scholarly journals Current aspects of COVID-19 vaccine prophylaxis: big steps from laboratory to clinical practice

2021 ◽  
Vol 18 (4) ◽  
pp. 5-16
Author(s):  
D. V. Grinko ◽  
D. V. Moiseev ◽  
E. V. Voropaev ◽  
I. O. Stoma

For more than a year and a half, the entire world has been experiencing the COVID-19 pandemic. Only the development of safe and effective vaccines may make the most significant changes in the fight against this infection. The World Health Organization (WHO) and its partners are contributing to accelerated development of vaccines because it is the vaccination along with social distancing and the use of personal protective equipment that is an effective way to prevent the coronavirus disease. This review covers general characteristics of vaccines registered or approved by at least one national regulator, the risks and side effects of the vaccines, as well as approaches to assess the effectiveness of COVID-19 vaccination.

2020 ◽  
Vol 10 (31) ◽  
pp. 87-95
Author(s):  
Nicole Maria Miyamoto Bettini ◽  
Fabiana Tomé Ramos ◽  
Priscila Masquetto Vieira de Almeida

A Organização Mundial da Saúde - OMS confirmou a circulação internacional do novo Coronavírus em janeiro de 2020, nomeando-o como COVID-19 e, declarando uma pandemia. É de extrema importância que durante a pandemia, os profissionais de saúde tenham acesso e conhecimento sobre o uso correto dos Equipamentos de Proteção Individual (EPIs) e suas indicações, tomando assim, as devidas precauções na prevenção de infecções. O presente estudo buscou identificar a padronização mundial quanto ao uso dos EPIs utilizados no atendimento a pacientes suspeitos e/ou confirmados de COVID-19 no Brasil, EUA, China, Espanha, Itália e demais países europeus. Os guidelines apresentam a padronização quanto ao uso dos EPIs utilizados no atendimento a suspeitos e/ou confirmados de COVID-19, indo ao encontro das recomendações fornecidas pela OMS. Até o momento, o uso de EPIs é sem dúvida a estratégia mais importante e eficaz para proteger os profissionais de saúde durante a assistência ao paciente com COVID-19.Descritores: Infecções por Coronavírus, Equipamento de Proteção Individual, Pessoal de Saúde, Enfermagem. Recommendations for personal protective equipment to combat COVID-19Abstract: The World Health Organization - WHO confirmed the international circulation of the new Coronavirus in January 2020, naming it as COVID-19 and declaring a pandemic. It is extremely important that during the pandemic, health professionals have access and knowledge about the correct use of Personal Protective Equipment (PPE) and its indications, thus taking appropriate precautions to prevent infections. The present study sought to identify the worldwide standardization regarding the use of PPE utilized to take care of suspected and confirmed patients with COVID-19 in Brazil, USA, China, Spain, Italy and other European countries. The guidelines present a standardization regarding the use of PPE utilized to take care of suspected and confirmed with COVID-19, in line with the recommendations provided by WHO. To date, the use of PPE is undoubtedly the most important and effective strategy to protect healthcare professionals during care for patients with COVID-19.Descriptors: Coronavirus Infections, Personal Protective Equipment, Health Personnel, Nursing. Recomendaciones para el equipo de protección personal para combatir COVID-19Resumen: La Organización Mundial de la Salud - La OMS confirmó la circulación internacional del nuevo Coronavirus en enero de 2020, nombrándolo COVID-19 y declarando una pandemia. Es extremadamente importante que durante la pandemia, los profesionales de la salud tengan acceso y conocimiento sobre el uso correcto del Equipo de Protección Personal (EPP) y sus indicaciones, tomando así las precauciones adecuadas para prevenir infecciones. El presente estudio buscó identificar la estandarización mundial con respecto al uso de EPP utilizado para atender a pacientes sospechosos y/o confirmados con COVID-19 en Brasil, Estados Unidos, China, España, Italia y otros países europeos. Las pautas presentan la estandarización con respecto al uso de EPP utilizado para cuidar COVID-19 sospechoso y/o confirmado, de acuerdo con las recomendaciones proporcionadas por la OMS. Hasta la fecha, el uso de EPP es, sin duda, la estrategia más importante y efectiva para proteger a los profesionales de la salud durante la atención de pacientes con COVID-19.Descriptores: Infecciones por Coronavirus, Equipo de Protección Personal, Personal de Salud, Enfermería.


