Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

Introduction: At the end of 2019, a new coronavirus caused pneumonia in Wuhan, China. Several studies have described the clinical features and immune manifestations in COVID-19 patients with moderate to severe symptoms, while their clinical relevance is less clear. This study investigates the effects of clinical symptoms and laboratory values of COVID-19 patients' tests at the time of hospitalization on their clinical outcomes. Methodology: This descriptive cross-sectional study was performed on COVID-19 patients hospitalized in Arak hospitals from April 2020 to March 2020. Medical records of all the hospitalized patients were retrieved. Trained personnel extracted general information (age and gender) and clinical profiles (the complete blood count and other required tests). Findings: Analyzing the laboratory indices of the blood count and LDH and CPK levels revealed a positive relationship between the patients' serum CPK levels, and the mortality rate (P = 0.001) and length of hospitalization (P = 0.015). Conclusion: The patients' serum LDH levels and fever were also associated with the mortality rate, and the need for mechanical ventilation, respectively. We hope this information helps physicians treat COVID-19 patients. Keywords: COVID-19, clinical symptoms, laboratory tests

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Rubella Outbreak in Heballi Agasi Ward, Dharwad District, Karnataka, India, 2014–2015

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1014 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s380-s380

Author(s):

Sree Kalpana Mohankumar ◽

Vishweshwarayya Hiremath ◽

Rajashree Koppad

Keyword(s):

Attack Rate ◽

Clinical Symptoms ◽

Cross Sectional Study ◽

Routine Immunization ◽

Serum Samples ◽

Cross Sectional ◽

Epidemic Curve ◽

Surveillance Report ◽

And Gender ◽

Rubella Vaccination

Background: Countries that have good rubella surveillance, report ∼10,000–20,000 rubella cases annually. In India, not many cases of rubella are reported. The Hebballi Agasi ward of Dharwad district in Karnataka state, India, reported rubella cases on the last week of January 2015. Objective: We investigated the outbreak by time, place, person, and clinical symptoms. Methods: We performed a cross-sectional study. We defined a case as any resident of Heballi Agasi who had fever and rash, with or without lymphadenopathy, arthralgia, conjunctivitis, coryza, and cough, after December 15, 2014. We collected sociodemographic details and clinical symptoms of patients. We collected 5 serum samples and sent them to the National Measles Laboratory, Bangalore. We tested for measles and rubella antibodies. We drew an epidemic curve and a spot map. We computed mean age of cases, and we calculated attack rates by mean age and gender. We calculated proportions to describe clinical symptoms, and we interviewed stakeholders regarding rubella vaccination. We continued surveillance until March 2015. Results: The population of Heballi Agasi was 1,458. We identified 15 rubella cases (9 girls and 6 boys). The outbreak lasted between December 10, 2014, and February 21, 2015, with a peak on January 16, 2015. The overall attack rate was 1% (15 of 1,458). The mean age of the cases was 6 years (range, 1–23). The attack rate was high (7.7%) among those aged 1–6 years (11 of 143). The attack rate among those aged >6 years was 0.3% (4 of 1,315). In addition to fever and rash, 93% of cases (14 of 15) had coryza, 47% had cough (7 of 15), and 40% had conjunctivitis (6 of 15). Lymphadenopathy was present in only 1 case (1 of 15), and arthralgia was absent among all 15 cases. There was no death among the cases. All 5 sera were positive for rubella and negative for measles. Rubella vaccination was not given for any of the cases because no rubella vaccination is provided in the routine immunization program. Conclusions: There was a rubella outbreak in Heballi Agasi ward. Children aged 1–6 years were most affected. We recommend rubella vaccination in the routine immunization.Funding: NoneDisclosures: None

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The prevalence of symptomatic knee osteoarthritis and its correlation analysis with complete blood count: a multicenter cross-sectional study in China

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2021.02.292 ◽

2021 ◽

Vol 29 ◽

pp. S214-S215

Author(s):

Y. Qiu ◽

J. Gao ◽

Q. Xue ◽

J. Lin

Keyword(s):

Correlation Analysis ◽

Knee Osteoarthritis ◽

Blood Count ◽

Complete Blood Count ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Symptomatic Knee Osteoarthritis ◽

