scholarly journals Effects of Alpha-Tocopherol on Biochemical Parameters in Adult Mice

2021 ◽  
Vol 11 (12) ◽  
pp. 83-90
Author(s):  
Franck Arnaud Moukobolo Kinsangou ◽  
Henriette Poaty ◽  
Dimitry Moudiongui Mboungou
Keyword(s):  
Vitamin E ◽  
Biochemical Parameters ◽  
Blood Lipid ◽  
Alpha Tocopherol ◽  
High Dose ◽  
Beneficial Effects ◽  
Adult Mice ◽  
Blood Biochemical ◽  
High Dietary Intake ◽  
High Doses

Background: Numerous reviews report the beneficial effects of alpha tocopherol in preventive supplementation and also as an adjuvant in the treatment of some pathologies (cardiovascular, cancers). In this work, we analyzed the effects of vitamin E at high doses on some biochemical parameters. Methods: Thirty-two adult male and female mice (CD1 albino mice) were randomly selected for a 4-week experiment. The mice were supplemented with alpha tocopherol at doses of 150, 400 and 750mg/day. With a high dietary intake of vitamin E Results: According to our analyses, we can note Excess weight predominated in groups 4 to 7. All the blood lipid parameters showed an abnormal concentration, as of the 400 mg dose of α-T-acetate. Hyperglycemia and hyperlipidemia were observed. These variations were more pronounced for total cholesterol and triglycerides than for HDL and LDL fractions. Conclusion: The study showed significant effects of high-dose α-T supplementation on biochemical parameters, mainly hyperglycemia and dyslipidemia. Key words: Vitamin E, Alpha-tocopherol, blood biochemical parameters.

scholarly journals Effects of Vitamin E and Vitamin C on Mercury Induced Toxicity in Mice

2013 ◽  
Vol 19 (2) ◽  
pp. 93-100 ◽  
Author(s):  
MA Huq ◽  
MA Awal ◽  
M Mostofa ◽  
A Ghosh ◽  
AR Das
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Vitamin C ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Protective Role ◽  
Alpha Tocopherol ◽  
Post Mortem ◽  
Group B ◽  
Vitamin E And C

The present study was undertaken to find out the efficacy of vitamin E and/or vitamin C against mercury (Hg) induced toxicity in mice. Sixty mice were randomly divided into 5 equal groups (n=12). One group of mice (Group A) was kept as control and each of rest four groups (B, C, D and E) were fed with mercuric chloride (HgCl2) in drinking water @ 65 mg/L. In addition to HgCl2 alpha-tocopherol (vitamin E) @ 100 mg/L, ascorbic acid (vitamin C) @ 250 mg/L and combination of vitamin E and vitamin C at same dose were given to the mice of groups C, D and E respectively. All treatments were continued for 28 consecutive days. Four mice of each group were sacrificed on day 1, 14 and 28 and efficacy of vitamin E and vitamin C against Hg induced toxicity were evaluated by observing toxic signs, body weight, hemato-biochemical parameters and postmortem lesions. Mild (++) toxic signs as evident by reduced feed and water intake, salivation, vomiting, excitement, muscle tremor, ataxia, restlessness, incordination and ruffled hair coat were observed from 2nd week (group B) and from 3rd week (group C and D) by intoxication with HgCl2. Significant (P<0.01) reduction of body weight (18.38%) and hematological parameters i.e. TEC (19.88%), TLC (27.89%), Hb content (34.09%) and PCV (9.15%) were observed at day 28 in HgCl2 induced intoxicated mice (group B). At identical period in same group biochemical parameters i.e. AST (46.99%) and ALT (58.72%) increased significantly (p<0.01). Pinpoint hemorrhages throughout the liver and highly (++++) congested kidney was also observed at post mortem (group B). All the parameters i.e. toxic signs, body weight, hemato-biochemical and post mortem lesions were found to be slight (+) or mild (++) and/or improved in rest three groups of mice following treatment with vitamin E, vitamin C and combination of vitamin E and vitamin C. The present study reveals that vitamin E and C have a protective role against Hg poisoning. However, combination of vitamin E and C gave better results.DOI: http://dx.doi.org/10.3329/pa.v19i2.16949 Progress. Agric. 19(2): 93 - 100, 2008

scholarly journals Vitamin E Ameliorates High Dose trans-Dehydrocrotonin-Associated Hepatic Damage in Mice

