scholarly journals The The role of Sarvang sundar rasa Orally and Mahamash tail locally in the management of Amavata WSR to Rheumatoid Arthritis –A case study.

2021 ◽  
Vol 5 (04) ◽  
Author(s):  
Swati Sukhdeo Tayade ◽  
Subhash Jamdhade
Keyword(s):  
Rheumatoid Arthritis ◽  
Spinal Column ◽  
The Body ◽  
Essential Factor ◽  
Fatty Food ◽  
Loss Of Appetite ◽  
Cardinal Symptoms ◽  
First Time

Amavata is term derives from the word as Ama and vata.Ama is a type of metabolic toxin; it is an essential factor in development of pathology.Mandagni (low digestive fire) produce Ama in the body,when ama get associated with vitiated vata and starts circulating in the body accupies in shleshmal sthana(asthi sandhi) results in painful disease Amavata. Madhavakara (900 AD) has identified first time the disease.Amavata as seprate entity and discribed the disease in detail.Madhavakara describes etiopathology of amavata that the person with weak digestion (Mandagni) if he is posseses a secondary life (nishchalasya)or if he indulges into virrudha aaharaand vihara e.g.excessive exercise after taking heavy and fatty food,ama is produced and vata get vitiated. This ama provoks by vata (Vayuna preritah),Circulates in the body especially towards shleshmal sthanas. the resultant of cardinal symptoms of amvata are painful swelling of the joints (sarujashotham ) of hands,feet,ankle,knee,hip,Spinal column,and stiffness(jadyata),fever( Jwara),loss of appetite (aruchi),indigestion (apaka),Constipation(vibandhata),gurguling(antrakujanam)etc. this impairs the day to day functions of person.in spite of presence of NSAID,DMRD,steroids etc. the rheumatology remains refractory to treatment but Ayurvedic drug which are therapeutically safe and effectiveness.

scholarly journals ROLE OF AUSHADHA SEVAN KAAL IN AYURVEDA COMPARATIVE TO CHRONO THERAPEUTICS

2021 ◽  
Vol 9 (8) ◽  
pp. 1839-1849
Author(s):  
Gayatri Gayatri ◽  
Suvitha S V ◽  
Sarika Yadav ◽  
Yadav C. R.
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Modern Science ◽  
The Body ◽  
Essential Factor ◽  
Substantial Impact ◽  
Medication Schedule ◽  
Impact On Treatment ◽  
The Right

According to Ayurveda Aushadha Sevan Kaal is the type of Avasthika Kaal. Kaal is an essential factor to consid- er when treating disease because it refers to the right timing of drug administration. Aushadha (medicine) is con- sidered under Trisutra. According to Acharya Charaka, Aushadha having reverse properties of Desha (Habitat), Matra (Dose) and Kaal (Time) can cure the diseases effortlessly. Our Acharya has enlightened the connection of Kaal and Dosha and suggested consideration while treating the patients. The precise timing at which patients take their medications is critical since it has a substantial impact on treatment outcomes. In Ayurveda, lots of Acharya has specified different Bhaishajya Kaal along with the Dosha, disease, general condition of the body, and in line with the type of preparations (Swaras, Kalka, Kwatha). Chrono Therapeutics is a term used in modern science to describe the concept of timed dose. It recommends synchronizing your medication schedule with your body's nat- ural clock. Though treating a disease success can be attained only when there is a proper arrangement of Desha(Region), Kaal (Time), Pramana (Dosage), Satmya (Wholesomeness), Asatmya (Unwholesomeness), Pathya (useful) & Apathya (harmful). In this study, an attempt was made to compare the Aushadha Kaal Prayoga with chronotherapeutics in modern science. The comparison was done on Aushadha Prayoga Kaal of certain diseases such as allergic rhinitis, asthma, rheumatoid arthritis, peptic ulcer, diabetes mellitus. Overall look, both are having similarities vs dissimilarities too. Keywords: Aushadha Sevan Kaal, Bhaishajya, Chrono Therapeutics, Circadian rhythm.

