scholarly journals The Transmission Potential of Sars-Cov-2 during the Early Outbreak

1969 ◽  
Vol 11 (4) ◽  
pp. 211-216
Author(s):  
Hamzullah Khan

Background: The newly emerging respiratory disease called COVID-19 , originated from a metropolitan city of the HubeiProvince of China, called Wuhan, in Dec 2019, demonstrated its epidemic potential with a rapid spread of this virus across the globein just 2 months period. This highlights the higher rate of transmissibility of this virus and further its higher morbidity and mortalityspecially in aged population or people with co-morbidities and immune gap.Objectives: To determine the clinical significance of travel history to an epidemic area and social distancing with COIVD -19infections.Material and methods: This cross sectional study was conducted in major/only tertiary care hospital of Nowshera in collaborationwith District Health Office, Nowshera from 15th Feb to 24th April 2020. Relevant information's were recorded in a predesignedproforma prepared in SPSS version 25th for descriptive and inferential analysis.Results: Out of total 378 suspects/patients, 272(72%) were males and 106(28%) females. The Mean with Standard deviation ofage of the suspects was 35+16.1 years. A significant relationship of an increase in age with positive cases (Chi-squarevalue=10.73, p=0.013) was observed. 13/41(31.70%) of the positive cases had a history of travel to an epidemic area. A statisticallysignificant relationship between COVID-19 infection and travel history (Chi-Square=5.86, p=0.015) was noted. The probability ofthe infection in patients/suspects with history of travel to an epidemic area was 2.38 times(OR=2.38, 95%CI, 2.5-14.9). The relativerisk of infection was (rr=1.75, 95%CI, 1.16-4.88) as compared to suspects with no contact(rr=0.81, 95%CI, 0.6-1.0) respectively.Conclusion: There is a significant impact of travel history to an area with COVID19 epidemics. This data also speaks itself on theimportance of social distancing in terms of history of travel to combat COVID-19.Key words: COVID-19, Travel history, Social distancing, risk assessment, probability of disease, correlation of disease.

2020 ◽  
Vol 24 (2) ◽  
pp. 149-155
Author(s):  
Hamzullah Khan ◽  
Mohammad Zahid Khan ◽  
Mian Mohammad Naveed

Objective: To determine the frequency of COVID-19 and characteristics of patients presenting to the COVID-19 clinic at Qazi Hussain Ahmed Medical Complex (QHAMC) Nowshera. Methodology: This cross-sectional study was conducted from 21st Feb 2019 to April 8, 2020, in QHAMC Nowshera. Relevant information was collected on a pre-designed Performa prepared following the objectives of the study. Results: Out of 220 patients, 165(75%) were males, and 55(25%) females. 96(43.6%) of the patients were in the age range 18-30 years followed by 52(23.6%) in age range 31-45years and 17(7.7%) with age>60 years etc. Out of total the nasopharyngeal swabs of 26(11.6%) strong suspects were sent for PCR testing. 208(94.5%) were sent home while 12(5.5%) were advised quarantine. Forty-seven (21.4%) had a travel history to an epidemic area in the last 14 days. 51(23.2%) had a positive history of contact. Eighty-five (38.6%) had a fever and sore throat followed by 27(12.3%) with (fever & cough), 24(10.9%) with (cough and shortness of breath/dyspnea) and 14(6.4%) with a simple flue, etc. Out of 26 cases, 6(2.7%) were COVID-19 Positive, 12(5.5%) were negative and results of 8(3.6%) were still awaited. The PCR repeated the test for confirmed cases showed;  4(1.8%) negative, one died and one was refractory positive.  A positive correlation (p=0.03, r=0.4) of an increase in age with the severity of the disease/outcome was recorded. Conclusion: The frequency of infectivity with COVID-19 was 2.6%. A higher number of patients with mild symptoms attend the COVID clinic. The rate of infection and mortality was higher in age> 60 years.


2021 ◽  
pp. 46-48
Author(s):  
Muzaffer Rashid Shawl ◽  
Fahad ul Islam Mir ◽  
Saad Abdul Rahman ◽  
Anil C Anand ◽  
Manav Wadhawan ◽  
...  

