Comparative Studies of Platelet-Rich Plasma (PRP) and Prolotherapy for Proximal Biceps Tendinitis

PURPOSE: This research sought to study Platelet-Rich Plasma therapy (PRP) and prolotherapy for shoulder pain and dysfunction related to symptomatic biceps tendinopathy, and to judge effective results.MATERIALS AND METHODS: We selected 100 cases that had significant inflammatory effusion of the biceps tendon (that was shown on MRI), and was refractory to conservative treatment. The cases were followed up for more than one year and were divided into 2 groups. The 1st group received PRP therapy; the 2nd group received prolotherapy under sonographic guidance. We evaluated results for visual analog score (VAS), (Korean Shoulder Society Score (KSS), UCLA Score, Constant Shoulder Score (CSS) for 12 months.RESULTS: There was no significant difference between the 2 groups in the first month after the procedure. However, in the third, sixth, and twelfth months after the procedure, the 1st group showed significant improved results for VAS, KSS, UCLA, and CSS scores compared to the 2nd group (p<0.05).CONCLUSION: Among nonsurgical treatments, both PRP and prolotherapy could be effective against biceps tendinopathy. But, PRP treatment is considered as more reliable method than prolotherapy for maintaining effective results.

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Poster 215 Platelet-Rich Plasma Therapy for Chronic Distal Biceps Tendon Tear: A Case Report

PM&R ◽

10.1016/j.pmrj.2014.08.606 ◽

2014 ◽

Vol 6 (9) ◽

pp. S260-S261

Author(s):

Michael J. Ingraham ◽

Arthur J. Deluigi ◽

Bryan Murtaugh

Keyword(s):

Case Report ◽

Platelet Rich Plasma ◽

Biceps Tendon ◽

Distal Biceps Tendon ◽

Tendon Tear ◽

Plasma Therapy ◽

Distal Biceps

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A Comparative Study of Efficacy of Miniature Punch Grafting and Platelet Rich Plasma Therapy in Treatment of Focal Stable Vitiligo in 50 Cases

International Journal of Research and Review ◽

10.52403/ijrr.20220104 ◽

2022 ◽

Vol 9 (1) ◽

pp. 28-33

Author(s):

Vijay Soyal ◽

Deval N Vora ◽

Jinali Makwana

Keyword(s):

Skin Disorder ◽

Platelet Rich Plasma ◽

Treatment Options ◽

Average Response ◽

Plasma Therapy ◽

Treatment Assessment ◽

The Past ◽

Pre Treatment ◽

Score Result ◽

One Year

Introduction: Vitiligo, a depigmented skin disorder is characterized by selective loss of melanocytes, which in turn leads to pigment dilution in the affected areas of the skin. The characteristic lesion is a totally amelanotic, non scaly, chalky white macule with distinct margins. If the disease is not progressing for the past one year it is described as stable vitiligo. There are various treatment options available for the treatment of focal stable vitiligo. It can be safely treated with miniature punch grafting as well as platelet rich plasma therapy. Aims and Objectives: Aim of this study is to compare efficacy of miniature punch grafting and platelet rich plasma therapy and to evaluate the outcome of treatment of focal stable vitiligo. Materials and Methods: Total 50 patients were selected and divided into two groups. One group was treated with miniature punch grafting while the other group underwent platelet rich plasma therapy. Pre-treatment and post treatment assessment was done by VASI (Vitiligo area scoring index) score. Result: A total of 25 patients were selected for grafting. Perigraft pigmentation was evident from 3rd week of grafting steadily increasing up to the end point of record i.e 6months. 17 patients showed good response, 4 patients showed average response while 4 patients showed poor or no response at all. Out of the 25 patients taken for platelet rich plasma therapy, 7 patients showed good response, 7 patients showed average response while 11 patients showed poor or no response at all. Conclusion: Miniature punch grafting showed better response as compared to platelet rich plasma therapy but both the therapies have their pros and shortcomings. Keywords: Vitiligo, miniature punch grafting, platelet rich plasma, VASI.

