Influence of an antivertiginous combination preparation of cinnarizine and dimenhydrinate on event-related potentials, reaction time and psychomotor performance – a randomized, double-blind, 3-way crossover study in healthy volunteers

2004 ◽  
Vol 42 (04) ◽  
pp. 218-231 ◽  
Author(s):  
D. Philipova ◽  
B. Tzenova ◽  
A. Iwanowitsch ◽  
I. Bognar-Steinberg
Keyword(s):  
Reaction Time ◽  
Crossover Study ◽  
Healthy Volunteers ◽  
Psychomotor Performance ◽  
Event Related Potentials ◽  
Double Blind ◽  
Related Potentials ◽  
Combination Preparation

Responses to External Emotions or their Transitions at Central to Peripheral Nervous System Levels: A Methodological Contribution to Mental Health

2020 ◽  
Vol 16 (2) ◽  
pp. 138-152
Author(s):  
Bingren Zhang ◽  
Chu Wang ◽  
Chanchan Shen ◽  
Wei Wang
Keyword(s):  
Healthy Volunteers ◽  
Psychiatric Patients ◽  
Event Related Potentials ◽  
Emotional Stimuli ◽  
Non Invasive ◽  
Related Potentials ◽  
Different Populations ◽  
Invasive Techniques ◽  
Psychiatric Problems ◽  
Different Levels

Background: Responses to external emotional-stimuli or their transitions might help to elucidate the scientific background and assist the clinical management of psychiatric problems, but pure emotional-materials and their utilization at different levels of neurophysiological processing are few. Objective: We aimed to describe the responses at central and peripheral levels in healthy volunteers and psychiatric patients when facing external emotions and their transitions. Methods: Using pictures and sounds with pure emotions of Disgust, Erotica, Fear, Happiness, Neutral, and Sadness or their transitions as stimuli, we have developed a series of non-invasive techniques, i.e., the event-related potentials, functional magnetic resonance imaging, excitatory and inhibitory brainstem reflexes, and polygraph, to assess different levels of neurophysiological responses in different populations. Results: Sample outcomes on various conditions were specific and distinguishable at cortical to peripheral levels in bipolar I and II disorder patients compared to healthy volunteers. Conclusions: Methodologically, designs with these pure emotions and their transitions are applicable, and results per se are specifically interpretable in patients with emotion-related problems.

Clinical and attentional effects of acute nicotine treatment in Tourette’s syndrome

2004 ◽  
Vol 19 (2) ◽  
pp. 102-112 ◽  
Author(s):  
Anne L. Howson ◽  
Sue Batth ◽  
Vadim Ilivitsky ◽  
Armand Boisjoli ◽  
Martine Jaworski ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Event Related Potentials ◽  
Placebo Treatment ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Continuous Performance Task ◽  
Open Label ◽  
Double Blind ◽  
Nicotine Treatment ◽  
Related Potentials

AbstractEvidence from pre-clinical infrahuman investigations, open-label clinical trials, and a single controlled trial found acute nicotine treatment potentiated up to 4 weeks neuroleptic-induced reductions of dyskinetic symptoms characterizing Tourette’s syndrome (TS). Given the attentional disturbances associated with this syndrome, and the improvements in attentional processes reported with nicotine, this randomized, double-blind, placebo-controlled trial examined the acute (4 h) and sustained (2 weeks) effects of a single dose of transdermal nicotine on clinical (i.e., tics), attentional (continuous performance task, event-related potentials, patient and parental reports) and behavioral symptoms in 23 children and adolescents with TS receiving neuroleptic treatment. In the 14 evaluable patients with complete primary efficacy data, nicotine (compared to placebo) failed to alter symptoms at 4 h but counteracted ERP-P300 signs of diminished attention seen 2 weeks following placebo treatment. Secondary efficacy measures, including patient self-reports and parental ratings, found nicotine to reduce complex tics and improve behaviors related to inattention. Additional work with intermittent dosing schedules is required to characterize optimal clinical and cognitive effects with nicotine treatment.

