scholarly journals Diagnostic value of glucose transporter 1 (glut-1) expression in nested variant of urothelial carcinoma

2018 ◽  
Author(s):  
Ceren Boyaci ◽  
Kemal Behzatoglu
Keyword(s):  
Urothelial Carcinoma ◽  
Glucose Transporter ◽  
Diagnostic Value ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Nested Variant

Differential glycolytic and glycogenogenic transduction pathways in male and female bovine embryos produced in vitro

2012 ◽  
Vol 24 (2) ◽  
pp. 344 ◽  
Author(s):  
M. Garcia-Herreros ◽  
I. M. Aparicio ◽  
D. Rath ◽  
T. Fair ◽  
P. Lonergan
Keyword(s):  
Glucose Metabolism ◽  
Protein Expression ◽  
Glucose Uptake ◽  
Glucose Transporter ◽  
Glycogen Synthase ◽  
Bovine Embryos ◽  
High Concentration ◽  
Glucose Transporter 1 ◽  
Male And Female ◽  
Glut 1

Previous studies have shown that developmental kinetic rates following IVF are lower in female than in male blastocysts and that this may be related to differences in glucose metabolism. In addition, an inhibition of phosphatidylinositol 3-kinase (PI3-K) inhibits glucose uptake in murine blastocysts. Therefore, the aim of this study was to identify and compare the expression of proteins involved in glucose metabolism (hexokinase-I, HK-I; phosphofructokinase-1, PFK-1; pyruvate kinase1/2, PK1/2; glyceraldehyde-3-phosphate dehydrogenase, GAPDH; glucose transporter-1, GLUT-1; and glycogen synthase kinase-3, GSK-3) in male and female bovine blastocysts to determine whether PI3-K has a role in the regulation of the expression of these proteins. Hexokinase-I, PFK-1, PK1/2, GAPDH and GLUT-1 were present in bovine embryos. Protein expression of these proteins and GSK-3 was significantly higher in male compared with female blastocysts. Inhibition of PI3-K with LY294002 significantly decreased the expression of HK-I, PFK-1, GAPDH, GSK-3 A/B and GLUT-1. Results showed that the expression of glycolytic proteins HK-I, PFK-1, GAPDH and PK1/2, and the transporters GLUT-1 and GSK-3 is regulated by PI3-K in bovine blastocysts. Moreover, the differential protein expression observed between male and female blastocysts might explain the faster developmental kinetics seen in males, as the expression of main proteins involved in glycolysis and glycogenogenesis was significantly higher in male than female bovine embryos and also could explain the sensitivity of male embryos to a high concentration of glucose, as a positive correlation between GLUT-1 expression and glucose uptake in embryos has been demonstrated.

scholarly journals Hypoxia Marker GLUT-1 (Glucose Transporter 1) is an Independent Prognostic Factor for Survival in Bladder Cancer Patients Treated with Radical Cystectomy

2016 ◽  
Vol 2 (1) ◽  
pp. 101-109 ◽  
Author(s):  
P.J. Boström ◽  
J. Thoms ◽  
J. Sykes ◽  
O. Ahmed ◽  
A. Evans ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Radical Cystectomy ◽  
Glucose Transporter ◽  
Independent Prognostic Factor ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Hypoxia Marker

scholarly journals Maternal nutritional manipulation of placental growth and glucose transporter 1 (GLUT-1) abundance in sheep

Reproduction ◽  
2001 ◽  
Vol 122 (5) ◽  
pp. 793-800 ◽  
Author(s):  
J Dandrea
Keyword(s):  
Glucose Transporter ◽  
Glucose Transporter 1 ◽  
Glut 1

Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

2013 ◽  
Vol 31 (9) ◽  
pp. 607-615 ◽  
Author(s):  
Hanbyoul Cho ◽  
You Sun Lee ◽  
Julie Kim ◽  
Joon-Yong Chung ◽  
Jae-Hoon Kim
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Poor Prognosis ◽  
Glucose Transporter ◽  
Glucose Transporter 1 ◽  
Glut 1

scholarly journals Expression of Glucose Transporter 1 Confers Susceptibility to Human T-Cell Leukemia Virus Envelope-Mediated Fusion

