Efficacy of Allium Sativum, Curcuma Longa and Zingiber Officinale Extract on Serum Vasculoendothelial Growth Factors Levels of Breast Cancer Patients

2021 ◽  
Vol 8 (10) ◽  
pp. 396-401
Author(s):  
Michael Yang ◽  
Dairion Gatot ◽  
Andri Iskandar Mardia
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Allium Sativum ◽  
Complete Blood Count ◽  
Curcuma Longa ◽  
Zingiber Officinale ◽  
Serum Levels ◽  
Breast Cancer Patients ◽  
Open Label ◽  
Before And After

ntroduction: Breast cancer requires high nutrition, oxygen and metabolism where VEGF-triggered angiogenesis is needed. VEGF is triggered via the HIF-1 pathway and also via the NF-Kappa B pathway. VEGF is associated with tumor growth and metastasis. Some plant extracts have anti-angiogenesis effects such as Curcuma longa, Allium sativum and Zingiber officinale. Objective: To determine serum levels of SGOT, SGPT, ureum, creatinine, albumin and VEGF before and after administration of Curcuma longa, Allium sativum and Zingiber officinale extracts Method: An open label clinical trial study with a one group pretest posttest design involving 21 patients from breast cancer community in Medan collected by consecutive sampling from June – July 2021 in USU hospital where these patients met the inclusion criteria. All patients were tested for complete blood count, urea, creatinine, SGOT, SGPT, albumin, serum VEGF before and after being given a combination extract of Curcuma longa 150 mg, Allium sativum 200 mg and Zingiber officinale 150 mg twice daily for 28 days. Statistical analysis was performed by paired analytical T test or Wilcoxon. Results: The study involved 20 subjects. From the examination of kidney function obtained results before and after the administration of a combination extract VEGF results before and after the administration of the combination (1110(760-7893) μg / ml vs. 864 (532-5650 μg / ml, p = 0.001). Conclusion: VEGF serum breast cancer patients had a significant reduction after being given a combination of extracts of Allium sativum, Curcuma longa and Zingber officinale. Keywords: VEGF, Allium sativum, Curcuma longa, Zingiber officinale.

scholarly journals Efficacy of Allium sativum, Curcuma longa and Zingiber officinale Extract on Cancer Antigen 15-3 (CA 15-3) Levels of Breast Cancer Patients

2021 ◽  
Vol 8 (10) ◽  
pp. 196-201
Author(s):  
Agnes Santoso ◽  
Dairion Gatot ◽  
Andri Iskandar Mardia
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Allium Sativum ◽  
Curcuma Longa ◽  
Sampling Technique ◽  
Zingiber Officinale ◽  
Breast Cancer Patients ◽  
Open Label ◽  
Before And After

Introduction: Breast cancer is the most common malignancy in women. Progressivity of breast cancer evaluated through examination of tumor markers. Serum Ca 15-3 is tumor markers used to assess the progression. Various treatments have been developed to suppress the progression, one of which the provision of plant extractions. Extracts of Allium sativum, Curcuma longa and Zingiber officinale considered useful as anti-cancer, but no research discusses the combined benefits of extracts against breast cancer, especially Ca 15 -3. Method: Open label clinical trial study with one group pretest posttest design was conducted at USU hospital on June 28, 2021 to July 18, 2021. Population came from breast cancer survivor community in Medan, consecutive sampling technique. Samples that met inclusion and exclusion criteria were examined for Ca 15 -3 before and after administration of extract Allium sativum, Curcuma longa and Zingiber officinale with dose 500 mg twice a day for 28 days. Data were analyzed using SPSS version 22. Results: Of 20 breast cancer patients analyzed with mean age of 52.7 years, majority stage III A or III B breast cancer (30%). Median CA 15-3 before administration of extracts of Allium sativum, Zingiber and Curcuma longa 12.82 (3.29-45.81) g/mL and after administration of extracts 8.24 (2.83-47.46) g/mL, decrease but not statistically significant. Conclusion: There was decrease in median CA 15-3 before and after extraction, but not statistically significant. Keywords: Breast Cancer, CA 15 – 3, Allium sativum, Curcuma longa and Zingiber officinale.

scholarly journals The Effect of Allium Sativum, Curcuma Longa and Zingiber Officinale Extract on Carcinoembryonic Antigen (CEA) Levels of Breast Cancer Patients

2021 ◽  
Vol 8 (10) ◽  
pp. 391-395
Author(s):  
M. Rivandio Artianda Simatupang ◽  
Dairion Gatot ◽  
Andri Iskandar Mardia
Keyword(s):  
Breast Cancer ◽  
Allium Sativum ◽  
Curcuma Longa ◽  
Tumor Development ◽  
Zingiber Officinale ◽  
Wilcoxon Test ◽  
Breast Cancer Patients ◽  
Open Label ◽  
Anti Cancer ◽  
Before And After

