scholarly journals Medicinal plants of the Unified Health System (Sistema Único de Saúde) with antifungal potential

2021 ◽  
pp. 1-9
Author(s):  
Mônica Jachetti Maciel ◽  
Claudete Rempel ◽  
Amanda Luisa Stroher ◽  
Patrícia Caye Bergmann ◽  
Diorge Jônatas Marmitt
Keyword(s):  
Antifungal Activity ◽  
Medicinal Plants ◽  
Health System ◽  
Herbal Medicines ◽  
Inhibitory Effect ◽  
Fungal Species ◽  
Therapeutic Effects ◽  
Alternative Source ◽  
Unified Health System ◽  
Antifungal Action

Medicinal plants synthesize various secondary metabolites that can be used for therapeutic and antimicrobial purposes. In Brazil, the Unified Health System (SUS) offers several herbal medicines as an alternative in the treatment of various diseases. Considering the importance of these plants in the production of chemicals that expand therapeutic options and improve the health of SUS users, this review was carried out to quantitatively determine the antifungal activity of plants used as phytotherapeutics at RENAME. The selection of papers was performed at three distinct stages: examining and choosing titles related to antifungal action, reading the abstracts, and reading the whole selected articles. This review selected 22 studies of interest; 12 of them were conducted in Brazil and 10 were carried out in other countries. The papers chosen tested the growth inhibitory effect of plants against fungal species of agricultural and health importance, ranging from filamentous to yeast-like fungi, and Candida albicans was the most tested species. The growth of 39 fungal species were inhibited by some concentration of the extract used, with either an increase or decrease in antifungal activity depending on the extract used. The most frequently analyzed plant was the species Schinus terebinthifolius Raddi., studied in seven papers. The results found demonstrate the importance of analyzing medicinal plants and incorporating plant-based medicines in healthcare as an alternative source of treatment, highlighting the need for studies that evaluate the mechanisms action of their cytotoxicity and therapeutic effects in the human body.

scholarly journals Regulation of herbal medicines in Brazil: advances and perspectives

2011 ◽  
Vol 47 (3) ◽  
pp. 467-473 ◽  
Author(s):  
Ana Cecília Bezerra Carvalho ◽  
João Paulo Silvério Perfeito ◽  
Leandro Viana Costa e Silva ◽  
Lívia Santos Ramalho ◽  
Robelma France de Oliveira Marques ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Health System ◽  
National Policy ◽  
Herbal Medicines ◽  
Health Surveillance ◽  
Safety And Efficacy ◽  
Unified Health System

The National Policy of Integrative and Complementary Practices (PNPIC) in the Brazilian Unified Health System (SUS), and The National Policy of Medicinal Plants and Herbal Medicines (PNPMF) were launched in 2006. Based on these, the Brazilian Health Surveillance Agency (ANVISA) re-edited rules related to herbal medicines such as the Guideline to herbal medicine registration (RDC 14/10), the Good Manufacture Practices Guideline (RDC 17/10) and the List of references to assess the safety and efficacy of herbal medicines (IN 05/10). The requisites to prove herbal medicine's safety and efficacy were updated. Therefore, this review aims at presenting and commenting these new rules.

scholarly journals Taxonomic synopsis of medicinal Lamiales species used in Alta Floresta, Mato Grosso, Brazil: Potentialities for the Unified Health System

2021 ◽  
Vol 10 (11) ◽  
pp. e340101119686
Author(s):  
José Martins Fernandes
Keyword(s):  
Rural Communities ◽  
Medicinal Plants ◽  
Health System ◽  
Glandular Trichomes ◽  
National Policy ◽  
Plant Morphology ◽  
Medicinal Species ◽  
Mato Grosso ◽  
Unified Health System ◽  
The Status

This work presents the morphology of 16 medicinal species of Lamiales used in Alta Floresta, Mato Grosso, Brazil, as well comments about phytogeography, popular use in the municipality, the status of the species in the National Policy on Medicinal Plants and Phytotherapeutics, and examples of preclinical trials. The work was performed between March and September 2020, through botanical sample of the Lamiales species presented in the book " Plantas medicinais de Alta Floresta: com contribuição a etnobotânica", obtained in rural communities and urban neighborhoods in the municipality of Alta Floresta, State of Mato Grosso. The morphological study was carried out at the Laboratory of Plant Morphology, located at the University Campus of Alta Floresta, Universidade do Estado de Mato Grosso. In general, the species are native (56%) with wide distributions in Brazil. Most species have glandular trichomes (72%) on the leaves and/or flowers and have been shown to be efficient and/or promising (85.5%) in studies. However, only 37.5% of these studies were conducted by the Ministry of Health. None of the species are offered as a phytotherapeutic by the Unified Health System (SUS), although six are on the last National Report of Medicinal Plants of Interest published by SUS. Based on the information provided, it is evident that these species could be used in studies about new phytotherapeutics for SUS users.