Author(s):  
Rami AL Edwan

Background: The healthcare workers are exposed to dangerous pathogen agents during the outbreak of the new coronavirus COVID-19. To minimize the risk of becoming infected by this virus, healthcare workers need to wear the most appropriate personal protective equipment (PPE). Objective: The objective of this study was to analyze the guidelines that the World Health Organization (WHO) and the Centers for the Disease Control and Prevention (CDC) recommend for the rational use of EPP to protect healthcare workers against the novel coronavirus COVID-19.Methodology: To learn how to effectively protect healthcare workers against the COVID-19, a detailed analysis and comparison of the WHO and CDC guidelines related to the proper use of personal protection equipment (PPE) in different healthcare settings was carried out. Results: The results of this study based on an analysis of PPE recommended by the World Health Organization (WHO) and the Centers for the Disease Control and Prevention (CDC) indicated that the safety and protection of healthcare workers can be maximized if the guidelines suggested by these institutions are followed. In general, the WHO and CDC recommendations based on medical practices are similar, and depending on the healthcare activities and settings where the healthcare workers perform their work, suggest wearing medical/surgical facemasks, respirators, googles and face shields (eye protection), gloves, gowns and aprons. Conclusions: The protection and safety of the healthcare workers can be maximized during the outbreak of COVID-19 by following the WHO and CDC recommendations described in this study. The general guidelines offered by these institutions are similar and based on medical practices.


1970 ◽  
Vol 1 (1) ◽  
pp. 56-58
Author(s):  
SC Kohli ◽  
UK Shrestha ◽  
VM Alurkar ◽  
A Maskey ◽  
M Parajuli ◽  
...  

The global program to eliminate Lymphatic Filariasis created by The World Health organization in 1997 is based on mass administration of single annual doses of diethylcarbamazine ( DEC) plus albendazole in non African regions and of albendazole plus ivermectin in Africa. The usual side effects of DEC treatment include fever, chills, arthralgia, headaches, nausea, and vomiting. Albendazole is associated with relatively few side effects consisting of occasional nausea, vomiting, abdominal pain, headache, reversible alopecia, elevated aminotransferases and rarely leucopenia and rash. We report a case of polyneuropathy in a young individual following DEC and albendazole during mass drug administration. Keywords: Albendazole; DEC; Polyneuropathy. DOI: http://dx.doi.org/10.3126/njms.v1i1.5800   Nepal Journal of Medical Sciences. 2012; 1(1): 56-58


2020 ◽  
Vol 10 (6) ◽  
pp. 1375-1383 ◽  
Author(s):  
Leandro Pecchia ◽  
Davide Piaggio ◽  
Alessia Maccaro ◽  
Claudio Formisano ◽  
Ernesto Iadanza

Abstract COVID-19 pandemic is plaguing the world and representing the most significant stress test for many national healthcare systems and services, since their foundation. The supply-chain disruption and the unprecedented request for intensive care unit (ICU) beds have created in Europe conditions typical of low-resources settings. This generated a remarkable race to find solutions for the prevention, treatment and management of this disease which is involving a large amount of people. Every day, new Do-It-Yourself (DIY) solutions regarding personal protective equipment and medical devices populate social media feeds. Many companies (e.g., automotive or textile) are converting their traditional production to manufacture the most needed equipment (e.g., respirators, face shields, ventilators etc.). In this chaotic scenario, policy makers, international and national standards bodies, along with the World Health Organization (WHO) and scientific societies are making a joint effort to increase global awareness and knowledge about the importance of respecting the relevant requirements to guarantee appropriate quality and safety for patients and healthcare workers. Nonetheless, ordinary procedures for testing and certification are currently questioned and empowered with fast-track pathways in order to speed-up the deployment of new solutions for COVID-19. This paper shares critical reflections on the current regulatory framework for the certification of personal protective equipment. We hope that these reflections may help readers in navigating the framework of regulations, norms and international standards relevant for key personal protective equipment, sharing a subset of tests that should be deemed essential even in a period of crisis.


