A Comparative Study of Efficacy of Miniature Punch Grafting and Platelet Rich Plasma Therapy in Treatment of Focal Stable Vitiligo in 50 Cases

Introduction: Vitiligo, a depigmented skin disorder is characterized by selective loss of melanocytes, which in turn leads to pigment dilution in the affected areas of the skin. The characteristic lesion is a totally amelanotic, non scaly, chalky white macule with distinct margins. If the disease is not progressing for the past one year it is described as stable vitiligo. There are various treatment options available for the treatment of focal stable vitiligo. It can be safely treated with miniature punch grafting as well as platelet rich plasma therapy. Aims and Objectives: Aim of this study is to compare efficacy of miniature punch grafting and platelet rich plasma therapy and to evaluate the outcome of treatment of focal stable vitiligo. Materials and Methods: Total 50 patients were selected and divided into two groups. One group was treated with miniature punch grafting while the other group underwent platelet rich plasma therapy. Pre-treatment and post treatment assessment was done by VASI (Vitiligo area scoring index) score. Result: A total of 25 patients were selected for grafting. Perigraft pigmentation was evident from 3rd week of grafting steadily increasing up to the end point of record i.e 6months. 17 patients showed good response, 4 patients showed average response while 4 patients showed poor or no response at all. Out of the 25 patients taken for platelet rich plasma therapy, 7 patients showed good response, 7 patients showed average response while 11 patients showed poor or no response at all. Conclusion: Miniature punch grafting showed better response as compared to platelet rich plasma therapy but both the therapies have their pros and shortcomings. Keywords: Vitiligo, miniature punch grafting, platelet rich plasma, VASI.

A Clinical Study of Maltyadi Tail in the Management of Darunak W.R.S. To Dandruff

Darunak is a Vata –Kaphaj Vyadhi. Sushruta mentioned it under Kshudra roga. Chakradatta has mentioned application of Maltyadi Tail (Jaati, Karveer, Chitrak, Karanj, base oil- Tila Tail) in the treatment of Darunak. Aggravation of Kapha and Vata in Darunak causes, itching, falling of hair, loss of sensation, dryness and small cracks of the skin of the scalp. Several factors increase the risk of developing dandruff, including a person’s age, the weather, stress levels, fungus, medical conditions, and choice of hair products. Oiling is the best way to get a healthy scalp. Aim and objective: To evaluate efficacy of Maltyadi Tail in the management of Darunak w.s.r to dandruff. Materials and Methods: In this clinical study total 46 Patients of Darunak were registered out of which 3 patients left the treatment; remaining 43 patients were divided into 2 groups. 23 patients were treated in group A (test drug- Maltyadi Tail) and 20 patients were treated in group B (control drug- Tila Tail) for 30 days. The effect of therapy was assessed on the basis of changes in grading score. Result: In clinical study, All the cardinal and associate symptoms except Raag, Daah, Ruja were statistically significant improved after the complete course of test drug (Maltyadi Tail). Effect of Group A reduced Kesha Bhoomi Rookshta by 92.68%, Kandu by 100%, Keshbhoomi Prapatan by 92.68% and Keshchyuti by 87.50% which was statistically highly significant. Conclusion: The study revealed that test drug (Maltyadi tail) is more effective in Darunak /dandruff compare to control drug (Tila Tail).

Arthroscopic Debridement Combined with Rehabilitation Training in the Treatment of Knee Osteoarthritis

Objective: The clinical effect of arthroscopic debridement combined with rehabilitation training in the treatment of knee arthritis was studied and analyzed. Methods: A total of 90 patients with knee osteoarthritis treated in our hospital from August 2017 to August 2018 were selected as the research objects. All patients were divided into the observation group and the control group by using the random number method. The control group was treated by arthroscopic cleaning operation, and the observation group was treated by combined rehabilitation training on the basis of the treatment in the control group. The total effective rate and simple McGill pain of the two groups were compared Score and lyshoim score. Result: The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05), the difference was statistically significant; after treatment, the simple McGill pain score of the observation group was significantly lower than that of the control group (P < 0.05), the difference was statistically significant, the lyshoim score of the observation group was significantly better than that of the control group (P < 0.05), the difference was statistically significant. Conclusion: In the treatment of knee osteoarthritis, arthroscopic debridement combined with rehabilitation training has a significant effect, which can significantly reduce the pain and improve the prognosis of patients. It is worth popularizing in clinical treatment.