NAFLD is hepatic pandemic of the twenty rst century, being leading cause of chronic hepatic disease in western world. We did a cross sectional study to nd out prevalence of NAFLD among prospective healthy liver donors at a tertiary care hospital at New Delhi, India over a period from June 2014 to March 2016. 124 apparently healthy prospective liver donors were selected. Exclusion criteria were set to exclude all those who had signicant history of alcohol intake (dened as greater than 30g/day for men and greater than 20g/day for women over last two years), Hepatitis B or C infection, severe surgical weight loss or emaciation, Obstructive Sleep Apnea, Celiac disease, history of drug intake known to cause hepatic steatosis. Out of 124 prospective liver donors included in this study, 29 (23%) donors were found to have fatty liver on USG abdomen; 38 (31%) donors had fatty liver on unenhanced CTof the abdomen (LAI of ≤ 5 HU); 61 (49%) donors had fatty liver on magnetic resonance.


Author(s):  
Pooja Gupta ◽  
Mariyam Faruqi ◽  
Subrat Chandra ◽  
Sameer S. Shah ◽  
Rupita Kulshreshtha

Background: The study was undertaken to see the correlation between cervical cytology, histopathology and colposcopy in the diagnosis and management of various cervical lesions.Methods: It is a cross sectional study conducted at a tertiary care hospital in Mumbai, in the department of obstetrics and gynecology from February 2007 to March 2008. A total 55 sexually active women were enrolled for the study who belonged to age group greater than 20 years with history of chronic leucorrhoea or post-coital bleeding/spotting, intermenstrual bleeding/spotting or examination findings of erosion, an unhealthy cervix, a lesion bleeding on touch or an abnormal or suspicious Papanicolaou smear. These women then underwent cytology, colposcopy and cervical biopsy.Results: The accuracy of cytology when compared to colposcopy was 81.82%. The accuracy of colpo-histopathology was 83.6%. The combined accuracy was 76.36%.Conclusions: The simultaneous use of cytological studies and screening colposcopy has been shown to increase the cervical cancer detection. Colposcopy offers an excellent tool in the hands of a gynaecologist to evaluate the uterine cervix and it is not possible to develop this kind of perspective by any other method.


2012 ◽  
Vol 30 (2) ◽  
pp. 78-84
Author(s):  
L Khondker ◽  
AM Choudhury ◽  
MOR Shah ◽  
M Shahidullah ◽  
MSI Khan ◽  
...  

A cross sectional study, conducted in the department of  Dermatology and Venereology, Bangabandhu Sheikh Mujib  Medical University (BSMMU) for duration of January 2009  to December 2010. Hundred twenty patients with  onychomycosis were selected by purposive type of nonprobability  sampling technique. Majority of the patients  61(150.8%) were in the age group of 21-30 years old. Mean  age of the patients were 32.8±14 years and most of the  patients were house wives 36(30.0%). Disfigurement  117(97.5%) and discomfort 89(74.2%) were more common  chief complaints of the patients. The mean duration of  disease was 20.4±15.4 months and nail fold changes were  associated with 37(30.8%) patients and more than a half  63(52.5%) of the patients had history of wet works.  Regarding the history of past illness, it was observed that  previous onychmycosis found 26(21.7%), nail trauma  26(21.7%) and immune suppression 6(5.0%). In  endocrinopathies, hypothyroidism was observed in 1(0.8%),  Diabetes Mellitus 6(5.0%) etc. Regarding the pattern of nail  changes, thickening of nail plate 88(73.3%), onycholysis  67(55.8%), subungunal hyperkeratosis 61(50.8%) were  more common changes. Paronychia was observed in 34  (28.3%) cases. In concomitant fungal infection, it was  observed that T. manuum in 6(5.0%), T. pedis 3(2.5%),  Interdigital intertrigo 2(1.7%) and T. cruris 1(0.8%). This  was a study on a limited number of cases. Future studies  must include economical support, then large sample size  could be ensured and study finding would be more reliable.  There is a great need of epidemiological studies also, with  sufficient follow-up, systematic reviews and meta-analyses  on this issue.   DOI: http://dx.doi.org/10.3329/jbcps.v30i2.11408   J Bangladesh Coll Phys Surg 2012; 30: 78-84    


2019 ◽  
Vol 57 (219) ◽  
Author(s):  
Ananta Uprety ◽  
Binod Pantha ◽  
Lochan Karki ◽  
Suresh Prasad Nepal ◽  
Milan Khadka