Isolating pediatric asthma from pediatric pneumonia is one of the serious issues in remote territories. These sicknesses have covering side effects, however require radically extraordinary medicines. Existing rules for pneumonia order in asset poor areas from The World Health Organization require the utilization of bronchodilator test to isolate asthma from pneumonia. In any case, bronchodilator is a costly test to direct and not effectively accessible in remote regions. In this investigation, we star represent an imaginative and novel system utilizing hack sound examination to isolate pneumonia cases from asthma. In crafted by this paper we dissected hack sound information from 20 subjects (10 pneumonia and 10 asthma patients). Utilizing scientific highlights of hack sounds, a HMM classifier was prepared to distinguish pneumonic hack and asthmatic hack. At that point by registering Pneumonic Cough Index every patient was delegated either into pneumonia or asthma. Proposed strategy accomplished a precision of 90% (affectability = 100% and explicitness = 80%) in arranging pneumonia and asthma patients. Our outcomes demonstrate that hack sound convey basic data which can be utilized to isolate asthma patients from pneumonia. Proposed strategy in this paper indicates potential to turn into an option for bronchodilator test in the asset poor zones of the world


2021 ◽  
Vol 4 ◽  
pp. 102-106
Author(s):  
Ankita Kar ◽  
Udayan Bhaumik ◽  
Vineeth Kumar ◽  
V. Shwetha ◽  
Shruthi Nagaraja

The coronavirus pandemic of 2019 has increased the risk of occupational cross infections among dentists. Dental procedures are inherently risky in this scenario due to the need for close proximity with patients and generation of aerosols and splatters. Regulatory dental health bodies, including World Health Organization, Center for Disease Control, and American Dental Association, have devised guidelines for various forms Personal protective equipment for routine outpatient procedures during this pandemic and in the post-COVID-19 world. Stringent regulations are also advisable to conserve these resources at a time when the threat of COVID-19 is likely to persist indefinitely.


2021 ◽  
Vol 9 (2) ◽  
pp. 83-90
Author(s):  
Laksita Barbara ◽  
Mareta Dea Rosaline ◽  
Akhiyan Hadi Susanto

