperative trismus, there was no statistically significant difference (p > 0.05) between the scores of Group A and Group B. Conclusion As a conclusion, we can state that the use of ibuprofen-arginine allows for significantly better control of pain and edema, and shows a tendency toward better recovery from trismus, although without statistical significance. Based on this, we can assert that arginine improves the anti-inflammatory power of ibuprofen, thus generating better tissue healing after surgery of the impacted third molar.

scholarly journals Crossover Analysis of the Astringent, Antimicrobial, and Anti-inflammatory Effects of Illicium verum/Star Anise in the Oral Cavity

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Ali A. Assiry ◽  
Mohmed Isaqali Karobari ◽  
Shaeesta Khaleelahmed Bhavikatti ◽  
Anand Marya
Keyword(s):  
Antimicrobial Properties ◽  
Microbial Count ◽  
Star Anise ◽  
Study Results ◽  
Significant Difference ◽  
Crossover Analysis ◽  
Group A ◽  
Illicium Verum ◽  
Anti Inflammatory ◽  
Group B

Introduction. Illicium verum commonly known as star anise has been widely used in many Asian countries for pharmaceutical treatment for many diseases. The aim of the present study was to investigate the anti-inflammatory, astringent, and antimicrobial properties of an Illicium verum mouthwash. Methods. The present double blinded randomized clinical trial was conducted on fifty subjects, divided into groups A and B. Illicium verum mouthwash (group A) and placebo (group B) were provided to subjects for 21 days; after 14 days, washout period mouthwashes were switched as per crossover design between groups for 21 days. The gingival index (GI), papillary bleeding index (PBI), and oral microbial count were recorded at each stage of study. Results. The significant intragroup difference was observed, before crossover in group A and after crossover in group B for GI, PBI, and oral microbial count at different stages of study. On comparing both group A and group B at the first and second follow-up for GI, PBI, and oral microbial count, a statistically significant difference ( p < 0.05 ) was observed. A statistically highly significant mean intergroup and intragroup difference was seen for all the clinical parameters at different stages of study. Conclusion. The study revealed that the Illicium verum/star anise has potent antibacterial, anti-inflammatory, and astringent properties.

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