scholarly journals Hereditary and environmental factors causing total joint replacement due to hip and knee osteoarthritis – a twin registry based prospective cohort study

2016 ◽  
Vol 26 (1-2) ◽  
Author(s):  
Karin Magnusson ◽  
Kåre Birger Hagen
Keyword(s):  
Environmental Factors ◽  
Knee Joint ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Population Based ◽  
Genetic Contribution ◽  
Questionnaire Response ◽  
Knee Oa ◽  
Relative Contribution ◽  
Twin Registry

The relative contribution of genetic factors and more modifiable environmental factors to a clinically<br />relevant osteoarthritis (OA) diagnosis is unkown. In this paper we present an ongoing study on the genetic<br />contribution to total joint replacement (TJR) due to hip and knee OA and effects of lifestyle and lifestyle<br />related conditions on TJR due to OA. We have linked data on incident OA from the Norwegian Arthroplasty<br />Registry were l with the Norwegian Twin Registry on the National ID number in 2014, thus obtaining a<br />population based cohort of same-sex twins born 1915-60. Data on height, weight and lifestyle were selfreporteded<br />in questionnaires conducted between 1978 and 1992. The monozygotic (MZ) and dizygotic<br />(DZ) concordances as well as the genetic contribution vs. contribution of more modifiable, environmental<br />factors to arthroplasty will be examined in separate analyses for the hip and the knee joint. The sample<br />comprised N=18058 twins (N=3803 MZ and N=5226 DZ pairs) including N=9650 (53.4%) females and a<br />mean (SD) age of 38 (12.3) years at questionnaire response. Some preliminary analyses have been performed<br />showing a higher concordance for TJR due to hip OA among MZ (0.36) than DZ twins (0.16), which may<br />be consistent with a genetic contribution to hip OA. TJR due to hip OA may be determined by genetic<br />factors. Results for the knee joint as well as final results from hereditary analyses and co-twin control<br />analyses of will be published consecutively from 2016.

scholarly journals Extended follow-up of patients suspected of having joint sepsis after total joint replacement

1985 ◽  
Vol 95 (3) ◽  
pp. 655-664 ◽  
Author(s):  
O. M. Lidwell ◽  
E. J. L. Lowbury ◽  
W. Whyte ◽  
R. Blowers ◽  
D. Lowe
Keyword(s):  
Knee Joint ◽  
Failure Rate ◽  
Joint Replacement ◽  
Total Joint Replacement ◽  
Joint Infection ◽  
Hospital Records ◽  
Knee Joint Replacement ◽  
Total Hip

SUMMARYDuring an average follow-up time of about 2½ years after total hip or knee-joint replacement in 8052 patients, suspected joint infection was recorded in 85 patients whose joints had not been re-operated during that period. The hospital records of 72 of these patients were examined after a further period, averaging about 5 years. Thirty-five of these had suffered continuing major problems with the joint, 18 of which had been revised, and a further 9 joints needed such treatment. Infection was confirmed in 17 of the 35. These numbers are proportionately about three times greater than those observed among a set of matched controls followed-up for a similar period. The evidence from the extended follow-up suggests that the failure rate, unassociated with infection, reached about 5% by 7 years after operation and that late infections, manifested between about 2½ and 7 years after operation, were about as frequent as those confirmed during the first 2½ years.

scholarly journals Comparison of Total Joint Replacement Rate Between Patients With Hemophilia A and Patients With Hemophilia B: A Population-Based and Retrospective Cohort Study

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 163S-170S
Author(s):  
Wen-Ya Lin ◽  
Jiaan-Der Wang ◽  
Yu-Tse Tsan ◽  
Wei-Cheng Chan ◽  
Kwok-Man Tong ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Hemophilia A ◽  
Total Joint Replacement ◽  
Population Based ◽  
Hemophilia B ◽  
Clotting Factor ◽  
Research Database ◽  
Increased Risk ◽  
The Difference ◽  
Factor Concentrate

Recurrent hemarthrosis in patients with hemophilia (PWH) results in chronic arthropathy requiring total joint replacement (TJR). This study aimed to compare the difference in TJR rate between patients with hemophilia A (HA) and hemophilia B (HB). A final total of 935 PWH (782 HA and 153 HB) without inhibitors were collected from the Taiwan’s National Health Insurance Research Database between 1997 and 2013. Demographics, clinical characteristics, and TJR rate were compared between the 2 groups. The annual use of clotting factor concentrate was not different between HA and HB groups ( P = .116). The rate of comorbidities except for 29 PWH having HIV who were all in the HA group was also not different between the 2 groups. A total of 99 (10.6%) PWH had undergone 142 TJR procedures during the study period. All of them had received on-demand therapy. No difference was found in the cumulative incidence of TJR between HA and HB ( P = .787). After adjusting for various confounders including age, pyogenic arthritis, and HIV infection, no increased risk of TJR was found in patients with HA versus Patients with HB (hazard ratio: 0.92, 95% confidence interval 0.54-1.58). This finding suggests that the rate of TJR between patients with HA and HB is not significantly different.

