CLINICAL MANIFESTATIONS OF DRY EYE SYNDROME

Vestnik ◽  
2021 ◽  
pp. 71-72
Author(s):  
М.Ж. Инкарбеков ◽  
Ж.К. Бурибаева
Keyword(s):  
Clinical Manifestation ◽  
Dry Eye ◽  
Clinical Manifestations ◽  
Dry Eye Syndrome ◽  
Pronounced Decrease ◽  
Tear Production ◽  
Mucous Membranes ◽  
The Stability

Синдром сухого глаза - это комплекс поражений конъюнктивы и роговицы, возникающих в связи с выраженным снижением слезопродукции и нарушением стабильности слезной пленки. Цель исследования. Изучить особенности клинического проявления синдрома «сухого глаза. Материалы и методы. Данный анализ основывается на данных международных и отечественных статей по синдрому «сухого глаза». Результаты и обсуждение. На сегодняшний день, классический синдром «сухого глаза» встречается относительно редко.Сухость конъюнктивы и роговицы, слизистой рта и носа являются непременными признаками этого синдрома. Dry eye syndrome is a complex of lesions of the conjunctiva and cornea that occur in connection with a pronounced decrease in tear production and a violation of the stability of the tear. Purpose of the study. To study the features of the clinical manifestation of dry eye syndrome. Materials and methods. This analysis is based on data from international and domestic articles on dry eye syndrome Results and discussion. Today, the classic dry eye syndrome is relatively rare. Dryness of the conjunctiva and cornea, mucous membranes of the mouth and nose are indispensable signs of this syndrome.

scholarly journals Stimulation of Basal Secretion in the Treatment of Dry Eye Syndrome

2019 ◽  
Vol 16 (1) ◽  
pp. 70-75
Author(s):  
L. I. Uchakova ◽  
S. V. Balalin ◽  
V. L. Zagrebin
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Goblet Cells ◽  
Dry Eye Syndrome ◽  
Ophthalmological Examination ◽  
Basal Secretion ◽  
Tear Production ◽  
Before And After ◽  
The Stability ◽  
Conjunctival Goblet Cells

The aim is to evaluate the effectiveness of Stillavit in the treatment of dry eye syndrome (DES) and its effect on the density of conjunctival goblet cells and the functional parameters of tear production. Methods. There were analyzed treatment results of 18 patients (36 eyes) with DES at the age of 48 to 80 years (average 60.6 ± 1.3 years) including 17 women and 1 male before and after 1 and 3 months after Stillavit prescription. In all patients in addition to a standard ophthalmological examination the results of Schirmer I, Norn, as well as the LIPCOF test were evaluated and the density of conjunctival goblet cells was examined. Results. After 1 and 3 months there was a significant improvement in the results of the Norn test: from 5.17 ± 0.22 seconds to 7.18 ± 0.17 seconds which indicated an increase in the stability of the tear film. After 3 months there was a significant increase in the density of conjunctival goblet cells, improvement in the Schirmer sample: from 9.26 ± 0.89 to 11.7 ± 0.6 mm (t = 2.28, p < 0.05) and LIPCOF test (t = 2.18, p < 0.05) which indicated an increase in tear production and a significant decrease in the inflammatory process and edema of the conjunctiva. Conclusion. Treatment of DES with the use of Stillavit leads after 3 months to a significant increase in the density of conjunctival goblet cells, increases tear production and stability of the tear film.

scholarly journals Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Xinyuan Zhang ◽  
Lin Zhao ◽  
Shijing Deng ◽  
Xuguang Sun ◽  
Ningli Wang
Keyword(s):  
Diabetes Mellitus ◽  
Dry Eye ◽  
Keratoconjunctivitis Sicca ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Dry Eye Syndrome ◽  
Surface System ◽  
Patients With Diabetes ◽  
Function Unit ◽  
Substantial Progress

There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years. The pathogenesis and specific features of DMDES remain uncertain and interventions are limited to those used in DES. This review outlines the pathogenesis, clinical manifestations, and the current preventive and treatment strategies for diabetes-related DES.

Corneal topography and classical test in the diagnosis of dry eye syndrome in patients with myopia and myopic astigmatism before keratorefractive surgery

2021 ◽  
pp. 39-43
Author(s):  
Y.V. Kutuzova ◽  
◽  
I.V. Dutchin ◽  
E.L. Sorokin ◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Risk Groups ◽  
Corneal Topography ◽  
Dry Eye Syndrome ◽  
Film Rupture ◽  
Keratorefractive Surgery ◽  
The Stability ◽  
High Degree ◽  
Myopic Astigmatism