Introduction: Organophosphorous poisoning is a common problem prevalent in Nepal. Intermediate syndrome is a common clinical feature seen among the patients those have ingested poison. There is a scarcity of data related to intermediate syndrome and other general complications in patients with organophosphorous poisoning in context of Nepal. This study was carried out to observe the prevalence of intermediate syndrome and the general complications of oraganophosphorus poisoning among admitted patients in a tertiary care hospital. Methods: This was a descriptive cross-sectional study conducted at a tertiary care hospital from April 2008 to June 2009 after ethical approval was from Institiutional Review Board of tertiary care hospital. Forty four patients with history of ingestion of organophosphorus poisoning within 24 hours were included in our study through convenience sampling. Clinical examinations were done to look for Intermediate syndrome. Data was entered in Statistical Package for Social Sciences and point estimate at 95% of CI was calculated along with frequency and proportion for binary data. Results: Out of 44 patients, features of intermediate syndrome were seen in 40 (90.9%) at 95% of CI (84.2-97.6) patients in the study. The frequency of intermediate syndrome signs like weakness of neck flexion, inability to sit up and swallowing difficulty were seen among the patients. Complications like pneumonia 4 (9.09%), hyponatremia 3 (6.8%), hypokalemia 1 (2.27%) and bradycardia 1 (2.27%) were seen in the study. Mortality seen in the study was 2 (4.5%) among the admitted patients. Conclusions: Prevalence of intermediate syndrome was higher compared to other studies done in similar settings. Complications like pneumonia, hyponatremia, hypokalemia and bradycardia were seen among the patients.


Author(s):  
Chintan Upadhyay ◽  
Nisha Upadhyay

Background: When clinical pregnancy is established, the risk of spontaneous pregnancy loss is ~12-14%, and therefore the incidence of Recurrent Pregnancy Loss (RPL) by chance alone would be in the order of 0.35%. It occurs in 0.5-3% of women. The objective of this study was to evaluate the obstetric outcome in pregnancies with history of one or more abortions.Methods: It is a retrospective cross-sectional study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore. Record review of cases was done from January 2005 to December 2009. Inclusion criteria were pregnancies with history of previous abortions.Results: There were 400 cases with previous history of abortions. There were 266 (66.4%) booked cases while 134 (33.5%) were unbooked cases. 272 (68.0%) patients crossed viable period of pregnancy (more than 28 weeks). Around 56 (14.0%) cases had repeat abortions, 276 (69.0%) cases underwent vaginal delivery and 124 (31.0%) underwent cesarean section. Almost 91 (22.8%) of Babies were low birth weight while others were above 2.5 kg. There were 52 (13.0%) preterm babies and 28 (7.0%) Intrauterine demise of fetuses.Conclusions: Patients with previous history of abortions are at increased risk of adverse maternal and perinatal outcome.


2021 ◽  
pp. 16-18
Author(s):  
Shivali Aggarwal ◽  
Seema Goel ◽  
Dimple Chopra

BACKGROUND: Perniosis is a localised inammatory disorder affecting the unprotected skin regions of individuals exposed to damp, nonfreezing cold. The exact pathogenesis has not been elucidated, however, it is thought to be a microvascular disease. AIMS: To study the demographic prole of patients presenting with perniosis and examine the nailfold capillaroscopic (NFC) changes. MATERIAL AND METHODS: This was an observational, cross-sectional study conducted at a Tertiary care hospital of North India over a period of three months (November 2020- January 2021). Patients with idiopathic perniosis were included in the study. After detailed history and clinical examination, proximal nailfold (PNF) video capillaroscopy was performed in the affected digits. RESULTS: A total of 47 patients with idiopathic perniosis were recruited in the study consisting of 35 females and 12 males with female to male ratio of 2.9:1. A majority of individuals belonged to age group 21-35 years (38.29%). Lesions were localized to both hands and feet in 23 patients (48.9%), only hands in 19(40.4%) and only toes in rest 5 (10.6%) patients. Ten (21.2%) patients had family history of similar complaints and history of smoking was present in 2 (4%) patients. The mean BMI 2 recorded in 37 patients aged >20 years was 20.72+4.32kg/m . Finger nail videocapillaroscopy performed in 42 patients showed dilated capillaries in 42.8%, tortuosity in 40.4% and microhaemorrhages in 28.5% patients. CONCLUSION: In the present study, presence of nailfold capillaroscopic changes suggested that an organic damage to the microcirculation is present in perniosis. Low BMI is an important association for development of perniosis. LIMITATIONS: Long term follow up is required for patients with chilblains to assess permanency of nailfold capillaroscopic changes.


