Bioelectric Medicine: Magicall Tools for Treatment of Many Diseases

2021 ◽  
pp. 304-308
Author(s):  
Vikram B. Madane ◽  
Sasmit N. Mali
Keyword(s):  
Embedded System ◽  
Science Fiction ◽  
Symptom Management ◽  
Biological Effect ◽  
The Body ◽  
Clinical Use ◽  
Underlying Condition ◽  
Bladder Control ◽  
Bioelectronic Medicine ◽  
Early Results

Bioelectronic medicine is a relatively new area that focuses on developing methods for treating diseases that do not need medications. Bioelectronic medicine treatments are now possible thanks to a small embedded system that produces and delivers frequent digital doses to nerve bundles, resulting in a disease-fighting effect that can last hours or days and is based on mechanisms similar to drug therapies. Although this may sound like science fiction, electronic brain and nerve stimulators are now presence applicable to treat so many of ailments, including epilepsy, Parkinson's disease, and bladder control. Progress in treating such disorders has opened up possibilities for boosting memory, improving eyesight, strengthening a shaky gait, and even improving a golfer's swing. Those self-improvement dreams may be a long way off, but bioelectronic medicine is gaining traction as a new way to treat difficult diseases. What distinguishes bioelectronic medicine is its biological effect on the body, which goes beyond symptom management to treat the underlying condition by using the body's own mechanisms. With promising early results in many trials and further trials ongoing, bioelectronic therapies are likely to be accepted for clinical use within the next few years. To make this advancement possible, forward-thinking scientists, engineers, doctors, and innovators with specialised talents combined old and new discoveries in ways no one had before.

Vorklinische Untersuchung zur Organverteilung und Strahlenbelastung von Radiojod-Jodlisurid

1991 ◽  
Vol 30 (04) ◽  
pp. 137-140
Author(s):  
H. Flade ◽  
B. Johannsen ◽  
V. Pink ◽  
U. Herold ◽  
R. Harhammer ◽  
...  
Keyword(s):  
Radiation Dose ◽  
The Body ◽  
Organ Distribution ◽  
Clinical Use ◽  
Isolated Organs

The distribution in rats of 125l-iodolisuride was studied. Three rats each were sacrificed at fixed intervals between 5 min and 24 h p. i., and the radioactivity was measured in isolated organs and parts of the body. The organ distribution and biexponential blood disappearance were similar to values for unlabeled lisuride. The radiation dose was estimated for man assuming a 123l label. The resulting doses were comparable to those from other radiopharmaceuticals in clinical use.

Measuring Exposome Associated with Health

2020 ◽  
pp. 46-50
Keyword(s):  
Mass Spectrometry ◽  
Remote Sensing ◽  
High Resolution ◽  
Biological Effect ◽  
High Resolution Mass Spectrometry ◽  
The Body ◽  
Ecological Environment ◽  
Special Issue ◽  
The Life Course ◽  
Resolution Mass

The concept of exposome has received increasing discussion, including the recent Special Issue of Science –"Chemistry for Tomorrow's Earth,” about the feasibility of using high-resolution mass spectrometry to measure exposome in the body, and tracking the chemicals in the environment and assess their biological effect. We discuss the challenges of measuring and interpreting the exposome and suggest the survey on the life course history, built and ecological environment to characterize the sample of study, and in combination with remote sensing. They should be part of exposomics and provide insights into the study of exposome and health.

scholarly journals Mucormycosis (Black fungus): An alarming sign for COVID-19 patients

2021 ◽  
Vol 6 (3) ◽  
pp. 136-139
Author(s):  
Ritesh Kumar Srivastav ◽  
Vishal Kumar Vishwakarma ◽  
Shiv Kumar Srivastav ◽  
Mahesh Prasad ◽  
Tarique Mahmood ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Fungal Spores ◽  
Body Part ◽  
The Body ◽  
Fatality Rate ◽  
Health Issues ◽  
Pulmonary Infections ◽  
Skin Injury ◽  
Underlying Condition ◽  
Disseminated Mucormycosis

