The Relationship between Weaning Method and its Time and Severe Early Childhood Caries

Abstract Aim: The study aimed to investigate the relationship between the occurrence of Severe Early Childhood Caries (S-ECC) and breast milk lactose, in infants aged 12 to 24 months.Material and Methods: This cross-sectional descriptive-analytical study was carried out in April to July 2020 on 30 children aged 12 to 24 months with or without S-ECC who were solely breastfed Also, the mothers answered questions about their breastfeeding. After the child's dental visit, the mother was asked to express 10 to 20 ml of her milk as a sample and give it to the researchers. The samples were immediately kept at -4 ° C and then they were tested to lactose measurement. Finally, the test results were analyzed by SPSS 21 software. Results: The average amount of lactose in the breast milk of cases with S-ECC infant was 5.74g/100 ml, and the average amount of lactose in the breast milk of cases without S-ECC infant was 4.64g/100 ml. There was no significant difference in lactose concentration between the two groups (p=0/64). The average number of breastfeeding times in cases with S-ECC infants was 7.87 per day while in the healthy cases this was 7.33 per day. There was no significant difference between the numbers of breastfeeding times per day in the two groups.Conclusion: According to this study, the average level of lactose in the breast milk samples was lower than the average level of lactose in breast milk in other countries, and the amount of lactose in breast milk of children with S-ECC was slightly higher than the amount of lactose in breast milk in children with healthy teeth.

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Korelasi Jumlah Streptococcus mutans (S. mutans) dan Level Ekspresi Interlukin 8 (IL-8) pada Severe Early Childhood Caries

Majalah Kedokteran Gigi Indonesia ◽

10.22146/majkedgiind.9227 ◽

2015 ◽

Vol 20 (2) ◽

pp. 142 ◽

Cited By ~ 3

Author(s):

Muhammad Luthfi ◽

Retno Indrawati ◽

Ira Arundina ◽

Yoes Prijatna Dachlan

Keyword(s):

Flow Cytometry ◽

Early Childhood ◽

Streptococcus Mutans ◽

Early Childhood Caries ◽

Interleukin 8 ◽

Tooth Surface ◽

Average Value ◽

The Relationship ◽

Severe Early Childhood Caries ◽

Childhood Caries

Karies gigi pada anak usia dini merupakan masalah kesehatan yang sangat serius karena merupakan penyakit infeksi kronis yang menular. Dalam beberapa tahun terakhir pandangan tentang neutrofil telah berubah secara dramatis. Neutrofil tidak hanya berperan sebagai pembunuh mikroba melalui proses fagositosis, pelepasan reactive oxigen species (ROS) dan peptida antimikrobialnya tetapi neutrofil turut mengatur aktifasi respon imun. Interleukin-8 (IL-8) berfungsi sebagai aktivator kuat dan kemoatraktan neutrofil oleh karena itu IL-8 merupakan mediator kunci dalam migrasi neutrofil ke lokasi peradangan dan infeksi. Untuk menganalisis hubungan dari jumlah S. mutans dan ekspresi IL-8 neutrofil saliva pada anak usia dini bebas karies dan severe early childhood caries (S-ECC). Perlakuan dilakukan pada dua kelompok yaitu isolasi dan menghitung jumlah S. mutans pada sampel saliva dan sampel hasil kumur dengan NaCl 1,5% yang diisolasi neutrofilnya kemudian dianalisis ekspresi IL-8 menggunakan flow cytometry dari 20 anak bebas karies dan 20 anak severe early childhood caries. Hasil nilai rata-rata diketahui bahwa jumlah S. mutans anak usia dini bebas karies lebih rendah (513.500,00±185.565,28 CFU/ml) dibandingkan dengan S-ECC (977.000,00±222.500,15 CFU/ml), sedangkan ekspresi IL-8 neutrofil saliva anak usia dini bebas karies lebih tinggi (3,31±0,50) dibandingkan dengan S-ECC (2,95+0,56). Penurunan ekspresi IL-8 neutrofil saliva kemungkinan sebagai penyebab meningkatnya jumlah S. mutans pada S-ECC.Correlation of Streptococcus mutans (S. mutans) Level and Interleukin 8 (IL-8) Expressions of Salivary Neutrophils in Severe Early Childhood Caries. Early childhood caries is a very serious health problem because it is a chronic infectious disease that is contagious. Dental caries begins after the primary teeth grow and develop on the tooth surface very quickly and progressively. In recent years the views of neutrophils have changed dramatically. Neutrophils not only act as a microbe killer through phagocytosis, the release of reactive oxigen species (ROS) and its antimicrobial peptide, but neutrophil activation also helps regulate the immune response. To analyze the relationship between the amount S. mutans and IL-8 expression of salivary neutrophils in severe early Childhood caries. Two groups, namely Isolation of S. mutans were performed on saliva samples taken from 20 caries-free and 20 severe early childhood caries and samples Nacl 1,5% mouthwash results of 20 caries-free and 20 severe early childhood caries salivary neutrophils that were analysis of IL-8 expression by flow cytometry. Based on the average value, it is known that S. mutans level in early Childhood caries-free is lower (513.500,00 +185.565,28 CFU/ml) in comparison to the severe early Childhood caries (977.000,00 +222.500,15 CFU/ml), but the expression of IL-8 neutrophil salivary neutrophils in early Childhood caries-free is higher (3,31+0,50) in comparison to the severe early Childhood caries (2,95+0,56). The increased S. mutans level is probably caused by the decrease in the expression of IL-8 salivary neutrophils in severe early childhood caries.