2010 ◽  
Vol 5 (4) ◽  
pp. 1934578X1000500
Author(s):  
Alana Fontales Lima Rabelo ◽  
Marjorie Moreira Guedes ◽  
Adriana da Rocha Tomé ◽  
Patricia Rodrigues Lima ◽  
Maria Aparecida Maciel ◽  
...  
Keyword(s):  
Vitamin E ◽  
Hepatic Damage ◽  
High Dose ◽  
Histological Alterations ◽  
Effective Antioxidant ◽  
High Doses ◽  
Croton Cajucara

trans-Dehydrocrotonin ( t-DCTN), the diterpenoid from Croton cajucara Bentham, exhibits hypoglycemic and hypolipidemic activities, but in high doses is associated with a discrete hepatotoxicity. In the search for measures to mitigate this, pretreatment with the antioxidants N-acetylcysteine and vitamin E has been examined. Mice that received a high dose t-DCTN (100 mg/kg) manifested hepatic damage, as evidenced by significant elevations in serum ALT and AST, and hepatic GSH, and histological alterations, which could be obliterated by pretreatment with vitamin E, but not with N-acetylcysteine, possibly by creating an effective antioxidant balance.

scholarly journals Serum Metabolomic Response to Low and High Dose Vitamin E Supplementation in Two Randomized Controlled Trials

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1810-1810
Author(s):  
Jiaqi Huang ◽  
Stephanie Weinstein ◽  
Wendy Mack ◽  
Howard Hodis ◽  
Demetrius Albanes
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Prevention ◽  
Low Dose ◽  
Alpha Tocopherol ◽  
P Value ◽  
High Dose ◽  
Atbc Study ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

Abstract Objectives Vitamin E is an essential micronutrient and critical human antioxidant that has been tested for cancer and cardiovascular preventative effects for decades with conflicting results. For example, prostate cancer incidence was reduced by a low-dose vitamin E supplement in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, but the findings were not replicated by high-dose vitamin E trials such as the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The present investigation examined the serum metabolomic responses to low- and high-dose vitamin E supplementation in order to gain biological insight into the divergent trial outcomes. Methods We examined baseline and on-study serum samples for 154 men randomly assigned to receive 400 IU vitamin E (as alpha-tocopheryl acetate; ATA) or placebo daily in the Vitamin E Atherosclerosis Prevention Study (VEAPS), and 100 men administered 50 IU ATA or placebo daily in the ATBC Study. Over 970 known metabolites were identified using an ultrahigh-performance LC-MS/MS platform. Linear regression models estimated the change in serum metabolites of men supplemented with vitamin E to those assigned to placebo in VEAPS compared with ATBC. Results Serum alpha-carboxyethyl hydrochroman (CEHC) sulfate, alpha-tocopherol, and beta-/gamma-tocopherol were significantly altered by supplementation with ATA in both the VEAPS and ATBC trials (all P-values ≤ 5.1 × 10−5, the Bonferroni multiple-comparisons corrected statistical threshold). Serum C22 lactone sulfate was also significantly decreased in response to the high-dose vitamin E supplement in VEAPS (β = −0.70, P-value = 8.1 × 10−6), but not altered in the low-dose ATBC trial (β = −0.17, P-value = 0.4). Additionally, changes in several androgenic steroid metabolites were strongly related to the vitamin E supplement-associated change in C22 lactone sulfate only in the high-dose VEAPS trial. Conclusions We found evidence of a dose-dependent vitamin E supplementation effect on a novel C22 lactone sulfate compound as well as several androgenic steroids that may have relevance to previous controlled trial findings for prostate cancer. Funding Sources This research was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Department of Health and Human Services.

Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study

Neurology ◽  
1998 ◽  
Vol 50 (6) ◽  
pp. 1900-1902 ◽  
Author(s):  
G. T. Vatassery ◽  
S. Fahn ◽  
M. A. Kuskowski
Keyword(s):  
Vitamin E ◽  
Alpha Tocopherol ◽  
High Dose ◽  
High Dose Vitamin

Hormesis and risk assessment

2005 ◽  
Vol 24 (5) ◽  
pp. 255-257 ◽  
Author(s):  
Karl K Rozman
Keyword(s):  
Mathematical Method ◽  
Risk Assessment ◽  
Point Estimate ◽  
High Dose ◽  
Low Doses ◽  
Beneficial Effects ◽  
Dose Effects ◽  
High Doses ◽  
Living Organisms

It is postulated in this paper that at low doses all chemicals have hormetic/hormoligotic (beneficial) effects in living organisms. It has been known since Paracelsus that at high doses all chemicals are toxic. The combination of low and high dose effects can be empirically described by a β-curve or an inverted β-curve. A mathematical method is suggested to determine the maximum of the β-curve or the minimum of the inverted β-curve, yielding a point estimate for risk assessment.

scholarly journals EFFECT OF GRINDED OLIVE LEAVES SUPPLIMENTATION IN MILK PRODUCTION AND ITS COMPONENTS AND SOME BLOOD TRAITS IN NATIVE DOES.

2016 ◽  
Vol 47 (5) ◽  
Author(s):  
AL-Musawi & et al.
Keyword(s):  
Body Weight ◽  
Milk Production ◽  
Milk Yield ◽  
Biochemical Parameters ◽  
Fat Percentage ◽  
Olive Leaves ◽  
Blood Biochemical Parameters ◽  
Beneficial Effects ◽  
Blood Biochemical ◽  
Lactating Goats

The present study was carried out at the Animal Farm College of Veterinary Medicine University of Baghdad during the period from 20/4/2015 to1/6/2015. This study was conducted to investigate the effect of olive leaves (grinded) supplementation to diet on milk yield, composition and some blood biochemical  parameters.Ten local lactating goats and its mean initial live body weight41.38± 0.46 kg, and 2-3.5 years old were allocated according to their body weight and milk yield  into two groups (5does/group). The first one (G1) was control, the second (G2) fed on diet with 2% olive leaves powder (of diet weight). The animals in both groups were fed the experimental diets 2 % DM of live body weight plus alfalfa hay (1 kg / head/day). Results showed the olive leaves powder supplementation had no significant effect on the average body weight in the end of experiment, while the milk production was  significantly (P<0.05)increased in (G2) being 13.68 kg/Doe compared with 10.76 kg/Doe(G1), milk compositions (lactose. protein and fat percentage) and milk energy value did not significantly different between (G1) and (G2).Moreover blood biochemical parameters did not different in both groups. It can be concluded that olive leaves powder exerted have beneficial effects on the performance of lactating goats and no effect on blood biochemical parameters.

Lower dietary n-6 : n-3 ratio and high-dose vitamin E supplementation improve sperm morphology and oxidative stress in boars

2017 ◽  
Vol 29 (5) ◽  
pp. 940 ◽  
Author(s):  
Qing Liu ◽  
Yuanfei Zhou ◽  
Runjia Duan ◽  
Hongkui Wei ◽  
Siwen Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Antioxidant Capacity ◽  
Sperm Morphology ◽  
Tocopherol Content ◽  
High Dose ◽  
Beneficial Effects ◽  
And Oxidative Stress ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

A 2 × 2 factorial experiment (10 boars per treatment) was conducted for 16 weeks to evaluate the effects of the dietary n-6 : n-3 ratio (14 : 1 vs 6 : 1) and vitamin E (200 vs 400 mg kg–1) on boar sperm morphology and oxidative stress. Sperm mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA damage (8-hydroxydeoxyguanosine; 8-OHdG), seminal lipoperoxidation (malondialdehyde; MDA) and antioxidant capacity in the serum, spermatozoa and seminal plasma were assessed as indicators of oxidative stress. Sperm production was similar among groups but increased (P < 0.05) throughout the 16 weeks of the study. Although sperm α-tocopherol content, ROS and seminal MDA did not differ between the two dietary n-6 : n-3 ratio treatments, enhanced antioxidant enzyme activity and MMP, but decreased 8-OHdG, were found in spermatozoa from boars consuming the 6 : 1 diet. The diet with the 6 : 1 ratio positively affected sperm morphology at Weeks 12 and 16 (P < 0.05). The α-tocopherol content and antioxidant capacity increased in boars with increasing levels of vitamin E supplementation. Compared with low-dose vitamin E, high-dose vitamin E supplementation improved sperm morphology. Overall, the results indicate that an n-6 : n-3 ratio of 6 : 1 and 400 mg/kg vitamin E have beneficial effects on sperm morphology by improving antioxidative stress.