Comparison of proximal femoral nailing (PFN) and proximal femoral locking plate (PFLP) for intertrochanteric femur fracture in elderly.

Objective: To compare the functional outcome of PFN and PFLP for the treatment of unstable four part intertrochanteric femur fracture. Study Design: Randomized Controlled Trial study. Setting: Orthopedics Department, Dow International Medical College, Karachi. Period: February 2019 to January 2020. Material & Methods: 281 patients were included and assigned to each group PFNA and PFLP alternatively. Both groups were compared for functional evaluation by Harris hip score. Result: Duration of surgery, perioperative hemoglobin loss, and duration of fracture healing were significantly lower in PFNA group as compared to PFLP, P<0.05. But Harris Hip score was significantly higher in PFNA group as compare to PFLP P>0.05. Conclusion: PFN has better functional outcome. This makes it a better method of fixation as compared to PFLP in elderly intertrochanteric femur fracture.

The Effect of Minecraft Video Game on Students’ English Vocabulary Mastery

Vocabulary mastery is important to acquire a language. Learning vocabulary has several barriers that slow down the progress. Minecraft application is used as a new method of learning English vocabulary. The goal of this research was to investigate whether there is a significance positive effect after used Minecraft application on students’ vocabulary mastery for 5th grade elementary students. A quasi-experimental method was used in this research with 63 students of SDN Poris Plawad 1 Tangerang, which separated into an experimental group (n=31) and a control group (n=32). The results revealed that Minecraft has better score result than the conventional method. Besides, the students’ behavior also resulted to be better than the conventional method. The survey also revealed that the students agreed that Minecraft was making the learning easier, less boring, less stressful and happier. However, the results could not be generalized due to the small sample taken in this research.

The Use of Four-Square Technique to Improve Students’ Writing Ability

This research was quasi-experimental research that aimed to find out the extent of the improvement students' writing ability by using the Four Square Technique on the descriptive text at students X SMAN 3 Takalar. the researcher took 53 samples, 28 students as the experimental group and 25 students as the control group. The research data was obtained by giving a pre-test and post-test and analyzed by using the Dependent Sample T- Test. The result of the data showed that students' writing ability improved. It was proved from score result of tobs (16,673) which was higher than ttable (2.052) and sig. P (0.05) was higher than sig.score (0.000). Students' writing ability improve by 0.1% after using the Four Square Technique from pre-test mean score was 65.07 and the post-test mean score was 75.14. So, it can be concluded that using Four Square Technique can improve students' writing ability in writing a descriptive text at students X SMAN 3 Takalar. By using it, students showed that they can be motivated in writing, students more easily generate and organize their ideas into a text so that students’ writing was more organized also easy to understand.

Association of the 12-Gene Breast DCIS Score® Assay With Local Recurrence in Patients With Ductal Carcinoma In Situ Treated on Accelerated Partial Breast Radiotherapy Protocols

BackgroundThe following analysis explores clinicopathologic factors and the 12-gene Breast DCIS Score test result in order to better define an appropriate DCIS (ductal carcinoma in situ) population eligible for APBI (accelerated partial breast radiotherapy).MethodsThis exploratory analysis aimed to retrospectively measure the association between the 12-gene Oncotype DX Breast DCIS Score® assay (Redwood City, CA) and relevant clinicopathologic factors with locoregional recurrence in a pooled cohort of women treated with local excision and APBI on prospective phase II (NCT01185145) and phase III (NCT01185132) clinical trials. Univariable Cox proportional hazards regression was used to determine whether there was an association between local recurrence and DCIS Score result risk group (≥ 39 vs &lt; 39) and clinicopathologic factors.ResultsThis analysis included 104 evaluable patients (n = 18 from NCT01185145 and n = 86 from NCT01185132). The median age was 60 years (range: 40-79). Seventy-nine percent of patients were postmenopausal. The median span of DCIS was 10 mm (range 2-45 mm). Two-thirds of the cohort presented with necrosis (71%). The distribution of DCIS Score® results ranged from 0 to 82, with 69% of patients having a DCIS Score result &lt; 39. The median follow-up time was 8.2 years in NCT01185145 versus 3.0 years in NCT01185132. There were 6 local ipsilateral breast recurrences. DCIS Score result was significantly associated with local recurrence in univariable modeling, hazard ratio = 10.3 (95% CI 1.7, 198.4); p = 0.010. None of the clinicopathologic characteristics resulted in any significant association with locoregional recurrence.ConclusionThe Breast DCIS Score assay demonstrated risk stratification in this cohort of patients treated with local excision and APBI pooled from two clinical trials. These results are consistent with those recently published utilizing whole breast radiotherapy. Due to the small number of local recurrence events and limited follow-up time, further investigations are needed to confirm findings.

