scholarly journals Natural Superdisintegrants for the Formulation of Orally Disintegrating Tablets

2021 ◽  
Vol 8 (11) ◽  
pp. 123-128
Author(s):  
Femi Joseph ◽  
K. Premaletha
Keyword(s):  
Geriatric Patients ◽  
Low Cost ◽  
Oral Route ◽  
Dosage Forms ◽  
Disintegration Time ◽  
Routes Of Administration ◽  
Natural Agents ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Synthetic Agents

Oral route is the most favoured and preferred route for the administration for most of the dosage forms because it offers so many advantages over other routes of administration. Sometimes the oral route is associated with a problem called dysphagia. This condition can be seen in a population of paediatric, geriatric, patients with neurological problems, bedridden patients and so on. In order to overcome such a problem orodispersible tablets will be a better choice, because it will disintegrate within seconds when comes in contact with saliva. Natural agents offers so many advantages like nontoxic, easy availability, low cost, biocompatible and biodegradable in nature over synthetic agents. This superdisintegrants will cause the increase in drug release and decrease the disintegration time. This natural superdisintegrants will be a good option for the preparation of ODTs. Keywords: orodispersible tablets, natural superdisintegrants, advantages, dysphagia .

scholarly journals Preparation and evaluation of diclofenac sodium orally disintegrating tablets

2016 ◽  
Vol 27 (1) ◽  
pp. 58-61
Author(s):  
Valeriu Iancu ◽  
Florentina Roncea ◽  
Radu George Cazacincu ◽  
Dumitru Lupuleasa
Keyword(s):  
Diclofenac Sodium ◽  
Magnesium Stearate ◽  
Dosage Forms ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Wetting Time ◽  
Preparation And Evaluation

Abstract Orally disintegrating tablets (ODTs) are dosage forms which disintegrate in mouth within seconds without need of water. This type of quality in dosage form can be attained by addition of different varieties of excipients. Pharmaburst™ 500 is a co-processed excipient system which allows rapid disintegration and low adhesion to punches. The aim of the present study was to develop and evaluate 25 mg diclofenac sodium ODTs (orodispersible tablets) batches by direct compression method at different compression forces 10 kN (F1) and 20 kN (F2) and directly compressible excipients used in different ratio (Avicel PH 102, magnesium stearate and coprocessed excipient Pharmaburst™ 500, 70% and 80% w/w). The obtained batches were analyzed for appearance, tablet thickness, uniformity of weight, hardness, friability, disintegration time, and non-compendial methods (wetting time). Co-processed Pharmaburst™ 500 excipient 70% used for sodium diclofenac ODT obtaining determined good results for quality control tests evaluation.

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

Natural Polymers in Fast Dissolving Tablets

2021 ◽  
pp. 2859-2866
Author(s):  
Ratnaparkhi M.P. ◽  
Karnawat G.R. ◽  
Andhale R.S.
Keyword(s):  
Geriatric Patients ◽  
Nutritional Supplement ◽  
Synthetic Polymers ◽  
Oral Route ◽  
Water Soluble ◽  
Natural Polymers ◽  
Disintegration Time ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Oral route is most preferable route of administration for various drugs, because it is convenient, economical, safest route. Fast dissolving tablets are popular nowadays, as they disintegrated in mouth within a few seconds without using water for swallow. Problems like Dysphagia in pediatric and geriatric patients have been overcome by formulating Fast dissolving tablet. Natural polymers are preferable because they are chemically inert, nontoxic, less expensive, biodegradable, and available easily than synthetic polymers. Natural polymers are obtained from the natural origin so they are devoid of any side effect. It is proved from the previous studies that Natural polymers are more-safe and effective than the synthetic polymers. Natural polymers improve the properties of tablet and they are used as binder, diluent, superdisintegrant, they also enhance the solubility of poorly water-soluble drug, decrease the disintegration time and provide nutritional supplement. The aim of the present article is to study various natural polymers used in fast dissolving tablets.

scholarly journals Development and characterization of paracetamol medicated lollipops

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Hatem A. Hejaz ◽  
Ayat Kanan ◽  
Mahmood Al Mohtaseb ◽  
Ameer Ja’bari
Keyword(s):  
Patient Compliance ◽  
Geriatric Patients ◽  
Research Study ◽  
Low Cost ◽  
Oral Route ◽  
Alternative Formulation ◽  
Attractive Alternative ◽  
Weight Variation ◽  
Solid Form

