scholarly journals Diagnostic Ability of High-definition Imaging Using Ultraslim Endoscopes in Early Gastric Cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Tomomi Sugita ◽  
Sho Suzuki ◽  
Ryoji Ichijima ◽  
Kanako Ogura ◽  
Chika Kusano ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
High Definition ◽  
Diagnostic Ability

scholarly journals Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study

2016 ◽  
Vol 20 (2) ◽  
pp. 297-303 ◽  
Author(s):  
Osamu Dohi ◽  
Nobuaki Yagi ◽  
Atsushi Majima ◽  
Yusuke Horii ◽  
Tomoko Kitaichi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Prospective Study ◽  
Magnifying Endoscopy ◽  
Blue Laser ◽  
Laser Imaging ◽  
Diagnostic Ability ◽  
Blue Laser Imaging ◽  
A Prospective Study

scholarly journals Discovering Biomarkers in Gastric Cancer by Urine Metabolomics

2021 ◽  
Author(s):  
Yuan Kong ◽  
Hongya Zhang ◽  
Shuang Li ◽  
Jian Suo ◽  
Shaopeng Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cluster Analysis ◽  
Early Gastric Cancer ◽  
Partial Least Square ◽  
Least Square ◽  
Urine Samples ◽  
Diagnostic Ability ◽  
Healthy Group ◽  
Cancer Group ◽  
Gastric Cancer Group

Abstract IntroductionGastric cancer is one of the most common gastrointestinal tumors, ranking forth in incidence and second in mortality worldwide. Discovering molecular biomarkers for early gastric cancer diagnosis is of great importance. MethodsUrine and related clinical data of 40 patients with gastric cancer (20 in advanced stage and 20 in early stage) and 20 healthy volunteers from Jilin University First Hospital were collected. Liquid chromatography-mass spectrometry (LC-MS) was used to detect urine samples and the metabolic differences between the three groups of urine samples were analyzed. The principal component analysis was performed after data processing, and different metabolites were found using analysis of variance. Partial least square discriminant analysis was performed to further narrow the range of different metabolites. The precise mass to charge ratios of different metabolites were imported into the Human Metabolomics Database (HMDB). Finally, the identified different metabolites were further screened by cluster analysis and ROC curve. ResultsUrine samples of the healthy group (NOR), the early gastric cancer group (EGC), and the advanced gastric cancer group (AGC) were different metabolites. 324 statistically significant metabolites are screened out. The cluster analysis showed 7-Methylguanine, vinylacetylglycine, butyric acid, 4-Vinylphenol sulf,
5`-biotinyl-AMP, and 3-Amino-2-piperido in EGC, AGC and NGO were similar. 7-Methylguanine, vinylacetylglycine and 4-Vinylphenolsulfate had good diagnostic ability in EGC and NOR (p<0.05), and gastric cancer and NOR (p<0.05). ConclusionDifferences in the metabolites in urine between the early gastric cancer group and the healthy group were found. 7-Methylguanine, Vinylacetylglycine, and 4-Vinylphenolsulfate have good diagnostic ability and may be potential biomarkers of early gastric cancer.

scholarly journals Diagnostic value of high definition magnifying endoscopy combined with i-scan electronic staining in early gastric cancer

2015 ◽  
Vol 23 (30) ◽  
pp. 4876
Author(s):  
Chun-Xiao Wu ◽  
Shuang-Jun Wang ◽  
Bin Zhou ◽  
Guang-Ming Hou ◽  
Fei-Long Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Diagnostic Value ◽  
Magnifying Endoscopy ◽  
High Definition

scholarly journals Evaluation of the Diagnostic Ability of Optical Enhancement System in Early Gastric Cancer Demarcation

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Misato Nagao ◽  
Jun Nishikawa ◽  
Ryo Ogawa ◽  
Sho Sasaki ◽  
Munetaka Nakamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
False Negative ◽  
Three Dimensional ◽  
Diagnostic Ability ◽  
Mahalanobis Distances ◽  
Color Differences ◽  
Light Mode ◽  
Mean Vectors ◽  
The Mean

This study aimed to evaluate the utility of optical enhancement (OE) in early gastric cancer demarcation. Twenty lesions of early gastric cancer were examined by PENTAX endoscopy system with OE-1 and OE-2 functions. The areas of tumor demarcation identified by 12 evaluators (6 novice and 6 experienced) were compared to the corresponding correct areas determined by postoperative histopathology findings. The misdiagnosed scores that were the sums of false-positive and false-negative areas were compared. Color of one hundred pixels from the inside of the cancerous area and the outside of the cancerous area was expressed as three-dimensional RGB component vectors. The mean vectors and covariance matrixes were calculated and the Mahalanobis distance, indicative of color differences between two areas, was tested. Comparisons of the misdiagnosed score revealed that OE-1 was preferred over WL-1 for gastric cancer demarcation for all 12 evaluators (p=0.008) and in novice evaluators (p=0.026). OE-2 was not significantly different from WL-2 in all cases. OE-1 images gave significantly larger Mahalanobis distances, indicative of color differences, than WL-1 images (p=0.002). It was demonstrated that the OE Mode 1 has a significant advantage over the white light mode in demarcation of early gastric cancer.

scholarly journals Improved Visibility of Early Gastric Cancer after Successful Helicobacter pylori Eradication with Image-Enhanced Endoscopy: A Multi-Institutional Study Using Video Clips

2021 ◽  
Vol 10 (16) ◽  
pp. 3649
Author(s):  
Shinya Matsumura ◽  
Osamu Dohi ◽  
Nobuhisa Yamada ◽  
Akihito Harusato ◽  
Takeshi Yasuda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Early Gastric Cancer ◽  
Cross Sectional Study ◽  
Blue Laser ◽  
High Definition ◽  
Cross Sectional ◽  
Detection And Diagnosis ◽  
Linked Color Imaging