2005 ◽  
Vol 79 (7) ◽  
pp. 4150-4158 ◽  
Author(s):  
Ayse Kubra Coskun ◽  
Richard E. Sutton
Keyword(s):  
T Cell ◽  
Glucose Transporter ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Mdbk Cells

ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus identified and causes both adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-1-associated myelopathy, among other disorders. In vitro, HTLV-1 has an extremely broad host cell tropism in that it is capable of infecting most mammalian cell types, although at the same time viral titers remain relatively low. Despite years of study, only recently has a bona fide candidate cellular receptor, glucose transporter 1 (glut-1), been identified. Although glut-1 was shown to bind specifically to the ectodomain of HTLV-1 and HTLV-2 envelope glycoproteins, which was reversible with small interfering RNA directed against glut-1, cellular susceptibility to HTLV upon expression of glut-1 was not established. Here we show that expression of glut-1 in relatively resistant MDBK cells conferred increased susceptibility to both HTLV-1- and HTLV-2-pseudotyped particles. glut-1 also markedly increased syncytium formation in MDBK cells after exposure to HTLV-1. Another assay also demonstrated HTLV-1 envelope-cell fusion in the presence of glut-1. Taken together, these results provide additional evidence that glut-1 is a receptor for HTLV.

Membranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous system

2000 ◽  
Vol 26 (1) ◽  
pp. 91-97 ◽  
Author(s):  
M. Loda ◽  
X. Xu ◽  
A. Pession ◽  
A. Vortmeyer ◽  
F. Giangaspero
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glucose Transporter ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
The Central Nervous System

scholarly journals Expression of glucose transporter 1 (GLUT 1) in the epithelial layer of an ex vivo produced human oral mucosa equivalent.

2001 ◽  
Vol 47 (5) ◽  
pp. 289-292 ◽  
Author(s):  
Kenji IZUMI ◽  
Hiroto TERASHI ◽  
Michiko YOSHIZAWA ◽  
Cynthia L. MARCELO ◽  
Stephen E. FEINBERG
Keyword(s):  
Oral Mucosa ◽  
Glucose Transporter ◽  
Ex Vivo ◽  
Epithelial Layer ◽  
Glucose Transporter 1 ◽  
Glut 1

scholarly journals Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2159 ◽  
Author(s):  
Suliman Almahmoud ◽  
Xiaofang Wang ◽  
Jonathan L. Vennerstrom ◽  
Haizhen A. Zhong
Keyword(s):  
Ligand Binding ◽  
Drug Target ◽  
Glucose Transporter ◽  
Docking Studies ◽  
Conformational Switching ◽  
Structure Based Drug Design ◽  
Glucose Transporter 1 ◽  
Conformational Studies ◽  
Glut 1 ◽  
Important Target

Glucose transporter 1 (GLUT1) is a facilitative glucose transporter overexpressed in various types of tumors; thus, it has been considered as an important target for cancer therapy. GLUT1 works through conformational switching from an outward-open (OOP) to an inward-open (IOP) conformation passing through an occluded conformation. It is critical to determine which conformation is preferred by bound ligands because the success of structure-based drug design depends on the appropriate starting conformation of the target protein. To find out the most favorable GLUT 1 conformation for ligand binding, we ran systemic molecular docking studies for different conformations of GLUT1 using known GLUT1 inhibitors. Our data revealed that the IOP is the preferred conformation and that residues Phe291, Phe379, Glu380, Trp388, and Trp412 may play critical roles in ligand binding to GLUT1. Our data suggests that conformational differences in these five amino acids in the different conformers of GLUT1 may be used to design ligands that inhibit GLUT1.

GLUCOSE TRANSPORTER-1 PROTEIN (GLUT-1) MEMBRANOUS EXPRESSION IS A MARKER OF EMBRYONAL NEOPLASMS OF CENTRAL NERVOUS SYSTEM

1996 ◽  
Vol 55 (5) ◽  
pp. 653
Author(s):  
F. Glangaspero ◽  
X. Xu ◽  
A. Pession ◽  
V. Risi ◽  
A. Vortmeyer ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glucose Transporter ◽  
Glucose Transporter 1 ◽  
Glut 1
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