Hypothetical Role of Growth Factors to Reduce Intervertebral Disc Degeneration Significantly through Trained Biological Transformations

2020 ◽  
Vol 26 ◽  
Author(s):  
Cristian Muresanu ◽  
Siva G. Somasundaram ◽  
Sergey V. Vissarionov ◽  
Liliya V. Gavryushova ◽  
Vladimir N. Nikolenko ◽  
...  
Keyword(s):  
Growth Factors ◽  
Blood Circulation ◽  
Seminal Fluid ◽  
Prostate Gland ◽  
The Body ◽  
Personal Experiences ◽  
Biological Transformation ◽  
The Mind

Background: From the evidence of failed injection-based growth factor therapies, it has been proposed that a naturally triggered uninterrupted blood circulation of the growth factors would be superior. Objective: We seek to stimulate discussions and more research about the possibility of using the already available growth factors found in the prostate gland and endometrium by starting a novel educable physiology, known as biological transformations controlled by the mind. Methods: We summarized the stretch-gated ion channel mechanism of the cell membrane, and offer several practical methods that can be applied by anyone, in order to stimulate and enhance the blood circulation of the growth factors from the seminal fluid to sites throughout the body. This details the practical application of our earlier published studies about biological transformations. Results: A previously reported single-patient case study has been extended, adding more from his personal experiences continually improving this novel physiological training and extending the ideas from our earlier findings in detail. Conclusion: The biological transformation findings demonstrate the need additional research to establish the benefits of these natural therapies to repair and rejuvenate tissues affected by various chronic diseases or aging processes.

scholarly journals Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Wei Zhang ◽  
Guoyu Yin ◽  
Heping Zhao ◽  
Hanzhi Ling ◽  
Zhen Xie ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Dependent Manner ◽  
Collagen Induced Arthritis ◽  
Intracellular Degradation ◽  
Main Pathway ◽  
First Time

AbstractIn inflamed joints, enhanced hyaluronic acid (HA) degradation is closely related to the pathogenesis of rheumatoid arthritis (RA). KIAA1199 has been identified as a hyaladherin that mediates the intracellular degradation of HA, but its extracellular function remains unclear. In this study, we found that the serum and synovial levels of secreted KIAA1199 (sKIAA1199) and low-molecular-weight HA (LMW-HA, MW < 100 kDa) in RA patients were significantly increased, and the positive correlation between them was shown for the first time. Of note, treatment with anti-KIAA1199 mAb effectively alleviated the severity of arthritis and reduced serum LMW-HA levels and cytokine secretion in collagen-induced arthritis (CIA) mice. In vitro, sKIAA1199 was shown to mediate exogenous HA degradation by attaching to the cell membrane of RA fibroblast-like synoviosytes (RA FLS). Furthermore, the HA-degrading activity of sKIAA1199 depended largely on its adhesion to the membrane, which was achieved by its G8 domain binding to ANXA1. In vivo, kiaa1199-KO mice exhibited greater resistance to collagen-induced arthritis. Interestingly, this resistance could be partially reversed by intra-articular injection of vectors encoding full-length KIAA1199 instead of G8-deleted KIAA119 mutant, which further confirmed the indispensable role of G8 domain in KIAA1199 involvement in RA pathological processes. Mechanically, the activation of NF-κB by interleukin-6 (IL-6) through PI3K/Akt signaling is suggested to be the main pathway to induce KIAA1199 expression in RA FLS. In conclusion, our study supported the contribution of sKIAA1199 to RA pathogenesis, providing a new therapeutic target for RA by blocking sKIAA1199-mediated HA degradation.

scholarly journals Portraits of Undergraduate Discipline-Specific Thinking: Guiding Students from Novice to Proficient Learner

2020 ◽  
Vol 20 (2) ◽  
Author(s):  
Patricia Stovey ◽  
Tiffany Trimmer
Keyword(s):  
Undergraduate Students ◽  
Habits Of Mind ◽  
College Level ◽  
Student Centered ◽  
Cognitive Behaviors ◽  
Second Nature ◽  
Historical Methods ◽  
First Time

This case study presents our experiences, insights, and the pedagogical techniques used to guide undergraduate students toward discipline-specific thinking. It demonstrates the role of student-centered practices in moving students from what we categorize as novice to proficient, a common goal in rite-of-passage courses across the disciplines. Our study follows two semesters of students in undergraduate college-level Historiography and Historical Methods courses to identify common stumbling blocks encountered when learning contextualization (our discipline-specific thinking skill). We analyze students’ habits of mind, cognitive behaviors, and assumptions when learning to think differently. We present a qualitative portrait demonstrating the range of student cognitive behaviors as they attempt to move towards proficiency. As experts immersed in our fields of study and its practices, we can sometimes forget that what comes second-nature to us is far from natural to our students—regardless of their enthusiasm. We may overestimate the background knowledge that our students have, and underestimate the brain bandwidth required when trying—for the first time—to think differently.