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A comparative study of efficacy and safety of platelet rich plasma versus fractional co2 laser in the treatment of post acne scars

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20191760 ◽

2019 ◽

Vol 5 (2) ◽

pp. 254

Author(s):

Amita Murali Babu ◽

Vinma H. Shetty ◽

Saumya Goel ◽

Hafsa Eram

Keyword(s):

Comparative Study ◽

Platelet Rich Plasma ◽

Subjective Assessment ◽

Treatment Session ◽

Grading System ◽

Efficacy And Safety ◽

The Third ◽

Acne Scars ◽

Significant Difference ◽

Group A

Background: Facial scars prompt restorative issues and have mental impacts, for example, humiliation, poor confidence, and social isolation. This study intends to assess efficacy and safety of platelet rich plasma (PRP) versus CO2 laser in post acne scar treatment.Methods: It is an outpatient based comparative study. All patients enlisted in this study were separated into two groups, ten in each treatment group. In group A, patients received PRP month to month for 3 sittings and followed up eight weeks after the third sitting. In group B, patients received fractional CO2 laser month to month for 3 sittings and followed up eight weeks after the third sitting. Improvement of acne scars was assessed utilizing digital photographs with identical camera settings and Goodman and Baron’s qualitative grading system at beginning, after each sitting and followed up eight weeks after the third sitting. Patients subjectively evaluated clinical improvement eight weeks after the last sitting. Software (SPSS, version 16.0 statistical packages) was used.Results: Assessment using qualitative acne scars grading system prior to and after treatment as well as patient’s subjective assessment 2 months after the third treatment session showed significant improvement in both groups. The baseline scores before treatment for group A and B were similar (p=0.7678) and final scores of both treatment groups showed no significant difference (p=0.8011) after treatment.Conclusions: This study shows that PRP as well as fractional CO2 laser result in significant clinical change in the quality of post acne scars.

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ALLOGENEIC PLATELET-RICH PLASMA FOR ROTATOR CUFF REPAIR

Acta Ortopédica Brasileira ◽

10.1590/1413-785220172501163417 ◽

2017 ◽

Vol 25 (1) ◽

pp. 38-43 ◽

Cited By ~ 4

Author(s):

CHRIS HYUNCHUL JO ◽

JI SUN SHIN ◽

SEUNG YEON LEE ◽

SUE SHIN

Keyword(s):

Rotator Cuff ◽

Rotator Cuff Repair ◽

Platelet Rich Plasma ◽

Level Of Evidence ◽

Cross Sectional ◽

Significant Difference ◽

One Year ◽

Arthroscopic Rotator Cuff ◽

Retrospective Comparative Study ◽

Cuff Repair

ABSTRACT Objective: To investigate the safety and efficacy of allogeneic platelet-rich plasma (PRP) in rotator cuff repair . Methods: Seventeen patients with a full-thickness rotator cuff tear were included. Ten patients underwent arthroscopic rotator cuff repair with allogeneic, and seven patients with autologous PRP. Three PRP gels in a volume 3 ml each were applied between the torn end and the greater tuberosity. Clinical outcomes were assessed preoperatively and at a minimum of 2 years after surgery. Structural outcomes were evaluated with the presence of retear and the change of the cross-sectional area (ACT) of the supraspinatus . Results: Allogeneic PRP did not cause any adverse events during the follow-up period. There was no significant difference in the clinical outcome measures between the two groups (all p > 0.05). The retear rate was 33.3% and 25.0% in the allogeneic group and autologous group, respectively (p = 0.764). The change between the one-year postoperative and immediately postoperative ACT was not also significantly different between the two groups (p = 0.373) . Conclusion: Allogeneic PRP in arthroscopic rotator cuff did not cause any local or general complications and that has the efficacy comparable to autologous PRP with respect to the clinical and structural outcomes. Level of Evidence III, Retrospective Comparative Study.

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Platelet-rich plasma for the improvement in shoulder function in rotator cuff disorders

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20185339 ◽

2018 ◽

Vol 5 (1) ◽

pp. 156

Author(s):

Shashi Kant Kumar Singh ◽

Ankur Ojha

Keyword(s):

Rotator Cuff ◽

Shoulder Pain ◽

Platelet Rich Plasma ◽

Shoulder Function ◽

Rotator Cuff Tears ◽

Time Interval ◽

New Treatment ◽

One Year ◽

Partial Rotator Cuff Tear ◽

Shoulder Score

Background: Among causes of shoulder pain, rotator cuff disorders are very common. The exact pathogenesis of rotator cuff tears is not clearly understood. To improve outcomes, the relatively new technique of injection of PRP is under investigation. Purpose of this study is to clinically evaluate the efficacy of new treatment of PRP injection in shoulder pain due to rotator cuff pathology.Methods: A prospective, observational study, on patients with shoulder pain diagnosed as rotator cuff disorders admitted in Department of Orthopaedics, RIMS, Ranchi during one year time interval (from 10th October 2016 to 09th October 2017) in the age ranging from 41 to 80 years with a mean age of 57.90 years was conducted. 20 Patients were selected for the study. Initial pre-injection score of patient taken on constant shoulder score and noted. Patient underwent intra-articular injection of PRP in shoulder joint through posterior approach under local anaesthesia. Patients were followed up at 1st post-injection day, 1 month, 3 months and 6 months after the injection.Results: Results were analysed according to constant shoulder score. In partial tear 5 (41.67%) have excellent, 6 (50%) have good and 1 (8.33%) has fair outcome on 6 months follow up and in full tear all 8 (100%) patients have poor outcome and none of the patients developed any complication.Conclusions: A single injection of PRP resulted in a safe, significant, sustained improvement in pain and functional outcomes for patients with refractory partial rotator cuff tear (RCT).