Mucormycosis (also known as zygomycosis) is a dangerous but uncommon fungal infection caused by a fungus known as mucormycetes. Mucormycosis can be caused by a variety of fungi. Mucormycetes are fungi that belong to the Mucorales scientific order. Molds can be found all over the place. Mucormycosis is a fungal infection that primarily affects persons who have health issues or who use medications that reduce the body's capacity to resist infections and illness. After inhaling fungal spores from the air, it most usually affects the sinuses or lungs. The majority of people are unaffected by these fungus. Breathing in mucormycete spores, on the other hand, can induce an infection in the lungs or sinuses, which can spread to other regions of the body in patients with compromised immune systems. It can also happen as a result of a cut, a burn, or another sort of skin injury. The fatality rate varied based on the patient's underlying condition, the type of fungus, and the affected body part (for example, the mortality rate was 46 percent among people with sinus infections, 76 percent for pulmonary infections, and 96 percent for disseminated mucormycosis). Antifungal medicines such as amphotericin-B, isavuconazole, posaconazole, and various combinations are used to inhibit the growth. Mucormycosis was studied for its spread, symptoms, treatment, prevention, and consequences.

Eugenic Nostalgia: Self-Narration and Internalized Ableism in Kazuo Ishiguro’s Never Let Me Go

2020 ◽  
Vol 14 (4) ◽  
pp. 437-452 ◽  
Author(s):  
Will Kanyusik
Keyword(s):  
Science Fiction ◽  
Genetically Engineered ◽  
The Body ◽  
Subject Position ◽  
Cultural Norms ◽  
Cultural Narratives ◽  
Person Perspective ◽  
Liberal Democratic ◽  
Disability Identity

Rosemarie Garland-Thomson has recently argued that Ishiguro’s novel Never Let Me Go deconstructs ableism’s binary structure by postulating the existence of clone characters who occupy an abject position in a eugenic dystopia precisely because their genetically engineered, idealized able bodies exist to be used to “cure” the disabilities of others. The article builds on Garland-Thomson’s work, discussing the role of science fiction in Ishiguro’s book as a means to explore how ableist narratives contribute to cultural norms that enable an overt disciplining of disabled bodies that still occurs, despite it no longer being socially acceptable, and posits protagonist Kathy H.’s story as a narrative of disability identity that exposes the contradictory nature of a belief in the able body and its opposition to disability. Putatively able-bodied, Kathy narrates her experience of the world from a subject position that undermines a stable construction of the body within an ableist framework, ultimately showing these distinctions to be untenable. By discussing the role of first-person perspective in Ishiguro’s novel as a means to interrogate internalized cultural narratives that perpetuate ableist practices, the article examines how cultural notions of ability and disability function as terms that define through exclusion the citizen-subject in liberal democratic societies.

Secretions

2021 ◽  
pp. 119-158
Author(s):  
Rex Ferguson
Keyword(s):  
Twentieth Century ◽  
Science Fiction ◽  
Genetic Research ◽  
Forensic Analysis ◽  
Dna Profiling ◽  
The Body ◽  
Autobiographical Texts ◽  
Late Twentieth ◽  
Living Organisms ◽  
Late Twentieth Century

DNA profiling, in which individual being is identified by its cellular structures, was first developed by the geneticist Alec Jeffreys in the 1980s. That this source of identity also forms the instructions through which living organisms are generated has complicated profiling’s place in the cultural imaginary of the late twentieth century. So, while profiling actually deals only in non-coding regions of the genome—matter often referred to as ‘junk DNA’—the significance of DNA as a substance of forensic analysis, in the late twentieth century imaginary, is its resonance as the apparent blueprint of existence. The notable features that this blurring of concepts brings about include a conceptualization of identity as a mass of information; notions to do with codes and coding; the presence of the body in the fluids which spill beyond its bounds; and a sense of the body as an archive of heredity and primitivism. In writing specifically about genetic research, Richard Powers’s The Gold Bug Variations (1991) serves a dual function in this chapter, as both an explicatory document and thematic example. But the more substantive analysis is reserved for the work of J. G. Ballard which, from its science fiction origins in novels such as The Drowned World (1962), through the controversial era of Crash (1973), to its trilogy of autobiographical texts (Empire of the Sun (1984), The Kindness of Women (1991), and Miracles of Life (2008)) articulates a form of identity that has close, though often oblique, affinities with all the most prominent features of DNA profiling.

