scholarly journals Surface Plasmon Resonance Biosensor in Healthcare Application Using Kretschsmann & Otto Configuration

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Nusrat Alim ◽  
Mohammad Nasir Uddin

In this study, a planar D-shape optical fiber sensor based on Surface Plasmon Resonance phenomenon using two different excitation methods has been demonstrated. The proposed bio-sensor uses Amplitude-Wavelength hybrid detection technique to determine the change in urine refractive index that depends on resonance parameters. The analysis employs finite element method to investigate the optical properties of the proposed sensor. From the results it can be evident that Otto configuration offers greater amount of reflected light intensity dip for a particular urine refractive index in comparison with Kretschmann configuration. For an example, for Otto configuration the dip of reflected light intensity measured in terms of reflectance which attains a value 0.5 for ns (urine refractive index) of 1.489 while Kretschmann configuration provides a dip of 0.65 for the same value of ns. Results also show that the sharpness of reflectance is comparatively higher for the sensor using Otto configuration in comparison with Kretschmann configuration in case of wavelength interrogation. Thus, Otto configuration offers better performance in comparison with Kretschmann configuration.

2018 ◽  
Vol 8 (7) ◽  
pp. 1172 ◽  
Author(s):  
Nunzio Cennamo ◽  
Luigi Zeni ◽  
Ester Catalano ◽  
Francesco Arcadio ◽  
Aldo Minardo

In this paper, we show that light-diffusing fibers (LDF) can be efficiently used as host material for surface plasmon resonance (SPR)-based refractive index sensing. This novel platform does not require a chemical procedure to remove the cladding or enhance the evanescent field, which is expected to give better reproducibility of the sensing interface. The SPR sensor has been realized by first removing the cladding with a simple mechanical stripper, and then covering the unclad fiber surface with a thin gold film. The tests have been carried out using water–glycerin mixtures with refractive indices ranging from 1.332 to 1.394. The experimental results reveal a high sensitivity of the SPR wavelength to the outer medium’s refractive index, with values ranging from ~1500 to ~4000 nm/RIU in the analyzed range. The results suggest that the proposed optical fiber sensor platform could be used in biochemical applications.


2020 ◽  
Vol 16 (2) ◽  
pp. 83-91
Author(s):  
N. K. Quang ◽  
N. P. Q. Anh ◽  
H. C. Hieu

This article describes a simple numerical simulation of three-layer surface plasmon resonance (SPR) in the Kretschmann configuration. The calculation was performed in Google Sheets, a web-based spreadsheet environment that functions similarly to Microsoft Excel where it is easily accessible for students via the internet. Specifically, Fresnel’s equations were utilized to calculate the intensity of the reflected light for the p-polarized incident light on a three-layer system. The complex functions were utilized to plot the SPR curves. We examined the change of the resonance angle by the influence of the incident wavelength. The simulation was also performed for different thicknesses of the gold film layer. To demonstrate the sensitivity, we obtained the SPR curves with the variation of the refractive index in the sensitive medium. The SPR accuracy was analysed by comparing our obtained result with the published work. It is intended to incorporate into undergraduate instrumental analysis courses.


2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Iraj S. Amiri ◽  
Siti Anis Khairani Alwi ◽  
Sofiah Atirah Raya ◽  
Nur Aina’a Mardhiah Zainuddin ◽  
Nurul Syazwani Rohizat ◽  
...  

AbstractThis research focuses on the side-polished Single-Mode Optical Fibers (SMOF) as refractive index (RI) sensor utilizing properties of Surface Plasmon Resonance. The SMOF with cladding stripped off shows a D-shaped optical fiber with high sensitivity functionalization. Here we show silver protected by graphene oxide (GO) as viable candidates. A few layers of GO on top of silver thin layer were applied as a material to overcome silver coating degradation process. This silver/GO sensor was characterized using various RIs of analyte likely deionized water and alcohol solutions. Sensor with GO has shown fast response and high sensitivity in respect of RI, where sensitivity increases in range from 1.30 to 1.34 RIU (refractive index unit). This device shows highest sensitivity of up to 833.33 nm/ RIU. The polishing process using SMOF stops at few microns above the core of the fiber with the drop of output power fixed to be 1 dB as an indication to standardize the amount of cladding been removed. The thickness of 30 nm Ag was deposited using electron beam evaporation method on D-shaped optical fiber with subsequent protected layer of GO in solutions form. The use of COMSOL Multiphysics has also been carried out to observe numerical findings. The response of the GO has shown a sensitivity improvement which proves new promising approaches for the newly developed sensors.


Photonics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 41
Author(s):  
Najat Andam ◽  
Siham Refki ◽  
Hidekazu Ishitobi ◽  
Yasushi Inouye ◽  
Zouheir Sekkat

The determination of optical constants (i.e., real and imaginary parts of the complex refractive index (nc) and thickness (d)) of ultrathin films is often required in photonics. It may be done by using, for example, surface plasmon resonance (SPR) spectroscopy combined with either profilometry or atomic force microscopy (AFM). SPR yields the optical thickness (i.e., the product of nc and d) of the film, while profilometry and AFM yield its thickness, thereby allowing for the separate determination of nc and d. In this paper, we use SPR and profilometry to determine the complex refractive index of very thin (i.e., 58 nm) films of dye-doped polymers at different dye/polymer concentrations (a feature which constitutes the originality of this work), and we compare the SPR results with those obtained by using spectroscopic ellipsometry measurements performed on the same samples. To determine the optical properties of our film samples by ellipsometry, we used, for the theoretical fits to experimental data, Bruggeman’s effective medium model for the dye/polymer, assumed as a composite material, and the Lorentz model for dye absorption. We found an excellent agreement between the results obtained by SPR and ellipsometry, confirming that SPR is appropriate for measuring the optical properties of very thin coatings at a single light frequency, given that it is simpler in operation and data analysis than spectroscopic ellipsometry.


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