Chapter-18 Benign and Malignant Tumors of the Head and Neck

The mainstay of curative therapy for head and neck skin cancers relies upon surgery and/or radiation therapy. However, for some aggressive, non-resectable or recurrent tumors, systemic therapy is necessary. Recent emerging classes of drugs have shown to improve survival for high-risk, recurrent, and unresectable variants of these tumors. The goal of this paper is to review options for systemic therapies for head and neck skin cancers including melanoma, non-melanoma skin cancers and other rare and non-malignant tumors.

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Clinical Evaluation of Immunological Parameters in Patients with Malignant Tumors of Head and Neck

Practica oto-rhino-laryngologica Suppl ◽

10.5631/jibirinsuppl1986.1989.supplement33_127 ◽

1989 ◽

Vol 1989 (Supplement33) ◽

pp. 127-135

Author(s):

Junichi Yoda ◽

Tadahito Saito ◽

Takaaki Kawaguchi ◽

Hiroki Arai ◽

Toshihide Tabata

Keyword(s):

Head And Neck ◽

Clinical Evaluation ◽

Malignant Tumors ◽

Immunological Parameters

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Unusual Malignant Tumors of the Head and Neck

Radiology ◽

10.1148/86.6.1090 ◽

1966 ◽

Vol 86 (6) ◽

pp. 1090-1095 ◽

Cited By ~ 8

Author(s):

Robert Lindberg

Keyword(s):

Head And Neck ◽

Malignant Tumors

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REVIEW OF THE CURRENT STATE OF THE PROBLEM OF PRIMARY DETECTION OF MALIGNANT TUMORS OF THE CAVITY

The actual problems in dentistry ◽

10.18481/2077-7566-2019-15-2-50-55 ◽

2019 ◽

Vol 15 (2) ◽

pp. 50-55

Author(s):

Наталья Нуриева ◽

Natal'ya Nurieva ◽

Александр Гузь ◽

Aleksandr Guz ◽

Александр Захаров ◽

...

Keyword(s):

Oral Cavity ◽

Head And Neck ◽

Malignant Tumors ◽

Malignant Neoplasm ◽

Diagnostic Procedures ◽

Primary Diagnosis ◽

Malignant Neoplasms ◽

Dental Rehabilitation ◽

Late Treatment ◽

Clinically Significant

Subject: malignant neoplasms of the oral cavity, primary detectability, appeal to specialists, terms of treatment before hospitalization. Objective: based on a five-year analysis of the medical records of patients with a verified diagnosis of malignant neoplasm of the oral cavity, to identify significant criteria for primary diagnosis, doctors of the first contact, including non-cancer profile. Methodology. Malignant neoplasms occupy one of the leading places among all medical and social problems. This is due to a number of reasons, among which are particularly high rates of morbidity and mortality, late treatment of patients and frequent disability. the Purpose of early detection of malignant tumors of the oral cavity is to increase the effectiveness and radicality of treatment, increase the possibility of dental rehabilitation, reduction of disability. To write this article, we conducted a five-year analysis of the primary detection of malignant tumors of the oral cavity in 76 patients hospitalized for treatment in the head and neck Department of the Chelyabinsk district Oncology center. All patients with histologically confirmed diagnosis. Everyone needs specialized anti-tumor treatment. In addition to standard diagnostic procedures, all patients were surveyed on the issues of primary complaints and appeals to medical specialists. Results. On the example of the received questionnaires as well as the standard medical examinations conducted upon admission to the head and neck Department, the trends of the primary referral of patients to primary contact doctors, the terms of treatment before referral to a specialized oncological institution, the stage of the process and the presence of metastasis of the primary focus during treatment, the presence of aggravating factors are analyzed. Conclusions. The results for the five-year period in patients with primary malignant neoplasm of the oral cavity were evaluated, practical recommendations on clinically significant symptoms of malignant tumors of the oral cavity, orientation on the timing of observation were given.

