scholarly journals Assumption of heparin-induced thrombocytopenia in mucopolysaccharidoses

2021 ◽  
Vol 4 (3) ◽  
pp. 419-422
Author(s):  
Liliya Aleksandrovna Osipova ◽  
Lyudmila Mikhailovna Kuzenkova
Keyword(s):  
Heparan Sulfate ◽  
Blood Count ◽  
Complete Blood Count ◽  
Lysosomal Storage Diseases ◽  
Cross Sectional Study ◽  
P Value ◽  
Lysosomal Storage ◽  
Cross Sectional ◽  
Female Ratio ◽  
Mps I

Background: Mucopolysaccharidoses (MPSs) are a group of lysosomal storage diseases, resulted from glycosaminoglycans’ breakdown failure (GAGs). The study aims to determine the presence of thrombocytopenia, its prevalence, clinical implication, and correlation with the types of MPSs and with the types of glycosaminoglycans storage. Methods: A retrospective cross-sectional study of complete blood count data was conducted among 108 children with a confirmed diagnosis of MPS in the National Medical Research Center for Children's Health, Moscow, Russian Federation. STATISTICA 10 (Stat Soft, Inc. 1984-2011) was used for statistical analysis. A p-value of ≤0.05 was considered significant. Results: The median age of children was 65 [IQR: 41; 102] months, range: 3 – 102 months. The male to female ratio was 3:1. The prevalence of fluctuating or persistent thrombocytopenia in all children with MPS was 19.0%. Thrombocytopenia occurred in patients with MPS I (14.0%), II (19.0%), and III (31.0%). Neither of the patients with MPS IV nor VI demonstrated low platelet count. There was a non-significant predominance (P=0.068) of thrombocytopenia frequency in patients with heparan sulfate storage (22.0%) compared with patients without heparan sulfate burden (0%). Conclusion: Routine checkups of patients with MPSs must include complete blood count with platelet measurement. Cases of thrombocytopenia that requiring treatment, immunomodulatory/ immunosuppressive therapy should be considered. Further research is needed to look for the laboratory confirmation of autoimmune variants of HIT in patients with MPS I, II, III.

scholarly journals Detecting chronic kidney disease in diabetic adults by estimating glomerular filtration rate and Serum Creatinine

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ahmed Kh. Mohammed Almaawi
Keyword(s):  
Risk Factors ◽  
Serum Creatinine ◽  
Cross Sectional Study ◽  
P Value ◽  
Diabetic Patients ◽  
Kappa Index ◽  
Chi Square ◽  
Cross Sectional ◽  
Female Ratio ◽  
Qualitative Variables

Objective: To assess CKD prevalence and risk factors including socio-demography among diabetics by estimating GFR rather than serum creatinine (sCr). Methods: A cross-sectional study was conducted in Dec. 15 2019 through Aug. 15 2020, among 800 diabetics attending tertiary diabetes centers, Baghdad. Data was collected by self-administered questionnaire. SPSS was used for data analysis by (mean, standard deviation and T-test) for quantitative variables and (frequency, percentage, Chi-square test and Kappa index) for qualitative variables. P-Value less than 0.05 was considered significant.  Results: 800 diabetics for last 5-40 years, 95.6% with type2. Aged 52.1±13.2 years, with male: female ratio 1.03:1, 63.6% were with no income, sCr level was 0.86±0.3 mg/dl, and eGFR by Cockcroft Gault (CG) and CKD-EPI equations was 100.4±36.5 & 92.2±25.5 ml/min/1.73m2 respectively. CKD prevalence based on sCr, and eGFR assessed by above equations was 13.3%, 20% and 15.9% respectively (p<0.001). Those with CKD were hypertensive, females, and living in peripheries. Conclusions: Diabetic patients, mainly those with risk factors are more likely to develop CKD. It is better to detect CKD intially by estimating the GFR, rather than serum creatinine level alone. Furthermore, using CKD-EPI equation might be better than the CG formula to estimate the GFR.

Increased frequency of fibromyalgia among patients with chronic pain presenting to internal medicine clinics of a tertiary care hospital: a cross sectional study

2022 ◽  
Vol 71 (12) ◽  
Author(s):  
Sana Javed ◽  
Muhammad Zaid ◽  
Sumera Imran ◽  
Ayesha Hai ◽  
Muhammad Junaid Patel
Keyword(s):  
Internal Medicine ◽  
Tertiary Care ◽  
Chronic Fatigue ◽  
Cross Sectional Study ◽  
National Language ◽  
P Value ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio

