scholarly journals Prevalence and Utility of Positive Pneumococcal Urinary Antigen Tests in Australian Patients with Community-Acquired Pneumonia

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Lauren K. Troy ◽  
Keith K. H. Wong ◽  
David J. Barnes
Keyword(s):  
Clinical Utility ◽  
Length Of Hospital Stay ◽  
Community Acquired Pneumonia ◽  
Urinary Antigen ◽  
Single Centre ◽  
Cross Sectional ◽  
Single Centre Study ◽  
Antigen Tests ◽  
Positive Results ◽  
Care Support

Background and Objectives. The pneumococcal urinary antigen test (UAT) has superior sensitivity to other investigations in determining the aetiology of community-acquired pneumonia (CAP), but data specific to Australian populations is limited. This study aimed to establish the prevalence and clinical utility of positive UAT in patients admitted to hospital with CAP, as well as associations with positive testing. Methods. A prospective, cross-sectional, single-centre study was performed. Urine antigen tests were performed on all adult patients admitted to hospital with the diagnosis of CAP. Sputum and blood culture results, CURB-65 score of severity, current and prior antibiotics, comorbidities, mortality, and length of hospital stay were recorded. Results. There was a positive test prevalence of 13/170 [7.6% (95% confidence intervals 4.3–13%)]. The overall prevalence of pneumococcal pneumonia was 19/170 (11%), including 8 patients confirmed on positive UAT alone. Patients with a positive UAT result had a higher mean CURB-65 score compared with those with a negative result (P=0.01), and a greater likelihood of requiring intensive care support (P=0.006). Conclusions. The prevalence of positive UAT was low. Positive results were more often recorded in those with greater severity pneumonia. The clinical utility of the test in this cohort of patients was low.

Urinary antigen tests and the investigation of suspected community acquired pneumonia

2019 ◽  
Vol 79 (4) ◽  
pp. 389-399
Author(s):  
Sakib Rokadiya ◽  
Poppy Denniston ◽  
William Ricketts ◽  
Jonathan Lambourne
Keyword(s):  
Community Acquired Pneumonia ◽  
Urinary Antigen ◽  
Antigen Tests

scholarly journals Factors associated with anxiety and depression among type 2 diabetes outpatients in Malaysia: a descriptive cross-sectional single-centre study

BMJ Open ◽  
2014 ◽  
Vol 4 (4) ◽  
pp. e004794 ◽  
Author(s):  
Kurubaran Ganasegeran ◽  
Pukunan Renganathan ◽  
Rizal Abdul Manaf ◽  
Sami Abdo Radman Al-Dubai
Keyword(s):  
Type 2 Diabetes ◽  
Anxiety And Depression ◽  
Single Centre ◽  
Cross Sectional ◽  
Centre Study ◽  
Factors Associated ◽  
Single Centre Study

Plasma HDL as a predictor of aspirin resistance in stroke patients: A cross-sectional single centre study

2013 ◽  
Vol 333 ◽  
pp. e156
Author(s):  
S. Azmin ◽  
R. Sahathevan ◽  
R. Rabani ◽  
W.Y. Nafisah ◽  
H.J. Tan ◽  
...  
Keyword(s):  
Aspirin Resistance ◽  
Stroke Patients ◽  
Single Centre ◽  
Cross Sectional ◽  
Centre Study ◽  
Single Centre Study

scholarly journals Antimicrobial switch therapy in pediatric patients hospitalized by uncomplicated community-acquired pneumonia

2020 ◽  
Vol 11 (3) ◽  
pp. 482
Author(s):  
Ronaldo MORALES-JUNIOR ◽  
Anna C. BARRIENTOS ◽  
Raquel M. SCALCO ◽  
Aline G. FEVEREIRO ◽  
Sulim ABRAMOVICI ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Antibiotic Therapy ◽  
Length Of Hospital Stay ◽  
Venous Access ◽  
Cross Sectional Study ◽  
Community Acquired Pneumonia ◽  
Cross Sectional ◽  
Clinical Criteria ◽  
Switch Therapy ◽  
Severe Community Acquired Pneumonia

