scholarly journals Biochemical effects of Cigarettes Smoking on Liver functions of Sudanese diabetics smokers

2018 ◽  
pp. 41-53
Author(s):  
Salah Ahmed Mohamed Ali , Abdelraouf Ahmed Abass
Keyword(s):  
Liver Function ◽  
Total Protein ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Diabetes Mellitus Type Ii ◽  
Function Tests ◽  
Significant Difference ◽  
Liver Functions ◽  
Proteins Metabolism

The present study was conducted in Khartoum state (Sudan) as a cross-sectional study in 200 participants (100 smokers and 100 non-smokers), to investigate the effects of Cigarettes Smoking on Liver functions of Sudanese smokers. The smokers were categorized into either current smokers (70 participants) or past smokers (30 Participants). Parameters were analyzed by using spectrophotometer. From the results, the levels of liver function tests (TB, Albumin and globulin) were significantly higher in non-smokers (6.0, 3.6 and 2.43 g/dl) as compared to current smokers (4.4, 2.4 and 1.98 g/dl) and past smokers (4.7, 2.7 and 1.93 g/dl). Meanwhile, ALT was significantly increased in current and past smokers as compared to non-smokers, where as AST was significantly higher in current smokers as compared to non-smokers, while there was no significant difference between current and past smokers as well as between past and non-smokers for this parameter. In addition, heavy and long duration of smoking were both associated with low total protein, albumin and AST levels .Also liver function tests were not significantly differing in current smoker's non-diabetics and non-smokers diabetics except total protein. From the results when, liver enzymes raised that may lead to increase proteins metabolism and increase blood glucose. These signs may place cigarettes smoking one of the top causes of hepatitis, pancreatitis, insulin resistance and finally diabetes mellitus type II. On the other hand, smoking cessation in diabetics lead to decrease the risk of hepatitis, Also regular physical activity and using medication regularly in diabetics lead to the same actions above; in addition diabetes complications were decreased.

scholarly journals SPONTANEOUS BACTERIAL PERITONITIS

2018 ◽  
Vol 21 (04) ◽  
pp. 606-612
Author(s):  
Ahsan Ayub ◽  
Muhammad Ishfaq
Keyword(s):  
Liver Function ◽  
Fibrous Tissue ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Abnormal Liver Function ◽  
P Value ◽  
Cross Sectional ◽  
Exact Test ◽  
Function Tests ◽  
Asymptomatic Patients

Cirrhosis of liver is a chronic process characterized by structurally abnormalnodules in the liver, with diffuse generalized increased fibrous tissue in the liver. Spontaneousbacterial peritonitis(SBP) is a serious complication occurring in 10 to 30% of patients hospitalizedwith cirrhotic ascites. Objective: Assess the frequency of SBP in asymptomatic patients of livercirrhosis. Study design: Cross sectional study. Setting: Hepatitis clinic medical unit- 1 Serviceshospital, Lahore. Duration of study: One year. Sample size: Total 100 patients of cirrhoticascites. Results: Ten patients were found to have SBP (10%, 95% CI, 4.1 to15.9) and 90 patientswere found to have no SBP (90%, 95%CI, 84.1 to 95.9). Seven SBP patients (70%) had pyurea(Fisher’s exact test p- value< 0.01), and abnormal liver function tests (Chi square-value<0.01).Conclusions: We concluded that 10% of asymptomatic patients with cirrhotic ascites had SBP.SBP patients had significantly abnormal liver function tests and pyuria.

scholarly journals A cross-sectional study of liver function tests in HIV-infected persons in Western India

2017 ◽  
Vol 73 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Sunny Pathania ◽  
Navjyot Kaur ◽  
Sandeep Kumar ◽  
V.K. Sashindran ◽  
Pankaj Puri
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Western India ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Tests

scholarly journals Effects of coffee, smoking, and alcohol on liver function tests: a comprehensive cross-sectional study

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Eun Sun Jang ◽  
Sook-Hyang Jeong ◽  
Sung Ho Hwang ◽  
Hyun Young Kim ◽  
So Yeon Ahn ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Tests

scholarly journals Severity of Liver Involvement in Children with Dengue Infection

2021 ◽  
Vol 7 (2) ◽  
pp. 90-94
Author(s):  
Afsana Yasmin ◽  
Rozina Akhter ◽  
Shahina Pervin Shapla ◽  
Laila Yeasmin
Keyword(s):  
Liver Function ◽  
Liver Dysfunction ◽  
Dengue Infection ◽  
Liver Function Tests ◽  
Liver Involvement ◽  
P Value ◽  
Cross Sectional ◽  
Function Tests ◽  
Variable Level ◽  
Significant Difference

