scholarly journals Perancangan aplikasi perawatan dan penitipan hewan pada Garden 7 Petshop berbasis android (design of animal care and care at garden 7 petshop based on android)

2021 ◽  
Vol 5 (4) ◽  
pp. 741
Author(s):  
Annisa Amelia ◽  
Bertha Meyke Waty Hutajulu ◽  
Dewi Anjani
Keyword(s):  
Animal Care

Jasa penitipan hewan merupakan salah satu solusi terbaik bagi sebagian besar masyarakat indonesia. Namun, dalam melakukan proses bisnisnya selama ini masih menggunakan pencatatan secara manual yang terkadang menyebabkan kerugian baik dalam hal materi maupun kepercayaan pelanggan. Tujuan penelitian ini untuk menanggulangi permasalahan tersebut, yaitu dengan merancang sistem pengelolaan perawatan dan penitipn hewan peliharaan secara terintegrasi dan terorganisir lebih baik dengan memanfaatkan teknologi informasi yang sudah berkembang pesat. Metodologi dalam penelitian ini menggunakan pendekatan kualitatif, dengan mengumpulkan data yang berhubungan dengan masalah-masalah yang hendak diteliti dan perancangan aplikasi yang digunakan adalah aplikasi android. Bedasarkan peneliti yang telah dilakukan, dihasilkan luaran tampilan-tampilan layar aplikasi seperti tampilan splashscreen, login, pelayanan, produk, pembayaran hingga laporan cetak faktur. Maka dari itu, berdasarkan aplikasi yang dikembangkan didapatkan hasil bahwa perancangan aplikasi perawatan dan penitipan hewan pada Garden 7 Petshop dapat dijadikan sebagai sarana untuk memudahkan transaksi pembelian dan penjualan, agar mudah untuk mengetahui jumlah stok barang, sebagai sarana untuk memudahkan pelayanan dan agar dihasilkan laporan-laporan yang lebih cepat dan akurat.

Learning organizations and animal care programs in the absence of appropriate national legislation

2021 ◽  
pp. 002367722110192
Author(s):  
Lazara Martínez-Muñoz
Keyword(s):  
Latin American ◽  
Laboratory Animal ◽  
Management Education ◽  
Education Programs ◽  
Animal Science ◽  
Five Disciplines ◽  
Research Facilities ◽  
Animal Care ◽  
Latin American Countries ◽  
Working Method

The absence, in many nations, of appropriate and corresponding legislation for the protection of experimental animals as well as continual management education programs, significantly affects the inclusion and recognition of experimental results, worldwide. For more than a decade, researchers from Latin American countries have unsuccessfully struggled to get proper legislation. Until today, not many effective results have been seen. After reviewing previous literature and carefully analyzing the available methodologies and practical examples, this paper aims at redesigning the actions and strategies of the members of the research facilities to implement an effective laboratory animal care and use program, and permit the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) accreditation, independent of national legislative network .This paper also suggests a domestic working method for the teamwork to assume international harmonized legislation, through the application of the Five Disciplines stated by Senge, as methodological process linked with laboratory animal science as scientific background.

112 Rational design of chimeric antigen receptor T cells against glypican 3 decouples toxicity from therapeutic efficacy

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A124-A124
Author(s):  
Letizia Giardino ◽  
Ryan Gilbreth ◽  
Cui Chen ◽  
Erin Sult ◽  
Noel Monks ◽  
...  
Keyword(s):  
T Cells ◽  
Chimeric Antigen Receptor ◽  
Antigen Receptor ◽  
Single Chain ◽  
High Affinity ◽  
Car T Cells ◽  
Car T ◽  
Animal Care ◽  
Cytotoxic Function