Objective: To estimate the frequency of patients with fibromyalgia (by using the 2010 Modified Criteria for Fibromyalgia by American College of Rheumatology ( ACR ) presenting to Internal Medicine clinics  Methods: A cross-sectional study conducted in the department of Internal Medicine, the Indus Hospital, khi, Pakistan between December 2016 and March 2018. Patients who visited internal medicine clinics, met the selection criteria, were included in the study. After taking informed consent patients were assessed for fibromyalgia according to the new 2010 Fibromyalgia Diagnostic criteria questionnaire. The patients were asked the questions in the national language, Urdu. Data analyzed using SPSS version 21. P value of < 0.05 was considered significant. Results: Of the 267 patients presenting to the internal medicine clinics and consenting for participating in the study 149 (55.80%) met at least one of the 2010 Fibromyalgia Criteria. The prevalence of fibromyalgia as estimated in this study was 56% with no difference in gender. Mean age of patients with fibromyalgia was 42.3 ± 14.6 and patients without fibromyalgia was 38.9 ± 13.7 which was statistically significant (p-value = 0.05, 10% level of significance). Of the 267 patient 197 (73.8%) were female and 70 (26.2%) were males, a male to female ratio of 1:2.81.  Conclusion: All patients with generalized pain should be evaluated for fibromyalgia and a diagnosis made to reduce the cost of further referrals and investigations and delay in the management of this debilitating disorder. Keywords: Fibromyalgia, Chronic fatigue, Generalized Pain  

scholarly journals Characteristics of overweighed and obese adults attended Nutritional clinic in Dewaniyah governorate,Iraq,2014

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Fatima AL Khalidi
Keyword(s):  
Educational Level ◽  
Food Habit ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Nutritional Deficiencies ◽  
P Value ◽  
Cross Sectional ◽  
Female Ratio ◽  
Obesity Rate ◽  
Important Challenge

over all world,thecommunity is undergoing a rapid epidemiological and nutritional transition characterized by persistent nutritional deficiencies or increasing overweight and obesity rate which is one of important challenge that need to change in food habit and life style toward healthy diet and regular physical exercise. In Iraq this problem is not fixed,but according to Stepwise Surveillance of Chronic NCD Risk Factor 2006 the overweight and obesity rate was 67% (34 % overweight,32 % obesity). This study aimed to estimate the describe BMI status andcharacteristics factor that associated with overweight and obesity.A file base descriptive cross sectional study conducted in 2016. Files of adults aged >18 years attended the Nutritional clinic during 2014 were reviewed. Demographics characteristics and BMI status considered and presented as percentage. Mean of age computed and some variables crosstab with BMI classification recommended by WHO. Statistical significant considered when p value ≤ 0.05.A total study sample were 722,Male to female ratio was 1:6,and the mean of age was 32.8 ± 9.9. About 20.5% was normal BMI while the overweight and obesity was 79.5%. The study showed that the overweight and obesity rate was higher in female than male (88.2 % vs. 21.8%,p value > 0.001).it is also higher in married status than single (81.7% vs. 18.3%,p > 0.001). Basic educational level had high overweight and obesity rate which was 46.1% with statistical significant association (p value = 0.05). We conclude that the overweight and obesity rate was high among female, married and persons have basic educational level in Iraqi community.

scholarly journals CORRELATION BETWEEN WDF, WNR, AND RET ABNORMAL SCATTERGRAM DETECTED BY SYSMEX XN-1000 AND PARASITEMIA OF MALARIA PATIENTS IN MERAUKE HOSPITAL

2019 ◽  
Vol 26 (1) ◽  
pp. 91
Author(s):  
Merylin Ranoko ◽  
Aryati Aryati ◽  
Arifoel Hajat
Keyword(s):  
General Hospital ◽  
Health Problem ◽  
Gold Standard ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Response To Therapy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Degree Of Severity

Malaria remains a health problem in Indonesia. Microscopic examination with Giemsa staining is the gold standard for diagnosing malaria. The density of parasites correlates with the degree of severity and response to therapy of malaria. Malaria-causing plasmodium can be detected by Sysmex XN-1000 which is marked by abnormalities in the WDF, WNR and RET scattergram. This research aimed to determine the correlation of WDF, WNR and RET abnormal scattergram detected by Sysmex XN-1000 and the parasitemia index of malaria at the Merauke General Hospital. This was a cross-sectional study with observational approach conducted between November 2017 – February 2018 at the Merauke General Hospital. Positive malaria samples were stained with Giemsa, their parasitemia index was calculated, routine complete blood count using Sysmex XN-1000 was performed, and the scattergram abnormalities were then analyzed. There were 65 positive malaria samples as follows: P.falciparum (35%), P.vivax (60%), P.ovale (3.1%), and P.malariae (1.5%), but the species did not correlate with parasitemic index (p=0.691). Abnormalities of WDF and WNR scattergram were predominantly found than RET scattergram (80% vs. 27.7%). P.vivax predominantly caused abnormalities of the WDF and WNR scattergram in 36 of 39 samples (92.3%), whereas P.falciparum predominantly caused abnomalities of the RET scattergram in 14 of 23 samples (60.9%). There was 95% positivity of an abnormality in WDF/WNR/RET scattergram with a cut-off of > 5,0165.5/µL. There was correlation between WDF, WNR, RET scattergram detected by Sysmex XN-1000 and the parasitemia index.