Symptomatic Knee

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CORRELATION BETWEEN WDF, WNR, AND RET ABNORMAL SCATTERGRAM DETECTED BY SYSMEX XN-1000 AND PARASITEMIA OF MALARIA PATIENTS IN MERAUKE HOSPITAL

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v26i1.1521 ◽

2019 ◽

Vol 26 (1) ◽

pp. 91

Author(s):

Merylin Ranoko ◽

Aryati Aryati ◽

Arifoel Hajat

Keyword(s):

General Hospital ◽

Health Problem ◽

Gold Standard ◽

Blood Count ◽

Complete Blood Count ◽

Cross Sectional Study ◽

Response To Therapy ◽

Sectional Study ◽

Cross Sectional ◽

Degree Of Severity

Malaria remains a health problem in Indonesia. Microscopic examination with Giemsa staining is the gold standard for diagnosing malaria. The density of parasites correlates with the degree of severity and response to therapy of malaria. Malaria-causing plasmodium can be detected by Sysmex XN-1000 which is marked by abnormalities in the WDF, WNR and RET scattergram. This research aimed to determine the correlation of WDF, WNR and RET abnormal scattergram detected by Sysmex XN-1000 and the parasitemia index of malaria at the Merauke General Hospital. This was a cross-sectional study with observational approach conducted between November 2017 – February 2018 at the Merauke General Hospital. Positive malaria samples were stained with Giemsa, their parasitemia index was calculated, routine complete blood count using Sysmex XN-1000 was performed, and the scattergram abnormalities were then analyzed. There were 65 positive malaria samples as follows: P.falciparum (35%), P.vivax (60%), P.ovale (3.1%), and P.malariae (1.5%), but the species did not correlate with parasitemic index (p=0.691). Abnormalities of WDF and WNR scattergram were predominantly found than RET scattergram (80% vs. 27.7%). P.vivax predominantly caused abnormalities of the WDF and WNR scattergram in 36 of 39 samples (92.3%), whereas P.falciparum predominantly caused abnomalities of the RET scattergram in 14 of 23 samples (60.9%). There was 95% positivity of an abnormality in WDF/WNR/RET scattergram with a cut-off of > 5,0165.5/µL. There was correlation between WDF, WNR, RET scattergram detected by Sysmex XN-1000 and the parasitemia index.

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Varying association of laboratory values with reference ranges and outcomes in critically ill patients: an analysis of data from five databases in four countries across Asia, Europe and North America

BMJ Health & Care Informatics ◽

10.1136/bmjhci-2021-100419 ◽

2021 ◽

Vol 28 (1) ◽

pp. e100419

Author(s):

Haoran Xu ◽

Louis Agha-Mir-Salim ◽

Zachary O’Brien ◽

Dora C Huang ◽

Peiyao Li ◽

...

Keyword(s):

Clinical Outcomes ◽

Critically Ill ◽

Critically Ill Patients ◽

Cross Sectional Study ◽

Specific Reference ◽

Reference Ranges ◽

Cross Sectional ◽

Laboratory Values ◽

Laboratory Results ◽

The Usa

BackgroundDespite wide usage across all areas of medicine, it is uncertain how useful standard reference ranges of laboratory values are for critically ill patients.ObjectivesThe aim of this study is to assess the distributions of standard laboratory measurements in more than 330 selected intensive care units (ICUs) across the USA, Amsterdam, Beijing and Tarragona; compare differences and similarities across different geographical locations and evaluate how they may be associated with differences in length of stay (LOS) and mortality in the ICU.MethodsA multi-centre, retrospective, cross-sectional study of data from five databases for adult patients first admitted to an ICU between 2001 and 2019 was conducted. The included databases contained patient-level data regarding demographics, interventions, clinical outcomes and laboratory results. Kernel density estimation functions were applied to the distributions of laboratory tests, and the overlapping coefficient and Cohen standardised mean difference were used to quantify differences in these distributions.ResultsThe 259 382 patients studied across five databases in four countries showed a high degree of heterogeneity with regard to demographics, case mix, interventions and outcomes. A high level of divergence in the studied laboratory results (creatinine, haemoglobin, lactate, sodium) from the locally used reference ranges was observed, even when stratified by outcome.ConclusionStandardised reference ranges have limited relevance to ICU patients across a range of geographies. The development of context-specific reference ranges, especially as it relates to clinical outcomes like LOS and mortality, may be more useful to clinicians.