scholarly journals Impact of the Training of Professionals from São Paulo Public Health System in Phytotherapy Practice

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
Linete Maria Menzenga Haraguchi ◽  
Adriana Sañudo ◽  
Eliana Rodrigues ◽  
Herbert Cervigni ◽  
Elisaldo Luiz de Araujo Carlini
Keyword(s):  
Public Health ◽  
Medicinal Plants ◽  
Health System ◽  
Health Professionals ◽  
Public Health System ◽  
Positive Impact ◽  
National Policy ◽  
Herbal Medicines ◽  
Sao Paulo ◽  
São Paulo

Abstract: Introduction: Following the introduction in 2006 of the National Policy on Integrative and Complementary Practices, and The National Policy on Medicinal Plants and Herbal Medicines, the Municipal Secretariat for the Environment of the City Hall of Sao Paulo initiated the Medicinal Plants Course, later expanded to The Medicinal Plants and Herbal Medicines Course for the training of health professionals. This study aimed to evaluate the impact of the 2014 and 2015 edition of the course “Medicinal Plants and Herbal Medicines” on health professional practices. Methods: An exploratory and descriptive study was conducted with a qualitative-quantitative approach. The quantitative process (Phase I) consisted of a questionnaire being emailed to health professionals who were involved in the course, divided into seven categories: biomedical professional, dental surgeon, nurse, pharmacist, physiotherapist, physician and nutritionist; and, out of 165 questionnaires, 114 responses were received (69.1%). The Qualitative and Quantitative process (Phase II), comprised semi-structured, in-person individual interviews to obtain detailed information on Phytotherapy practices, with 73 health professionals being interviewed, before and after the training, comparing their practices afterwards. Results: The course had a positive impact on the acceptance and application of Phytotherapy by health professionals with a significant increase (p<0.001) in the expansion of activities related to Phytotherapy (herbal tea “meetings”, medicinal herb gardens and capacity training), regarding the use of herbal products, such as Matricaria chamomilla (chamomile), Maytenus ilicifolia (espinheira-santa), Valeriana officinalis (valeriana). An increase in the knowledge of Phytotherapy risks was also observed, although there was no increase in the reporting of adverse reactions. The study confirmed the importance of the inclusion of Medicinal Plants and Herbal Medicines Courses as part of undergraduate and postgraduate school, as well as the technical training and continuing education for SUS health professionals. Conclusion: The positive impact found out in almost all evaluated aspects, such as the increase in the knowledge and in the prescription of herbal medicines, confirms the importance of such courses. The results suggest the training promoted a positive impact on the Phytotherapy practice of the Public Health System professionals in São Paulo.

scholarly journals Study of Antifungal Activity Using Three Chinese Medicine Herbs

2021 ◽  
Vol 71 (4) ◽  
pp. 322-329
Author(s):  
Anming Zhu ◽  
Shiming Ren ◽  
Xueqi Li ◽  
Xiaoqi Zhao ◽  
Lei Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Antifungal Activity ◽  
Herbal Medicines ◽  
Wood Preservative ◽  
Growth Cycle ◽  
Inhibitory Effect ◽  
Chinese Herbs ◽  
Primary Data ◽  
Chinese Herbal ◽  
Direct Killing

Abstract Chinese medicine herbal extracts are ideal candidates to replace toxic industrial wood preservatives thanks to their antifungal and nontoxic properties. To investigate the antifungal activity of Chinese herbal medicines, in this study, Trametes versicolor fungi were selected as test strains to evaluate the antifungal properties of Fructus Cnidii, Fructus Forsythiae, and Radix Stemonae. The results show that Fructus Cnidii has a strong inhibitory effect against T. versicolor, whereas Fructus Forsythiae and Radix Stemonae have a weak inhibitory effect. The hyphae growth cycle shows that the three studied Chinese herbs disrupt the growth of T. versicolor. Moreover, instead of direct killing, the Chinese herbal medicine demonstrated inhibition ability. Furthermore, the morphological and toxicological evidence shows that Fructus Cnidii affected the expression of proteins or enzymes to achieve the inhibition goal. In sum, this study could provide both primary data and a theoretical foundation for further developing and applying for traditional Chinese medicine as a green type of wood preservative.

