scholarly journals Folic Acid, Vitamin B6, B12 Co-supplementation Effect on Inflammatory Status of Diabetic Neuropathy Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 2044-2047
Author(s):  
Etisa Adi Murbawani ◽  
Enny Probosari ◽  
Siti Fatimah Muis ◽  
Heri Nugroho H.S ◽  
Amalia Sukmadianti ◽  
...  
Keyword(s):  
Folic Acid ◽  
Diabetic Neuropathy ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Vital Role ◽  
Control Group ◽  
Inflammatory Status ◽  
Trial Subject ◽  
And Control

Background: Diabetic neuropathy is common in diabetes mellitus patients with the prevalence of 50%. Inflammation takes a vital role in the complex pathogenesis of diabetic neuropathy. The decreased inflammation status is becoming a potential target of therapy and prevention of diabetes complication. Objective: to investigate the supplementation effect of vitamin B6, folic acid, and vitamin B12 in combination to inflammatory status of diabetic neuropathy patients. Method: experimental design with randomized controlled trial. Subject of study diabetic neuropathy patients. Place of study Tugurejo Hospital, Semarang in September 2018 to March 2019, with sample size of 75 subjects (treatment and control group). Results: Subjects of the study consists of 56 females and 19 males. The characteristic of subject in treatment and control group is not significantly different based on sex, vitamin B6, folic acid, vitamin B12 intake, and nutritional status. Compared with placebo, the effect of vitamin B6, folic acid, vitamin B12 co-supplementation is able to decrease serum Hs-CRP significantly with mean difference of -3.0 (CI 95% -4,95, -1,08; p <0,05. Conclusion: Co-supplementation of vitamin B6, folic acid, vitamin B12 is able to significantly decrease inflamation status. Keyword: Folic acid, vitamin B6, vitamin B12, inflammation status, diabetic neuropathy

scholarly journals Intravenous methylcobalamin effectively ameliorated painful diabetic neuropathy: A randomized double-blind placebo controlled trial

2021 ◽  
Vol 20 (3) ◽  
pp. 335-341
Author(s):  
Thomas Eko Purwata ◽  
◽  
I Putu Eka Widyadharma ◽  
Made Rudy ◽  
Andreas Soejitno ◽  
...  
Keyword(s):  
Treatment Group ◽  
Diabetic Neuropathy ◽  
Rating Scale ◽  
Controlled Trial ◽  
Control Group ◽  
Painful Diabetic Neuropathy ◽  
Double Blind ◽  
Entire Study ◽  
Double Blind Placebo ◽  
And Control

Objective. Painful diabetic neuropathy (PDN) is a prevalent debilitating consequence of diabetes mellitus with lack of satisfactory therapeutic options. Methylcobalamin (MeCbl) is one of vitamin B12 analogs with known neurotrophic effects. We aimed to determine if MeCbl can relieve PDN. Materials and methods. This was a randomized (1:1) double-blind placebo-controlled trial involving PDN patients. Treatment and control group received daily 12.5 mg oral amitriptyline bid with either 500 µg of intravenous MeCbl or saline injection given on alternating days, respectively, for a 9-consecutive day period. PDN was assessed with douleur neuropathique 4 (DN4) questionnaire. Numeric pain rating scale (NPRS) was used to monitor pain intensity and treatment response. All investigators and patients were kept blinded throughout the study period. Outcomes. 42 patients, 21 on each arm had completed the study. The NPRS reduction can already be observed as early as day 2 post-intervention. Both the treatment and control group demonstrated sustained reduction of NPRS by almost one point per each time point of evaluation in the first three days (p<0.001). NPRS reduction remained until the end of the study period. The treatment group had a significantly lower NPRS score by 1.29 than that of the control group during the entire study period (95% CI -1.84 – -0.75; p < 0.001). Treatment group experienced significantly higher NPRS reduction when compared with control (4.19±1.54 vs. 2.1± 0.83; 95% CI 1.32-2.87; p < 0.001), i.e. 62.6% from baseline. Conclusions. MeCbl significantly and safely relieved PDN in a relatively rapid onset.