scholarly journals Stress Factors among Dental Postgraduate Residents of Lahore, Pakistan

2021 ◽  
Vol 8 (4) ◽  
pp. 14-15
Author(s):  
Fizza Tahir ◽  
Aleshba Saba Khan ◽  
Hina Zafar Raja ◽  
Hira Butt ◽  
Maila Habib Piracha ◽  
...  
Keyword(s):  
Working Hours ◽  
Cross Sectional Study ◽  
Stress Factors ◽  
P Value ◽  
Weight Changes ◽  
Chi Square ◽  
Cross Sectional ◽  
Female Ratio ◽  
Post Graduate ◽  
Case Presentations

OBJECTIVES: The aim of this study was to identify the stress factors among dental postgraduate residents of Lahore, Pakistan. METHODOLOGY: A cross-sectional study was conducted using non-probability convenient sampling techniques. Total 150 dental postgraduate residents were enrolled in this study. Questionnaire was composed of questions regarding stress factors and the influence of stressors on individuals. The data was analyzed; Chi-square test was used to find the statistical association of level of stress with the demographic factors (gender, marital status, and accommodation), professional characteristics (working hours and practice) and impact on the individuals (mood change, weight change and headache). The level of significance was set at P≤0.05. RESULTS: Total 150 individuals responded with a mean age of 29 years (SD +/-2.96). Male to female ratio was 1:2.5. The most prevalent factors that contributed to stress were post-graduate examination (81%), clinical case presentations (80%), competition for higher performance (61%), inconsistency of feedback by supervisors (59%), research program (55%) and fear of failure to treat patients (53%). More than half of the respondents (69%) suffered from mood swings and (65%) from tension headaches followed by clenching and bruxism in nearly half of the residents (50%), musculoskeletal problems (49%) and weight changes (48%) with p-value<0.05. CONCLUSION: Post-graduate examination, competition for higher performance and increased workload are the most common stressors. There is a need to come up with effective strategies in the postgraduate curriculum to tackle stress.  

scholarly journals Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Misbah Ali ◽  
Mulazim Hussain Bukhari ◽  
Faiza Hassan ◽  
Maria Illyas
Keyword(s):  
Human Papilloma Virus ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Female Ratio ◽  
Papilloma Virus ◽  
Creative Commons ◽  
Significant Difference ◽  
Clinicopathological Study

Objective: To study the clinocopathological factors and presence of Human Pappiloma Virus in ameloblastoma by immnohistochemistry. Methods: It was a cross sectional study on 50 surgical specimens of ameloblastoma, completed in six months. These were selected and processed for initial screening by H&E and then by immunohistochemistry (IHC) for detection of Human Papilloma Virus (HPV). The questionnaire was designed to study the clinicopathological factors associated in these patients. Sections of 4µm were cut, placed on special positive charged glass slides in the Department of Pathology, King Edward Medical University. It was then examined by the histopathologists for grading and scoring of these lesions. Chi Square test was used to assess the differences found in types of ameloblastomas. The p-value was smaller than 0.05 (p < 0.05). Results: The mean age of the patients (12-80 years old) was 38.6±15.1 years, with male-female ratio 2.84: 1. HPV was positive in 9 (18%), whereas negative in of 41 (82%) patients. Among the positive, reactive HPV with score-1 was 8 and score-2 was 1. According to histological variant, follicular was present in 78%, Plexiform pattern in 8%, Conventional and Desmoplastic variants in one patient each; and Cystic and Acanthomatous were seen in two and three patients respectively. The mandible was involved in 39 patients, maxilla and right maxilla involved in 4 patients each, right retromolar, cheek and angle of mandible was seen in one patient each. About 16% patients had anterior, 66% had posterior and 18% had both anterior and posterior regions involved. Among the HPV positive reactive statistically, no significant difference was found with smoking, Paan and exposure to pesticides, factory or mine (p-value > 0.05). Among HPV positive reactive patients, eight had ameloblastoma whereas, 1 had ameloblastomic fibroma. There was no statistical significance of type, location and region of tumor in HPV positivity. Conclusion: Mandible and posterior region was more commonly involved. Follicular pattern was most common. There was no effect of exposure to pesticides, factory or mine, smoke and human papilloma virus in the etiology of ameloblastoma because only 18% of patients showed the association of HPV16 doi: https://doi.org/10.12669/pjms.35.6.909 How to cite this:Ali M, Bukhari MH, Hassan F, Illyas M. Clinicopathological study of ameloblastoma and detection of human papilloma virus by immunohistochemistry. Pak J Med Sci. 2019;35(6):1691-1696. doi: https://doi.org/10.12669/pjms.35.6.909 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The Association between Bone Mineral Density and Complete Blood Count in Postmenopausal Women: A Cross-Sectional Study