scholarly journals Antifungal Activity of N-(4-Halobenzyl)amides against Candida spp. and Molecular Modeling Studies

2021 ◽  
Vol 23 (1) ◽  
pp. 419
Author(s):  
Yunierkis Perez-Castillo ◽  
Ricardo Carneiro Montes ◽  
Cecília Rocha da Silva ◽  
João Batista de Andrade Neto ◽  
Celidarque da Silva Dias ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Benzoic Acid ◽  
Mechanism Of Action ◽  
Fungal Infections ◽  
Redox Balance ◽  
Inhibitory Effect ◽  
Candida Spp ◽  
Cellular Processes ◽  
Antifungal Action ◽  
Dynamics Simulations

Fungal infections remain a high-incidence worldwide health problem that is aggravated by limited therapeutic options and the emergence of drug-resistant strains. Cinnamic and benzoic acid amides have previously shown bioactivity against different species belonging to the Candida genus. Here, 20 cinnamic and benzoic acid amides were synthesized and tested for inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019. Five compounds inhibited the Candida strains tested, with compound 16 (MIC = 7.8 µg/mL) producing stronger antifungal activity than fluconazole (MIC = 16 µg/mL) against C. krusei ATCC 14243. It was also tested against eight Candida strains, including five clinical strains resistant to fluconazole, and showed an inhibitory effect against all strains tested (MIC = 85.3–341.3 µg/mL). The MIC value against C. krusei ATCC 6258 was 85.3 mcg/mL, while against C. krusei ATCC 14243, it was 10.9 times smaller. This strain had greater sensitivity to the antifungal action of compound 16. The inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019 was also achieved by compounds 2, 9, 12, 14 and 15. Computational experiments combining target fishing, molecular docking and molecular dynamics simulations were performed to study the potential mechanism of action of compound 16 against C. krusei. From these, a multi-target mechanism of action is proposed for this compound that involves proteins related to critical cellular processes such as the redox balance, kinases-mediated signaling, protein folding and cell wall synthesis. The modeling results might guide future experiments focusing on the wet-lab investigation of the mechanism of action of this series of compounds, as well as on the optimization of their inhibitory potency.

scholarly journals Isolation of bacterial fish pathogen Aeromonas hydrophila and therapeutic effects of medicinal plants on its invasion

2014 ◽  
Vol 2 (1) ◽  
pp. 76
Author(s):  
Md. Tareq-Uz-Zaman ◽  
Md. Bazlur Rashid Chowdhury ◽  
Md. Rasheduzzaman Khan Dipu
Keyword(s):  
Medicinal Plants ◽  
Aeromonas Hydrophila ◽  
Control Measure ◽  
Curcuma Longa ◽  
Bacterial Pathogen ◽  
Inhibitory Effect ◽  
Infected Fish ◽  
Effective Control ◽  
Therapeutic Effects ◽  
Pathogenicity Test

Aeromonas hydrophila, a bacterial pathogen,  was isolated form Pangasius hypophthalmus. For pathogenicity test, different doses were injected intramuscularly in Barbonymus gonionotus. Crude extracts were prepared from various parts Azadirachta indica, Curcuma longa, C. zedoaria, and Callotropis gigentia and applied to B. gonionotus for 7 days. Bath treatment was done up to their tolerance level and well ventilation was confirmed for aeration and 50% water was exchanged daily. Minimum inhibitory dose was detected as 7 mg/ml. High inhibitory effect was observed in case of A. indica and mixed extract of A. indica and C. gigentia. Both A. indica and C. gigentia showed the best result with 90-95% recovery of infected fish at a dose of 7 mg/l. C. zedoaria showed moderate to weak effect with 50-60% recovery at the same dose. The present study showed that medicinal plants would be an effective control measure against A. hydrophila.

scholarly journals MEDICINAL PLANTS AND HERBAL MEDICINES USAGE IN THE SOCIOECONOMIC REALITY OF NORTHEAST BRAZILIAN COCOA REGION