Acute cholecystokinin effects on event-related potentials in healthy volunteers

2002 ◽  
Vol 17 (6) ◽  
pp. 285-291 ◽  
Author(s):  
Verner J. Knott ◽  
Colleen Mahoney ◽  
Tove Gunnarsson ◽  
Jacques Bradwejn ◽  
Jakov Shlik
Keyword(s):  
Healthy Volunteers ◽  
Event Related Potentials ◽  
Related Potentials

scholarly journals The post-lunch effect of regular and decaffeinated coffee on psychomotor performance: a randomized double-blind cross-over study

2021 ◽  
Vol 10 (8) ◽  
pp. 954
Author(s):  
Suganthi S. Ramachandran ◽  
Vijay L. Kumar ◽  
S. N. Dwivedi ◽  
Vishwajeet Singh ◽  
Pooja Gupta
Keyword(s):  
Healthy Volunteers ◽  
Psychomotor Performance ◽  
Subjective Ratings ◽  
Double Blind ◽  
Flicker Fusion Frequency ◽  
Female Ratio ◽  
Cardiovascular Parameters ◽  
Significant Difference ◽  
Decaffeinated Coffee ◽  
The Mean

Background: This study aimed to compare the effect of regular coffee and decaffeinated coffee on psychomotor performance in healthy volunteers during post-lunch period.Methods: In this randomized double-blind cross-over study, adult healthy volunteers were given hot coffee (3 g each of regular or decaffeinated coffee) during post-lunch period. Psychomotor functions (critical flicker-fusion frequency (CFF), choice reaction time (CRT) and error count in hand-steadiness test (HST)), blood pressure and heart rate were measured pre-lunch, pre-coffee (1-hour post-lunch) and 1-hour post-coffee consumption. Subjective ratings of sleepiness and mood were also assessed during post-lunch sessions.Results: The mean age of the participants (n=16) was 27.4±2.7 years with a male: female ratio of 7:9. There was no significant deterioration in psychomotor performance post-lunch when compared to pre-lunch on both the days. The mean CFF, CRT, errors committed in HST and cardiovascular parameters did not differ significantly between regular coffee and decaffeinated groups during post-lunch sessions. There was no significant difference in values of cardiovascular parameters as well as subjective ratings of sleep and mood between two groups.Conclusions: In healthy adult individuals’ consumption of both regular coffee and decaffeinated coffee during the post-lunch period did not affect psychomotor performance.

scholarly journals Modality differences in ERP components between somatosensory and auditory Go/No-go paradigms in prepubescent children

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259653
Author(s):  
Hiroki Nakata ◽  
Miho Takezawa ◽  
Keita Kamijo ◽  
Manabu Shibasaki
Keyword(s):  
Reaction Time ◽  
Behavioral Responses ◽  
Event Related Potentials ◽  
Error Rates ◽  
Peak Latency ◽  
Peak Amplitude ◽  
Time Variability ◽  
Commission Error ◽  
Reaction Time Variability ◽  
Related Potentials

We investigated modality differences in the N2 and P3 components of event-related potentials (ERPs) between somatosensory and auditory Go/No-go paradigms in eighteen healthy prepubescent children (mean age: 125.9±4.2 months). We also evaluated the relationship between behavioral responses (reaction time, reaction time variability, and omission and commission error rates) and amplitudes and latencies of N2 and P3 during somatosensory and auditory Go/No-go paradigms. The peak latency of No-go-N2 was significantly shorter than that of Go-N2 during somatosensory paradigms, but not during auditory paradigms. The peak amplitude of P3 was significantly larger during somatosensory than auditory paradigms, and the peak latency of P3 was significantly shorter during somatosensory than auditory paradigms. Correlations between behavioral responses and the P3 component were not found during somatosensory paradigms. On the other hand, in auditory paradigms, correlations were detected between the reaction time and peak amplitude of No-go-P3, and between the reaction time variability and peak latency of No-go-P3. A correlation was noted between commission error and the peak latency of No-go-N2 during somatosensory paradigms. Compared with previous adult studies using both somatosensory and auditory Go/No-go paradigms, the relationships between behavioral responses and ERP components would be weak in prepubescent children. Our data provide findings to advance understanding of the neural development of motor execution and inhibition processing, that is dependent on or independent of the stimulus modality.