AbstractThere are numbers of Indonesian Youtube Videos that show steps to wear and remove Personal Protective Equipment (PPE) for Corona Virus Disease (COVID19). However, the conformity with the current guidelines remains unknown. This paper aims to determine the validity of these videos based on the World Health Organization (WHO) guidelines. We searched on the Youtube website for videos in donning and doffing PPE for droplet precaution and selected the videos using inclusion and exclusion criteria. Included videos were then evaluated with a checklist derived from WHO course on donning and doffing PPE for COVID-19 and WHO recommendation on PPE for Covid-19. The search that was undertaken resulted in 66 videos, and 40 videos were included for evaluation. There is no significant difference in the donning and doffing score between account types (personal, organizational/institutional, news). The average number of viewers of all videos is more than 2700 viewers. The average score of donning is less than 70% of the total score, and the average doffing score is under 65%. The vast majority of the videos do not follow the WHO recommendation on the PPE type and use more equipment than recommended. There are several contamination risks shown by the videos. Indonesian Youtube videos on PPE procedures for COVID-19 must be selected carefully to be used as an instructional or educational media since most of it presents a high risk of cross-contamination.Keyword: personal protective equipment, audiovisual, cross-contamination, trainingAbstrakTerdapat video dalam Bahasa Indonesia yang terkait cara memakai dan melepaskan Alat Pelindung Diri (APD) untuk Corona Virus Disease (COVID19). Namun, kesesuaian video terhadap pedoman terkini belum diketahui. Penelitian ini bertujuan untuk menentukan validitas video berdasarkan pedoman World Health Organization. Kami menelusuri Youtube untuk memperoleh video instruksi mengenakan dan melepas APD pencegahan kontaminasi droplet dan menyeleksi video tersebut berdasarkan kriteria inklusi dan eksklusi. Video yang telah diseleksi kemudian dievaluasi menggunakan checklist yang diturunkan dari langkah-langkah yang ditunjukan dalam kursus APD COVID-19 yang disediakan oleh WHO, serta rekomendasi APD dari WHO. Penelusuran Youtube menampilkan 66 video, dan dipilih 40 video yang sesuai dengan kriteria kelayakan. Tidak terdapat perbedaan signifikan dalam skor mengenakan dan melepaskan APD antara akun personal, organisasi/institusi, dan berita. Rata-rata jumlah penonton video adalah lebih dari 2700. Skor rata-rata pemakaian APD kurang dari 70% dari skor total, dan skor pelepasan APD kurang dari 65%. Sebagian besar video tidak mengikuti rekomendasi WHO dalam pemilihan tipe PPE dan menggunakan alat yang lebih banyak dari yang direkomendasikan. Terdapat sejumlah risiko kontaminasi yang dapat diobservasi dari langkah-langkah yang ditunjukan dalam video. Video Youtube prosedur APD untuk COVID-19 perlu diseleksi dengan cermat untuk digunakan sebagai media instruksi maupun pendidikan karena sebagian besar menunjukan risiko tinggi kontaminasi silang.Kata Kunci: alat pelindung diri, audiovisual, kontaminasi silang, pelatihan


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 385-390
Author(s):  
Dushyant Bawiskar ◽  
Pratik Phansopkar ◽  
Ayurva Vilas Gotmare

We are in the middle of an unprecedented pandemic named COVID-19 by the World Health Organization (WHO) which is caused by a novel coronavirus. The novelty of the virus and its disease is so new that the entire world is experiencing its consequences on various aspects. The pandemic is still unfolding and creating some new patterns around us. Besides the buzzword, that is, the vaccine is far from our sight. So naturally, we have to look for existing solutions if they can be implemented until the vaccine arrives. From Hydroxychloroquine (HCQ) to Bacillus Calmette Guèrin (BCG) all are being used in trials whether they can be pre-vaccine medicine or not. The variable effect on individual sections of the population has to be studied to deliver a targeted response, especially in resource lacking countries. In addition to these medical problems like social distress and quarantine measures which are taking a toll on people's minds, another unwarranted problem of Infodemic has struck us. So, this paper will review the ongoing steps and challenges and how we can efficiently respond to them to conquer this pandemic.


Author(s):  
Yash Jaiswal

As of late toward the finish of 2019, another illness was found in Wuhan, China. This illness was analyzed to be brought about by another kind of Covid and influenced nearly the entire world. Chinese scientists named this novel infection as 2019-nCov or Wuhan-Covid. Notwithstanding, to try not to misjudge the World Health Organization commotions it as COVID-19 infection while interfacing with the media COVID-19 is new internationally just as in India. This has upset peoples and group minds. There are different gossips and tidbits about the Covid in Indian culture which causes alarm in neighborhoods and people group minds. It is the need of society to know legends and realities about Covid to lessen the frenzy and make the correct preparatory moves for our security against the Covid. Subsequently, this article attempts to bring to the open fantasies and present current realities to the ordinary citizens. We have to confirm fantasies spreading through online media and keep our selves prepared with realities and be confident of what we know and do at this COVID 19 era at individual levels. Fitting these activities in individual minds across nations is bound to benefit the whole world.


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