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Research Progress of circRNAs in Head and Neck Cancers

Frontiers in Oncology ◽

10.3389/fonc.2021.616202 ◽

2021 ◽

Vol 11 ◽

Author(s):

Panchun Li ◽

Kunjie Zhu ◽

Yongzhen Mo ◽

Xiangying Deng ◽

Xianjie Jiang ◽

...

Keyword(s):

Head And Neck ◽

Malignant Tumors ◽

Treatment Resistance ◽

Disease Diagnosis ◽

Incidence Rates ◽

Head And Neck Cancers ◽

Research Progress ◽

Circular Rnas ◽

Patients With Cancer ◽

High Conservation

Circular RNAs (circRNAs) are a novel type of non-coding RNAs. Because of their characteristics of a closed loop structure, disease- and tissue-specificity, and high conservation and stability, circRNAs have the potential to be biomarkers for disease diagnosis. Head and neck cancers are one of the most common malignant tumors with high incidence rates globally. Affected patients are often diagnosed at the advanced stage with poor prognosis, owing to the concealment of anatomic sites. The characteristics, functions, and specific mechanisms of circRNAs in head and neck cancers are increasingly being discovered, and they have important clinical significance for the early diagnosis, treatment, and prognosis evaluation of patients with cancer. In this study, the generation, characteristics, and functions of circRNAs, along with their regulatory mechanisms in head and neck cancers have been summarized. We report that circRNAs interact with molecules such as transcription and growth factors to influence specific pathways involved in tumorigenesis. We conclude that circRNAs have an important role to play in the proliferation, invasion, metastasis, energy and substance metabolism, and treatment resistance in cancers.

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The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

BioMed Research International ◽

10.1155/2020/2329196 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Chongwen Xu ◽

Peng Han ◽

Wanli Ren ◽

Hao Dai ◽

Yanxia Bai ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Malignant Tumors ◽

Protective Role ◽

Neck Squamous Cell Carcinoma ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population

Purpose. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods. We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results. Our study revealed that rs7336610 (OR 1.77, 95 % CI = 1.09 ‐ 2.86 , and p = 0.021 ) and rs1428 (OR 1.73, 95 % CI = 1.07 ‐ 2.81 , and p = 0.025 ) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95 % CI = 0.12 ‐ 0.95 , and p = 0.040 ) compared with stage I/II. Conclusion. Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC.

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Effects of COVID-19 Pandemic on Otolaryngology Surgery in Italy: The Experience of Our University Hospital

Otolaryngology ◽

10.1177/0194599820928970 ◽

2020 ◽

Vol 163 (1) ◽

pp. 86-88 ◽

Cited By ~ 6

Author(s):

Massimo Ralli ◽

Antonio Minni ◽

Francesca Candelori ◽

Fabrizio Cialente ◽

Antonio Greco ◽

...

Keyword(s):

Head And Neck ◽

Bone Fractures ◽

Malignant Tumors ◽

Nasal Bone ◽

Upper Airway ◽

Neck Surgery ◽

University Hospital ◽

Outpatient Procedures ◽

Therapeutic Procedures ◽

Adults And Children

Otolaryngology and head and neck surgery underwent drastic changes during the COVID-19 pandemic. Since March 10, the first day of the lockdown in Italy, diagnostic and therapeutic procedures were limited to emergency and oncology cases, while outpatient procedures and clinical examinations were temporarily suspended to limit virus diffusion and to reallocate personnel into wards dedicated to COVID-19. In our otolaryngology unit, between March 10 and April 28, 2020, we performed 96 surgical procedures; they mainly consisted in diagnosis and treatment of malignant tumors of the head and neck (77%), management of acute upper airway obstruction in adults and children (14.7%), drainage of abscesses of the head and neck (6.2%), and treatment of nasal bone fractures (2.1%). When comparing these data with those of the same period in 2019 for emergency and oncology procedures, we noticed a drastic reduction of head and neck abscesses and nasal bone fractures, while oncology surgery remained stable.

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