The Role of Bodily Movement in Learning and Performing Music: Applications for Education

2012 ◽  
pp. 768-782 ◽  
Author(s):  
Jane W. Davidson
Keyword(s):  
Body Movement ◽  
The Body ◽  
Musical Experience ◽  
Performance Skills ◽  
Music Production ◽  
Bodily Movement ◽  
Musical Knowledge ◽  
And Performance

This article explores the fundamental role of bodily movement in the development of musical knowledge and performance skills; in particular, how the body can be used to understand expressive musical material and to communicate that meaning to coperformers and audience. The relevance to the educator is explored (whether working with a child or adult beginner, or a more advanced learner). The article is divided into six main sections, tracing the role of body movement skill in music production, expressive musical performance, developing learners to play their musical instruments with technical and expressive appropriateness, coperformer coordination, and projection for audience perception. The work builds on a growing interest in the embodied nature of musical experience. The article concludes with case study observations of practical insights and applications for the teacher.

Revealing Student Blogging Activities Using RSS Feeds and LMS Logs

2012 ◽  
pp. 234-249
Author(s):  
Michael Derntl
Keyword(s):  
Computer Mediated Communication ◽  
Activity Patterns ◽  
Lessons Learned ◽  
The Body ◽  
Mediated Communication ◽  
Activity Data ◽  
Computer Mediated ◽  
Rss Feeds ◽  
First Time

Blogs are an easy-to-use, free alternative to classic means of computer-mediated communication. Moreover, they are authentically aligned with web activity patterns of today’s students. The body of studies on integrating and implementing blogs in various educational settings has grown rapidly recently; however, it is often difficult to distill practical advice from these studies since the application contexts, pedagogical objectives, and research methodology differ greatly. This paper takes a step toward an improved understanding of employing blogs in education by presenting a follow-up case study on using blogs as reflective journals in an undergraduate computer-science lab course. This study includes lessons learned and adaptations following from the first-time application, the underlying pedagogical strategy, and a detailed analysis and discussion of blogging activity data obtained from RSS feeds and LMS logs.

Insurance regulations, risk and performance in Ghana

2019 ◽  
Vol 28 (1) ◽  
pp. 74-96
Author(s):  
Baah Aye Kusi ◽  
Abdul Latif Alhassan ◽  
Daniel Ofori-Sasu ◽  
Rockson Sai
Keyword(s):  
Random Effect ◽  
Least Square ◽  
Insurance Market ◽  
Content Type ◽  
Ordinary Least Square ◽  
Negative Effect ◽  
And Performance ◽  
First Time

Purpose This study aims to examine the hypothesis that the effect of insurer risks on profitability is conditional on regulation, using two main regulatory directives in the Ghanaian insurance market as a case study. Design/methodology/approach This study used the robust ordinary least square and random effect techniques in a panel data of 30 insurers from 2009 to 2015 to test the research hypothesis. Findings The results suggest that regulations on no credit premium and required capital have insignificant effects on profitability of insurers. On the contrary, this study documents evidence that both policies mitigate the effect of underwriting risk on profitability and suggests that regulations significantly mitigate the negative effect of underwriting risk to improve profitability. Practical implications The finding suggests that policymakers and regulators must continue to initiate, design and model regulations such that they help tame risk to improve the performance of insurers in Ghana. Originality/value This study provides first-time evidence on the role of regulations in controlling risks in a developing insurance market.

scholarly journals First identification of nanoparticles on thorax, abdomen and wings of the worker bee Apis dorsata Fabricius

