Near-net-shape fabrication of open-porous bone replacement materials of calcium phosphate and protein

2017 ◽  
Author(s):  
Berit Müller
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Stability ◽  
Bone Defects ◽  
Porous Scaffolds ◽  
Synthetic Bone ◽  
Bone Replacement Material ◽  
Bone Replacement ◽  
Near Net Shape ◽  
Composition Structure ◽  
Direct Incorporation

As today’s synthetic bone implants fulfil the requirements for the repair of bone defects only in part continuous research for their improvement is ongoing. This work aims at the fabrication of bone replacement materials with bone-like properties regarding composition, structure, mechanical stability, and resorbability. As appropriate fabrication method, the slurry-based freeze gelation process was chosen. It allows the direct incorporation of active bio-relevant compounds, such as proteins, during scaffold processing. Moreover, the process enables the fabrication of complex-shaped and open-porous scaffolds. As principal components for the scaffolds calcium phosphate and protein were selected as they are biocompatible and resorbable. This work analyses the interaction between calcium phosphate and protein in suspension and investigates the suitability of the fabricated calcium phosphate/protein scaffolds as bone replacement material and drug release depot. Table of Contents SUMMARY ...

The Obliteration of Noncritical Size Bone Defects With Bone Dust or Bone Replacement Material (Bioactive Glass S53P4)

2019 ◽  
Vol 40 (4) ◽  
pp. e415-e423 ◽  
Author(s):  
Anne Kluge ◽  
Marcus Neudert ◽  
Christiane Kunert-Keil ◽  
Susen Lailach ◽  
Thomas Zahnert ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Defects ◽  
Bone Replacement Material ◽  
Bone Replacement

scholarly journals Local and Systemic Inflammation After Implantation of a Novel Iron Based Porous Degradable Bone Replacement Material in Sheep Model

2021 ◽  
Author(s):  
Bernd Wegener ◽  
Maik Behnke ◽  
Stefan Milz ◽  
Volkmar Jansson ◽  
Christian Redlich ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
Bone Substitutes ◽  
Histological Evaluation ◽  
Control Group ◽  
Blood Levels ◽  
Porous Iron ◽  
Sheep Model ◽  
Bone Replacement Material ◽  
Bone Replacement ◽  
Iron Based

Abstract Despite a high regenerative potential of healthy bone, replacement of large bone defects is an currently ongoing medical challenge. Due to a lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load bearing properties. Degradable iron-based alloys are an attractive innovation. Therefore, a degradable iron-based bone replacement material has been developed.To test the suitability of a newly designed iron-based alloy, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. Even if degradation at the desired rate was not achieved, in the histological evaluation of the implants` environment we found degraded particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes.Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.

Ensuring defined porosity and pore size using ammonium hydrogen carbonate as porosification agent for calcium phosphate scaffolds

2013 ◽  
Vol 14 (1-2) ◽  
Author(s):  
Markus Lindner ◽  
Karolina Schickle ◽  
Christian Bergmann ◽  
Horst Fischer
Keyword(s):  
Calcium Phosphate ◽  
Pore Size ◽  
Ammonium Hydrogen Carbonate ◽  
Bone Replacement Material ◽  
Bone Replacement ◽  
Hydrogen Carbonate ◽  
Ammonium Hydrogen

AbstractUp to now, it has been very challenging to manufacture a degradable bone replacement material having a specific pore size as well as a specific percentage of porosity which can be set independently of one another. We hypothesize that this is possible by using ammonium hydrogen carbonate (NH

P.154 A new synthetic bone replacement material with an osteoinductive properties

2006 ◽  
Vol 34 ◽  
pp. 171
Author(s):  
V. Bienengraeber ◽  
S. Lenz ◽  
E. Rumpel ◽  
K.-O. Henkel
Keyword(s):  
Synthetic Bone ◽  
Bone Replacement Material ◽  
Bone Replacement

scholarly journals The preparation and application of calcium phosphate biomedical composites in filling of weight-bearing bone defects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lijia Cheng ◽  
Tianchang Lin ◽  
Ahmad Taha Khalaf ◽  
Yamei Zhang ◽  
Hongyan He ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Weight Bearing ◽  
Bone Defects ◽  
Type I ◽  
Artificial Bone ◽  
Thermosensitive Hydrogel ◽  
Bone Repairing ◽  
Histological Staining