scholarly journals Holo-Transcobalamin Is an Early Marker of Changes in Cobalamin Homeostasis. A Randomized Placebo-controlled Study

2002 ◽  
Vol 48 (10) ◽  
pp. 1768-1771 ◽  
Author(s):  
Ebba Nexo ◽  
Anne-Mette Hvas ◽  
Øyvind Bleie ◽  
Helga Refsum ◽  
Sergey N Fedosov ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Oral Treatment ◽  
Controlled Study ◽  
Control Group ◽  
Oral Vitamin ◽  
Intraindividual Variation ◽  
Early Marker ◽  
B Vitamin

Abstract Background: We examined the effect of oral vitamin B12 treatment on fluctuations in plasma total cobalamin and its binding proteins transcobalamin (TC) and haptocorrin (HC). Methods: Patients (n = 88; age range, 38–80 years) undergoing coronary angiography (part of the homocysteine-lowering Western Norway B-Vitamin Intervention Trial) were allocated to daily oral treatment with (a) vitamin B12 (0.4 mg), folic acid (0.8 mg), and vitamin B6 (40 mg); (b) vitamin B12 and folic acid; (c) vitamin B6; or (d) placebo. EDTA blood was obtained before treatment and 3, 14, 28, and 84 days thereafter. Results: The intraindividual variation for patients not treated with B12 was ∼10% for plasma total cobalamin, total TC, apo-TC, and apo-HC, and &lt;20% for holo-TC and TC saturation. In B12-treated patients, the maximum change in concentrations was observed already after 3 days for total TC (−16%), holo-TC (+54%), and TC saturation (+82%). At this time holo-HC (+20%) and plasma total cobalamin (+28%) showed an initial burst, but had increased further at 84 days. All changes were highly significant compared with the control group (P &lt;0.0001). Conclusions: Oral vitamin B12 treatment produces maximal effects on total TC, holo-TC, and TC saturation within 3 days, whereas maximal increases in holo-HC and plasma total cobalamin occur later. The results support the view that holo-TC is an early marker of changes in cobalamin homeostasis.

scholarly journals Effects of a simple educational intervention in well-baby clinics on women’s knowledge about and intake of folic acid supplements in the periconceptional period: a controlled trial

2014 ◽  
Vol 18 (6) ◽  
pp. 1119-1126 ◽  
Author(s):  
Denhard J de Smit ◽  
Stephanie S Weinreich ◽  
Martina C Cornel
Keyword(s):  
Folic Acid ◽  
Controlled Trial ◽  
Effective Means ◽  
Intervention Group ◽  
Control Group ◽  
Post Intervention ◽  
Actual Use ◽  
Baby Clinic ◽  
Periconceptional Period ◽  
And Control

AbstractObjectiveTo test the hypothesis that a concise intervention to promote the preconception use of folic acid (FA) supplements among mothers who visit a well-baby clinic (WBC) for the 6-month check-up of their youngest child is effective. Effectiveness was measured as intention to use or actual use of FA supplements before a next pregnancy among women who expected to be pregnant within 0–12 months.DesignControlled intervention study with independent samples of intervention and control mothers. The intervention took place at the 6-month visit. A post-intervention measurement was done in the intervention group and a comparable measurement in the control group at the 11-month check-up visit.SettingThe intervention, verbal and in writing, was implemented in four Dutch WBC and given by the WBC physician to the mothers who visited the WBC.SubjectsAll mothers visiting the WBC were eligible for inclusion, unless they were unable to complete a questionnaire. The intervention group consisted of 198 (68 %) mothers recruited from 291 6-month intervention visits and the control group of 215 (84 %) mothers recruited from 255 11-month normal visits.ResultsIn mothers who expected to be pregnant within 0–12 months, the proportion using or intending to use FA was 65 % in the intervention group (n 49) v. 42 % in the control group (n 43; difference 23 %, 95 % CI 4, 43 %, P<0·05).ConclusionsHealth education intervention at the 6-month WBC visit is an effective means to promote the use of FA supplements or the intention to do so.

