The relationship of miR-146a gene polymorphism with carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus

2015 ◽  
Vol 136 (6) ◽  
pp. 1149-1155 ◽  
Author(s):  
Jing Shen ◽  
Min Zhang ◽  
Mingfang Sun ◽  
Kang Tang ◽  
Bo Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Carotid Atherosclerosis ◽  
Chinese Patients ◽  
Relationship Of ◽  
The Relationship

scholarly journals ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yan-Hong Pan ◽  
Min Wang ◽  
Yan-Mei Huang ◽  
Ying-Hui Wang ◽  
Yin-Ling Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Patients ◽  
Ace Gene ◽  
Polymerase Chain ◽  
Relationship Of ◽  
The Relationship

Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m2and subjects were classified into 4 groups (lean, normal, overweight, and obese). PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients. Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained. Frequencies of the ACE genotypes (DD, ID, and II) were not significant among the 4 groups of BMI-defined patients (P=0.679) while ACE II carriers showed higher systolic blood pressure (SBP) and pulse pressure (PP) (allP<0.050). Hyperglycemia, hypertension, and dyslipidemia in these T2DM patients were found to be significantly associated with BMI. In conclusion, the relationship of ACE gene I/D polymorphism with obesity is insignificant in Chinese patients with T2DM. SBP and PP might be higher in the ACE II carriers than in the DD and ID carriers.

scholarly journals Relationship of Type 2 Diabetes Mellitus Duration with The Occurrence of Erectile Dysfunction at Puskesmas Denpasar Barat I

2021 ◽  
Vol 2 (1) ◽  
pp. 23-28
Author(s):  
Alexander Petra Sihite ◽  
I Gusti Ngurah Pramesemara ◽  
I Wayan Surudarma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Number Of Patients ◽  
Relationship Of ◽  
The Relationship

Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease. Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED. Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test. Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022). Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months)  have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.

scholarly journals Vascular Endothelial Growth Factor Gene Polymorphism (rs2010963) and Its Receptor, Kinase Insert Domain-Containing Receptor Gene Polymorphism (rs2071559), and Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Sebastjan Merlo ◽  
Jovana Nikolajević Starčević ◽  
Sara Mankoč ◽  
Marija Šantl Letonja ◽  
Andreja Cokan Vujkovac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vascular Endothelial Growth Factor ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Carotid Atherosclerosis ◽  
Vascular Endothelial ◽  
Receptor Kinase ◽  
Endothelial Growth Factor

Background. The current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor (VEGF) gene (rs2010963) and its receptor, kinase insert domain-containing receptor (KDR) gene polymorphism (rs2071559), and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Patients and Methods. 595 T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Genotyping of VEGF/KDR polymorphisms (rs2010963, rs2071559) was performed using KASPar assays.Results. Genotype distributions and allele frequencies of the VEGF/KDR polymorphisms (rs2010963, rs2071559) were not statistically significantly different between diabetic patients and controls. In our study, we demonstrated an association between the rs2071559 of KDR and either CIMT or the sum of plaque thickness in subjects with T2DM. We did not, however, demonstrate any association between the tested polymorphism of VEGF (rs2010963) and either CIMT, the sum of plaque thickness, the number of involved segments, hsCRP, the presence of carotid plaques, or the presence of unstable carotid plaques.Conclusions. In the present study, we demonstrated minor effect of the rs2071559 of KDR on markers of carotid atherosclerosis in subjects with T2DM.

scholarly journals PECAM-1 gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

2016 ◽  
Vol 19 (1) ◽  
pp. 63-70 ◽  
Author(s):  
D Popović ◽  
J Nikolajević Starčević ◽  
M Šantl Letonja ◽  
J Makuc ◽  
A Cokan Vujkovac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Carotid Atherosclerosis ◽  
Control Group ◽  
Minor Effect ◽  
Initial Examination ◽  
Increased Risk

