scholarly journals Risk factors of cerebral microbleeds in young and middle-aged patients with hypertension

2021 ◽  
Vol 26 (4) ◽  
pp. 685-691
Author(s):  
Pingping He ◽  
Rui Jiang ◽  
Jianhao Li ◽  
Peng Wang ◽  
Feizhou Du
Keyword(s):  
Risk Factors ◽  
Lipid Metabolism ◽  
Brain Tissue ◽  
Rating Scale ◽  
Cerebral Microbleeds ◽  
Smoking History ◽  
Middle Aged ◽  
Aged Patients ◽  
Abnormal Lipid Metabolism ◽  
Deep Brain

Background & Objectives: This study aimed to explore the incidence and potential risk factors of cerebral microbleeds (CMBs) in young and middle-aged patients with hypertension. Methods: We retrospectively analyzed the clinical data of young and middle-aged patients with hypertension in the Department of Neurology, General Hospital of Western Theater Command, Chengdu, China between August 2018 and December 2020. The demographic baseline, laboratory parameters and clinical imaging data were collected. Microbleed anatomical rating scale (MARS) was applied to evaluate the presence, amount, and topographical distributions of CMBs. Results: Among 196 young and middle-aged patients with hypertension, 84 (42.9%) patients had CMBs. CMBs were more likely to occur in the deep brain tissue regions (41.8%), followed by lobar or infratentorial region. White matter hyperintensity (OR, 5.262; 95%CI, 1.314-21.075; P=0.019), abnormal lipid metabolism (OR, 3.832; 95%CI, 1.578-9.306; P=0.003), usage of anti-platelet aggregation drugs (OR, 2.947; 95%CI, 1.138-7.632; P=0.026), smoking history (OR, 3.218; 95%CI, 1.073-9.651; P=0.037), and hyperhomocysteinemia (OR, 1.415; 95%CI, 1.018-1.967; P=0.039) were independently associated with deep or infratentorial CMBs in young and middle-aged patients with hypertension. However, the occurrence of strictly lobar CMBs was only independently associated with abnormal lipid metabolism (OR, 4.162; 95%CI, 1.685-10.282; P=0.002). Conclusions: The rate of CMBs was high in young and middle-aged patients with hypertension, most commonly occurring in the deep brain tissue region. While multiple risk factors were identified to be associated with deep or infratentorial CMBs, the occurrence of strictly lobar CMBs was only associated with abnormal lipid metabolism.

Risk factors of cerebral microbleeds in young and middle-aged patients with hypertension

2018 ◽  
Vol 40 (5) ◽  
pp. 413-418 ◽  
Author(s):  
Ruihan Ni ◽  
Lan Chu ◽  
Dafei Xu ◽  
Ya Li ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Microbleeds ◽  
Middle Aged ◽  
Aged Patients

scholarly journals Risk factors for osteoporosis are common in young and middle-aged patients with femoral neck fractures regardless of trauma mechanism

2013 ◽  
Vol 84 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Amer N Al-Ani ◽  
Gustaf Neander ◽  
Bodil Samuelsson ◽  
Richard Blomfeldt ◽  
Wilhelmina Ekström ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Neck ◽  
Femoral Neck Fractures ◽  
Trauma Mechanism ◽  
Middle Aged ◽  
Aged Patients

scholarly journals Racial Disparities in Adverse Cardiovascular Outcomes After a Myocardial Infarction in Young or Middle‐Aged Patients

2021 ◽  
Author(s):  
Mariana Garcia ◽  
Zakaria Almuwaqqat ◽  
Kasra Moazzami ◽  
An Young ◽  
Bruno B. Lima ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Socioeconomic Status ◽  
Coronary Artery ◽  
Racial Disparities ◽  
Middle Aged ◽  
Aged Patients ◽  
Black Patients ◽  
Artery Disease

Background Black patients tend to develop coronary artery disease at a younger age than other groups. Previous data on racial disparities in outcomes of myocardial infarction (MI) have been inconsistent and limited to older populations. Our objective was to investigate racial differences in the outcome of MI among young and middle‐aged patients and the role played by socioeconomic, psychosocial, and clinical differences. Methods and Results We studied 313 participants (65% non‐Hispanic Black) <61 years old hospitalized for confirmed type 1 MI at Emory‐affiliated hospitals and followed them for 5 years. We used Cox proportional‐hazard models to estimate the association of race with a composite end point of recurrent MI, stroke, heart failure, or cardiovascular death after adjusting for demographic, socioeceonomic status, psychological, and clinical risk factors. The mean age was 50 years, and 50% were women. Compared with non‐Black patients, Black patients had lower socioeconomic status and more clinical and psychosocial risk factors but less angiographic coronary artery disease. The 5‐year incidence of cardiovascular events was higher in Black (35%) compared to non‐Black patients (19%): hazard ratio (HR) 2.1, 95% CI, 1.3 to 3.6. Adjustment for socioeconomic status weakened the association (HR 1.3, 95% CI, 0.8–2.4) more than adjustment for clinical and psychological risk factors. A lower income explained 46% of the race‐related disparity in outcome. Conclusions Among young and middle‐aged adult survivors of an MI, Black patients have a 2‐fold higher risk of adverse outcomes, which is largely driven by upstream socioeconomic factors rather than downstream psychological and clinical risk factors.

