scholarly journals The Benefits of Consuming Sardines to Prevent Hypertension and Type 2 Diabetes Mellitus for Senior Citizens

2021 ◽  
Vol 1 (1) ◽  
pp. 893-906
Author(s):  
Vallensia Nurdiana Febriyanti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Senior Citizens ◽  
Insulin Receptors ◽  
Omega 3 ◽  
Literature Study ◽  
Study Approach ◽  
Social And Economic Development

Along with the increasing number of senior citizens in Indonesia, the number of cases of non-communicable diseases (NCDs), especially hypertension and diabetes mellitus experience escalation too, which certainly will have a direct impact on human resource productivity, social and economic development. In addition, hypertension and type 2 diabetes mellitus are the causes of the highest mortality rates in Indonesia. This article aims to encourage the public especially the senior citizens to prevent hypertension and type 2 diabetes mellitus by consuming fish containing high omega 3, EPA, and DHA, such as sardines at least twice a week or the equivalent of 200-400 grams a week. In terms of the methods, a literature study approach was employed in elaborating the research topic. The findings of this study demonstrate that sardines contain anti-inflammatory, antioxidant roles, boost the membrane fluidity, boost the number of insulin receptors and insulin action, and also contain hypotensive and hypoglycemic effects. In this manner, sardines are highly proven to be able to effectively prevent type 2 diabetes mellitus, prevent hypertension, and lower blood pressure, especially for senior citizens.

scholarly journals Omega‐3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial

2020 ◽  
Vol 91 (10) ◽  
pp. 1318-1327 ◽  
Author(s):  
Nidia C. Castro dos Santos ◽  
Naira M. R. B. Andere ◽  
Cássia F. Araujo ◽  
Andrea C. Marco ◽  
Alpdogan Kantarci ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Clinical Trial ◽  
Omega 3 ◽  
Periodontal Debridement

Treating Type 2 Diabetes: A Cross-sectional Audit of Naturopathic Standards of Care Using the Naturopathic Patient Database

2012 ◽  
Vol 17 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Christopher Habib ◽  
Matthew Gowan ◽  
Stefan Podgrabinski ◽  
Tom Grodski ◽  
Brenda Leung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
American Diabetes Association ◽  
Management Tool ◽  
Standards Of Care ◽  
Dependent Diabetes Mellitus ◽  
Omega 3 ◽  
Patient Database

The Naturopathic Patient Database is a data management tool developed by the Canadian College of Naturopathic Medicine to collect patient data from its teaching clinic, the Robert Schad Naturopathic Clinic. This study investigated how type 2 diabetes mellitus was managed at the Robert Schad Naturopathic Clinic from May 2009 to February 2011. Cases of type 2 diabetes mellitus from the Robert Schad Naturopathic Clinic reported in the Naturopathic Patient Database were extracted based on an International Classification of Diseases, 10th revision code assessment of E11 (non-insulin-dependent diabetes mellitus) and files were audited. The American Diabetes Association 2010 standards of medical care in diabetes were used as guidelines for the audit. Multiple categories in diagnosis, physical exam, laboratory tests, and management were graded on a 0 to 2 scale. The average audit score was 55.5/90. The most common interventions being used are diet and aerobic exercise, followed by supplements (omega-3 fatty acids) and botanicals. These data suggest that the American Diabetes Association standards of care for type 2 diabetes mellitus are not followed stringently. Education and creation of a naturopathic standard of care may improve audit performance and patient outcomes.

A Review of Type 2 Diabetes Mellitus Predisposing Genes

2019 ◽  
Vol 16 (1) ◽  
pp. 52-61 ◽  
Author(s):  
Tajudeen O. Yahaya ◽  
Titilola F. Salisu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pancreatic Beta Cells ◽  
Healthcare Providers ◽  
Insulin Receptors ◽  
Relevant Information ◽  
Insulin Biosynthesis ◽  
Google Search

Introduction:Scientists are considering the possibility of treating diabetes mellitus (DM) using a personalized approach in which various forms of the diseases will be treated based on the causal gene and its pathogenesis. To this end, scientists have identified mutations in certain genes as probable causes of Type 2 diabetes mellitus (T2DM) with diverse mechanisms.Aim:This review was aimed at articulating already identified T2DM genes with their mechanisms of action and phenotypic presentations for the awareness of all stakeholders.Method:Method: The Google search engine was used to retrieve relevant information on the subject from reliable academic databases such as PubMed, Medline, and Google Scholar, among others.Results:At least seventy (70) genes are currently being suspected in the biogenesis of T2DM. However, mutations in, or variants of KCNJ11, PPARG, HNF1B and WFS1 genes, are the most suspected and reported in the pathogenesis of the disease. Mutations in these genes can cause disruption of insulin biosynthesis through the destruction of pancreatic beta cells, change of beta cell morphology, destruction of insulin receptors, among others. These cellular events may lead to insulin resistance and hyperglycemia and, along with environmental triggers such as obesity and overweight, culminate in T2DM. It was observed that each identified gene has its distinct mechanism by which it interacts with other genes and environmental factors to cause T2DM.Conclusion:Healthcare providers are advised to formulate T2DM drugs or treatment by targeting the causal genes along with their mechanisms.

scholarly journals Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu Bai ◽  
Ke Mo ◽  
Guirong Wang ◽  
Wanling Chen ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptors ◽  
Control Group ◽  
Sensitivity Index

As a severe metabolic disease, type 2 diabetes mellitus (T2DM) has become a serious threat to human health in recent years. Gastrodin, as a primary chemical constituent in Gastrodia elata Blume, has antidiabetic effects. However, the possible mechanisms are unclear. The aim of the present study was to investigate the effects and possible mechanisms of gastrodin on the treatment of T2DM. In vivo, after treatment with gastrodin for 6 weeks, fasting blood glucose levels, blood lipid metabolism, and insulin sensitivity index values were remarkably reduced compared with those of the diabetic control group. The values of aspartate aminotransferase and alanine aminotransferase also showed that gastrodin alleviates liver toxicity caused by diabetes. Moreover, gastrodin relieved pathological damage to the pancreas in T2DM rats. In vitro, gastrodin alleviated insulin resistance by increasing glucose consumption, glucose uptake, and glycogen content in dexamethasone-induced HepG2 cells. The Western blotting results showed that gastrodin upregulated the expression of insulin receptors and ubiquitin-specific protease 4 (USP4) and increased the phosphorylation of GATA binding protein 1 (GATA1) and protein kinase B (AKT) in vivo and in vitro. Furthermore, gastrodin decreased the ubiquitin level of the insulin receptor via UPS4 and increased the binding of GATA1 to the USP4 promoter. Additionally, administration of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway inhibitors MK-2206 and LY294002 abolished the beneficial effects of gastrodin. Our results indicate that gastrodin promotes the phosphorylation of GATA1 via the PI3K/AKT pathway, enhances the transcriptional activity of GATA1, and then increases the expression level of USP4, thereby reducing the ubiquitination and degradation of insulin receptors and ultimately improving insulin resistance. Our study provides scientific evidence for the beneficial actions and underlying mechanism of gastrodin in the treatment of T2DM.

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