AbstractNowadays, artificial bone materials have been widely applied in the filling of non-weight bearing bone defects, but scarcely ever in weight-bearing bone defects. This study aims to develop an artificial bone with excellent mechanical properties and good osteogenic capability. Firstly, the collagen-thermosensitive hydrogel-calcium phosphate (CTC) composites were prepared as follows: dissolving thermosensitive hydrogel at 4 °C, then mixing with type I collagen as well as tricalcium phosphate (CaP) powder, and moulding the composites at 37 °C. Next, the CTC composites were subjected to evaluate for their chemical composition, micro morphology, pore size, Shore durometer, porosity and water absorption ability. Following this, the CTC composites were implanted into the muscle of mice while the 70% hydroxyapatite/30% β-tricalcium phosphate (HA/TCP) biomaterials were set as the control group; 8 weeks later, the osteoinductive abilities of biomaterials were detected by histological staining. Finally, the CTC and HA/TCP biomaterials were used to fill the large segments of tibia defects in mice. The bone repairing and load-bearing abilities of materials were evaluated by histological staining, X-ray and micro-CT at week 8. Both the CTC and HA/TCP biomaterials could induce ectopic bone formation in mice; however, the CTC composites tended to produce larger areas of bone and bone marrow tissues than HA/TCP. Simultaneously, bone-repairing experiments showed that HA/TCP biomaterials were easily crushed or pushed out by new bone growth as the material has a poor hardness. In comparison, the CTC composites could be replaced gradually by newly formed bone and repair larger segments of bone defects. The CTC composites trialled in this study have better mechanical properties, osteoinductivity and weight-bearing capacity than HA/TCP. The CTC composites provide an experimental foundation for the synthesis of artificial bone and a new option for orthopedic patients.

scholarly journals A bone replacement-type calcium phosphate cement that becomes more porous in vivo by incorporating a degradable polymer

2021 ◽  
Vol 32 (7) ◽  
Author(s):  
Akiyoshi Shimatani ◽  
Hiromitsu Toyoda ◽  
Kumi Orita ◽  
Yuta Ibara ◽  
Yoshiyuki Yokogawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Alginic Acid ◽  
Setting Time ◽  
Zealand White Rabbit ◽  
Control Group ◽  
Degradable Polymer ◽  
Low Viscosity ◽  
Bone Replacement

AbstractThis study investigated whether mixing low viscosity alginic acid with calcium phosphate cement (CPC) causes interconnected porosity in the CPC and enhances bone replacement by improving the biological interactions. Furthermore, we hypothesized that low viscosity alginic acid would shorten the setting time of CPC and improve its strength. CPC samples were prepared with 0, 5, 10, and 20% low viscosity alginic acid. After immersion in acetate buffer, possible porosification in CPC was monitored in vitro using scanning electron microscopy (SEM), and the setting times and compressive strengths were measured. In vivo study was conducted by placing CPC in a hole created on the femur of New Zealand white rabbit. Microcomputed tomography and histological examination were performed 6 weeks after implantation. SEM images confirmed that alginic acid enhanced the porosity of CPC compared to the control, and the setting time and compressive strength also improved. When incorporating a maximum amount of alginic acid, the new bone mass was significantly higher than the control group (P = 0.0153). These biological responses are promising for the translation of these biomaterials and their commercialization for clinic applications.

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bernd Wegener ◽  
Maik Behnke ◽  
Stefan Milz ◽  
Volkmar Jansson ◽  
Christian Redlich ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
Bone Substitutes ◽  
Histological Evaluation ◽  
Control Group ◽  
Blood Levels ◽  
Porous Iron ◽  
Sheep Model ◽  
Bone Replacement ◽  
Alloy Particles ◽  
Iron Based

AbstractDespite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.

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