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Risk of venous thromboembolism following surgical treatment of superficial venous incompetence

VASA ◽

10.1024/0301-1526/a000656 ◽

2017 ◽

Vol 46 (6) ◽

pp. 484-489 ◽

Cited By ~ 7

Author(s):

Tom Barker ◽

Felicity Evison ◽

Ruth Benson ◽

Alok Tiwari

Keyword(s):

Venous Thromboembolism ◽

Varicose Vein ◽

Lower Incidence ◽

Varicose Veins ◽

Secondary Data ◽

Foam Sclerotherapy ◽

Increased Risk ◽

Significant Difference ◽

Chi Squared ◽

One Year

Abstract. Background: The invasive management of varicose veins has a known risk of post-operative deep venous thrombosis and subsequent pulmonary embolism. The aim of this study was to evaluate absolute and relative risk of venous thromboembolism (VTE) following commonly used varicose vein procedures. Patients and methods: A retrospective analysis of secondary data using Hospital Episode Statistics database was performed for all varicose vein procedures performed between 2003 and 2013 and all readmissions for VTE in the same patients within 30 days, 90 days, and one year. Comparison of the incidence of VTEs between procedures was performed using a Pearson’s Chi-squared test. Results: In total, 261,169 varicose vein procedures were performed during the period studied. There were 686 VTEs recorded at 30 days (0.26 % incidence), 884 at 90 days (0.34 % incidence), and 1,246 at one year (0.48 % incidence). The VTE incidence for different procedures was between 0.15–0.35 % at 30 days, 0.26–0.50 % at 90 days, and 0.46–0.58 % at one year. At 30 days there was a significantly lower incidence of VTEs for foam sclerotherapy compared to other procedures (p = 0.01). There was no difference in VTE incidence between procedures at 90 days (p = 0.13) or one year (p = 0.16). Conclusions: Patients undergoing varicose vein procedures have a small but appreciable increased risk of VTE compared to the general population, with the effect persisting at one year. Foam sclerotherapy had a lower incidence of VTE compared to other procedures at 30 days, but this effect did not persist at 90 days or at one year. There was no other significant difference in the incidence of VTE between open, endovenous, and foam sclerotherapy treatments.

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Stimulated Platelet Aggregation, Thromboxane B2 Formation and Platelet Sensitivity to Prostacyclin - A Critical Evaluation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650170 ◽

1981 ◽

Vol 45 (03) ◽

pp. 204-207 ◽

Cited By ~ 42

Author(s):

Wolfgang Siess ◽

Peter Roth ◽

Peter C Weber

Keyword(s):

Arachidonic Acid ◽

Platelet Count ◽

Platelet Aggregation ◽

Reliable Method ◽

Platelet Rich Plasma ◽

Critical Evaluation ◽

Vascular Diseases ◽

Thromboxane B2 ◽

Test Time ◽

Stimulation Of

SummaryPlatelets have been implicated in the development of atherosclerotic and thrombotic vascular diseases. Evaluation of platelet aggregation in relation to endogenously formed compounds which affect platelet function may provide information of clinical and pharmacological relevance. We describe a method in which thromboxane B2 (TXB2) formation was analyzed following stimulation of platelet-rich plasma (PRP) with ADP, 1-epinephrine, collagen, and arachidonic acid. In addition, we determined platelet sensitivity to prostacyclin following ADP- and collagen-induced platelet aggregation. The parameters under study were found to depend on the platelet count in PRP, on the type and dose of the aggregating agent used, and on the test time after blood sampling. By standardization of these variables, a reliable method was established which can be used in clinical and pharmacological trials.

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Levels of Prothrombin Fragment F1+2 in Patients with Hyperhomocysteinemia and a History of Venous Thromboembolism

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665405 ◽

1997 ◽

Vol 78 (05) ◽

pp. 1327-1331 ◽

Cited By ~ 21

Author(s):

Paul A Kyrle ◽

Andreas Stümpflen ◽

Mirko Hirschl ◽

Christine Bialonczyk ◽

Kurt Herkner ◽

...