BackgroundChimeric antigen receptor (CAR)-T therapy has yielded impressive clinical results in hematological malignancies and it is a promising approach for solid tumor treatment. However, toxicity, including on-target off-tumor antigen binding, is a concern hampering its broader use.MethodsIn selecting a lead CAR-T candidate against the oncofetal antigen glypican 3 (GPC3), we compared CAR bearing a low and high affinity single-chain variable fragment (scFv,) binding to the same epitope and cross-reactive with murine GPC3. We characterized low and high affinity CAR-T cells immunophenotype and effector function in vitro, followed by in vivo efficacy and safety studies in hepatocellular carcinoma (HCC) xenograft models.ResultsCompared to the high-affinity construct, the low-affinity CAR maintained cytotoxic function but did not show in vivo toxicity. High-affinity CAR-induced toxicity was caused by on-target off-tumor binding, based on the evidence that high-affinity but not low-affinity CAR, were toxic in non-tumor bearing mice and accumulated in organs with low expression of GPC3. To add another layer of safety, we developed a mean to target and eliminate CAR-T cells using anti-TNFα antibody therapy post-CAR-T infusion. This antibody functioned by eliminating early antigen-activated CAR-T cells, but not all CAR-T cells, allowing a margin where the toxic response could be effectively decoupled from anti-tumor efficacy.ConclusionsSelecting a domain with higher off-rate improved the quality of the CAR-T cells by maintaining cytotoxic function while reducing cytokine production and activation upon antigen engagement. By exploring additional traits of the CAR-T cells post-activation, we further identified a mechanism whereby we could use approved therapeutics and apply them as an exogenous kill switch that would eliminate early activated CAR-T following antigen engagement in vivo. By combining the reduced affinity CAR with this exogenous control mechanism, we provide evidence that we can modulate and control CAR-mediated toxicity.Ethics ApprovalAll animal experiments were conducted in a facility accredited by the Association for Assessment of Laboratory Animal Care (AALAC) under Institutional Animal Care and Use Committee (IACUC) guidelines and appropriate animal research approval.

scholarly journals 344 The Ag Guide serves as a primary standard for animal scientists and AAALAC accreditation of Ag research programs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 71-72
Author(s):  
Janeen Salak-Johnson
Keyword(s):  
Animal Welfare ◽  
Primary Standard ◽  
Animal Research ◽  
Third Party ◽  
Best Interests ◽  
Professional Judgment ◽  
High Quality ◽  
Accreditation Program ◽  
Agricultural Animal ◽  
Animal Care

Abstract Institutions that engage in animal research and production must ensure that high standards of animal care and use meet expectations of society while being ethical stewards of the animals they use in research. In order to achieve engagement in best practices, the Ag Guide is the most appropriate standard for assessing agricultural animals used in research and teaching. The Ag Guide minimizes the potential to overuse performance standards while enhancing the ability to appropriately address specific performance-derived exceptions to situations for which they have been validated. The primary objectives of the standards established in the Ag Guide are well-aligned with the goals of the AAALAC International accreditation program. The Ag Guide provides scientifically-sound, performance-based approaches to animal care and housing, which meet the expectations of AAALAC’s accreditation program. AAALAC provides a third-party peer review of all facets of the animal care and use program that serves as an effective mechanism to ensure institutions meet the standards of the Ag Guide. The process is designed to help identify the strengths and weaknesses of the program to ensure high-quality scientific outcomes and a high level of animal welfare. AAALAC accreditation program for agricultural animal research program is built on the cornerstone of the Ag Guide standards and connects science and responsible animal care. AAALAC accreditation promotes a comprehensive, institutionally supported program with a commitment to continuous improvement, humane and ethical animal care resulting in high-quality animal welfare, and scientific validity. AAALAC takes the position that, in accredited programs, the housing and care for agricultural animals should meet the standards that prevail on a high-quality, well-managed farm and the Ag Guide serves as this foundation. Therefore, the use of the Ag Guide for agricultural animal programs ensures a review that is based on science, professional judgment, and the best interests of the animal.

scholarly journals Why IACUCs Need Ethicists

ILAR Journal ◽  
2020 ◽  
Author(s):  
Nathan Nobis
Keyword(s):  
Animal Research ◽  
Animal Care

Abstract Some animal research is arguably morally wrong, and some animal research is morally bad but could be improved. Who is most likely to be able to identify wrong or bad animal research and advocate for improvements? I argue that philosophical ethicists have the expertise that makes them the likely best candidates for these tasks. I review the skills, knowledge, and perspectives that philosophical ethicists tend to have that makes them ethical experts. I argue that, insofar as Institutional Animal Care and Use Committees are expected to ensure that research is ethical, they must have philosophical ethicists as members.

