scholarly journals Synergistic Interactions of Schizostatin Identified from Schizophyllum commune with Demethylation Inhibitor Fungicides

2020 ◽  
Vol 36 (6) ◽  
pp. 579-590
Author(s):  
Min Young Park ◽  
Byeong Jun Jeon ◽  
Ji Eun Kang ◽  
Beom Seok Kim
Keyword(s):  
Schizophyllum Commune ◽  
Synergistic Interactions ◽  
Demethylation Inhibitor

Studi Taksonomi dan Potensi Beberapa Jamur Liar di Pulau Belitong

2020 ◽  
Vol 3 (1) ◽  
pp. 24
Author(s):  
Ivan Permana Putra
Keyword(s):  
Bioactive Compounds ◽  
Schizophyllum Commune ◽  
Ecological Role ◽  
Future Potential

Abstract : Macrofungi or mushroom are cosmopolitan heterotrophic organisms which have a very important ecological role. Information on the presence and description of macrofungi can be used as a reference for conservation steps and future potential utilization. The purpose of this study was to provide  description of macro fungi and their potential utilization at Belitong Island. All macro fungi found were Basidiomycota. The identification results showd there were 11 species of mushrooms, i.e. Chlorophyllum molybdites, Lepiota sp., Marasmius sp., Parasola sp., Phallus indusiatus, Lentinus sp.1, Lentinus sp.2, Microporus sp., Polyporus cf. tricholoma, Russula sp., dan Schizophyllum commune. All mushrooms are decomposer at the study site. Some mushrooms have potential as food, medicine and source of other bioactive compounds. This paper explains how to use macroscopic characters to help the identification of macrofungi.Abstrak : Jamur makro merupakan organisme heterotof kosmopolitan yang memiliki peran ekologis yang sangat penting. Informasi mengenai keberadaan dan deskripsi jamur makro dapat dijadikan acuan untuk langkah konservasi serta pemanfaatan potensinya di masa mendatang. Tujuan dari penelitian ini adalah untuk menyediakan deskripsi jamur makro dan potensi pemanfaatannya di Pulau Belitong. Seluruh jamur makro yang ditemukan merupakan Filum Basidiomycota. Hasil identifikasi menunjukan terdapat 11 spesies jamur yaitu Chlorophyllum molybdites, Lepiota sp., Marasmius sp., Parasola sp., Phallus indusiatus, Lentinus sp.1, Lentinus sp.2, Microporus sp., Polyporus cf. tricholoma, Russula sp., dan Schizophyllum commune. Seluruh jamur merupakan dekomposer pada lokasi penelitian. Beberapa jamur berpotensi sebagai bahan pangan, obat, dan sumber senyawa bioaktif lainnya. Pada tulisan ini dijelaskan cara menggunakan karakter makroskopik untuk membantu identifikasi jamur.

A Program for Analyzing Synergistic Interactions from Dose-Effect Data

Analgesia ◽  
1998 ◽  
Vol 3 (5) ◽  
pp. 297-305 ◽  
Author(s):  
Jeffrey D. McCary ◽  
Ronald J. Tallarida
Keyword(s):  
Dose Effect ◽  
Effect Data ◽  
Synergistic Interactions

Anticancer Hybrid Combinations: Mechanisms of Action, Implications and Future Perspectives

2019 ◽  
Vol 24 (36) ◽  
pp. 4312-4333 ◽  
Author(s):  
Eva M. Domínguez-Martín ◽  
Ana M. Díaz-Lanza ◽  
Célia M. C. Faustino
Keyword(s):  
Paradigm Shift ◽  
Molecular Level ◽  
Chemotherapeutic Agent ◽  
Synergistic Effects ◽  
Extensive Literature ◽  
Synergistic Interactions ◽  
Extensive Literature Search ◽  
Preclinical And Clinical Studies ◽  
Phytochemical Components ◽  
Combination Regimens

The exponential growth of cancer cases worldwide together with recent advances concerning the pathophysiological mechanisms of the disease at the molecular level led to a paradigm shift in chemotherapy, from monotherapy to targeted drug combination regimens. However, adverse effects and the emergence of multidrug resistance (MDR) limit the effectiveness of these therapies. In this context, hybrid combinations mixing anticancer drugs and bioactive phytochemical components from medicinal plants, or even plant extracts, that can act synergistically on multiple targets and signaling pathways represent a promising approach with the potential to expand the current therapeutic arsenal. This review aims to provide a synopsis on anticancer hybrid combinations based on their multi-target mechanisms and synergistic effects from an extensive literature search focusing mainly on publications from the last ten years. In most of these combinations, the phytochemical component was shown to enhance the anticancer activity of the chemotherapeutic agent and to sensitize chemoresistant tumors in several types of cancer. Hybrid combinations, due to synergistic interactions, are also associated with less severe adverse events since lower doses can be used to achieve the same therapeutic effect. Further preclinical and clinical studies are needed, as well as the development of an adequate regulatory framework, before hybrid combination therapy can be translated into clinical practice.

Periodontal Pathogens and Neuropsychiatric Health

2020 ◽  
Vol 20 (15) ◽  
pp. 1353-1397 ◽  
Author(s):  
Abhishek Wadhawan ◽  
Mark A. Reynolds ◽  
Hina Makkar ◽  
Alison J. Scott ◽  
Eileen Potocki ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Low Grade ◽  
Periodontal Pathogens ◽  
Synergistic Interactions ◽  
Brain Vasculature ◽  
Micro Rnas ◽  
Clinical Conditions ◽  
Low Grade Inflammation ◽  
Neuropsychiatric Illness

Increasing evidence incriminates low-grade inflammation in cardiovascular, metabolic diseases, and neuropsychiatric clinical conditions, all important causes of morbidity and mortality. One of the upstream and modifiable precipitants and perpetrators of inflammation is chronic periodontitis, a polymicrobial infection with Porphyromonas gingivalis (P. gingivalis) playing a central role in the disease pathogenesis. We review the association between P. gingivalis and cardiovascular, metabolic, and neuropsychiatric illness, and the molecular mechanisms potentially implicated in immune upregulation as well as downregulation induced by the pathogen. In addition to inflammation, translocation of the pathogens to the coronary and peripheral arteries, including brain vasculature, and gut and liver vasculature has important pathophysiological consequences. Distant effects via translocation rely on virulence factors of P. gingivalis such as gingipains, on its synergistic interactions with other pathogens, and on its capability to manipulate the immune system via several mechanisms, including its capacity to induce production of immune-downregulating micro-RNAs. Possible targets for intervention and drug development to manage distal consequences of infection with P. gingivalis are also reviewed.

Sign in / Sign up

Export Citation Format

Share Document