scholarly journals Cardiovascular Risk Factor Control and Lifestyle Factors in Young to Middle-Aged Adults with Newly Diagnosed Obstructive Coronary Artery Disease

Cardiology ◽  
2019 ◽  
Vol 142 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Michael S. Garshick ◽  
Georgeta D. Vaidean ◽  
Anish Vani ◽  
James A. Underberg ◽  
Jonathan D. Newman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Obstructive Coronary Artery Disease ◽  
Coronary Intervention ◽  
Cvd Risk Factors ◽  
Middle Aged ◽  
Cvd Risk ◽  
Aged Patients ◽  
Artery Disease

Background: While progress in the prevention of cardiovascular disease (CVD) has been noted over the past several decades, there are still those who develop CVD earlier in life than others. Objective: We investigated traditional and lifestyle CVD risk factors in young to middle-aged patients compared to older ones with obstructive coronary artery disease (CAD). Methods: A retrospective analysis of patients with a new diagnosis of obstructive CAD undergoing coronary intervention was performed. Young to middle-aged patients were defined as those in the youngest quartile (n = 281, mean age 50 ± 6 years, 81% male) compared to the other three older quartiles combined (n = 799, mean age 69 ± 7.5 years, 71% male). Obstructive CAD was determined by angiography. Results: Young to middle-aged patients compared to older ones were more likely to be male (p < 0.01), smokers (21 vs. 9%, p < 0.001), and have a higher body mass index (31 ± 6 vs. 29 ± 6 kg/m2, p < 0.001). Younger patients were less likely to eat fruits, vegetables, and fish and had fewer controlled CVD risk factors (2.7 ± 1.2 vs. 3.0 ± 1.0, p < 0.001). Compared to older patients, higher levels of psychological stress (aOR 1.6, 95% CI 1.1–2.4), financial stress (aOR 1.8, 95% CI 1.3–2.5), and low functional capacity (aOR 3.3, 95% CI 2.4–4.5) were noted in the young to middle-aged population as well. Conclusion: Lifestyle in addition to traditional CVD risk factors should be taken into account when evaluating risk for development of CVD in a younger population.

scholarly journals Age characteristics of risk cardiovascular complications in women with left breast cancer with preserved ejection fraction at the stage of chemotherapy and radiotherapy

Kardiologiia ◽  
2019 ◽  
Vol 59 (7S) ◽  
pp. 23-30
Author(s):  
I. V. Vologdina ◽  
R. M. Zhabina
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Ejection Fraction ◽  
Elderly Patients ◽  
The Elderly ◽  
Cardiovascular Complications ◽  
Left Breast ◽  
Middle Aged ◽  
Aged Patients ◽  
Score Risk

Aim. A study of the risk factors for middle-aged and elderly women HER2neu with negative left breast cancer and a normal ejection fraction at the stage of chemoradiotherapy in everyday clinical practice. Matherial and methods. 61 women with left breast cancer without severe cardiovascular pathology were examined at the stage of doxorubicin therapy and 3D conformal radiation therapy. Group 1 comprised 32 patients of middle age (49.8 ± 4.5 years). Group 2 comprised 29 elderly patients (68.3 ± 3.6 years). In addition to Score risk assessment, additional factors, including psychosocial factors, were studied. All patients underwent ECG, echocardiography and 24-hour ECG monitoring. Anxiety levels were assessed using the HADS scale and scale CH. D. Spielberger –Yu.L. Khanin. The study was conducted before the start of treatment, after the completion of the doxorubicin course and after the completion of the course of radiotherapy. Results with discussion. In middle-aged patients, moderate Score risk was found in 21.9%, in the elderly at 58.6% (p = 0.0043, RR 2.68, 95% CI 1.301–5.520). A high Score risk was found in 15.6% of middle-aged patients and 41.4% of elderly patients (p = 0.0438, RR 2.648, 95% CI 1061–6.607). The most common risk factors in the patients studied in addition to age were heredity, overweight, hypercholesterolemia and diabetes mellitus. All examined patients had moderate reactive anxiety. Patients of middle age have moderate personal anxiety, in elderly patients high personal anxiety. After treatment with doxorubicin in a cumulative dose not exceeding 360 mg/m2 , a reduction in the ejection fraction below 50% was found in 6 middle-aged patients and 17.2% in elderly patients. Asymptomatic diastolic dysfunction was detected in 31.3% of middle-aged patients and 55.2% of the elderly. In patients of both groups, after arranging treatment, arrhythmia was detected. Conclusions. The obtained data indicate to the need for in-depth examination of middle-aged and especially elderly patients with left breast cancer with an assessment of risk factors and conducting an in-depth examination using Echocardiography, 24-hour ECG monitoring and psychological testing to prevent and early detection of cardiovascular complications.