Objective: To evaluate the duration of intravenous (IV) antibiotic therapy and the practice of switch therapy to oral in the treatment of children aged 2 months to 5 years with uncomplicated severe community acquired pneumonia (CAP) in a pediatric public hospital. Methods: Retrospective, observational and cross-sectional study in which patients who started IV ampicillin treatment were selected. The patients were classified as “eligible” or “ineligible” to undergo switch therapy after 48 and 72 hours of hospitalization according to clinical criteria. Patients with length of stay <or ≥7 days were compared regarding demographic characteristics and antibiotic therapy, considering p <0.05 significant. Results: Eighty-six patients were evaluated, aged 14.4 (IQR: 10.8-22.7) months. The duration of IV therapy was 4 (IQR: 3-6) days; 56% of patients were classified as eligible for switch therapy within 48h and 74% as eligible within 72h. However, only 19 cases (22%) underwent switch therapy at the appropriate time. The main reason for the transition was the accidental loss of venous access (61%). The group with length of stay <7 days had a higher rate of switch and, consequently, shorter IV therapy duration (p <0.01). Conclusion: The switch therapy in the first 48 to 72 hours is not routinely used in the clinical practice in patients hospitalized with CAP. The findings warn of the need for institutional initiatives on this practice, aiming at improving the quality of care with shorter IV therapy duration and impact on length of hospital stay.

scholarly journals Clinical characteristics and outcomes in diabetes patients admitted with COVID-19 in Dubai: a cross-sectional single centre study.

2020 ◽  
Author(s):  
Rahila Bhatti ◽  
Amar Omer ◽  
Samara Khattib ◽  
Seemin Shiraz ◽  
Glenn Matfin
Keyword(s):  
Length Of Stay ◽  
Clinical Characteristics ◽  
Single Centre ◽  
Cross Sectional ◽  
Centre Study ◽  
Icu Admission ◽  
Patients With Diabetes ◽  
Single Centre Study ◽  
D Dimer ◽  
Diabetes Patients

Aim: To describe the clinical characteristics and outcomes of hospitalised Coronavirus Disease 2019 (COVID-19) patients with diabetes. Methods: A cross-sectional observational study was conducted in patients with diabetes admitted with COVID-19 to Mediclinic Parkview Hospital in Dubai, United Arab Emirates (UAE) from 30th March to 7th June 2020. They had laboratory and/or radiologically confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), known as COVID-19. Variation in characteristics, length of stay in hospital, diabetes status, comorbidities and outcomes were examined. Results: A total of 103 patients with confirmed COVID-19 presentations had diabetes. During the same timeframe, 410 patients overall were admitted with COVID-19 infection. This gives a total proportion of persons admitted with COVID-19 infection and coexistent diabetes/prediabetes of 25%. 67% (n=69) of the COVID-19 diabetes cohort were male. Patients admitted with COVID-19 and diabetes represented 17 different ethnicities. Of these, 59.2% (n=61) were Asians and 35% (n=36) were from Arab countries. Mean age (SD) was 54 (12.5) years. 85.4% (n=88) were known to have diabetes prior to admission, while 14.6% (n=15) were newly diagnosed with either diabetes or prediabetes during admission. Most patients in the study cohort had type 2 diabetes or prediabetes, with only 3% overall having type 1 diabetes (n=3). 46.9% of patients had evidence of good glycaemic control of their diabetes during the preceding 4-12 weeks prior to admission as defined arbitrarily by admission HbA1c <7.5%. 73.8% (n=76) had other comorbidities including hypertension, ischaemic heart disease, and dyslipidaemia. Laboratory data Mean(SD) on admission for those who needed ward-based care versus those needing intensive care unit (ICU) care: Fibrinogen 462.75 (125.16) mg/dl vs 660 (187.58) mg/dl ; D-dimer 0.66 (0.55) mcg/ml vs 2.3 (3.48) mcg/ml; Ferritin 358.08 (442.05) mg/dl vs 1762.38 (2586.38) mg/dl; and CRP 33.9 (38.62) mg/L vs 137 (111.72) mg/L were all statistically significantly higher for the ICU cohort (p<0.05). Average length of stay in hospital was 14.55 days. 28.2% of patients needed ICU admission. 4.9% (n=5) overall died during hospitalisation (all in ICU). Conclusions: In this single-centre study in Dubai, 25% of patients admitted with COVID-19 also had diabetes/prediabetes. Most diabetes patients admitted to hospital with COVID-19 disease were males of Asian origin. 14.6% had new diagnosis of diabetes/prediabetes on admission. The majority of patients with diabetes/prediabetes and COVID-19 infection had other important comorbidities (n=76; 73.8%). Only 4 patients had negative COVID-19 RT-PCR but had pathognomonic changes of COVID-19 radiologically. Our comprehensive laboratory analysis revealed distinct abnormal patterns of biomarkers that are associated with poor prognosis: Fibrinogen, D-dimer, Ferritin and CRP levels were all statistically significantly higher (p<0.05) at presentation in patients who subsequently needed ICU care compared with those patients who remained ward-based. 28.2% overall needed ICU admission, out of which 5 patients died. More studies with larger sample sizes are needed to compare data of COVID-19 patients admitted with and without diabetes within the UAE region.