scholarly journals Plants Extracts Loaded in Nanocarriers: An Emergent Formulating Approach

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Anna Rita Bilia ◽  
Vieri Piazzini ◽  
Martina Asprea ◽  
Laura Risaliti ◽  
Giulia Vanti ◽  
...  
Keyword(s):  
Essential Oils ◽  
Therapeutic Efficacy ◽  
Subcritical Water ◽  
Drug Carrier ◽  
Drug Loading ◽  
The Body ◽  
Clinical Use ◽  
Intrinsic Dissolution ◽  
Optimal Drug ◽  
Increasing Demand

Over the millennia, plants have represented for Humankind the main source of food, but also a vast resource to maintain health, for prophylactic properties or to cure human and animal diseases. Presently, between 65 and 80% of populations in developing countries use medicinal plants as therapeutic remedies for their primary healthcare and in Europe and USA there is an increasing demand of botanical products both on the form of food supplements and herbal medicinal products. Botanicals on the market are mainly based on traditional (infusions or decoctions), conventional (using organic solvents) and innovative (supercritical CO2 or subcritical water) extracts but there is an increasing demand of essential oils for aromatherapy. Conversely, the clinical use of many extracts is limited due to the need of repeated administrations or high doses because of low hydrophilicity and intrinsic dissolution rate(s), or physical/ chemical instability. Other limits are low absorption, poor pharmacokinetics and bioavailability, scarce biodistribution, first pass metabolism, trivial penetration and accumulation in the organs of the body. In the case of essential oils, the high volatility and instability are further limitations. Nowadays, the design and production of appropriate drug delivery systems, in particular nanosized ones (between 50 and 300 nm), have already entered into clinical use and can offer an advanced approach to optimized the therapeutic efficacy of extracts and essential oils. A successful drug carrier system should have optimal drug loading and release properties, a long shelf life, and exert a much higher therapeutic efficacy as well as lower side effects. Polymeric nanoparticles and lipid based-nanocarriers including micelles, vesicles, nanocochleates, micro- and nanoemulsions represent successful examples of extract nanoformulations overcoming these limitations. This review reports on some paradigmatic success stories of extract and EO nanoformulations with remarkable advantages over conventional formulations, which include increase of solubility, stability, permeation and bioavailability, sustained delivery. Paradigmatic examples include formulations of extracts from Vitex agnus-castus, Sylibum marianum, Phyllanthus amarus, Ginkgo biloba, Panax notoginseng, Hypericum perforatum and thyme essential oil.

Treatment protocol and effectiveness of cosmeceuticals in aesthetic practice

2020 ◽  
Vol 9 (4) ◽  
pp. 148-153
Author(s):  
Lucy Millar-Hume
Keyword(s):  
Antibiotic Resistance ◽  
Biological Effect ◽  
Treatment Protocol ◽  
Antibiotic Use ◽  
The Body ◽  
Level Of Evidence ◽  
Physiological Functions ◽  
Drug Products ◽  
Aesthetic Practice ◽  
Oral Isotretinoin

Pharmaceuticals are essentially drug products containing active ingredients that prevent, mitigate, treat disease and/or affect the anatomy or physiological functions of the body. Cosmeceuticals is a term blending the meaning and action of pharmaceuticals and cosmetics, resulting in a product that cannot exert a biological effect on cells, but can nonetheless improve the quality and condition of the skin. Traditional medical methods of treating acne centre around antibiotic use and oral isotretinoin. Antibiotic resistance is a growing problem, and it means aesthetic practitioners must find alternatives. Attention is turning to cosmeceuticals as a solution, but this raises the question of the level of evidence for their growing use.

scholarly journals Radiofrequency Ablation, Where It Stands in Interventional Radiology Today

2019 ◽  
Vol 36 (05) ◽  
pp. 398-404
Author(s):  
Vipulkumar Patel ◽  
Charles A. Ritchie ◽  
Carlos Padula ◽  
J. Mark McKinney
Keyword(s):  
Interventional Radiology ◽  
Radiofrequency Ablation ◽  
The Body ◽  
Locoregional Therapy ◽  
Rapid Decline ◽  
Cancer Therapies ◽  
Clinical Use ◽  
Safety And Efficacy ◽  
Body Of Knowledge ◽  
Widespread Acceptance