Purpose.To conduct a comparative analysis of the effectiveness of assessing the stability of the tear film using corneotopography and the classic Norn test in patients with myopia and myopic astigmatism before keratorefractive surgery. Material and methods. The study included 26 patients planned for keratorefractive surgery for myopia and myopic astigmatism, aged 18 to 47 years. 7 people there was a mild degree of myopia, in 14 people – medium degree, in 5 people – high degree. The average degree of corneal astigmatism was 2.25 diopters. The stability of the pre-corneal tear film was assessed using computed keratotopography and Norn's test – the tear film rupture time (TFRT) was deter- mined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome. A comparison was made of the indicators of the stability of the tear film obtained by the methods of corneotopography and the Norn's test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4%), the TFRT index corresponded to the age norm. In the remaining 9 people (34.6%), indicators of stability of the tear film were reduced both by corneotopography (12±4 sec) and by Norn's test (13.5±4.5 sec), and there were also subjective signs of dry eye syndrome according to data questionnaire. The data turned out to be comparable. Conclusions. 1. Among the total population of patients, 34.6% were persons with impaired tear film stability and subjective manifestations of dry eye syndrome. 2. Assessment of the stability of the tear film, determined using the method of corneal topography, showed a high degree of comparability with the results of Norn's test. A significant advantage of the keratotopography method is its non-invasiveness. 3. It is necessary to pay attention to the condition of the ocular surface and identify risk groups to avoid chronicity or aggravation of existing disorders. Key words: dry eye syndrome, tear film, keratotopography, Norn's test.

«Dry eye» syndrome and primary glaucoma: possibilities of treatment

Reflection ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 42-44
Author(s):  
L.I. Solovyova ◽  
◽  
T.V. Gavrilova ◽  
F.G. Mugumova ◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Open Angle Glaucoma ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Rupture Time ◽  
Eye Drops ◽  
Film Rupture ◽  
Good Tolerability ◽  
Primary Glaucoma ◽  
The Stability

The article presents the results of Ocuhyl C using in the treatment of «dry eye syndrome» (DES) in 47 eyes of 26 patients with different stages of compensated primary open-angle glaucoma. Experience of instillation of hypotensive eye drops with preservatives was from 1 year to 35 years. Assessment of subjective signs of DES was performed by questioning. Functional tests were performed (for the stability of the precorneal tear film –Norn test, for the level of total tear production –Shirmer test). Examinations were carried out at the first examination before prescribing the drug, then after 4 and 8 weeks of its use. All the patients noted good tolerability of the drug, no side effects. Indicators characterizing the feeling of a foreign body, dryness and redness of the eyes have significantly decreased. Precorneal tear film rupture time has significantly increased. Ocuhyl C can be recommended for clinical use. Key words: primary glaucoma; “dry eye” syndrome; tear forming; tear film rupture time; Ocuhyl C.

Dry eye syndrome in patients with gout

2021 ◽  
pp. 6-11
Author(s):  
K.N. Odinaeva ◽  
◽  
N.S. Al Khateeb ◽  
M.A. Frolov ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Correlation Coefficient ◽  
Dry Eye ◽  
Strong Correlation ◽  
Strong Dependence ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Rupture ◽  
High Tendency ◽  
Tear Production

Purpose. To determine and study the features of the development of dry eye syndrome (DES) in gout, depending on urate-lowering therapy, the duration of the gout disease and the concentration of uric acid in the tear. Material and methods. The study involved 149 male patients (261 eyes) aged 35 to 75 years (mean age 60.63 ± 11.00 years). Among them, 110 people (202 eyes) with an established diagnosis: "Cataract with concomitant gout disease" and 39 people (59 eyes) with cataracts without clinical and laboratory signs of gout. All patients underwent both standard ophthalmological examinations and special ones. The concentration of uric acid in tears was determined by high performance liquid chromatography (HPLC). The diagnosis of gout was confirmed according to the criteria recommended by ACR / EULAR (2016). Results. In patients with gout who do not take a urate-lowering drug, DES occurs more often (82.1%) than in patients without gout (23.1%). With an increase in the concentration of uric acid in the tear, there is a high tendency to a shortening of the tear film rupture time (strong correlation coefficient r=-0.51, p<0.001) and to a decrease in tear production (Schirmer I test) (strong correlation coefficient r=-0.59, p<0.001). Conclusion. The data obtained indicate clear changes in the functional parameters of total tear production (Schirmer I's test) and the stability of the pre-corneal tear film (Norn's test) in patients with gout. This can be considered as a fact of the predisposition of this category of patients to the development of DES. A strong dependence of changes in tear production and HRVP on the concentration of uric acid in the tear was established. There is an obvious need for additional examination of this category of patients and an adequate choice of therapy, as well as the timely appointment of "artificial tear" drugs. Key words: dry eye syndrome, uric acid, gout.

scholarly journals Profilo farmacologico clinico e farmacoeconomico di un gel oftalmico a base di carbomero 974P e PVA (Siccafluid®) nella terapia della cheratocongiuntivite secca

2005 ◽  
Vol 6 (3) ◽  
pp. 185-196
Author(s):  
Lorenzo Pradelli ◽  
Letizia Vacchini
Keyword(s):  
Quality Of Life ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Lubricating Film ◽  
Tear Production ◽  
Ocular Discomfort ◽  
Ophthalmic Solutions