PATHOLOGY AND RENAL OUTCOME OF THREE UNCOMMON FACES OF CRESCENTRIC GLOMERULONEPHRITIS

2021 ◽  
pp. 7-12
Author(s):  
Keya Basu ◽  
Dipankar Sircar ◽  
Manimoy Bandopadhyay
Keyword(s):  
Iga Nephropathy ◽  
Survival Data ◽  
Periodic Acid ◽  
Rapidly Progressive Glomerulonephritis ◽  
Renal Outcome ◽  
Single Centre ◽  
Periodic Acid Schiff ◽  
Cross Sectional ◽  
Single Centre Study ◽  
Hematoxylin Eosin

AIMS: Rapidly progressive glomerulonephritis (RPGN) presents with rapidly deteriorating renal function (> 50% loss of glomerular ltration rate /GFR within 3 months) associated with nephritic urinary sediments and crescents in biopsy. Crescentric IgA Nephropathy, Anti-GBM (Glomerular basement membrane) disease and combined IgA Nephropathy with Anti-GBM disease are three uncommon reasons of RPGN. We have compared clinicopathological. Immunouorescence (DIF) and renal outcome of three groups. Setting and designs: Prospective, cross-sectional, single centre study. METHODS AND MATERIALS :Ultrasonography guided core biopsies obtained, one stained with hematoxylin-eosin, periodic acid-Schiff, Masson's trichrome, and silver methenamine stain another one with immunouorescence conjugated IgG, IgM, IgA, C3, C1q, kappa and lambda stain. Demographic, clinicopathological and therapeutic parameters with survival data were collected. STATISTICAL ANALYSIS USED: Done using software (GraphPad PRISM 6). RESULTS: We have included 9 cases of crescentric IgA Nephropathies, 6 cases of AntiGBM diseases and 2 cases of combined IgA Nephropathy and AntiGBM diseases. Signicant difference seen in the incidences of hypertension, hemoptysis, serum creatinine, anti GBM antibody, total number of crescents and mesangial hypercellularity, fragmentation of GBM etc. IgG, IgA and kappa positivity in DIF show signicant difference. Survival analysis and mortality versus dialysis dependence and complete and partial remission versus no remission showed no difference between these three groups. CONCLUSIONS: Proper and early clinicopathological diagnosis is important since all are of poor renal outcome. Further renal outcome of the combined disease is same as that of individual ones.

scholarly journals The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Birute Zilaitiene ◽  
Marius Dirzauskas ◽  
Rasa Verkauskiene ◽  
Rytas Ostrauskas ◽  
Joerg Gromoll ◽  
...  
Keyword(s):  
Fsh Receptor ◽  
Single Centre ◽  
Time To Pregnancy ◽  
Cross Sectional ◽  
Centre Study ◽  
Single Centre Study ◽  
The Impact ◽  
Fsh Receptor Polymorphism ◽  
Receptor Polymorphism
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