2021 ◽  
Vol 104 (3) ◽  
pp. 432-437
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Study Results ◽  
The Relationship

Objective: To demonstrate the relationship between anemia and complete blood count (CBC) parameters with bone mineral density (BMD) in postmenopausal women. Materials and Methods: A cross-sectional chart-review study was conducted between November 2017 and June 2019. Three hundred twenty-four postmenopausal women aged 50 years or older who had BMD and CBC results were included in the present study. Results: The prevalence of osteopenia and osteoporosis diagnosed by T-score were 53.1% and 32.7%, respectively. Simple and multiple linear regression analyses showed that no association between CBC parameter with BMD except basophil count, which was negatively associated with BMD (p=0.011). There was no correlation between anemia and BMD status (p=0.168). Conclusion: CBC parameters such as hemoglobin or white blood cell count were not statistically correlated with BMD. This is the first study demonstrating that basophil count may be an associated factor for deceased BMD. Keywords: Postmenopausal women, Bone mineral density, Complete blood count, Basophil

scholarly journals RISK FACTORS OF MORTALITY IN CHILDREN WITH WILMS’ TUMOR AT SOETOMO HOSPITAL SURABAYA

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Maria Christina Shanty ◽  
Sherly Yuniarchan ◽  
Mia Ratwita Andarsini ◽  
I Dewa Gede Ugrasena ◽  
Bambang Permono ◽  
...  
Keyword(s):  
Risk Factors ◽  
Complete Blood Count ◽  
Wilms Tumor ◽  
Significant Risk ◽  
Stage Iv ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Cross Sectional ◽  
Female Ratio

Objective: Wilms’ tumor is the most common childhood renal tumor for about 6% of pediatric malignant disease. The 5-year survival rate in United States increased from approximately from 70% (1970-1973) to 92% (1989-1996). This study was aim to analyze the risk factors of mortality in children with Wilms’ tumor. Material & Methods: A cross-sectional study was conducted in children with Wilms’ tumor at Soetomo Hospital during 2006-2011. The data of demographic, clinical profile, complete blood count, blood urea nitrogen, glomerular filtration rate, histological type, disease stage, metastases and relapse were analyzed as risk factors of mortality using logistic regression. Results: There were 37 Wilms’ tumor children and 5 children were excluded because of incomplete data. The mean age was 3.0 (SD 2.6) years, and male-to-female ratio was 2.5 : 1. There were 5/32 children in stage I, 7/32 children in stage II, 8/32 children in stage III, 11/32 children in stage IV, and 1/32 children in stage V. There were 15/32 children underwent operation. Complete remission occurred in 12/32 children and 1/32 children relapsed. There were 20/32 children died, associated with anemia (P=0.033, OR=6.111, 95% CI=1.056-35.352) and advanced stage (P=0.021, OR=8.000, 95% CI=1.575-40.632). The risk of mortality increased 3.284 folds with every increased stage (P=0.007, 95% CI=1.338-7.775). Conclusion: Disease stage is the significant risk factor of mortality in children with Wilms’ tumor.  

scholarly journals SPECTRUM OF PANCYTOPENIA

2016 ◽  
Vol 23 (05) ◽  
pp. 620-626
Author(s):  
Tariq Hameed Rehmani Rehmani ◽  
Mizna Arif ◽  
Sajjad Heraid ◽  
Sarah Arif ◽  
Rabia Ahmad ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Predominance ◽  
Medical College ◽  
Study Setting

Pancytopenia refers to a reduction in all the three cellular elements of blood.Pancytopenia is a common but important hematological problem encountered in routineclinical Practice. It may be a presenting feature of many underlying serious and life threateningillnesses. Objective: Present study was planned to appraise various clinico- etiologicalfactors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: HematologyDepartment of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period:July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients withPancytopenia were included in the study. Complete blood count, bone marrow aspirations andtrephine biopsies were performed after clinical history and physical exam. Data were analyzedby using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bonemarrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiologicalfactors with male predominance. Fever and pallor were striking presenting clinical features.Conclusion: We conclude that Pancytopenia is a common problem with an exhaustive listof differential diagnosis, some of which are easily treatable and reversible. Therefore earlydetection with optimal diagnostic approach to Pancytopenia is required for better managementof patients.

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