Abstract Objectives The oral route is the most common route of administration of drugs because of the low cost of therapy, ease of administration, patient compliance, and flexibility in formulation. Taking oral medicine is extremely odious to some patients, such as pediatric and geriatric patients. Paracetamol is one of the most used antipyretic and analgesic drugs, used in the management of fever and headache. Difficulty in swallowing (dysphagia) is common among pediatric and geriatric patients. Accordingly, there is a need for a solid form of medicine that is in a form easy to take and swallow, such as lollipops. The main objective of the present research study is to provide a solid form of medicine that is in a form that makes it pleasant to take and swallow by pediatric, geriatric, and bedridden patients, and avoid the dangers of being swallowed as do the other solid forms in those patients. However, lollipop is designed to improve patient compliance, acceptability, transportation, etc. Methods In the present research study, an attempt has been made to prepare sugar-based paracetamol medicated lollipops for pediatrics, geriatrics, and bedridden patients to overcome the administration problem. The paracetamol medicated lollipops were prepared using sucrose and corn syrup. All the formulations prepared were subjected to various physicochemical parameters like hardness, friability, weight variation, drug content, etc. Results The hardness of these lollipops ranges between 8 and 11 kg/cm3 with good physical characteristics like taste and color, they have good stability and moisture content below 1% and no variation in the IR spectrum. Conclusions Conventional dosage forms have some limitations that make it hard to use in pediatric and geriatric patients such as dysphagia, while medicated lollipops are found to be favorable by them and also effective in delivering the drug with advantages like bypass of the first-pass metabolism and increasing drug contact time in the mouth which increases its bioavailability. Paracetamol medicated lollipops can provide an attractive alternative formulation in the treatment of fever and pain in pediatric and geriatric patients because they are easily swallowed.

scholarly journals Research Article. Kinetics and Mechanism of Drug Release from Loratadine Orodispersible Tablets Developed without Lactose

2017 ◽  
Vol 63 (1) ◽  
pp. 23-26
Author(s):  
Adriana Ciurba ◽  
Emőke Rédai ◽  
Ioana Pop ◽  
Paula Antonoaea ◽  
Nicoleta Todoran
Keyword(s):  
Zero Order ◽  
Order Kinetic ◽  
Dissolution Profile ◽  
Disintegration Time ◽  
Research Article ◽  
Orodispersible Tablets ◽  
Orally Disintegrating Tablets ◽  
Dissolution Properties ◽  
Gelatinized Starch ◽  
Croscarmellose Sodium

Abstract Objective: The aim of this study is to develop lactose-free orodispersible tablets with loratadine for patients with lactose intolerance. Materials and methods: Seven compositions (F1-F7) of 10 mg loratadine were prepared in form of orally disintegrating tablets, by direct compression, using croscarmellose sodium and pre-gelatinized starch in various concentrations as superdisintegrants, diluted with microcrystalline cellulose and combined with mannitol and maltodextrin as binder agents. The tablets had been studied in terms of their pharmacotechnical characteristics, by determining: the weight uniformity of the tablets, their friability, breaking strength and disintegration time, drug content and the dissolution profile of loratadine. The statistical analyses were performed with GraphPad Prism Software Inc. As dependent variables, both the hardness of the tablets and their disintegration ability differ between batches due to their compositional differences (as independent variables). DDSolver were used for modeling the kinetic of the dissolution processes by fitting the dissolution profiles with time-dependent equations (Zero-order, First-order, Higuchi, Korsmeyer-Peppas, Peppas-Sahlin). Results: All proposed formulas shows rapid disintegration, in less than 15 seconds, and the dissolution loratadine spans a period of about 10 minutes. Akaike index as well as R2 adjusted parameter have demonstrated that the studied dissolution profiles are the best fitted by Zero-order kinetic. Conclusion: In conclusion, association of croscarmellose sodium (7.5%) with pre-gelatinized starch (6%) as superdisintegrants and mannitol as the binder agent (35%), positively influences the dissolution properties of loratadine from orally fast dispersible tablets.

scholarly journals Development and evaluation of mosapride citrate orally disintegrating tablets for dogs

2016 ◽  
Vol 46 (11) ◽  
pp. 2064-2069
Author(s):  
Tingting Yi
Keyword(s):  
Low Cost ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Mosapride Citrate ◽  
Orally Disintegrating Tablets ◽  
Croscarmellose Sodium ◽  
Sodium Carboxymethyl Starch ◽  
In Vitro Disintegration

ABSTRACT: The purpose of the study was to prepare orally disintegrating tablets (ODTs) of mosapride citrate for dogs with fast disintegration and low cost. The ODTs were developed by varying the components and the ratio of excipients. A direct compression method was used. The properties of the ODTs, including hardness, friability, active ingredient content, and in vitro disintegration time, were investigated, and an economic analysis of the formulations was performed. For all formulations, friability was less than 1%, and the hardness varied from 37.69±4.08 to 48.73±5.62 N, which indicated that the tablets had sufficient mechanical integrity to withstand packaging and carrying. Results showed that Formulation (F) 2, containing 5% sodium carboxymethyl starch; F3, containing 5% low-substituted hydroxypropylcellulose; and F5 had not only shorter disintegration times but also lower costs, which were suitable for mosapride citrate ODTs. Although F1, contained 5% croscarmellose sodium, and F4, contained 5% crospovidone, with shorter disintegration times, the costs of F1 and F4 were 25.8% and 22.6% higher than that of F5, respectively. Results also revealed that the disintegration time of F5 was not significantly different from those of F1, F2, F3, and F4 (p>0.05), all of which contained superdisintegrants. Without superdisintegrants, F5, which contained a mixture of microcrystalline cellulose, mannitol, and lactose, was also able to achieve a short disintegration time and to meet the requirements of ODTs for dogs.

