The relationship of hs-CRP with regulation of hypertension in patients who have both Type 2 diabetes mellitus and hypertension

Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease. Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED. Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test. Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022). Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months) have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.

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The relationship of vitamin D with compensation of carbohydrate metabolism in patients with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.14.4.2018.140184 ◽

2018 ◽

Vol 14 (4) ◽

pp. 323-327

Author(s):

Yu.A. Titova ◽

K.V. Misura ◽

N.O. Kravchun

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Fatty Liver Disease ◽

Alcoholic Fatty Liver ◽

Relationship Of ◽

The Relationship ◽

Alcoholic Fatty Liver Disease

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Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus

Frontiers in Endocrinology ◽

10.3389/fendo.2021.695750 ◽

2021 ◽

Vol 12 ◽

Author(s):

Mengni Li ◽

Rongping Fan ◽

Xuemin Peng ◽

Jiaojiao Huang ◽

Huajie Zou ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Serum Levels ◽

Hs Crp ◽

The Relationship

BackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear.AimTo Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status.MethodsA total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models.ResultsSerum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P <0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P<0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=<0.001) but no significant correlation to HOMA-IR(respectively; P>0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P<0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P<0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%.ConclusionThis study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN.

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The relationship of miR-146a gene polymorphism with carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus

Thrombosis Research ◽

10.1016/j.thromres.2015.10.013 ◽

2015 ◽

Vol 136 (6) ◽

pp. 1149-1155 ◽

Cited By ~ 12

Author(s):

Jing Shen ◽

Min Zhang ◽

Mingfang Sun ◽

Kang Tang ◽

Bo Zhou

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gene Polymorphism ◽

Carotid Atherosclerosis ◽

Chinese Patients ◽

Relationship Of ◽

The Relationship

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The Relationship of Compliance to Follow Prolanis with the Stability of Blood Sugar Levels of Patients with Type 2 Diabetes Mellitus at the Lumpue Health Center in Pare-Pare City

IAKMI Public Health Journal Indonesia ◽

10.46366/iphji.1.1.21-26 ◽

2020 ◽

Vol 1 (1) ◽

pp. 21-26

Author(s):

Sri Syatriani ◽

Yenni Purnamawati

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Health Center ◽

Blood Sugar ◽

Sugar Levels ◽

The Stability ◽

Relationship Of ◽

The Relationship

Diabetes Mellitus is a disease that can cause complications to prevent complications can be done by maintaining the stability of blood sugar in people with diabetes. One of the efforts of patientss of Diabetes mellitus (DM) in maintaining the stability of blood sugar levels is to adhere to one of the Corneal Disease Management Programs (PROLANIS). The prevalence of diabetes mellitus in Indonesia in 2018 will reach 10.9%. The purpose of this study was to determine the relationship of compliance to follow prolanis with the stability of blood sugar levels of patientss with type 2 diabetes mellitus. This type of research is analytic research with cross sectional study design. The sample in this study were all patientss of diabetes mellitus who participated in the prolanis activities of 40 respondents at the Lumpue Health Center in Parepare City in September 2018 - January 2019 which were selected by total sampling technique. Data were analyzed by Chi-Square test. The results showed that most of the respondents included in the category of obediently followed prolanis, as many as 31 (77.5%) people and the majority with stable blood sugar, as many as 31 (77.5%) people. Relationship test results obtained p value (0,000) <α (0.05), which means there is an relationship compliance to follow Prolanis with the stability of blood sugar in patientss with diabetes mellitus in the Lumpue Health Center in Parepare City. The conclusion of this research is that there is an relationship compliance to follow Prolanis with the stability of blood sugar. Patientss with diabetes mellitus are expected to routinely participate in prolanis activities held at each puskesmas to stabilize blood sugar levels.

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The relationship of health beliefs and complication prevention behaviors of Chinese individuals with Type 2 Diabetes Mellitus

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2004.02.021 ◽

2004 ◽

Vol 66 (1) ◽

pp. 71-77 ◽

Cited By ~ 30

Author(s):

Ming Yeong Tan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Health Beliefs ◽

Relationship Of ◽

The Relationship

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The relationship of HbA1c levels with creatinin levels in diabetes mellitus type 2 patients

PUINOVAKESMAS ◽

10.29238/puinova.v1i2.980 ◽

2020 ◽

Vol 1 (2) ◽

pp. 84-93

Author(s):

Putri Nur Cahyani ◽

Atik Martsiningsih ◽

Budi Setiawan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Secondary Data ◽

Rank Test ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship ◽

Hba1c Levels

Background: People with Type 2 Diabetes Mellitus in Indonesia continue to increase in prevalence. Understanding of complications due to this disease, one of which is diabetic nephropathy or damage to kidney nephrons. Objective: To determine the relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus. Method: This study was an observational experiment using a cross sectional approach based on secondary data. The research was carried out in February to April 2020. The population of this research study is a member of Prolanis (Chronic Disease Management Advanced Program) in Gamping 1 Puskesmas Sleman Yogyakarta. Sample with 24 patients. Analysis of data using the Spearman’s test. Results: From the results of the normality test using the Shapiro Wilk test data obtained were not normally distributed so that continued with the Spearman rank test obtained r of -0.006 and p values with sig. (2-tailed) of 0.961 or> 0.05 (H0 received). This means that there is no relationship between HbA1c levels and blood creatinine levels in patients with type 2 DM. Conclusion: There is no relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus.

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