ABSTRACTThe platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important role in many inflammatory processes, including the development of atherosclerosis. Polymorphism rs668 of the PECAM-1 gene (373C/G) is functional, and it was reported to be associated with increased serum levels of PECAM-1. We investigated the association between the rs668 polymorphism of PECAM-1 and subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Geno-typing of the PECAM-1 gene polymorphism (rs668) was performed using KASPar assays. The control examinations were performed 3.8 ± 0.5 years after the initial examination. Higher CIMT was found in patients with T2DM in comparison with subjects without T2DM. Statistically sig-nificantly faster progression of the atherosclerotic markers was shown in subjects with T2DM in comparison with the control group. When adjusted to other risk factors, the rs668 GG genotype was associated with an increased risk of carotid plaques in subjects with T2DM. We concluded that our study demonstrated a minor effect of the rs668 PECAM-1 on markers of carotid atherosclerosis in subjects with T2DM.

The Relationship of Compliance to Follow Prolanis with the Stability of Blood Sugar Levels of Patients with Type 2 Diabetes Mellitus at the Lumpue Health Center in Pare-Pare City

2020 ◽  
Vol 1 (1) ◽  
pp. 21-26
Author(s):  
Sri Syatriani ◽  
Yenni Purnamawati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Center ◽  
Blood Sugar ◽  
Sugar Levels ◽  
The Stability ◽  
Relationship Of ◽  
The Relationship

Diabetes Mellitus is a disease that can cause complications to prevent complications can be done by maintaining the stability of blood sugar in people with diabetes. One of the efforts of patientss of Diabetes mellitus (DM) in maintaining the stability of blood sugar levels is to adhere to one of the Corneal Disease Management Programs (PROLANIS). The prevalence of diabetes mellitus in Indonesia in 2018 will reach 10.9%. The purpose of this study was to determine the relationship of compliance to follow prolanis with the stability of blood sugar levels of patientss with type 2 diabetes mellitus. This type of research is analytic research with cross sectional study design. The sample in this study were all patientss of diabetes mellitus who participated in the prolanis activities of 40 respondents at the Lumpue Health Center in Parepare City in September 2018 - January 2019 which were selected by total sampling technique. Data were analyzed by Chi-Square test. The results showed that most of the respondents included in the category of obediently followed prolanis, as many as 31 (77.5%) people and the majority with stable blood sugar, as many as 31 (77.5%) people. Relationship test results obtained p value (0,000) <α (0.05), which means there is an relationship compliance to follow Prolanis  with the stability of blood sugar in patientss with diabetes mellitus in the Lumpue Health Center in Parepare City. The conclusion of this research is that there is an relationship compliance to follow Prolanis with the stability of blood sugar. Patientss with diabetes mellitus are expected to routinely participate in prolanis activities held at each puskesmas to stabilize blood sugar levels.

scholarly journals The relationship of HbA1c levels with creatinin levels in diabetes mellitus type 2 patients

PUINOVAKESMAS ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 84-93
Author(s):  
Putri Nur Cahyani ◽  
Atik Martsiningsih ◽  
Budi Setiawan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Secondary Data ◽  
Rank Test ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship ◽  
Hba1c Levels

Background: People with Type 2 Diabetes Mellitus in Indonesia continue to increase in prevalence. Understanding of complications due to this disease, one of which is diabetic nephropathy or damage to kidney nephrons. Objective: To determine the relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus. Method: This study was an observational experiment using a cross sectional approach based on secondary data. The research was carried out in February to April 2020. The population of this research study is a member of Prolanis (Chronic Disease Management Advanced Program) in Gamping 1 Puskesmas Sleman Yogyakarta. Sample with 24 patients. Analysis of data using the Spearman’s test. Results: From the results of the normality test using the Shapiro Wilk test data obtained were not normally distributed so that continued with the Spearman rank test obtained r of -0.006 and p values with sig. (2-tailed) of 0.961 or> 0.05 (H0 received). This means that there is no relationship between HbA1c levels and blood creatinine levels in patients with type 2 DM. Conclusion: There is no relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus.

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