MANAGEMENT OF RELAPSE CLUBFOOT BY PERCUTANEOUS TENDON RELEASE WITH APPLICATION OF CORRECTIVE CAST AND ANALYSIS OF RESULT THROUGH PIRANI SCORE, PODOGRAPH FOOT BIMALLEOLAR ANGLE, RADIOLOGICAL FOOT ANGLES AND FUNCTIONAL FOOT SCORE.

Aim:-The aim of our study to evaluate the effectiveness of percutaneous tendon release and application of corrective cast in children who had undergone serial corrective cast but had some Residual deformity Material and method :-We have included total 18 patient of Relapse clubfoot (with 22 clubfeet) in our study.The age group of patient between 6 month to 36 month.All these patient treated by percutaneous tendon release procedure and application of corrective cast.then result analysis by pirani score, podograph foot bimalleolarangle,and radiological foot angles at follow up of 1,6,12 month. Result:-pirani score result excellent in 10 feet (score<0.5),good in 10 feet(score<1.5),and fair in 2feet (score<2). Podograph foot bimalleolar angle(FBA) in 19 feet (87%)[angle >75°],FBA in 2 feet (9%)[angle70-74°],FBA in 1 feet (4% ) [angle 65-69°]. Radiological foot angleApTalocalcaneal angle mean change(7.42°) ,lateral Talocalcaneal angle mean change(7.09°) ,AP Talorst metatarsal angle mean(7.0°) , Tibiocalcaneal angle meanchange(18.66°) , Talocalcaneal index meanchange (14.65°) Laaveg ponseti and Cummings functional score excellent (85-100) in 4feet(18%),Good (70-84) in 12feet(54%), fair(60-69)in 3feet(14%), Poor (below 59)in 3feet(14%). Conclusion:-Percutaneous tendon release with application of corrective cast is safe and easy method for correction of Relapse clubfoot with less risk of wound complications,neurovascular injury and post operative scar mark.

An Internal Analysis of E-Learning Implementation Readiness: Present Evaluation and Future Planning

This study aims to see and analyse the readiness of Economic and Social Sciences Faculty of Fajar University to implement E-Learning based on the four factors by using Aydin & Tasci’s ELR Model, namely; people, technology, self-development, and innovation factor. This quantitative study used questionnaire was given to lecturers, and students with the total sample were 185. The average score of 3.41 is the minimum score for the level of readiness to implement e-learning. Based on the data, it found that lecturers obtained a total score 3.60 and students was 3.40. From four factors for lecturers, self-development factor was the only factor considered unprepared for implementing e-learning which needs some of the work to reach ready category. However, the rest of the factors are in the 'ready' category in the teaching process. On the other hand, students score result indicated 'not ready' to implement e-learning in the learning process. Even though in technology and innovation factors were showing 'un-readiness', in people factors and self-development indicated that students are 'ready' to implement e-learning even though it requires a few improvements. From the final score result for both lecturers and students, the data show that Economic and Social Sciences Faculty Fajar University is 'ready' to implement e-learning in teaching and learning process even needs a few improvements

Norway’s Development Assistance Policy: Legal Framework, Conceptual Ground and Current Trends

Goal – the goal of the present article is to put into perspective the conceptual framework of Norway’s development assistance policy. It argues that the Norwegian approach to development assistance stems from the welfare-state ideology, the position of moralism and the humane internationalism formed due to Norway’s identity as a small state. In this vein, Norway regards development assistance as a crucial way to promote its socio-political values and maintain international stability. Being one of the most generous donors of ODA in proportion to the size of its economy, Norway demonstrates its readiness to have a moral responsibility for the global common good. Research methodology – the methods used in the article are external research of offi cial documents and reports of Norwegian governmental agencies and international organizations, as well as historical analysis of key pillars and trends of Norwegian development assistance. Score/result – the article is distinguished by a high scientific level. Originality/value – the article represents the original complex approach to the pro blem of Norwegian development assistance providing substantial analysis of its legal framework and conceptual ground.