Introduction: Breast cancer is global problem and commonly in women. Tumor markers can assess tumor progression and response therapy. CEA is used as diagnostic, progression and response therapy. The treatment aims to suppress tumor development. Traditional medicine is considered beneficial and has minimal effect in suppressing tumor. Recent study, extracts of Allium sativum, Curcuma longa and Zingiber officinale consider useful as anti-cancer. However, no studies that discuss combined extraction Allium sativum, Curcuma longa and Zingiber of CEA levels. Method: Open label clinical trial with one group pretest posttest design , held on June 28, 2021 – July 18, 2021, was conducted at USU Hospital and the population was breast cancer survivor community in Medan. Samples were taken by consecutive sampling. Those who met inclusion and exclusion criteria will be measured for CEA before and after administration of extract Allium sativum, Curcuma longa and Zingiber officinale with dose 500 mg twice a day for 28 days. T test or wilcoxon test was used to measure comparison and analyzed with SPSS version 22th. Results: 21 subjects who participated, only 20 subjects were analyzed with mean age of 52.7 years, majority stage III A or IIIB (30%). Median CEA before intervention 2.05 (0.70-12.20) g/mL and after intervention of 2.7 (0.8-12.40) g/mL, increasing value and not statistically significant with p>0.05 ( p=0,238).Conclusion: Median CEA value increased before and after intervention and not statistically significant. Keywords: Breast Cancer, CEA, Allium sativum, Curcuma longa and Zingiber officinale.

scholarly journals Serum Long Non-Coding RNAs PVT1, HOTAIR, and NEAT1 as Potential Biomarkers in Egyptian Women with Breast Cancer

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 301
Author(s):  
Amal Ahmed Abd El-Fattah ◽  
Nermin Abdel Hamid Sadik ◽  
Olfat Gamil Shaker ◽  
Amal Mohamed Kamal ◽  
Nancy Nabil Shahin
Keyword(s):  
Breast Cancer ◽  
Logistic Regression ◽  
Cancer Patients ◽  
Breast Cancer Diagnosis ◽  
Serum Levels ◽  
Breast Cancer Patients ◽  
Multivariate Logistic Regression ◽  
Expression Levels ◽  
Non Coding Rnas ◽  
Pai 1

Long non-coding RNAs play an important role in tumor growth, angiogenesis, and metastasis in several types of cancer. However, the clinical significance of using lncRNAs as biomarkers for breast cancer diagnosis and prognosis is still poorly investigated. In this study, we analyzed the serum expression levels of lncRNAs PVT1, HOTAIR, NEAT1, and MALAT1, and their associated proteins, PAI-1, and OPN, in breast cancer patients compared to fibroadenoma patients and healthy subjects. Using quantitative real-time PCR (qRT-PCR), we compared the serum expression levels of the four circulating lncRNAs in patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The serum levels of PAI-1 and OPN were measured using ELISA. Receiveroperating-characteristic (ROC) analysis and multivariate logistic regression were used to evaluate the diagnostic value of the selected parameters. The serum levels of HOTAIR, PAI-1, and OPN were significantly higher in breast cancer patients compared to controls and fibroadenoma patients. The serum level of PVT1 was significantly higher in breast cancer patients than in the controls, while that of NEAT1 was significantly lower in breast cancer patients compared to controls and fibroadenoma patients. Both ROC and multivariate logistic regression analyses revealed that PAI-1 has the greatest power in discriminating breast cancer from the control, whereas HOTAIR, PAI-1, and OPN have the greatest power in discriminating breast cancer from fibroadenoma patients. In conclusion, our data suggest that the serum levels of PVT1, HOTAIR, NEAT1, PAI-1, and OPN could serve as promising diagnostic biomarkers for breast cancer.

Exploring The Clinical Significance of Serum Angiopoietin-2 In Breast Cancer Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Abeer I Abd Elmagid ◽  
Hala Abdel Al ◽  
Wessam El Sayed Saad ◽  
Seham Kamal Mohamed
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Tnm Staging ◽  
Control Group ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Female Patients ◽  
Significant Difference ◽  
Angiopoietin 2

Abstract Background Breast cancer is the most common cancer among women and one of the most important causes of death among them.Angiogenesis is an important step for primary tumor growth, invasiveness, and metastases. Angiopoietins are well-recognized endothelial growth factors that are involved in angiogenesis associated with tumors. Aim To explore the diagnostic significance of serum angiopoietin-2 (Ang-2) in breast cancer and to evaluate its prognostic efficacy through studying the degree of its association with the TNM staging of the disease. Patients and Methods This study was conducted on (35) Egyptian female patients who were diagnosed as breast cancer according to histopathological examination of breast biopsy (Group 1, Breast Cancer Patients) and (25) female patients with benign breast diseases (Group II, Pathological Control Patients), in addition to (20) age - matched apparently healthy, free mammogram, females serving as healthy controls (Group III, Healthy Controls). For all participants, measurement of serum Ang-2 was done using enzyme linked immunosorbent assay (ELISA) technique. Results A highly significant increased levels of Ang-2 was observed in breast cancer patients when compared to healthy control group (Z = 4.95, p < 0.01). However, no significant difference was observed in Ang-2 levels between breast cancer patients group and pathological control group (Z = 3.37, p > 0.05). No significant difference was detected in Ang-2 levels in relation to TNM stage and histological grade. No significant correlation was found between Ang-2 levels and serum levels of CA15-3, hormone receptors, HER2/new receptor status (p > 0.05, respectively). Conclusion This study revealed that Ang-2 serum levels were significantly increased in patient with breast cancer compared with healthy controls, indicating that high Ang-2 level is a promising non invasive biomarker for breast cancer diagnosis. However, no significant difference of Ang-2 levels was detected in relation of breast TNM staging in the population studied.

scholarly journals Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients

2012 ◽  
Vol 19 (13) ◽  
pp. 4003-4011 ◽  
Author(s):  
Juliette Christie ◽  
Gwendolyn P. Quinn ◽  
Teri Malo ◽  
Ji-Hyun Lee ◽  
Xiuhua Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Cancer Patients ◽  
Psychological Impact ◽  
Breast Cancer Patients ◽  
Before And After ◽  
Definitive Surgery
Sign in / Sign up

Export Citation Format

Share Document