An Evaluation of the Antihistamine Activity of Acrivastine and Its Onset in Human Skin

1992 ◽  
Vol 20 (2) ◽  
pp. 106-111 ◽  
Author(s):  
V K Manna ◽  
P Marks ◽  
J R Gibson
Keyword(s):  
Crossover Study ◽  
Healthy Volunteers ◽  
Human Skin ◽  
Treatment Plan ◽  
Onset Of Action ◽  
Double Blind ◽  
Time Points ◽  
Antihistamine Activity ◽  
Flare Response ◽  
Histamine Challenge

In a double-blind, two-period crossover study, 24 healthy volunteers were evaluated to establish the time of onset of action of activity of acrivastine in suppressing the weal and flare response to intradermally injected histamine. Volunteers received single doses of 8 mg acrivastine and placebo according to a fully randomized, balanced treatment plan. Acrivastine significantly ( P < 0.002) reduced the flare response induced by 0.4 μg histamine challenge 15 min after oral acrivastine dosing when compared with placebo. A significant ( P < 0.001) reduction of the weal response was noted at 25 min, although trends in this direction were already present at earlier time points. Dans d'une étude croisée à deux phase, réalisée en double aveugle et ayant porté sur 24 volontaires sains, on a tenté d'établir le moment du début de l'action de l'acrivastine dans la suppression de la réponse inflammatoire consécutive à l'injection intradermique d'histamine. Les volontaires ont reçu des doses uniques de 8 mg d'acrivastine et de placebo, selon un plan de traitement entièrement randomisé et équilibré. L'acrivastine a réduit significativement ( P < 0,002) la réponse de rubéfaction induite par 0,4 μg d'histamine 15 minutes après l'administration orale d'acrivastine, par rapport au placebo. Une réduction significative ( P < 0,001) de la réponse d'enflure a été notée à 25 minutes, bien qu'une tendance en ce sens ait déjà été observée à un stade plus précoce.

scholarly journals The Influence of Subclinical Neck Pain on Neurophysiological and Behavioral Measures of Multisensory Integration

2019 ◽  
Vol 9 (12) ◽  
pp. 362
Author(s):  
Antonia M. Karellas ◽  
Paul Yielder ◽  
James J. Burkitt ◽  
Heather S. McCracken ◽  
Bernadette A. Murphy
Keyword(s):  
Reaction Time ◽  
Neck Pain ◽  
Multisensory Integration ◽  
Performance Measures ◽  
Brain Activity ◽  
Event Related Potentials ◽  
Control Group ◽  
Neural Processing ◽  
Significant Group ◽  
Related Potentials

Multisensory integration (MSI) is necessary for the efficient execution of many everyday tasks. Alterations in sensorimotor integration (SMI) have been observed in individuals with subclinical neck pain (SCNP). Altered audiovisual MSI has previously been demonstrated in this population using performance measures, such as reaction time. However, neurophysiological techniques have not been combined with performance measures in the SCNP population to determine differences in neural processing that may contribute to these behavioral characteristics. Electroencephalography (EEG) event-related potentials (ERPs) have been successfully used in recent MSI studies to show differences in neural processing between different clinical populations. This study combined behavioral and ERP measures to characterize MSI differences between healthy and SCNP groups. EEG was recorded as 24 participants performed 8 blocks of a simple reaction time (RT) MSI task, with each block consisting of 34 auditory (A), visual (V), and audiovisual (AV) trials. Participants responded to the stimuli by pressing a response key. Both groups responded fastest to the AV condition. The healthy group demonstrated significantly faster RTs for the AV and V conditions. There were significant group differences in neural activity from 100–140 ms post-stimulus onset, with the control group demonstrating greater MSI. Differences in brain activity and RT between individuals with SCNP and a control group indicate neurophysiological alterations in how individuals with SCNP process audiovisual stimuli. This suggests that SCNP alters MSI. This study presents novel EEG findings that demonstrate MSI differences in a group of individuals with SCNP.

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