A Conceptual study of use  of Prajastapak Mahakshaya in BOH w. s. r. to recurrent abortion.

Acharya Charak in Sutrasthan has classified drug According to their mode of action as “MAHAKSHAYA” and has defined mode of action of Prajasthapan Mahakshaya as that removes the Doshas which cause hindrance in process of conception and for the viability and sustenance of pregnancy. In this study aim would be to analyze the mode of action of each drug with its Rasa,Guna,Virya,Vipak and Doshagnta in conception and maintenance of Preganacy especially in case of BOH due to Recurrent Abortion where there is fetal loss especially in First trimester .Prajasthapan Mahakshaya executes its mode of action by two means : 1st-Maintainence of Healthy Environment of Conception. 2nd-Preventing the loss of pregnancy This mode of action can be established by usage Prajasthapan Mahakshya in First trimester of Pregnancy instead of use of Human chorionicgonadotropin and micronized progesterone as support in first trimester of pregnancy .Hence effort has been made to provide an alternative to Modern drug and Theoretical establishing the efficacy and pharmacological action of Prajasthapan Mahakshaya.

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The Risk of Fetal Loss in Family Members of Probands with Factor V Leiden Mutation

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614367 ◽

1999 ◽

Vol 82 (10) ◽

pp. 1237-1239 ◽

Cited By ~ 33

Author(s):

Daniela Tormene ◽

Paolo Simioni ◽

Sonia Luni ◽

Barbara Innella ◽

Paola Sabbion ◽

...

Keyword(s):

Relative Risk ◽

Family Members ◽

Fetal Loss ◽

Factor V Leiden ◽

First Trimester ◽

Factor V ◽

Factor V Leiden Mutation ◽

First Trimester Of Pregnancy ◽

Late Miscarriage ◽

Normal Genotype

SummaryIn order to investigate the risk of fetal loss in carriers of factor V Leiden who are family members of probands with this mutation, we performed a retrospective cohort study including 109 women who had been pregnant at least once and were family members of 61 probands with venous thromboembolism and a single identified factor V Leiden mutation. The rate of pregnancies ending in unexplained fetal loss, early miscarriage, late miscarriage or stillbirth in women with the factor V Leiden was compared with that of women with normal genotype. In the 65 women who were carriers of factor V Leiden 31 of the 191 pregnancies (16.2% per pregnancy ) resulted in unexplained fetal loss, as compared to 13 of the 121 pregnancies (10.7% per pregnancy) in the 44 non-carriers (relative risk, 1.5; 95% CI, 0.8-3.2). After the first trimester of pregnancy, 25 pregnancies (13.1% per pregnancy) among carriers of factor V Leiden ended in fetal loss, as compared to 7 (5.8% per pregnancy) among females with normal genotype (relative risk, 2.3; 95% CI, 1.01 to 5.1). We conclude that carriers of factor V Leiden who are family members of probands with this mutation have a statistically significant and clinically important risk of late miscarriage or stillbirth. Studies addressing the benefit-to-risk ratio of adopting routinary thromboprophylactic measures following the first trimester of pregnancy in these women are strongly indicated.

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Parvovirus B19 Infection in the First Trimester of Pregnancy and Risk of Fetal Loss: A Population-based Case-Control Study

American Journal of Epidemiology ◽

10.1093/aje/kws177 ◽

2012 ◽

Vol 176 (9) ◽

pp. 803-807 ◽

Cited By ~ 16

Author(s):

J. Lassen ◽

A. K. V. Jensen ◽

P. Bager ◽

C. B. Pedersen ◽

I. Panum ◽

...

Keyword(s):

Case Control Study ◽

Parvovirus B19 ◽

Fetal Loss ◽

First Trimester ◽

Population Based ◽

Case Control ◽

Parvovirus B19 Infection ◽

First Trimester Of Pregnancy ◽

Control Study

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Features of the histological structure of trophoblast and chorionic villi with recurrent pregnancy loss in women with thrombophilias

I P Pavlov Russian Medical Biological Herald ◽

10.23888/pavlovj20174621-641 ◽

2017 ◽

Vol 25 (4) ◽

pp. 621-641

Author(s):

A. I. Mirov ◽

O. N. Kharkevich ◽

O. E. Golofast ◽

I. B. Glukhovets

Keyword(s):

Significant Role ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Chorionic Villus ◽

Fetal Loss ◽

First Trimester ◽

Control Group ◽

Histological Structure ◽

Chorionic Villi ◽

First Trimester Of Pregnancy

The frequency of recurrent pregnancy loss does not tend to decrease. This pathology continues to be one of the important problems of modern medicine. It is known that thrombophilia can play a significant role in the etiology of spontaneous reproductive losses. However, the pathogenesis of recurrent spontaneous loss of pregnancy in the presence of maternal thrombophilia is not fully understood. Aim. To identify the features of the histological structure of trophoblasts and chorionic villi in the first trimester of pregnancy in women with thrombophilia and recurrent pregnancy loss, with careful exclusion of other possible causes of fetal loss syndrome. Material and Methods. Histological examination of 49 chorion tissue samples from 24 patients with thrombophilia and recurrent pregnancy loss in the first trimester (study group) was performed. The controls were samples of chorion tissue taken during artificial abortion in 33 healthy women who had a history of 2 or more spontaneous labor without significant complications. Thrombophilia diagnosis and hemostasis system state evaluation was performed for all patients on the basis of analysis of 30 parameters according to standard methods. All studies were conducted at the Regional clinical hospital № 8 in Ryazan as well as the scientific and clinical center of hematology, oncology and immunology of the Ryazan State Medical University named after academician I.P. Pavlov of Health Ministry of the Russian Federation. Statistical processing of the obtained results was carried out with the help of computer program package Statistica (version 10). Results. Significant differences in the histological structure of trophoblast and chorionic villi in the studied women were revealed, in comparison with those in the control group. It is proved that the presence of thrombophilia negatively affects the process of embryogenesis and contributes to a significant reduction in the area of the chorionic villus vessels in the first trimester of pregnancy. Conclusion. It is proved that the presence of thrombophilia has a negative effect on the process of embryogenesis and significantly reduces the vascular area of chorionic villi that can probably play a significant role in the pathogenesis of recurrent pregnancy loss.

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Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.2.127 ◽

2008 ◽

Vol 58 (2) ◽

pp. 127

Author(s):

Kum Rae Kim ◽

Won Kyu Park ◽

Jae Woon Kim ◽

Woo Hyung Kwun ◽

Bo Yang Suh ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Case Reports ◽

First Trimester ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

First Trimester Of Pregnancy ◽

Deep Vein

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FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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