BACKGROUND: The dry eye sindrome refers to a group of disorders of the tear film due to reduced tear production or excessive tear evaporation that is associated with symptoms of ocular discomfort and may cause disease of the ocular surface. Dry eye syndrome varies in severity, duration and etiology. The cornerstone of dry eye syndrome therapies includes the intraocular gel or ophthalmic solutions instillation, reaching correct artificial lubrication. Molecules that can produce a stable lubricating film are the carbomers. METHODS: In the first step of our work we reviewed the data from literature reporting about carbomers’ characteristics in respect to other lacrimal substitutes. Then, a pharmacoeconomical analysis has been performed on ophtalmic gels derived from carbomers 974P and PVA. RESULTS: Dry eye sindrome, if not adequately treated, determines a deterioration of the patient’s quality of life, other than high secondary costs. CONCLUSION: The high therapeutical index of carbomers 974P and PVA-based gels, in addition to the their limited cost (totally free for Sjögren patients in Italy), suggests that this product is characterized by one of the best benefits-to-costs ratios in the treatment of dry eye sindrome.

Changes in Clinical Manifestations of Dry Eye Syndrome after Cataract Surgery and the Affecting Factors

2011 ◽  
Vol 52 (9) ◽  
pp. 1030 ◽  
Author(s):  
Young Rae Roh ◽  
Sang Mok Lee ◽  
Young Keun Han ◽  
Mee Kum Kim ◽  
Won Ryang Wee ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Dry Eye ◽  
Clinical Manifestations ◽  
Dry Eye Syndrome ◽  
Affecting Factors

Improvement of functional state of the eye in patients with dry eye syndrome under the influence of eye drops based on natural substances

2015 ◽  
pp. 188-193
Author(s):  
Zoya Veselovska ◽  
Nataliia Veselovska ◽  
Inna Zherebko ◽  
N. Kuchar
Keyword(s):  
Dry Eye ◽  
Open Angle Glaucoma ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Positive Influence ◽  
Dry Eye Syndrome ◽  
Eye Drops ◽  
Anterior Surface ◽  
Study Results

The article presents data on the use of a new generation of eye drops on the base of ectoine natural molecule in the treatment of dry eye syndrome (DES). Рurpose. To study the effect of eye drops on the base of ectoine on the status of the anterior surface of the eye in patients with clinical signs of DES. Material and methods. Thirty women with DES who use hormonal medications for the treatment of the menopausal clinical manifestations regularly (the first group), and thirty men with primary open-angle glaucoma and the DES caused by long-term use of glaucoma drops with a preservative (the second group) were involved in this study. Results. It was revealed the positive influence of natural molecule of ectoine on the tears film, eye surface and patients comfortable life. The authors analyzed the results of ordinary and special methods of eye examination and prove that the level of dynamics of reparative processes at the anterior surface of the eye becomes more expressive due to long-term use of eye drops on the base of ectoine.

Choosing the optimal method for preoperative risk assessment of dry eye syndrome development in patients with myopia

Reflection ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 30-36
Author(s):  
O.V. Kolenko ◽  
◽  
Y.V. Kutuzova ◽  
I.V. Dutchin ◽  
E.L. Sorokin ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Rupture Time ◽  
Film Rupture ◽  
Optimal Method ◽  
Film Stability ◽  
Tear Film Stability ◽  
Keratorefractive Surgery ◽  
The Stability

Aim. Comparative analysis of the effectiveness of keratotopography methods and classical Norn’s test in assessing the stability of the tear film (TF) in patients with myopia before photorefractive surgery. Methods. The study involved 26 patients. All of them were planned for keratorefractive surgery to correct myopic refraction and astigmatism. Their age averaged 32.5±14.5 years (18-47 years). The stability of pre-corneal tear film was assessed using computed keratotopography and Norn’s test - the tear film rupture time (TFRT) was determined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome (DES). A comparison was made of the indicators of tear film, stability obtained by the methods of keratotopography and Norn’s test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4 %), TFRT index corresponded to the age norm. In the remaining 9 people (34.6 %), indicators of tear film stability were reduced both by keratotopography (12±4 sec) and by Norn’s test (13.5± 4.5 sec), and there were also subjective signs of dry eye syndrome according to questionnaire data. The data turned out to be comparable. Conclusion. The incidence of impaired stability of the TF and subjective manifestations of DES among patients planned for keratorefractive surgery for myopia and myopic astigmatism was significant and, according to our data, made 34.6 %. To prevent complicated postoperative course of photorefractive surgery, it is necessary to assess the condition of the ocular surface immediately before refractive surgery, to identify the risk group for DES development. Key words: dry eye syndrome; tear film; keratotopography; Norn’s test; tear film rupture time.

Clinical manifestations of the dry eye syndrome for women in menopause

2014 ◽  
Vol 5 (2) ◽  
pp. 25-29
Author(s):  
Nataliya Nikolayevna Sadovnikova ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Clinical Manifestations ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Menopausal Syndrome ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Features ◽  
Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

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