Background: Liver involvement in dengue infection is one of the clinical presentations. Objective: This study was undertaken to see severity of liver dysfunction in children with dengue infection. Methods: It is a cross sectional observational study conducted in 100 consecutive children with serologically positive dengue infection aged between 2 months to 14 years of age. Liver function tests were done in all patients and were studied the severity of deranged LFT with severity of dengue infection. Results: Out of 100 admitted children with dengue infection, deranged liver function tests found in 57(57.0%). ALT was above normal in 10 (29.4% of DF, 19 (57.6%) cases of DHF and 19(57.6%) cases of DSS respectively. AST was above normal level in 12(35.3%) cases of DF, 23(69.7%) cases of DHF and 22(66.7%) cases of DSS respectively. Low albumin was found in 41.0% of cases, 15(45.5%) cases of DHF and 19(57.6%) cases of DSS. INR was high only 4 cases of DSS. The bilirubin was normal in all cases except one died due to ALF due to DSS. The mean ALT and mean AST statistically higher in DHF and DSS in compare to DF (P-value 0.011 and 0.037) respectively. However, there was no significant difference in meal ALT and AST between DHF and DSS respectively. Overall mortality in 2 cases with DHF and DSS. Conclusion: Dengue infection is associated with variable level of liver dysfunction. The severity of liver dysfunction can predict the severity of dengue infection. Bangladesh Journal of Infectious Diseases 2020;7(2):90-94

scholarly journals Liver function tests and fibrosis scores in a rural population in Africa: a cross-sectional study to estimate the burden of disease and associated risk factors

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e032890 ◽  
Author(s):  
Geraldine O'Hara ◽  
Jolynne Mokaya ◽  
Jeffrey P Hau ◽  
Louise O Downs ◽  
Anna L McNaughton ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Liver Function ◽  
Reference Range ◽  
Liver Function Tests ◽  
Sub Saharan Africa ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Function Tests ◽  
Glutamyl Transferase

ObjectivesLiver disease is a major cause of morbidity and mortality in sub-Saharan Africa, but its prevalence, distribution and aetiology have not been well characterised. We therefore set out to examine liver function tests (LFTs) and liver fibrosis scores in a rural African population.DesignWe undertook a cross-sectional survey of LFTs. We classified abnormal LFTs based on reference ranges set in America and in Africa. We derived fibrosis scores (aspartate aminotransferase (AST) to Platelet Ratio Index (APRI), fibrosis-4, gamma-glutamyl transferase (GGT) to platelet ratio (GPR), red cell distribution width to platelet ratio and S-index). We collected information about alcohol intake, and infection with HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV).SettingWe studied a population cohort in South-Western Uganda.ParticipantsData were available for 8099 adults (median age 30 years; 56% female).ResultsThe prevalence of HBV, HCV and HIV infection was 3%, 0.2% and 8%, respectively. The prevalence of abnormal LFTs was higher based on the American reference range compared with the African reference range (eg, for AST 13% vs 3%, respectively). Elevated AST/ALT ratio was significantly associated with self-reported alcohol consumption (p<0.001), and the overall prevalence of AST/ALT ratio >2 was 11% (suggesting alcoholic hepatitis). The highest prevalence of fibrosis was predicted by the GPR score, with 24% of the population falling above the threshold for fibrosis. There was an association between the presence of HIV or HBV and raised GPR (p=0.005) and S-index (p<0.001). By multivariate analysis, elevated LFTs and fibrosis scores were most consistently associated with older age, male sex, being under-weight, HIV or HBV infection and alcohol consumption.ConclusionsFurther work is required to determine normal reference ranges for LFTs in this setting, to evaluate the specificity and sensitivity of fibrosis scores and to determine the aetiology of liver disease.

scholarly journals Aminotransferases in Chronic Active and Chronic Persistent Hepatitis

2014 ◽  
Vol 41 (2) ◽  
pp. 17-19
Author(s):  
SMF Karim ◽  
MR Rahman ◽  
S Shermin ◽  
R Sultana
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Serum Bilirubin Level ◽  
Chronic Persistent Hepatitis ◽  
Diagnosis And Prognosis ◽  
Function Tests ◽  
Significant Difference ◽  
Student’S T ◽  
Serum Aminotransferases ◽  
Age And Sex

Chronic active hepatitis (CAH) and chronic persistent hepatitis (CPH), the two histologically distinct forms of viral hepatitis present with variable clinical features. So liver function tests play the key role in diagnosis and prognosis of these disorders. Among the liver function tests, determination of serum aminotransferases: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and AST/ALT ratio are still popularly used. In fact over the transaminase tests no other enzymatic tests have any particular value. In infiltrative disorders there is damage to both mitochondrial and cytoplasmic membranes. Therefore there is a proportionally greater increase in plasma AST activity than ALT. This comparative study was carried out in the department of Biochemistry, Sir Salimullah Medical College, Dhaka from January 2007 to December 2007 to observe the role of aminotransferases and AST/ALT ratio in CAH and CPH. With prefixed inclusion and exclusion criteria a total of 44 age and sex matched subjects were purposively enrolled in the study. Out of them 20 were CAH and 24 were CPH. Serum AST, ALT and total bilirubin were measured and AST/ALT ratio were calculated. Mentioned parameters were compared between groups. Unpaired student's t-test and chi (x2) square test were done to detect the significant difference between the groups using SPSS version 12.0. Mean age of the study subjects in CAH and CPH group were 32.20 ± 10.65 years (20-50 years) and 32.83 ± 10.68 years (20-49 years) respectively. There was no significant difference regarding age and sex distribution between the groups (p > 0.05). Mean ± SD serum AST was 295.08 ± 153.77 IU/L and 73.38 ± 45.72 IU/L and ALT was 352.44 ± 206.95 IU/L and 121.01 ± 58.77 IU/L in CAH and CPH respectively and both were statistically highly significant (p < 0.01). Mean ± SD of AST / ALT ratio in CAH and CPH were 0.87 ± 0.14 and 0.59 ± 0.14 respectively and was highly significant (p < 0.01). There was no significant difference in serum bilirubin level between the groups (20.78 ± 14.16 ?mol/L vs. 19.25 ± 15.90 ?mol /L) (p > 0.05). DOI: http://dx.doi.org/10.3329/bmj.v41i2.18795 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 17-19