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The Association between Bone Mineral Density and Complete Blood Count in Postmenopausal Women: A Cross-Sectional Study

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2021.03.11848 ◽

2021 ◽

Vol 104 (3) ◽

pp. 432-437

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Blood Count ◽

Complete Blood Count ◽

Cross Sectional Study ◽

Mineral Density ◽

Cross Sectional ◽

Study Results ◽

The Relationship

Objective: To demonstrate the relationship between anemia and complete blood count (CBC) parameters with bone mineral density (BMD) in postmenopausal women. Materials and Methods: A cross-sectional chart-review study was conducted between November 2017 and June 2019. Three hundred twenty-four postmenopausal women aged 50 years or older who had BMD and CBC results were included in the present study. Results: The prevalence of osteopenia and osteoporosis diagnosed by T-score were 53.1% and 32.7%, respectively. Simple and multiple linear regression analyses showed that no association between CBC parameter with BMD except basophil count, which was negatively associated with BMD (p=0.011). There was no correlation between anemia and BMD status (p=0.168). Conclusion: CBC parameters such as hemoglobin or white blood cell count were not statistically correlated with BMD. This is the first study demonstrating that basophil count may be an associated factor for deceased BMD. Keywords: Postmenopausal women, Bone mineral density, Complete blood count, Basophil

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Alexithymia and anxiety symptoms in Pakistani adolescents: a study of compounded directions

Journal of the Pakistan Medical Association ◽

10.47391/jpma.1247 ◽

2021 ◽

pp. 1-13

Author(s):

Sadia jafer ◽

Farzana Ashraf ◽

Amna Arif ◽

Admin

Keyword(s):

Psychological Health ◽

Clinical Symptoms ◽

Interactive Effect ◽

Age Groups ◽

Cross Sectional Study ◽

Anxiety Symptoms ◽

Cross Sectional ◽

Physical And Psychological Health ◽

And Gender ◽

Effect Of Age

Abstract Objectives: There is an empirical evidence that symptoms of internalizing disorders such as alexithymia and anxiety increase in adolescence and these symptoms varies across gender and age groups. The purpose of this study was to explore these differences in adolescents. Method: In this cross-sectional study conducted since November 2018 to March 2019, the sample of 185 adolescents selected through random sampling method from different schools. They were assessed on alexithymia and anxiety symptoms by administering Toronto Alexithymia Scale and Hamilton Anxiety Scale respectively. Multiple Analysis of Variance (MANOVA) was applied to determine the direct and interactive effect of age groups and gender on alexithymia and anxiety symptoms. Results: The results demonstrate that boys reported significantly (p<0.05) higher level of alexithymia symptoms partially (externally oriented) as compared to their counterparts. Further significant (p<0.05) interactive effect of age group and gender was also seen. Conclusion: The present study concluded that the presence of clinical symptoms in school going adolescents may hinder in the physical and psychological health of adolescents, which should be managed through suitable interventions. Keywords: Alexithymia symptoms, Anxiety symptoms, Continuous...

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SPECTRUM OF PANCYTOPENIA

The Professional Medical Journal ◽

10.29309/tpmj/2016.23.05.1594 ◽

2016 ◽

Vol 23 (05) ◽

pp. 620-626

Author(s):

Tariq Hameed Rehmani Rehmani ◽

Mizna Arif ◽

Sajjad Heraid ◽

Sarah Arif ◽

Rabia Ahmad ◽

...

Keyword(s):

Blood Count ◽

Complete Blood Count ◽

Megaloblastic Anemia ◽

Clinical History ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Male Predominance ◽

Medical College ◽

Study Setting

Pancytopenia refers to a reduction in all the three cellular elements of blood.Pancytopenia is a common but important hematological problem encountered in routineclinical Practice. It may be a presenting feature of many underlying serious and life threateningillnesses. Objective: Present study was planned to appraise various clinico- etiologicalfactors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: HematologyDepartment of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period:July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients withPancytopenia were included in the study. Complete blood count, bone marrow aspirations andtrephine biopsies were performed after clinical history and physical exam. Data were analyzedby using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bonemarrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiologicalfactors with male predominance. Fever and pallor were striking presenting clinical features.Conclusion: We conclude that Pancytopenia is a common problem with an exhaustive listof differential diagnosis, some of which are easily treatable and reversible. Therefore earlydetection with optimal diagnostic approach to Pancytopenia is required for better managementof patients.