2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Leonardo Galvão Cardoso ◽  
Rafael S. Silva ◽  
Gesael P. F. Júnior ◽  
Luiz A. M. Cardoso ◽  
Alexandre J. de Oliveira ◽  
...  
Keyword(s):  
Public Health ◽  
Medicinal Plants ◽  
Health System ◽  
Low Income ◽  
Health Professionals ◽  
Family Income ◽  
Public Health System ◽  
Herbal Medicines ◽  
Important Conclusion ◽  
Toxicity Potential

Objective: This work describes the medicinal plants and/or herbal medicines usage by the population assisted by Brazilian Public Health System (SUS), and their prescription by health professionals in the Brazilian Northeast. Methods: Questionnaires were applied for public health system users; pharmacists who work at compounding pharmacies; physicians and nurses. Data were submitted to descriptive statistical analysis. Results: The sociodemographic profile was individuals between 40 and 59 yearsold, majority of females, low family income, and low schooling levels. A great number of individuals (89.3%) used plant products, without prescription and based on traditional knowledge. There was a common trend regarding a lack of knowledge of plant toxicity potential. Regarding health professionals, 90% stated having knowledge about medicinal plants and/or herbal medicines, and 80% believe that its effect is important. Conclusion: The study reveals the major usage of herbal medicines and/or medicinal plants by familiar low income and low schooling level without prescription from a physician. These factors may cause a risk/benefit imbalance where could have a reduction in therapy efficacy and high toxicity potential of the drugs. This reinforces the need of pharmacosurveillance toward usage of medicinal plants and herbal medicines in the public health system.

scholarly journals PHYTOTHERAPY IN DENTISTRY: SURVEY OF PRODUCTS OF PLANT ORIGIN FOR HEALTH ORAL

2019 ◽  
pp. 35-40 ◽  
Author(s):  
Juan Arada ◽  
Zenon Perez
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Scientific Literature ◽  
Therapeutic Option ◽  
National Policy ◽  
Herbal Medicines ◽  
Plant Origin ◽  
Clinical Routine ◽  
Unified Health System ◽  
The Impact

Introduction: The National Policy of Integrative and Complementary Practices (PNPIC), of the Ministry of Health, inserts the use of medicinal plants and herbal medicine in the Unified Health System (SUS) and was the recognized practice of herbal medicine by the dentist regulated in 2008. by the Federal Council of Dentistry. However, for dentistry, this therapeutic option is still little used. Objectives: The aim of this study was to review and systematize data from the scientific literature on products of plant origin indicated for dentistry, contributing to promote their use by dentists. Methodology: The Medline and BIREME indexing bases on the theme of phytotherapics in dentistry were searched. 230 articles were found and 15 were selected, based on the impact factor of the publications. Conclusions: The difficulties of the use of Phytotherapy in the clinical routine are related to several aspects, such as the lack of qualification of professionals, difficulty of access to phytotherapeutic plants, cost, among others. KEY WORDS: Medicinal Plants; Drug; Herbal Medicines; Oral Health.

scholarly journals STUDIES ON THE AM FUNGAL DIVERSITY OF SOME SIGNIFICANT ETHANO-MEDICINAL PLANTS OF KARULAI HILLS, MALAPPURAM DISTRICT, KERALA

2017 ◽  
Vol 4 (3) ◽  
pp. 25-38
Author(s):  
Jothi C ◽  
Muthuraj K ◽  
Siva Priya K.T ◽  
Krishnan E ◽  
Nagarajan N
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Fungal Diversity ◽  
Herbal Medicines ◽  
Am Fungi ◽  
Fungal Species ◽  
Fungal Colonization ◽  
Piper Longum ◽  
Spore Population ◽  
Important Medicinal Plant

The study was carried out to observe the AM fungal diversity in some important medicinal plant species of Karulai hills, Malappuram district, Kerala. The root samples of all the collected plant species showed mycorrhizal infection. The percentage of AM fungal colonization ranged from 17 to 87. The highest AM fungal infection was exhibited in Desmodium triflorum (87%) and lowest in phyllanthes amarus (17%).The maximum spore population was observed in Desmodium gangeticum (874/100g of soil) and minimum in Piper longum (171/100g of soil). Totally 13 genera of AM fungi were found to be associated with the rhizosphere soil samples. Among them AM fungal species isolated, the dominant species is Rhizophagus fasciculatus. Ethanobotanical study reveals that the Cholanaykans tribes of Karullai hills posses great knowledge about the use of various herbal medicines to cure different ailments and are also conscious about the loss of their traditional medicinal practices. They know about number of medicinal plants and their applications.

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