AbstractRadiofrequency ablation (RFA) is one of the first developed minimally invasive definitive cancer therapies. The safety and efficacy of RFA is well documented and has led to its incorporation into multiple international societal guidelines. By expanding on the body of knowledge acquired during the clinical use of RFA, alternative ablative technologies have emerged and are successfully competing for locoregional therapy market share. The adaption of newer ablative technologies is leading to a rapid decline in the utilization of RFA by interventional radiologists despite the lack of proven superiority. In their 2010 article, Hong and Georgiades stated “… RFA is likely to remain the mainstay of ablations for small tumors until sufficient experience emerges for the widespread acceptance for alternative ablative modalities.” Within a decade of this publication, has this time arrived?

SOC-BASED BIOMEDICAL EMBEDDED SYSTEM DESIGN OF ARRHYTHMIA DETECTOR

2016 ◽  
Vol 78 (7-5) ◽  
Author(s):  
Kui Lin Kam ◽  
Tze Weng Ow ◽  
Wan Yong Chia ◽  
Rabia Bakhteri ◽  
Norhafizah Ramli ◽  
...  
Keyword(s):  
Embedded System ◽  
Interface Design ◽  
Sudden Cardiac Arrest ◽  
Disease Patient ◽  
Home Monitoring ◽  
Computation Time ◽  
The Body ◽  
Premature Ventricular Contractions ◽  
Knowledge Based ◽  
On Chip

Arrhythmia is an irregular heartbeat where the blood may not be delivered effectively throughout the body and cause sudden cardiac arrest (SCA). Immediate treatment is required to prevent SCA. However, most of the existing electrocardiogram (ECG) monitoring devices are bulky, cost expensive and lack arrhythmia detection and classification system. This paper proposes a front-end on-board graphical interface design of System-on-Chip (SoC) based arrhythmia detector which can be used as a first screening device for cardiac disease patient. The system consists of a knowledge-based arrhythmia classifier which is able to identify three types of arrhythmias which are ventricular fibrillation (VF), premature ventricular contractions (PVCs) and second-degree atrioventricular (AV) block. The system has been evaluated and benchmarked with ECG data from MIT-BIH arrhythmia database. The results show that its accuracy is up to 99.25% with a computation time of 6.385 seconds. It is highly portable and relatively inexpensive for installation in small clinics and home monitoring.  

scholarly journals Comparative study of rules employed for calculation of pediatric drug dosage

2005 ◽  
Vol 13 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Gracieli Prado Elias ◽  
Cristina Antoniali ◽  
Ronaldo Célio Mariano
Keyword(s):  
Body Surface ◽  
Pediatric Dentistry ◽  
Drug Dosage ◽  
The Body ◽  
Clinical Use ◽  
Age Group ◽  
Pediatric Drug ◽  
Parametric Test ◽  
Tukey Test ◽  
Surface Areas

The present study was conducted to evaluate the utilization of Clark's, Salisbury and Penna's rules and the Body Surface Area (BSA) formula for calculation of pediatric drug dosage, as well as their reliability and viability in the clinical use. These rules are frequently cited in the literature, but much controversy still exists with regards to their use. The pediatric drug dosage was calculated by utilization of the aforementioned rules and using the drugs Paracetamol, Dipyrone, Diclofenac Potassium, Nimesulide, Amoxicillin and Erythromycin, widely employed in Pediatric Dentistry. Weight and body surface areas were considered of children with ages between 1 and 12 years old as well as the dosage for the adult. The pediatric dosages achieved were compared to the predetermined dosages in mg kg-1 herein-named standard dosages. The results were submitted to the parametric test ANOVA and to the Tukey test (p<0,05). The antibiotics and Diclofenac provides acceptable utilization of the rules in pediatric dentistry, however for the Dipyrone, the dosages obtained by the rules suggest their clinical ineffectiveness. For the Paracetamol, the Penna's rule and the BSA formula should not be clinically employed, especially for children between 1 and 5 years old, once such dosages were much close to the hepatotoxic dosage of the drug. It can be concluded that the use of the rules for safe calculation of the pediatric drug dosage is possible and it depends on the used drug and age group.

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