scholarly journals Supplementary material to "Constraints on long term warming in a climate mitigation scenario"

Author(s):  
Benjamin Sanderson
2020 ◽  
Author(s):  
Benjamin Sanderson

Abstract. Cumulative emissions budgets and net-zero emission target dates are often used to frame climate negotiations (Frameet al., 2014; Millar et al., 2016; Van Vuuren et al., 2016; Rogelj et al., 2015b; Matthews et al., 2012). However, their utilityfor near-term policy decisions is confounded by an uncertainties in future negative emissions capacity (Fuss et al., 2014; Smith et al., 2016; Larkin et al., 2018; Anderson and Peters, 2016) and in long term Earth System response to climate forcers(Rugenstein et al., 2019; Knutti et al., 2017; Armour, 2017) which may impact the utility of an indefinite carbon budget if peak temperatures occur significantly after net zero emissions are achieved, the likelihood of which in a simple model is conditionalon prior assumptions about the long term dynamics of the Earth System. Here we illustrate that the risks associated with nearterm positive emissions can be framed using a definite cumulative emissions budget with a 2040 time horizon, allowing thenecessity and scope for negative emissions deployment later in the century to be better informed by observed warming overcoming decades.


Urban Science ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 27
Author(s):  
Lahouari Bounoua ◽  
Kurtis Thome ◽  
Joseph Nigro

Urbanization is a complex land transformation not explicitly resolved within large-scale climate models. Long-term timeseries of high-resolution satellite data are essential to characterize urbanization within land surface models and to assess its contribution to surface temperature changes. The potential for additional surface warming from urbanization-induced land use change is investigated and decoupled from that due to change in climate over the continental US using a decadal timescale. We show that, aggregated over the US, the summer mean urban-induced surface temperature increased by 0.15 °C, with a warming of 0.24 °C in cities built in vegetated areas and a cooling of 0.25 °C in cities built in non-vegetated arid areas. This temperature change is comparable in magnitude to the 0.13 °C/decade global warming trend observed over the last 50 years caused by increased CO2. We also show that the effect of urban-induced change on surface temperature is felt above and beyond that of the CO2 effect. Our results suggest that climate mitigation policies must consider urbanization feedback to put a limit on the worldwide mean temperature increase.


2021 ◽  
Author(s):  
Fabien Maussion ◽  
Quentin Lejeune ◽  
Ben Marzeion ◽  
Matthias Mengel ◽  
David Rounce ◽  
...  

<p>Mountain glaciers have a delayed response to climate change and are expected to continue to melt long after greenhouse gas emissions have stopped, with consequences both for sea-level rise and water resources. In this contribution, we use the Open Global Glacier Model (OGGM) to compute global glacier volume and runoff changes until the year 2300 under a suite of stylized greenhouse gas emission characterized by (i) the year at which anthropogenic emissions culminate, (ii) their reduction rates after peak emissions and (iii) whether they lead to a long-term global temperature stabilization or decline. We show that even under scenarios that achieve the Paris Agreement goal of holding global-mean temperature below 2 °C, glacier contribution to sea-level rise will continue well beyond 2100. Because of this delayed response, the year of peak emissions (i.e. the timing of mitigation action) has a stronger influence on mit-term global glacier change than other emission scenario characteristics, while long-term change is dependent on all factors. We also discuss the impact of early climate mitigation on regional glacier change and the consequences for glacier runoff, both short-term (where some basins are expected to experience an increase of glacier runoff) and long-term (where all regions are expecting a net-zero or even negative glacier contribution to total runoff), underlining the importance of mountain glaciers for regional water availability at all timescales.</p>


2017 ◽  
Vol 117 (03) ◽  
pp. 508-518 ◽  
Author(s):  
K.John Pasi ◽  
Kathelijn Fischer ◽  
Margaret Ragni ◽  
Beatrice Nolan ◽  
David J. Perry ◽  
...  

SummaryThe safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) were demonstrated in the Phase 3 B-LONG (adults/adolescents ≥12 years) and Kids B-LONG (children <12 years) studies of subjects with haemophilia B (≤2 IU/dl). Here, we report interim, long-term safety and efficacy data from B-YOND, the rFIXFc extension study. Eligible subjects who completed B-LONG or Kids B-LONG could enrol in B-YOND. There were four treatment groups: weekly prophylaxis (20–100 IU/kg every 7 days), individualised prophylaxis (100 IU/kg every 8–16 days), modified prophylaxis (further dosing personalisation to optimise prophylaxis), and episodic (ondemand) treatment. Subjects could change treatment groups at any point. Primary endpoint was inhibitor development. One hundred sixteen subjects enrolled in B-YOND. From the start of the parent studies to the B-YOND interim data cut, median duration of rFIXFc treatment was 39.5 months and 21.9 months among adults/adolescents and children, respectively; 68/93 (73.1 %) adults/adolescents and 9/23 (39.1 %) children had ≥100 cumulative rFIXFc exposure days. No inhibitors were observed. Median annualised bleeding rates (ABRs) were low in all prophylaxis regimens: weekly (≥12 years: 2.3; <6 years: 0.0; 6 to <12 years: 2.7), individualised (≥12 years: 2.3; 6 to <12 years: 2.4), and modified (≥12 years: 2.4). One or two infusions were sufficient to control 97 % (adults/adolescents) and 95 % (children) of bleeding episodes. Interim data from B-YOND are consistent with data from B-LONG and Kids B-LONG, and confirm the longterm safety of rFIXFc, absence of inhibitors, and maintenance of low ABRs with prophylactic dosing every 1 to 2 weeks.Supplementary Material to this article is available online at www.thrombosis-online.com.


2016 ◽  
Vol 115 (02) ◽  
pp. 361-367 ◽  
Author(s):  
Kristin Kornelia Utne ◽  
Waleed Ghanima ◽  
Siv Foyn ◽  
Susan Kahn ◽  
Per Morten Sandset ◽  
...  

SummaryPost-thrombotic syndrome (PTS) is a long-term complication of deepvein thrombosis (DVT). The Villalta scale is the recommended tool for diagnosing PTS, but requires a clinician’s assessment in addition to patient self-assessment. In the present study, we validated a self-administered tool for patient reporting of leg symptoms and signs as a mean to assess PTS. We first validated a form for patient self-reported Villalta (PRV1), then developed and validated a visually assisted form (PRV2). The validity of PRV1 and PRV2 was assessed in patients diagnosed with DVT between 2004 and 2012. Median time from DVT to inclusion was 5.1 and 3.5 years for PRV1 (n=162) and PRV2 (n=94), respectively. Patients were requested to complete the PRV form before a scheduled visit. PTS diagnosed by the original Villalta scale during the visit served as the reference method. PRV1 showed only moderate agreement for diagnosing PTS compared with the original Villalta scale (kappa agreement 0.60, 95 % CI 0.48–0.72), whereas PRV2 showed very good agreement (0.82, 95 % CI 0.71–0.94). In the validation of PRV2, PTS was diagnosed in 54 (57 %) patients according to the original Villalta scale and in 60 (64 %) by PRV2. The sensitivity of PRV2 to detect PTS was 98 % and the specificity was 83 %. We conclude that the visually assisted form for PRV is a valid and sensitive tool for diagnosing PTS. Such a tool could be applied in further clinical studies of PTS, making studies less resource demanding by reducing the need for in-person clinic visits.Supplementary Material to this article is available online at www.thrombosis-online.com.


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