Treatment of Skin Cancer by Topical Drug Delivery of Nanoparticles: A Review

2021 ◽  
pp. 5589-5598
Author(s):  
Navdeep Singh ◽  
Shivi Sondhi ◽  
Sanyam Sharma ◽  
Dheeraj Singh ◽  
Vishal Koundal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Technology Transfer ◽  
Skin Cancer ◽  
Cancer Therapy ◽  
Laser Irradiation ◽  
The Body ◽  
Topical Drug Delivery ◽  
Physical Methods ◽  
Dermal Delivery

Nanoparticles offer novel openings for the management of dermal diseases. The skin being a largest organ of the body poses a barrier to all the delivery system including nanoparticles to permeate deep in to the cells or tissues. This barrier was ruptured in case of skin trauma or injury and also in the case of skin cancer. This conditions of the skin allowed the nanoparticles to permeate through the skin for the treatment of cancer. Worldwide research is going in to the formulation and development of the Nano carrier for the dermal delivery through the skin. But the little or negligible technology transfer occur from the R&D to Industry for the treatment of skin cancer using nanoparticles. The main aim of review is to discuss about the basic fundamentals of cancer with relate to dermal delivery of drug through Nanoparticles. The nanotechnologies for dermal delivery of drugs were explained for their effective tool for skin cancer. In this review types of skin cancer with various nanotechnologies were discussed along with pathology of disease and various therapies used. Further we had discussed challenges in developing the nanoparticles for the treatment in the skin cancer therapy. Finally various therapies like Chemotherapies, Immunotherapy, Gene therapy, Nano carriers combined with physical methods and Laser irradiation therapies were summarized.

Microneedles for gene and drug delivery in skin cancer therapy

2021 ◽  
Author(s):  
Defu Zhi ◽  
Ting Yang ◽  
Tingyu Zhang ◽  
Mei Yang ◽  
Shubiao Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Cancer ◽  
Cancer Therapy

Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy

2018 ◽  
Vol 6 (40) ◽  
pp. 6424-6430 ◽  
Author(s):  
Caixia Huang ◽  
Jing Zheng ◽  
Dandan Ma ◽  
Na Liu ◽  
Cong Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug

An new drug delivery system to utilize the photodynamic-induced hypoxia for synergistic cancer therapy is proposed in this paper.

scholarly journals A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

2019 ◽  
Vol 12 (2) ◽  
Author(s):  
Temitayo Adeyemi
Keyword(s):  
Drug Delivery ◽  
Review Paper ◽  
New Technology ◽  
The Body ◽  
Topical Drug Delivery ◽  
Systemic Delivery ◽  
Multiple Sources ◽  
Comprehensive Review ◽  
Skin Physiology ◽  
Percutaneous Drug Delivery

Microneedles are a new technology for percutaneous drug delivery. They are often conveyed in a series of multiple simple microneedles used on the skin to facilitate systemic or topical drug delivery. They are manufactured using various techniques and they could be hollow, solid, coated or polymeric. Although classified as an emerging but expanding field of drug delivery, they are flawed in many ways. This paper will extensively discuss (in the context of skin physiology) the use of microneedles and their feasibility in delivering medication to sites of actions in the body. This paper is a review paper and data were collated from multiple sources including journals and articles. Microneedles show great potential; however, the physiology of the skin poses a great challenge for researches in this field.

scholarly journals Revolutionary Approach towards Transdermal Drug Delivery: Ethosomal Gels

2021 ◽  
pp. 35-43
Author(s):  
Ezekiel O. Kehinde ◽  
Shah Akrutiben ◽  
Janki Patel
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Circulation ◽  
The Body ◽  
Topical Drug Delivery ◽  
Biological Barrier ◽  
Advantages And Disadvantages ◽  
Non Invasive

The human body is up of the skin which is the largest organ in the body and hence acts as a biological barrier that obstructs drug movement across the stratum corneum into the systemic circulation. The topical drug delivery system serves as a delivery system in which drugs are delivered for systemic circulation through the skin. Low diffusion rate across the stratum corneum is the main disadvantage of this system and for this limitation to be overcome, an Ethosomal formulation can be formulated which acts as a delivery system for the drug to be delivered across the biological barrier of the skin into the body. In ethosomal gel formulation, The prepared Ethosome is converted into a gel that can be applied to the skin what makes ethosomal gel formulation unique which enables drugs to reach the deep skin layers and/or the systemic circulation and enhance the delivery of active agents. In addition to this, it is also a malleable vesicular delivery carrier, soft and non-invasive. There is also a higher influx of drugs transdermally into the skin as ethosomal gel formulation allows drug to penetrate deep into the skin and enters systemic circulation. There is the development of new and novel therapies for the treatment of disease through the ethosomal drug delivery system as it is safe and effective and also easy to prepare. Topics ranging from preparation of ethosomes, Ethosomal gel, advantages and disadvantages, and characterization techniques are focused on in this review article.

Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs

2019 ◽  
Vol 20 (7) ◽  
pp. 575-582 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Wei Duan ◽  
Beom-Jin Lee ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Skin Cancer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Transdermal Delivery ◽  
Drug Delivery Systems ◽  
Recent Literature ◽  
Tumor Site ◽  
Permeation Studies ◽  
Cancer Theranostics

Background: Recently, several strategies have been proposed for skin cancer therapy by transdermal delivery, and particularly the use of nanotechnology. Methods: This process disrupts the stratum corneum to deliver a drug through the skin, allowing it to accumulate at the tumor site. Results: Nanogels are drug delivery systems that can be applied to many diseases. Nanogel engineering has been widely studied for use in drug delivery, particularly in cancer theranostics. This review summarizes specific strategies for using nanogels to treat skin cancer, a topic that is limited in recent literature. Conclusion: Advanced techniques for effective skin cancer therapy based on the nanogel’s penetration and cellular uptake abilities will be discussed. Moreover, techniques for penetrating the skin, as well as drug release, permeation studies, and microscopic observations, will also be discussed.

A Current Review on Drug Loaded Nanofibers: Interesting and Valuable Platform for Skin Cancer Treatment

2020 ◽  
Vol 8 (3) ◽  
pp. 191-206
Author(s):  
Navneet Mehan ◽  
Manish Kumar ◽  
Shailendra Bhatt ◽  
Vipin Saini
Keyword(s):  
Drug Delivery ◽  
Skin Cancer ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Skin Diseases ◽  
Sun Exposure ◽  
The Body ◽  
Skin Malignancy ◽  
Melanoma Skin

Background: Nanofibers are used in topical medication for various skin diseases like wound healing, skin cancer and others. Non-melanoma skin cancers (NMSCs) are the most widely distributed diseases in the world, of which 99% of people are affected by either basal cell carcinomas (BCCs) or squamous cell carcinomas (SCCs) of the skin. Skin malignancy is caused by direct sun exposure and regular application of unsafe restorative items on the skin. Objective : This review presents the use of nanofibers in skin cancer treatment and advances made in skin cancer treatment. Methods: There are various methods used in the production of nanofibers such as bicomponent extrusion, phase separation, template synthesis, drawing, electrospinning, and others. Electrospinning is the most widely used technique for nanofiber fabrication. The nanofibers are produced in nanometer size range and mostly used in medication because of their low thickness, large surface area per unit mass and porosity. Nanofibers are also used as drug delivery system for sustaining the action of drugs or medicaments. Results: Nanofibers enhance the permeation and availability of those drugs having low bioavailability and low permeability. Nanofibers increase the sustainability of the drugs up to 10 days. Conclusion: Skin cancer is the abnormal growth of skin cells in the body influencing people of all colours and skin. In this review paper, the definition and production techniques of nanofibers and drugs used in skin cancer treatment and the relation between skin cancer and nanofiber are illustrated in detail. With the help of different techniques and drugs, the risk of non-melanoma skin cancer is reduced. Lay Summary: The risk of skin cancer and other skin problems is increasing day by day. In a previous study we found that the nanofibers are less used as a topical delivery system. We have studied the nanofibers as a drug delivery system in the treatment of skin cancer by using different drugs. According our study nanofibers are most useful in skin drug delivery and if the nanofiber, are merging with other drug delivery system like nanoparticles, it may maximize the output of drug into skin. The significance of this study is, to explain all information about nanofibers in skin cancer.

scholarly journals Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Manisha Lalan ◽  
Pranav Shah ◽  
Kalyani Barve ◽  
Khushali Parekh ◽  
Tejal Mehta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Cancer ◽  
Environmental Changes ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Magic Bullet ◽  
Main Body ◽  
Topical Drug Delivery ◽  
Cancer Statistics ◽  
Skin Cancers

Abstract Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. Main body of the abstract The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Short conclusion Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies. Graphic abstract

scholarly journals MICELLAR MICROPARTICLES: A NOVEL APPROACH TO TOPICAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (5) ◽  
pp. 1 ◽  
Author(s):  
Monisha Bansal ◽  
Shahid Jamil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Colloidal Particles ◽  
Great Depth ◽  
The Body ◽  
Topical Drug Delivery ◽  
Pharmaceutical Dosage Form ◽  
Novel Approach ◽  
Poorly Soluble

Topical drug delivery system is defined as the pharmaceutical dosage form which when applied onto the skin provides protection of skin and prevents serious skin disorders. Topical drug are being used for several years and still have its potential in new pharmaceutical technologies investigated. Skin is the most easily accessible organ of the body which has the potential to facilitate the delivery of several drugs with better efficacy, confining the pharmacological or other effect of the drug to the surface of the skin. Micelles are colloidal particles with a size smaller than 100 nm that allow a great depth of tissue penetration for targeted drug delivery, but rapidly disintegrate in the body. Microparticles containing micelles have the potential for delivering hydrophobic drug encapsulated in micelles on the target site in the specific part of the body. Micellar microparticles allow the improvement of solubility and dissolution of poorly soluble drugs. Microparticles containing micelles have the potential for delivering micelle-encapsulated hydrophobic drugs in targeted therapy. This article reviews the topical drug delivery system, colloidal drug delivery system and aspects and literature reviewed on micellar microparticles and its advantages in pharmaceuticals. An overview of reviews was conducted to locate published literature between 2000 and 2017. 

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