scholarly journals REVIEW: FAST DISSOLVING TABLET

2018 ◽  
Vol 10 (2) ◽  
pp. 5
Author(s):  
Aher Smita S. ◽  
Saudagar R. B. ◽  
Shinde Mayuri S.
Keyword(s):  
Dosage Form ◽  
Geriatric Patients ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Tablet Disintegration ◽  
Physical And Chemical ◽  
Pass Metabolism

Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like the first-pass metabolism. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.

PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (12) ◽  
pp. 60-62
Author(s):  
P. Jain ◽  
◽  
A Mishra ◽  
A. Pathak
Keyword(s):  
Content Uniformity ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Orodispersible Tablet ◽  
Sublimation Method ◽  
Dispersing Ability

Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating pores by sublimation methods in tablets and second, use of super disintegrantes like sodium starch glycolate to minimise disintegration time and promote fast dispersing ability. Prepared formulations were evaluated for weight variation, content uniformity, friability, hardness, wetting time, disintegration time, in vitro drug release and interaction study by differential scanning calorimetery. The best formulation was selected on the basis of evaluation results.

scholarly journals New Natural Marine Antacid Drug from Cuttlebone

2018 ◽  
Vol 24 (3) ◽  
pp. 227-234
Author(s):  
Azar Mostoufi ◽  
Neda Bavarsad ◽  
Sahar Aryanfar ◽  
Abbas Akhgari
Keyword(s):  
High Efficiency ◽  
Low Cost ◽  
Symptomatic Relief ◽  
Dosage Forms ◽  
Direct Compression ◽  
Disintegration Time ◽  
Natural Medicine ◽  
Acceptable Range ◽  
Low Efficiency

Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and low cost seems useful. Therefore, the aim of the present study was to prepare antacid tablets from Cuttlefish bone and assessment of its antacid properties. Methods: 24 different formulations of cuttlefish bone were prepared by direct compression using different fillers (starch, cellulose, lactose, and mixture of those) in different ratios of the drug. Characterization of powders and tablets was done on all formulations and marketed dosage forms (calcium carbonate and Al-Mg). Results: Weight uniformity, hardness, and friability of all formulations were in acceptable range. Tablets prepared by calcined cuttlebone disintegrated in longer time due to their higher hardness which were mostly higher than 5 Kg. Also, disintegration time of formulations 50-50 (lower dose of cuttlebone) was less than other tablets (2 minutes or less). Results of antacid capacity showed that formulations 90-10 and 80-20 raise the acidic pH of the medium above 7.5, which were the same as or more than the capacity of the marketed tablets.

Formulation and Evaluation of Baclofen Orally Disintegrating Tablets

1970 ◽  
Vol 2 (4) ◽  
pp. 733-738
Author(s):  
Dumpeti Janardhan ◽  
Joginapally Sreekanth ◽  
P.Theja Pavan Kumar ◽  
M.Vamshi Krishna
Keyword(s):  
Pilot Scale ◽  
Taste Masking ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Disintegration Time ◽  
Granulation Process ◽  
Good Taste ◽  
Orally Disintegrating Tablets ◽  
Human Volunteers ◽  
Eudragit Epo

The purpose of this study was to evaluate the potential of polymers for masking the taste of bitter drugs when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (baclofen) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. The optimal granulation process parameters were polymer selection and its concentration (w/w), suitable for pilot scale level. Dextrates, β- cyclodextrin, eudragit EPO and PVP K-30 were used in preparation of granules by using water and iso-propyl alcohol. Crospovidone was used intra and extra granularly as superdisintegrant.  Sodium bicarbonate and citric acid were used as effervescent for fast disintegration of tablets, which also optionally act as desensitizer of taste buds. Results from evaluation of tablets indicated a disintegration time (avg) of 30-35 sec and 100% drug release was achieved within 5 min. But taste masking was achieved by only with eudragit EPO. Results from an evaluation by a panel of six human volunteers demonstrated that the orally disintegrating tablets which are prepared by using polymer Eudragit EPO (5% and 7.5% w/w of tablet) and PVP (7.5% w/w of tablet) improved taste, significantly. On studying physical parameters, F9 formulation demonstrated acceptable level of hardness and friability with good taste masking and it was thus considered as an optimized formulation

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