scholarly journals Comparison of oral rifampicin with observation alone in treatment of acute central serous Chorioretinopathy

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Anum Badar ◽  
Sadaf Khan ◽  
Sobia Usman Shah ◽  
Mohammad Tahir ◽  
Saman Babree
Keyword(s):  
Liver Function ◽  
Central Serous Chorioretinopathy ◽  
Liver Function Tests ◽  
Macular Thickness ◽  
Function Tests ◽  
Single Person ◽  
Significant Difference ◽  
Group A ◽  
Acute Central Serous Chorioretinopathy ◽  
Group B

Introduction: A randomized control trial To compare efficacy of oral rifampicin in terms of drying of macula and decrease macular thickness with observation alone in patients of acute central serous Chorioretinopathy done in Layton Rahmatulla Benevolent Trust (LRBT) Free Eye and Cancer Hospital, Lahore from January 2017 to June 2017 Methods: After getting approval from hospital Ethical committee 140 patients of CSR were included in the study. The demographic details were noted and patients were randomized by lottery methods in two groups (group A& B). Group-A was observed for spontaneous resolution, routine treatment started if no improvement noted after 6 weeks of observation alone. Group B was given oral rifampicin 600mg per day for four weeks with liver function tests being done before commencement of treatment and after 2 weeks. Oral rifampicin was stopped if patient developed deranged liver function tests. Patients were followed up at 4 weeks for macular dryness and decrease macular thickness on optical coherence tomography(OCT). All the readings were carried out and noted by single person in order to minimize bias. Results: A total of 140 patents, 70 in each group, were included In study with mean age 38.77+7.74 in Group-A and 39.14+7.97 years in Group-B. regarding gender distribution 65.71 %(n=46) in Group-A and 613.43%(n=43) in Group-B were male.   Comparison of outcome of treatment of acute central serous chorioretinopathy with oral rifampicin vs observation showed that 18.57 %(n=13) in Group-A and 41.43%(n=29) in Group-B had dry macula. Conclusion: We concluded that there is a significant difference in drying of macula in acute central serous chorioretinopathy with Rifampicin versus observation alone.

scholarly journals A High Percentage of Patients Recovered From COVID-19 but Discharged With Abnormal Liver Function Tests

2021 ◽  
Vol 12 ◽  
Author(s):  
Qinyi Gan ◽  
Beilei Gong ◽  
Manli Sun ◽  
Zhujun Cao ◽  
Yuyan Zheng ◽  
...  
Keyword(s):  
Liver Function ◽  
Oxygenation Index ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transferase ◽  
Function Tests ◽  
Liver Functions ◽  
Global Health Issue ◽  
Treatment Data ◽  
Independent Risk Factors ◽  
Glutamyl Transferase

BackgroundCoronavirus disease 2019 (COVID-19) pandemic has become the most severe global health issue. Abnormal liver functions are frequently reported in these patients. However, liver function abnormality was often overlooked during COVID-19 treatment, and data regarding liver functions after cure of COVID-19 is limited. This study aimed to reveal the changes of liver function tests (LFTs) during hospitalization, and its clinical significance in patients with COVID-19.MethodsIn this retrospective, bi-center study, a total of 158 hospitalized patients diagnosed with COVID-19 in China were included from January 22nd, 2020 to February 20th, 2020. Clinical features, laboratory parameters including LFTs, and treatment data were collected and analyzed. LFTs included alanine transaminase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin. Patients were considered with abnormal LFTs when any value of these tests was higher than upper limit of normal.ResultsOf 158 patients with COVID-19, 67 (42.41%) patients had abnormal LFTs on admission and another 50 (31.65%) patients developed abnormal LFTs during hospitalization. The incidence of LFTs abnormality in severe COVID-19 cases was significantly higher than non-severe cases. All LFTs in COVID-19 patients were correlated with oxygenation index. There was no statistical difference in treatment between the patients with or without liver test abnormalities. By the time of discharge, there were still 64 (40.50%) patients with abnormal LFTs. Logistic regression analysis identified younger age, hypertension and low lymphocyte counts as independent risk factors for persistent abnormal LFTs during hospitalization.ConclusionLiver function tests abnormality was common in COVID-19 patients and was more prevalent in severe cases than in non-severe cases. A substantial percentage of patients still had abnormal LFTs by the time of discharge.

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