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Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries

Caries Research ◽

10.1159/000360868 ◽

2014 ◽

Vol 49 (1) ◽

pp. 63-69 ◽

Cited By ~ 8

Author(s):

Yan Si ◽

Shuang Ao ◽

Weijian Wang ◽

Feng Chen ◽

Shuguo Zheng

Keyword(s):

Mass Spectrometry ◽

Early Childhood ◽

Early Childhood Caries ◽

Expression Profiles ◽

Salivary Protein ◽

Preschool Age ◽

Diagnostic Model ◽

Peptide Mass ◽

Severe Early Childhood Caries ◽

Childhood Caries

Objective: To investigate the differential salivary protein expression profiles between children with severe early childhood caries (S-ECC) and caries-free (CF) children at the age of 3 years. Methods: We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads, and peptide mass fingerprints were created by scanning mass spectrometry signals. Salivary samples from 20 children were analyzed (10 for each group). Results: Eleven protein peaks were significantly different (p < 0.05) between the two groups. Eight of these peaks were higher in the S-ECC group and three were higher in the CF group. To establish a diagnostic model for discrimination between the two groups, we chose three peptides (3,186.2, 3,195.8 and 3,324.8 Da) that exhibited the best fitted curve, by which the two groups were better separated when compared with other combinations. Conclusions: The salivary biomarkers identified revealed significant differences between the CF and the S-ECC group. Our results provide novel insight into the salivary protein profile of preschool-age children with dental caries and may lead to the development of a new strategy for screening high-risk populations.

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Dental Treatments under the General Anesthesia in a Child with Keratitis, Ichthyosis, and Deafness Syndrome

Case Reports in Dentistry ◽

10.1155/2013/618468 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6

Author(s):

Sera Sımsek Derelioglu ◽

Yücel Yılmaz ◽

Sultan Keles

Keyword(s):

Early Childhood ◽

Case Report ◽

General Anesthesia ◽

Early Childhood Caries ◽

Sensorineural Deafness ◽

Oral Symptoms ◽

Severe Early Childhood Caries ◽

Childhood Caries

KID syndrome is a rare genodermatosis characterized by keratitis, ichthyosis, and sensorineural deafness. Although the dermatological, ophthalmologic, and sensorineural defects are emphasized in the literature, oral and dental evaluations are so superficial. In this case report, dental and oral symptoms of a three year and five months old boy with KID syndrome, suffering severe Early Childhood Caries (s-ECC) and dental treatments done under General Anesthesia (GA) were reported.

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Relationship between dental caries status and anemia in children with severe early childhood caries

The Kaohsiung Journal of Medical Sciences ◽

10.1016/j.kjms.2012.10.003 ◽

2013 ◽

Vol 29 (6) ◽

pp. 330-336 ◽

Cited By ~ 13

Author(s):

Ru-Shing Tang ◽

Meng-Chuan Huang ◽

Shun-Te Huang

Keyword(s):

Early Childhood ◽

Dental Caries ◽

Early Childhood Caries ◽

Severe Early Childhood Caries ◽

Childhood Caries

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Associations between early childhood caries, malnutrition and anemia: a global perspective

10.21203/rs.2.16567/v3 ◽

2020 ◽

Author(s):

Morenike Folayan ◽

Maha El Tantawi ◽

Robert J Schroth ◽

Ana Vukovic ◽

Authur Kemoli ◽

...