2016 ◽  
Vol 60 (1) ◽  
pp. 87-96
Author(s):  
Atanu Bhattacharyya ◽  
Shashidhar Viraktamath ◽  
Fani Hatjina ◽  
Santanu Bhattacharyya ◽  
Bhaktibhavana Rajankar ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Average Diameter ◽  
The Body ◽  
Apis Dorsata ◽  
Force Microscopy ◽  
Atomic Force ◽  
Transmission Electron ◽  
Calcium Phosphate Nanoparticles ◽  
First Time

Abstract The presence of nanoparticles on the body of the honeybee Apis dorsata Fabricius, was investigated for the first time to better understand the bee’s behaviour. These have been observed by using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and confirmed by Atomic Force Microscopy (AFM). Our study clearly denotes that the Indian rock honey bee Apis dorsata possess calcium silicate and calcium phosphate nanoparticles on its body surface of 5-50 nm in diameter. In particular, the nanoparticles on the abdomen and thorax of A. dorsata have an average diameter of about 10 nanometers and they are smaller than those found on wings of the same bees which are about 20 nanometers. The nanoparticles found are different of the ones previously observed on honey bees or other insects. The origin and role of these natural nanoparticles on the body of the Indian rock bee need to be to be further investigated; more research in the subject might raise important aspects in relation to the conservation of these unique pollinators.

Partial Harmonisation and European Social Policy: A Case Study on the Acquired Rights Directive

2003 ◽  
Vol 5 ◽  
pp. 173-193
Author(s):  
Amandine Garde
Keyword(s):  
Social Policy ◽  
Legal Order ◽  
Tobacco Advertising ◽  
Community Competence ◽  
European Social Policy ◽  
First Time ◽  
Community Directive ◽  
Community Legal Order

The question of Community competence has been one of the most debated issues since the ruling in Tobacco Advertising I, in which the Court annulled, for the first time, a Community Directive for lack of competence. This judgment is significant in terms of assessing the constitutional role of the Court in the Community legal order. The aim of this article is not to comment on the Tobacco Advertising judgment. Rather, it is to consider the question of competence from a different angle: that of partial harmonisation.

Nonlinear consistent valuation of CCP cleared or CSA bilateral trades with initial margins under credit, funding and wrong-way risks

2014 ◽  
Vol 01 (01) ◽  
pp. 1450001 ◽  
Author(s):  
Damiano Brigo ◽  
Andrea Pallavicini
Keyword(s):  
Interest Rate ◽  
Differential Equations ◽  
Credit Risk ◽  
Nonlinear Partial Differential Equations ◽  
Relative Size ◽  
Derivatives Pricing ◽  
Interest Rate Swaps ◽  
First Time

The introduction of Central Clearing Counterparties (CCPs) in most derivative transactions will dramatically change the landscape of derivatives pricing, hedging and risk management, and, according to the TABB Group, will lead to an overall liquidity impact of about USD 2 trillions. In this paper, we develop for the first time a comprehensive approach for pricing under CCP clearing, including variation and initial margins, gap credit risk and collateralization, showing concrete examples for interest rate swaps. This framework stems from our 2011 framework on credit, collateral and funding costs in Pallavicini et al. (Pallavicini, A., D. Perini and D. Brigo, 2011, Funding Valuation Adjustment: FVA consistent with CVA, DVA, WWR, Collateral, Netting and Re-hypothecation, arxiv.org, ssrn.com). Mathematically, the inclusion of asymmetric borrowing and lending rates in the hedge of a claim, and a replacement closeout at default, lead to nonlinearities showing up in claim dependent pricing measures, aggregation dependent prices, nonlinear Partial Differential Equations (PDEs) and Backward Stochastic Differential Equations (BSDEs). This still holds in presence of CCPs and CSA. We introduce a modeling approach that allows us to enforce rigorous separation of the interconnected nonlinear risks into different valuation adjustments where the key pricing nonlinearities are confined to a funding costs component that is analyzed through numerical schemes for BSDEs. We present a numerical case study for Interest Rate Swaps that highlights the relative size of the different valuation adjustments and the quantitative role of initial and variation margins, of liquidity bases, of credit risk, of the margin period of risk and of wrong-way risk correlations.

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