The visibility and diagnostic accuracy of early gastric cancer (EGC) after Helicobacter pylori (HP) eradication have been reported to improve using image-enhanced endoscopy (IEE) compared with white light imaging (WLI). The present study clarified the appropriate IEE for the detection and diagnosis of EGC in clinical settings. This prospective and cross-sectional study evaluated the visibility of EGC and endoscopic findings of gastric mucosa after successful HP eradication (n = 31) using videos with WLI and IEE. Three endoscopists evaluated high-definition videos in a randomized order. The mean visibility scores (MVSs) on linked color imaging (LCI) for atrophic border, intestinal metaplasia, map-like redness, and EGC were the highest among each modality (3.87 ± 0.34, 3.82 ± 0.49, 3.87 ± 0.50, and 3.35 ± 0.92, respectively). The MVSs with blue laser imaging (BLI) were highest for magnifying view of the demarcation line (DL), microsurface pattern (MSP), and microvascular pattern (MVP) for EGC (3.77 ± 0.49, 3.94 ± 0.25, and 3.92 ± 0.34, respectively). LCI had the highest visibility among findings of gastric mucosa and EGC after HP eradication, and BLI had the highest visibility of MVP, MSP, and DL in magnifying observation. These results suggest that LCI observation in the entire stomach and further magnifying BLI are the best methods for detecting and diagnosing EGCs after HP eradication, respectively.

scholarly journals Recent advances in the detection and management of early gastric cancer and its precursors

2020 ◽  
pp. flgastro-2018-101089 ◽  
Author(s):  
William Waddingham ◽  
Stella A V Nieuwenburg ◽  
Sean Carlson ◽  
Manuel Rodriguez-Justo ◽  
Manon Spaander ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Treatment Options ◽  
Survival Rates ◽  
Premalignant Lesions ◽  
High Definition ◽  
Gastric Intestinal Metaplasia ◽  
White Light Endoscopy

Despite declines in incidence, gastric cancer remains a disease with a poor prognosis and limited treatment options due to its often late stage of diagnosis. In contrast, early gastric cancer has a good to excellent prognosis, with 5-year survival rates as high as 92.6% after endoscopic resection. There remains an East-West divide for this disease, with high incidence countries such as Japan seeing earlier diagnoses and reduced mortality, in part thanks to the success of a national screening programme. With missed cancers still prevalent at upper endoscopy in the West, and variable approaches to assessment of the high-risk stomach, the quality of endoscopy we provide must be a focus for improvement, with particular attention paid to the minority of patients at increased cancer risk. High-definition endoscopy with virtual chromoendoscopy is superior to white light endoscopy alone. These enhanced imaging modalities allow the experienced endoscopist to accurately and robustly detect high-risk lesions in the stomach. An endoscopy-led staging strategy would mean biopsies could be targeted to histologically confirm the endoscopic impression of premalignant lesions including atrophic gastritis, gastric intestinal metaplasia, dysplasia and early cancer. This approach to quality improvement will reduce missed diagnoses and, combined with the latest endoscopic resection techniques performed at expert centres, will improve early detection and ultimately patient outcomes. In this review, we outline the latest evidence relating to diagnosis, staging and treatment of early gastric cancer and its precursor lesions.

scholarly journals Study on Blood Metabolomics of Early Gastric Cancer Based on Liquid Chromatography-Mass Spectrometry Technology

2021 ◽  
Author(s):  
Shanshan Qin ◽  
Qiong Wu ◽  
Rui Su ◽  
Wei Li ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Diagnostic Ability ◽  
Blood Samples ◽  
Cancer Group ◽  
Heparin Sulfate ◽  
Group A ◽  
Group B ◽  
Gastric Cancer Group

Abstract Background: Metabolomics is widely used to accurately find the basic characteristics and material basis of life activities. The purpose of this study is to use metabolomics to discover biomarkers for the diagnosis of early gastric cancer.Methods: We collected the blood samples and clinical data of 63 patients with gastric cancer from the First Hospital of Jilin University, including 26 patients with advanced gastric cancer (group A), 37 patients with early gastric cancer (group B), and 18 healthy volunteers (group C). Chromatography-mass spectrometry (LC-MS) is used for detect metabolites and obtain metabolic profile. Support vector machine (SVM) is used to screen the differential metabolites with a weight of 100% from the blood sample. Total ion current diagram, principal component analysis and analysis of variance (ANOVA) are used to identify differential metabolites. PCA and the quadratic discriminant analysis were used to evaluate the similarity between samples. The receiver characteristic curve (ROC) is used to evaluate the diagnostic ability of metabolites. After the nuclear ratio of the selected metabolites is imported into the Human Metabolome Database (HMDB), the structure is identified to determine the corresponding substances, and then the verification group is used to test the accuracy of the metabolites.Results: Through LC-MS, TIC, ANOVA and PCA, differential metabolites were found in different blood samples. Cluster analysis showed similar metabolites in the three groups A, B, and C. ROC curve represented the diagnostic ability of metabolites. The different metabolites between group A and C were spermine, enterostatin, heparin sulfate, and triacylglycerol. The difference metabolites between group A, group B and group C were same as those between group A and C. The cluster analysis and ROC also showed that all four metabolites had high specificity and sensitivity in the verification group. And the results of verification group were consistent with the experimental group.Conclusion: Spermine, enterostatin, heparin sulfate, and triacylglycerol may be potential biomarkers for the diagnosis of early gastric cancer.

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