scholarly journals Vitamin E–drug interactions: molecular basis and clinical relevance

2014 ◽  
Vol 27 (2) ◽  
pp. 215-231 ◽  
Author(s):  
Maren Podszun ◽  
Jan Frank
Keyword(s):  
Vitamin E ◽  
Drug Interactions ◽  
Prescription Drugs ◽  
Underlying Mechanism ◽  
High Dose ◽  
Do No Harm ◽  
High Doses ◽  
Randomised Controlled ◽  
Meta Analyses ◽  
High Dose Vitamin

Vitamin E (α-, β-, γ- and δ-tocopherol and -tocotrienol) is an essential factor in the human diet and regularly taken as a dietary supplement by many people, who act under the assumption that it may be good for their health and can do no harm. With the publication of meta-analyses reporting increased mortality in persons taking vitamin E supplements, the safety of the micronutrient was questioned and interactions with prescription drugs were suggested as one potentially underlying mechanism. Here, we review the evidence in the scientific literature for adverse vitamin E–drug interactions and discuss the potential of each of the eight vitamin E congeners to alter the activity of drugs. In summary, there is no evidence from animal models or randomised controlled human trials to suggest that the intake of tocopherols and tocotrienols at nutritionally relevant doses may cause adverse nutrient–drug interactions. Consumption of high-dose vitamin E supplements ( ≥  300 mg/d), however, may lead to interactions with the drugs aspirin, warfarin, tamoxifen and cyclosporine A that may alter their activities. For the majority of drugs, however, interactions with vitamin E, even at high doses, have not been observed and are thus unlikely.

scholarly journals Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

2010 ◽  
Vol 3 (4) ◽  
pp. 228-237 ◽  
Author(s):  
Jaouad Bouayed ◽  
Torsten Bohn
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Redox State ◽  
Fruits And Vegetables ◽  
Physiological Conditions ◽  
Beneficial Effects ◽  
Antioxidant Defense Systems ◽  
High Concentrations ◽  
High Doses ◽  
Endogenous Antioxidant

The balance between oxidation and antioxidation is believed to be critical in maintaining healthy biological systems. Under physiological conditions, the human antioxidative defense system including e.g., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and others, allows the elimination of excess reactive oxygen species (ROS) including, among others superoxide anions (O2.-), hydroxyl radicals (OH.), alkoxyl radicals (RO.) and peroxyradicals (ROO.). However, our endogenous antioxidant defense systems are incomplete without exogenous originating reducing compounds such as vitamin C, vitamin E, carotenoids and polyphenols, playing an essential role in many antioxidant mechanisms in living organisms. Therefore, there is continuous demand for exogenous antioxidants in order to prevent oxidative stress, representing a disequilibrium redox state in favor of oxidation. However, high doses of isolated compounds may be toxic, owing to prooxidative effects at high concentrations or their potential to react with beneficial concentrations of ROS normally present at physiological conditions that are required for optimal cellular functioning. This review aims to examine the double-edged effects of dietary originating antioxidants with a focus on the most abundant compounds, especially polyphenols, vitamin C, vitamin E and carotenoids. Different approaches to enrich our body with exogenous antioxidants such as via synthetic antioxidants, diets rich in fruits and vegetables and taking supplements will be reviewed and experimental and epidemiological evidences discussed, highlighting that antioxidants at physiological doses are generally safe, exhibiting interesting health beneficial effects.

Sign in / Sign up

Export Citation Format

Share Document