scholarly journals Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 395
Author(s):  
Triantafyllos Didangelos ◽  
Eleni Karlafti ◽  
Evangelia Kotzakioulafi ◽  
Eleni Margariti ◽  
Parthena Giannoulaki ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Vitamin B12 ◽  
Pain Score ◽  
Sural Nerve ◽  
Controlled Trial ◽  
Active Group ◽  
Control Group ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Sudomotor Function

Aim: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN). Patients and methods: In this prospective, double-blind, placebo-controlled trial, 90 patients with type 2 diabetes on metformin for at least four years and both peripheral and autonomic DN were randomized to an active treatment group (n = 44) receiving B12 and a control group (n = 46) receiving a placebo. All patients had B12 levels less than 400 pmol/L. Subjects underwent measurements of sural nerve conduction velocity (SNCV), sural nerve action potential (amplitude) (SNAP), and vibration perception threshold (VPT), and they performed cardiovascular autonomic reflex tests (CARTs: mean circular resultant (MCR), Valsalva test, postural index, and orthostatic hypotension). Sudomotor function was assessed with the SUDOSCAN that measures electrochemical skin conductance in hands and feet (ESCH and ESCF, respectively). We also used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE, respectively) and questionnaires to evaluate quality of life (QoL) and level of pain (pain score). Results: B12 levels increased from 232.0 ± 71.8 at baseline to 776.7 ± 242.3 pmol/L at follow-up, p < 0.0001, in the active group but not in the control group. VPT, MNSIQ, QoL, pain score, SNCV, SNAP, and ESCF significantly improved in the active group (p < 0.001, p = 0.002, p < 0.0001, p < 0.000, p < 0.0001, p < 0.0001, and p = 0.014, respectively), whereas CARTS and MNSIE improved but not significantly. MCR, MNSIQ, SNCV, SNAP, and pain score significantly deteriorated in the control group (p = 0.025, p = 0.017, p = 0.045, p < 0.0001, and p < 0.0001, respectively). Conclusions: The treatment of patients with DN with 1 mg of oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and QoL, but it did not improve CARTS and MNSIE.

scholarly journals Efek suplementasi kombinasi zat besi, vitamin C, dan asam folat terhadap peningkatan kadar hemoglobin dan kapasitas VO2 maks pada atlet sepak bola divisi utama dan satu nasional di Daerah Istimewa Yogyakarta

2006 ◽  
Vol 3 (2) ◽  
pp. 71
Author(s):  
Zainal Abidin ◽  
Woro Woro ◽  
Mochammad Noerhadi
Keyword(s):  
Folic Acid ◽  
Treatment Group ◽  
Vitamin C ◽  
Controlled Trial ◽  
Control Group ◽  
Football Players ◽  
Vo2 Max ◽  
Significant Difference ◽  
Combined Supplementation ◽  
And Control

Background: Excessive endurance exercise of football players may break their blood cells and decrease the level of haemoglobin (Hb). These will influence the aerobic capacity (VO2 max) and make the need for iron (Fe) of an athlete more than that of common people.Objective: To know the influence of Fe, vitamin C (ascorbic acid), and  folic  acid  combined supplementation to the increase of VO2 max capacity  of  the  national  main  and  first division  club football players in Daerah Istimewa Yogyakarta.Method: The study was RCT (Randomized Controlled Trial) experimental with a completely randomized design plan. The subjects were football players of Perserikatan Sepak Bola Indonesia Mataram (PSIM), Perserikatan Sepak Bola Sleman (PSS), and Perserikatan Sepak Bola Bantul (PERSIBA). They were then divided into two groups: treatment group and control group, each of them consisted of 35 players. Treatment group were given combined supplement capsules of 100 mg Fe, 100 mg vitamin C, and 2 mg folic acid three times a week for eight weeks, while the control group were given the placebo capsules. Before and after supplementation, their Hb and VO2  max were measured. However, the physical exercises were done based on the schedule, programmed by the clubs.Results: Combined supplementation of Fe, vitamin C, and folic acid could increase Hb level significantly (p=0.008), but there was no significant difference of VO2  max capacity between treatment group and control group (p=0.062). However, there was significant correlation between the increase of Hb level and VO  max capacity (r=0.712; p<0.001).Conclusion: Combined supplementation of Fe, vitamin C, and folic acid led to the increase of Hb level of main and first division clubs football players in Daerah Istimewa Yogyakarta, but could not influence their VO2 max capacity.