Keyword(s):

Venous Thromboembolism ◽

Thrombin Generation ◽

Oral Anticoagulant Therapy ◽

Oral Anticoagulants ◽

Control Group ◽

Prothrombin Fragment ◽

Hemostatic System ◽

Significant Difference ◽

System Activation ◽

One Year

SummaryIncreased thrombin generation occurs in many individuals with inherited defects in the antithrombin or protein C anticoagulant pathways and is also seen in patients with thrombosis without a defined clotting abnormality. Hyperhomocysteinemia (H-HC) is an important risk factor of venous thromboembolism (VTE). We prospectively followed 48 patients with H-HC (median age 62 years, range 26-83; 18 males) and 183 patients (median age 50 years, range 18-85; 83 males) without H-HC for a period of up to one year. Prothrombin fragment Fl+2 (Fl+2) was determined in the patient’s plasma as a measure of thrombin generation during and at several time points after discontinuation of secondary thromboprophylaxis with oral anticoagulants. While on anticoagulants, patients with H-HC had significantly higher Fl+2 levels than patients without H-HC (mean 0.52 ± 0.49 nmol/1, median 0.4, range 0.2-2.8, versus 0.36 ± 0.2 nmol/1, median 0.3, range 0.1-2.1; p = 0.02). Three weeks and 3,6,9 and 12 months after discontinuation of oral anticoagulants, up to 20% of the patients with H-HC and 5 to 6% without H-HC had higher Fl+2 levels than a corresponding age- and sex-matched control group. 16% of the patients with H-HC and 4% of the patients without H-HC had either Fl+2 levels above the upper limit of normal controls at least at 2 occasions or (an) elevated Fl+2 level(s) followed by recurrent VTE. No statistical significant difference in the Fl+2 levels was seen between patients with and without H-HC. We conclude that a permanent hemostatic system activation is detectable in a proportion of patients with H-HC after discontinuation of oral anticoagulant therapy following VTE. Furthermore, secondary thromboprophylaxis with conventional doses of oral anticoagulants may not be sufficient to suppress hemostatic system activation in patients with H-HC.

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LIME AND DAIRY PRODUCTION

Proceedings of the New Zealand Grassland Association ◽

10.33584/jnzg.1982.43.1608 ◽

1982 ◽

pp. 93-103

Author(s):

N.A. Thomson

Keyword(s):

Soil Moisture ◽

Dairy Cows ◽

Milk Production ◽

Soil Ph ◽

Dairy Production ◽

Pasture Production ◽

The Third ◽

One Year ◽

Plasma Magnesium

In a four year grazing trial with dairy cows the application of 5000 kg lime/ ha (applied in two applications of 2500 kg/ha in winter of the first two years) significantly increased annual pasture production in two of the four years and dairy production in one year. In three of the four years lime significantly increased pasture growth over summer/autumn with concurrent increases in milk production. In the last year of the trial lime had little effect on pasture growth but a relatively large increase in milkfat production resulted. A higher incidence of grass staggers was recorded on the limed farmlets in spring for each of the four years. In the second spring immediately following the second application of lime significant depressions in both pasture and plasma magnesium levels were recorded. By the third spring differences in plasma magnesium levels were negligible but small depressions in herbage magnesium resulting from lime continued to the end of the trial. Lime significantly raised soil pH, Ca and Mg levels but had no effect on either soil K or P. As pH levels of the unlimed paddocks were low (5.2-5.4) in each autumn and soil moisture levels were increased by liming, these factors may suggest possible causes for the seasonality of the pasture response to lime

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Bankruptcy Model Construction and its Limitation in Input Data Quality

Journal of Business and Economics ◽

10.15341/jbe(2155-7950)/02.10.2019/003 ◽

2019 ◽

Vol 10 (2) ◽

pp. 117-125

Author(s):

Dana Kubíčková ◽

◽

Vladimír Nulíček ◽

Keyword(s):

Data Quality ◽

Normal Distribution ◽

Input Data ◽

Model Construction ◽

The Third ◽

Third Stage ◽

Discriminant Analyses ◽

One Year ◽

The University ◽

Multivariate Discriminant

The aim of the research project solved at the University of Finance and administration is to construct a new bankruptcy model. The intention is to use data of the firms that have to cease their activities due to bankruptcy. The most common method for bankruptcy model construction is multivariate discriminant analyses (MDA). It allows to derive the indicators most sensitive to the future companies’ failure as a parts of the bankruptcy model. One of the assumptions for using the MDA method and reassuring the reliable results is the normal distribution and independence of the input data. The results of verification of this assumption as the third stage of the project are presented in this article. We have revealed that this assumption is met only in a few selected indicators. Better results were achieved in the indicators in the set of prosperous companies and one year prior the failure. The selected indicators intended for the bankruptcy model construction thus cannot be considered as suitable for using the MDA method.

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