scholarly journals Human–Animal Relations in Business and Society: Advancing the Feminist Interpretation of Stakeholder Theory

2021 ◽  
Author(s):  
Linda Tallberg ◽  
José-Carlos García-Rosell ◽  
Minni Haanpää
Keyword(s):  
Stakeholder Theory ◽  
Business And Society ◽  
Feminist Interpretation ◽  
Nonhuman Animals ◽  
Human Animal ◽  
Care Relationships ◽  
Human Actors ◽  
The Impact ◽  
Animal Care ◽  
Scholarly Attention

AbstractStakeholder theory has largely been anthropocentric in its focus on human actors and interests, failing to recognise the impact of nonhumans in business and organisations. This leads to an incomplete understanding of organisational contexts that include key relationships with nonhuman animals. In addition, the limited scholarly attention paid to nonhumans as stakeholders has mostly been conceptual to date. Therefore, we develop a stakeholder theory with animals illustrated through two ethnographic case studies: an animal shelter and Nordic husky businesses. We focus our feminist reading of Driscoll and Starik’s (J Bus Ethics 49:55–73, 2004) stakeholder attributes for nonhumans and extend this to include affective salience built on embodied affectivity and knowledge, memories, action and care. Findings reveal that nonhuman animals are important actors in practice, affecting organisational operations through human–animal care relationships. In addition to confirming animals are stakeholders, we further contribute to stakeholder theory by offering ways to better listen to nontraditional actors.

scholarly journals Severe Fever with Thrombocytopenia Syndrome in Cats and Its Prevalence among Veterinarian Staff Members in Nagasaki, Japan

Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1142
Author(s):  
Tsuyoshi Ando ◽  
Takeshi Nabeshima ◽  
Shingo Inoue ◽  
Mya Myat Ngwe Tun ◽  
Miho Obata ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Phylogenetic Analyses ◽  
The Body ◽  
Virus Growth ◽  
Specific Antibodies ◽  
Staff Members ◽  
Zoonotic Risk ◽  
Sentinel Animals ◽  
Animal Care ◽  
Severe Fever

In this study, we investigated severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) infection in cats in Nagasaki, Japan. In total, 44 of 133 (33.1%) cats with suspected SFTS were confirmed to be infected with SFTSV. Phylogenetic analyses of SFTSV isolates from cats indicated that the main genotype in Nagasaki was J1 and that unique reassortant strains with J2 (S segment) and unclassified genotypes (M and L segments) were also present. There were no significant differences in virus growth in cell cultures or fatality in SFTSV-infected mice between the SFTSV strains that were isolated from recovered and fatal cat cases. Remarkably, SFTSV RNAs were detected in the swabs from cats, indicating that the body fluids contain SFTSV. To evaluate the risk of SFTSV infection when providing animal care, we further examined the seroprevalence of SFTSV infection in veterinarian staff members; 3 of 71 (4.2%) were seropositive for SFTSV-specific antibodies. Our results provide useful information on the possibility of using cats as sentinel animals and raised concerns of the zoonotic risk of catching SFTSV from animals.

scholarly journals Foreword and Introduction to This Issue on Contemporary Safety Topics in Animal Research

ILAR Journal ◽  
2018 ◽  
Vol 59 (2) ◽  
pp. 125-126
Author(s):  
John Bradfield ◽  
Esmeralda Meyer ◽  
John N Norton
Keyword(s):  
Occupational Health ◽  
Health And Safety ◽  
Occupational Health And Safety ◽  
Well Being ◽  
Animal Research ◽  
Future Directions ◽  
The Status ◽  
Safety Considerations ◽  
Animal Care ◽  
Health And Well Being

Abstract Institutions with animal care and use programs are obligated to provide for the health and well-being of the animals, but are equally obligated to provide for safety of individuals associated with the program. The topics in this issue of the ILAR Journal, in association with those within the complimentary issue of the Journal of Applied Biosafety, provide a variety of contemporary occupational health and safety considerations in today’s animal research programs. Each article addresses key or emerging occupational health and safety topics in institutional animal care and use programs, where the status of the topic, contemporary challenges, and future directions are provided.

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