The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ellahe Mohyadin ◽  
Zohreh Ghorashi ◽  
Zahra Molamomanaei
Keyword(s):  
Controlled Trial ◽  
Intervention Group ◽  
Total Duration ◽  
Measurement Data ◽  
Labor Pain ◽  
Control Group ◽  
Chi Square ◽  
Nulliparous Women ◽  
Two Stages ◽  
And Control

AbstractBackgroundAnxiety and fear of labor pain has led to elevated cesarean section rate in some countries. This study was conducted to investigate the effect of yoga in pregnancy on anxiety, labor pain and length of labor stages.MethodsThis clinical trial study was performed on 84 nulliparous women who were at least 18 years old and were randomly divided into two groups of yoga and control groups. Pregnancy Yoga Program consisting of 6 60-min training sessions was started every 2 weeks from week 26 of pregnancy and continued until 37 weeks of gestation. Anxiety severity at maternal admission to labor was measured by the Spielbergers State-Trait Anxiety Inventory, and labor pain was measured by Visual Analogue Scale (VAS) at dilatation (4–5 cm) and 2 h after the first measurement. Data were analyzed using Chi-Square and t-test.ResultsIntervention group reported less pain at dilatation (4–5 cm) (p=0.001) and 2 h after the first measurement (p=0.001) than the control group. Stat anxiety was also lower in intervention group than the control group (p=0.003) at the entrance to labor room. Subjects in the control group required more induction compared to intervention group (p=0.003). Women in intervention group experienced shorter duration of the first phase of the labor than the control group (p=0.002). Also, the total duration of two stages of labor was shorter in intervention group than the control group (p=0.003).ConclusionsPracticing yoga during pregnancy may reduce women’s anxiety during labor; shorten labor stages, and lower labor pain.

scholarly journals Toe Clearance Rehabilitative Slippers for Older Adults With Fall Risk: A Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
pp. 215145932110291
Author(s):  
Atsuko Satoh ◽  
Yukoh Kudoh ◽  
Sangun Lee ◽  
Masumi Saitoh ◽  
Miwa Miura ◽  
...  
Keyword(s):  
Older Adults ◽  
Fall Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Berg Balance Scale ◽  
Control Group ◽  
Mobility Assessment ◽  
Before And After ◽  
Day Services ◽  
And Control

Introduction: To evaluate fall-prevention rehabilitative slippers for use by self-caring, independent older adults. Materials and Methods: This assessor-blinded, randomized, and controlled 1-year study included 59 self-caring, independent participants (49 women) who attended day services. The mean age of participants was 84.0 ± 5.3 years. Participants were randomly selected from 8 nursing homes. We tested slippers top-weighted with a lead bead (200, 300, or 400 g). Intervention group participants walked while wearing the slippers for 10-20 min, 1-3 days/week at the day service center. Fall risk was measured using the Berg Balance Scale and the Tinetti Performance-Oriented Mobility Assessment (POMA) before and at 3-month intervals after the intervention/control phase. Results: After 12 months, the intervention group demonstrated significant improvement. Berg Balance and POMA compared to the control group ( p < .05 p < .01, respectively). Mobility scores improved significantly for both measurements in the intervention group before and after ( p < .01), but the control group had significantly lower scores. Discussion: Overall, falls decreased in the intervention group from 10 to 7, and control group falls increased from 9 to 16 ( p = .02). No adverse events related to the intervention were reported. Conclusions: Rehabilitation training slippers may reduce falls in older adults.

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