Author(s):  
Devendra Chikara

Objective: To investigate the clinical profile of patients with allergic rhinitis in Central India. Material and Methods: Tertiary care hospital patients attending the E.N.T. OPD have been taken into account. The history of all sampled patients and the clinical evaluation were detailed and 800 cases were included in this study. Statistical Analysis: They were articulated in terms of plain proportion. Results: The majorities of patients are under the age of 30 years and are in the third decade of life. It was observed that the proportion of blockers was much higher than sneezers and runners. Most of the predisposing factors were seasonal and house dust. Conclusion: Allergic rhinitis can affect the physical, psychological and social aspects as well as the productivity of the job. There is an important need to raise awareness of different types of illness, including prevention, in the community. Keywords: allergic rhinitis, central India, sneezers.


2020 ◽  
Vol 6 (3) ◽  
pp. 16-19
Author(s):  
Hira Bakhtiar ◽  
Maria Malik A. Khaliq ◽  
Asif Nawaz ◽  
Muhammad Asif ◽  
Siraj Jamil ◽  
...  

Introduction: Postpartum depression has become a common complication in women in their postpartum period, affecting not only the mother but her child and her family. Due to lack of awareness regarding the subject it has been widely neglected, especially in Pakistan.Objective: To determine and compare the frequency and risk factors associated with postpartum depression in a public and a private tertiary care hospital in Peshawar.Materials & Methods: A comparative cross-sectional study was conducted in the Gynecology and Pediatrics OPD and Pediatrics ward of Rehman Medical Institute (RMI) and Gynecology and Pediatrics OPD as well as the vaccination center of Hayatabad Medical Complex (HMC) over a period of 6 months (January to June 2016). The women were interviewed after obtaining informed consent during 1-12 months of their postpartum period using the Edinburgh Postnatal Depression Scale (EPDS) as well as a pretested self-structured questionnaire. Chi Square test and binary logistic regression were used to determine the relative significance of various risk factors for PPD.Results: A total of 280 women were interviewed, 140 in each hospital, their ages ranging from 16 to 45 years. The frequency of PPD calculated at RMI was 62.7% and at HMC it was 37.3% (p=0.001). Risk factors that showed a close association with PPD included the level of education of women (p=0.008), family support (p=0.022), and history of previous trauma (p= 0.055).Conclusion: Postpartum depression is twice as likely to occur in a private tertiary care hospital compared to a public one, and appears related to educational status, family help, and history of trauma.Keywords: Depression, Postpartum; Postpartum Period, Mothers; Child; Breast Feeding; Childbirth


2021 ◽  
Vol 19 (1) ◽  
pp. 97-100
Author(s):  
Anjal Bisht ◽  
Samrat Shrestha ◽  
Priya Bajgai ◽  
Milan Khadka ◽  
Parimal Koirala ◽  
...  

Background: There is a close correlation between ankylosing spondylitis and uveitis, other less common ocular manifestations being episcleritis and scleritis. Though the prognosis of uveitis is good, prompt treatment is required to prevent long-term complications. This study aimed to estimate the prevalence of uveitis in patients with ankylosing spondylitis who follow outpatient clinic of a tertiary care hospital.Methods: A descriptive cross-sectional study was done in medicine outpatient department of a tertiary care hospital for 6 months. Ethical clearance was obtained from the institutional review board of National Academy of Medical Sciences. Convenient sampling was done. The data collected were entered in Microsoft excel to tabulate the data and analyze the results.Results: Out of 81 participants, 26 patients had a history of uveitis (32%). Most of the patients in this study were of 18-30 years. Uveitis was most common in patients with (axial to be added) spondylarthritis and peripheral inflammatory arthritis (41%) compared to those with just the axial disease (32%). Uveitis was more common among males (32.2%) than females (31.5%).Conclusion: In patients with spondyloarthritis uveitis was present in 32% of the patient with more common in patient with both axial and peripheral arthritis. Timely diagnosis of uveitis in ankylosing spondylitis can prevent the sequelae with prompt treatment. Keywords: Ankylosing spondylitis; spondyloarthritis; uveitis


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