Keyword(s):

Early Childhood ◽

Early Childhood Caries ◽

Linear Models ◽

National Income ◽

Global Perspective ◽

Country Level ◽

Eta Squared ◽

The Mean ◽

The Relationship ◽

Childhood Caries

Abstract Background: Malnutrition is the main risk factor for most common communicable diseases. The aim of this study is to determine the relationship between country-level prevalence of early childhood caries (ECC), malnutrition and anemia in infants and preschool children. Methods: Matched country-level ECC, malnutrition and anemia prevalence were generated from databases covering the period 2000 to 2017. Multivariate general linear models were developed to assess the relationship between outcome variables (prevalence of stunting, wasting, overweight, and anemia) and the explanatory variable (ECC prevalence) adjusted for gross national income per capita. Adjusted regression coefficients (B) and partial eta squared were computed. Results: The mean (standard deviation (SD)) ECC prevalence was 23.8 (14.8)% for 0-2 year-olds and 57.3 (22.4)% for 3-5-year-olds. The mean (SD) prevalence of wasting was 6.3 (4.8)%, overweight 7.2 (4.9)%, stunting 24.3 (13.5)%, and anemia 37.8 (18.1)%. For 0-2-year-olds, the strongest and only significant association was between the prevalence of ECC and overweight (η2= 0.21): one percent higher ECC prevalence was associated with 0.12% higher prevalence of overweight (B= 0.12, P= 0.03). In 3-5-year-olds, the strongest and only significant association was between the prevalence of ECC and anemia (η2= 0.08): one percent higher prevalence of ECC was associated with 0.14% lower prevalence of anemia (B= -0.14, P= 0.048). Conclusion: Country-level prevalence of ECC was associated with malnutrition in 0-2-year-olds and with anemia in 3-5-year-olds. The pathway for the direct relationship between ECC and overweight may be diet related. The pathway for the inverse relationship between ECC and anemia is less clear and needs further investigations.

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Associations between early childhood caries and malnutrition and anemia: A global perspective

10.21203/rs.2.16567/v1 ◽

2019 ◽

Author(s):

Morenike Folayan ◽

Maha El Tantawi ◽

Robert J Schroth ◽

Ana Vukovic ◽

Authur Kemoli ◽

...

Keyword(s):

Early Childhood ◽

Early Childhood Caries ◽

Linear Models ◽

National Income ◽

Global Perspective ◽

Country Level ◽

Age Related ◽

The Mean ◽

The Relationship ◽

Childhood Caries

Abstract Background To determine the relationship between country-level prevalence of early childhood caries (ECC), malnutrition and anemia in infants and preschool children.Methods Matched country level ECC, malnutrition and anemia prevalence information were generated from databases covering the period from 2000 to 2017. Multivariate general linear models were developed to assess the relationship between outcome variables (prevalence of stunting, wasting, overweight, and anemia) and the explanatory variable (ECC prevalence) adjusted for Gross National Income per capita. The adjusted regression coefficients (B) and partial eta squared were computed.Results The mean (standard deviation (SD)) ECC prevalence for 0-2 year-olds was 23.8 (14.8)% and 57.3 (22.4)% for 3-5 year-olds. The mean (SD) prevalence of wasting was 6.3 (4.8)%, overweight was 7.2 (4.9)%, stunting was 24.3 (13.5)%, and anemia was 37.8 (18.1)%. For 0-2-year-olds, the strongest and only significant association observed was between the prevalence of ECC and overweight (η2= 0.21): one percent higher ECC prevalence was associated with 0.12% higher prevalence of overweight (B= 0.12, P= 0.03). In 3-5-year-olds, the strongest and only significant association was observed between the prevalence of ECC and anemia (η2= 0.08): one percent higher prevalence of ECC was associated with 0.14% lower prevalence of anemia (B= -0.14, P= 0.048).Conclusion There were age-related disparities in the relationship between country-level prevalence of ECC, malnutrition and anemia. The relationship between ECC and overweight may be due to intake of sugars. The relationship between ECC and anemia needs further investigations.

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