Comparing cancer survivors' perceptions on lifestyle behaviors between adolescent-young adult (AYA) and middle-aged patients (pts).

2020 ◽  
Vol 38 (29_suppl) ◽  
pp. 207-207
Author(s):  
Spencer Soberano ◽  
Lawson Eng ◽  
RuiQi Chen ◽  
Ashraf Altesha ◽  
Subiksha Nagaratnam ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Cancer Survivorship ◽  
Age Groups ◽  
Well Being ◽  
Smoking History ◽  
Middle Aged ◽  
Aged Patients ◽  
Age Cohorts ◽  
Lifestyle Behaviours

207 Background: Lifestyle behaviours such as smoking, physical activity, and alcohol consumption are important determinants of cancer survivorship. Previous studies have compared the lifestyle behaviours of elderly and middle-aged patients (pts), yet no studies have compared these behavioural perceptions between AYA (aged 18-39 years) to those of middle-aged pts (MA, 40-64 years). Methods: Cancer pts across various tumour types at a comprehensive cancer centre were surveyed with respect to their perceptions of how their well-being was affected by smoking, physical activity and alcohol consumption after diagnosis. Univariate logistic regression models evaluated factors associated with perceptions on the effect of various adverse lifestyle behaviours on health and well-being. Results: Of 200 AYA (57% female, 43% male) and 772 MA (56% female, 44% male) pts, a positive smoking history was reported by 33% of AYA and 48% of MA (P<0.001). At time of diagnosis, 55% of AYA and 59% of MA pts consumed alcohol, 16% of AYA and 16% of MA were ex-drinkers, and 28% of AYA and 25% of MA were never drinkers (P=0.62). Among AYA, 26% exercised compared to 20% in the MA group (P=0.19). The majority (72-92%) of pts perceived that smoking and lack of activity after cancer diagnosis negatively affected quality of life, survival chances, and fatigue; there were no significant differences between age groups. In contrast, both age cohorts displayed misperceptions about how alcohol affects health, which was characterized by perceiving neutral or beneficial influence on their overall well-being: Fifty-seven percent of MA pts had a borderline greater misperception versus 49% of AYA pts (P=0.06). Misperceptions regarding how alcohol affects survival were observed in 49% of AYA pts and 58% of MA pts (P=0.05). Misperception with respect to how alcohol affects fatigue was observed in 40% of AYA pts compared to 52% of MA pts (P=0.005). Furthermore, MA pts had 1.63 (95% CI 1.16–2.29) times the odds to have misperceptions regarding how alcohol affects fatigue, and 1.41 (95% CI 1.01–1.97) times the odds to have misperceptions on how alcohol affects survival compared to AYA pts. Conclusions: Both the AYA and MA population were not adequately informed about how alcohol affects cancer survivorship health; with more misperceptions in MA pts. Results from this study advocate for survivorship programs to implement emphasis on the deleterious effects of alcohol, with particular efforts tailored to the MA group.

scholarly journals Spinal cord infarction presenting as Brown-Séquard syndrome from spontaneous vertebral artery dissection: a case report and literature review

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yang-Yang Meng ◽  
Le Dou ◽  
Chun-Mei Wang ◽  
De-Zheng Kong ◽  
Ying Wei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Spinal Cord ◽  
Vertebral Artery ◽  
Vertebral Artery Dissection ◽  
Artery Dissection ◽  
Spinal Cord Infarction ◽  
Black Blood ◽  
Middle Aged ◽  
Aged Patients ◽  
Brown Sequard Syndrome

Abstract Background Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. Case presentation An otherwise healthy 40-year-old man presented with acute right-sided body weakness. Six days earlier, he had experienced posterior neck pain without obvious inducement. Neurologic examination revealed a right Brown-Séquard syndrome. Magnetic resonance imaging (MRI) of the head was normal. Further, cervical spine MRI showed spinal cord infarction (SCI) on the right at the C1-C3 level. Three-dimensional high-resolution MRI (3D HR-MRI) volumetric isotropic turbo spin echo acquisition (VISTA) scan showed evidence of vertebral artery dissection (VAD). The patient was significantly relieved of symptoms and demonstrated negative imaging findings after therapy with anticoagulation (AC) and antiplatelets (AP) for 3 months. Conclusions The possibility of vertebral artery dissection (VAD) should be considered in the case of young and middle-aged patients without obvious risk factors for atherosclerosis. Furthermore the VISTA black blood sequence plays an important role in the pathological diagnosis of vertebral artery stenosis. Early correct diagnosis and active therapy are crucial to the prognosis.

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