scholarly journals Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rafael Fortuna ◽  
David A. Hart ◽  
Keith A. Sharkey ◽  
Rachel A. Schachar ◽  
Kelly Johnston ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Morbid Obesity ◽  
Gut Microbiota ◽  
Knee Joint ◽  
Systemic Inflammation ◽  
Joint Replacement ◽  
Health Clinic ◽  
Joint Function ◽  
Knee Oa

Abstract Background Osteoarthritis (OA) is a chronic and painful condition where the articular cartilage surfaces progressively degenerate, resulting in loss of function and progressive disability. Obesity is a primary risk factor for the development and progression of knee OA, defined as the “metabolic OA” phenotype. Metabolic OA is associated with increased fat deposits that release inflammatory cytokines/adipokines, thereby resulting in systemic inflammation which can contribute to cartilage degeneration. There is currently no cure for OA. Prebiotics are a type of dietary fiber that can positively influence gut microbiota thereby reducing systemic inflammation and offering protection of joint integrity in rodents. However, no human clinical trials have tested the effects of prebiotics in adults with obesity suffering from knee OA. Therefore, the purpose of this double-blind, placebo-controlled, randomized trial is to determine if prebiotic supplementation can, through positive changes in the gut microbiota, improve knee function and physical performance in adults with obesity and knee OA. Methods Adults (n = 60) with co-morbid obesity (BMI > 30 kg/m2) and knee OA (Kellgren-Lawrence grade II–III) will be recruited from the Alberta Hip and Knee Clinic and the Rocky Mountain Health Clinic and surrounding community of Calgary, Canada, and randomized (stratified by sex, BMI, and age) to prebiotic (oligofructose-enriched inulin; 16 g/day) or a calorie-matched placebo (maltodextrin) for 6 months. Anthropometrics, performance-based tests, knee pain, serum inflammatory markers and metabolomics, quality of life, and gut microbiota will be assessed at baseline, 3 months, 6 months (end of prebiotic supplementation), and 3 months following the end of the prebiotic supplementation. Clinical significance There is growing pressure on health care systems for aggressive OA treatment such as total joint replacement. Less aggressive, yet effective, conservative treatment options have the potential to address the growing prevalence of co-morbid obesity and knee OA by delaying the need for joint replacement or ideally preventing its need altogether. The results of this clinical trial will provide the first evidence regarding the efficacy of prebiotic supplementation on knee joint function and pain in adults with obesity and knee OA. If successful, the results may provide a simple, safe, and easy to adhere to intervention to reduce knee joint pain and improve the quality of life of adults with co-morbid knee OA and obesity. Trial registration Clinical Trials.gov NCT04172688. Registered on 21 November 2019.

scholarly journals Smoking, body weight, physical exercise, and risk of lower limb total joint replacement in a population-based cohort of men

2011 ◽  
Vol 63 (8) ◽  
pp. 2523-2530 ◽  
Author(s):  
George Mnatzaganian ◽  
Philip Ryan ◽  
Paul E. Norman ◽  
David C. Davidson ◽  
Janet E. Hiller
Keyword(s):  
Body Weight ◽  
Physical Exercise ◽  
Joint Replacement ◽  
Lower Limb ◽  
Total Joint Replacement ◽  
Population Based

scholarly journals MOBILE and the provision of total joint replacement

2008 ◽  
Vol 13 (3_suppl) ◽  
pp. 47-56 ◽  
Author(s):  
Paul Dieppe ◽  
Diane Dixon ◽  
Jeremy Horwood ◽  
Beth Pollard ◽  
Marie Johnston
Keyword(s):  
Knee Joint ◽  
Health Care Professionals ◽  
Mixed Methods Research ◽  
Total Joint Replacement ◽  
Population Based ◽  
Joint Replacements ◽  
The Public ◽  
Total Hip ◽  
Quantitative And Qualitative Research ◽  
Patient Related Outcome

Modern joint replacements have been available for 45 years, but we still do not have clear indications for these interventions, and we do not know how to optimize the outcome for patients who agree to have them done. The MOBILE programme has been investigating these issues in relation to primary total hip and knee joint replacements, using mixed methods research. There have been five main strands: (1) Epidemiological investigations to find out who is receiving total hip and knee replacements in the National Health Service (NHS). This has shown that there are extensive variations in different regions of the UK, with inequalities and probable inequities in the provision of these operations; (2) Epidemiological work to ascertain the population-based needs for the operations, showing under-provision of knee joint replacements, and a relative reluctance of both patients and GPs to consider knee surgery; (3) Quantitative and qualitative research into the views of patients, health care professionals and the public on the indications for, and prioritization of, total hip and knee joint replacements. This has shown lack of agreement within or between professional groups, as well as a mismatch between the views of patients and the public, and those of professionals; (4) Theoretical and experimental work on patient-related outcome measures, and the development of new instruments to assess both pain and function in people with osteoarthritis, based on the International Classification of Function, as well as a new integrated model of function; (5) Cohort studies of patients undergoing hip or knee joint replacements to find out what the determinants of good and bad outcomes are. These studies have emphasized the huge variation in disease severity at the time of surgery. The challenge now is to use and implement our findings for maximum patient benefit.

Sign in / Sign up

Export Citation Format

Share Document