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Assumption of heparin-induced thrombocytopenia in mucopolysaccharidoses

Journal of Ideas in Health ◽

10.47108/jidhealth.vol4.iss3.129 ◽

2021 ◽

Vol 4 (3) ◽

pp. 419-422

Author(s):

Liliya Aleksandrovna Osipova ◽

Lyudmila Mikhailovna Kuzenkova

Keyword(s):

Heparan Sulfate ◽

Blood Count ◽

Complete Blood Count ◽

Lysosomal Storage Diseases ◽

Cross Sectional Study ◽

P Value ◽

Lysosomal Storage ◽

Cross Sectional ◽

Female Ratio ◽

Mps I

Background: Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases, resulted from glycosaminoglycans’ breakdown failure (GAGs). The study aims to determine the presence of thrombocytopenia, its prevalence, clinical implication, and correlation with the types of MPSs and with the types of glycosaminoglycans storage. Methods: A retrospective cross-sectional study of complete blood count data was conducted among 108 children with a confirmed diagnosis of MPS in the National Medical Research Center for Children's Health, Moscow, Russian Federation. STATISTICA 10 (Stat Soft, Inc. 1984-2011) was used for statistical analysis. A p-value of ≤0.05 was considered significant. Results: The median age of children was 65 [IQR: 41; 102] months, range: 3 – 102 months. The male to female ratio was 3:1. The prevalence of fluctuating or persistent thrombocytopenia in all children with MPS was 19.0%. Thrombocytopenia occurred in patients with MPS I (14.0%), II (19.0%), and III (31.0%). Neither of the patients with MPS IV nor VI demonstrated low platelet count. There was a non-significant predominance (P=0.068) of thrombocytopenia frequency in patients with heparan sulfate storage (22.0%) compared with patients without heparan sulfate burden (0%). Conclusion: Routine checkups of patients with MPSs must include complete blood count with platelet measurement. Cases of thrombocytopenia that requiring treatment, immunomodulatory/ immunosuppressive therapy should be considered. Further research is needed to look for the laboratory confirmation of autoimmune variants of HIT in patients with MPS I, II, III.

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Can Simple Tests Prior to Endoscopy Predict the OLGA Stage of Gastritis?

Healthcare ◽

10.3390/healthcare8030230 ◽

2020 ◽

Vol 8 (3) ◽

pp. 230

Author(s):

Ertan Bulbuloglu ◽

Hasan Dagmura ◽

Emin Daldal ◽

Alev Deresoy ◽

Huseyin Bakir ◽

...

Keyword(s):

Intestinal Metaplasia ◽

Blood Count ◽

Rating Scale ◽

Complete Blood Count ◽

Numerical Rating Scale ◽

Inflammatory Marker ◽

Cross Sectional Study ◽

Cross Sectional ◽

Numerical Rating ◽

Stage Estimation

Gastritis is a progressive disease that evolves from a non-atrophic to atrophic state and progresses through intestinal metaplasia, with some cases leading eventually to gastric cancer. Since gastritis by definition is an inflammatory process of the mucosal lining of the stomach and is usually associated with pain, we aimed to identify any association between the severity of gastritis and pain and a simple inflammatory marker derived from a complete blood count (CBC). This was a prospective cross-sectional study which enrolled 155 consecutive adult patients who underwent an upper endoscopy. Prior to the endoscopy, all patients were given a questionnaire, numerical rating scale (NRS) and complete blood count evaluation. The biopsy was obtained from the gastric mucosa according to the modified Sydney classification and scored with the Operative Link for Gastritis Assessment (OLGA) scoring system. The results showed a significant correlation between NRS and intestinal metaplasia (p < 0.01); moreover, a correlation was also found between the NRS and OLGA stage (r = 0.469, p < 0.001). A nonlinear curve was constructed for OLGA stage estimation according to NRS scores (r2 was found to be 0.442, with p < 0.001). The results also showed a correlation between the neutrophil to the lymphocyte ratio (NLR) and OLGA stage (p < 0.01). No correlation was found between the other gastric parameters and NLR (p > 0.05). Helicobacter pylori positivity did not correlate with NRS and NLR. As a conclusion, pain measured by NRS and NLR, which are simply calculated from the CBC prior to endoscopy, may be used to predict OLGA stages and estimate the severity of gastritis in endoscopy patients.

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