Antioxidant effects of astaxanthin on electric field stimulated skin and sciatic nerve tissue

2021 ◽  
Vol 28 (5) ◽  
pp. 1003
Author(s):  
Fuat Uslusoy ◽  
Goktug Aslankoc ◽  
Arzu Yalcin ◽  
Selman Altuntas ◽  
Dudu Yavuz ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Electric Field ◽  
Nerve Tissue ◽  
Antioxidant Effects

scholarly journals Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Harun Alp ◽  
Sefer Varol ◽  
Muhammet Murat Celik ◽  
Murat Altas ◽  
Osman Evliyaoglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Neuroprotective Effect ◽  
Diabetic Rats ◽  
Nerve Tissue ◽  
Stress Index ◽  
Diabetic Rat ◽  
Beta Glucan ◽  
The Brain ◽  
Antioxidant Effects

There have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.

Ultrastructural changes in sciatic nerve tissue: Effects of passive maternal smoking

1983 ◽  
Vol 41 ◽  
pp. 650-651
Author(s):  
Amankwah K.S. ◽  
A.D. Weberg ◽  
R.C. Kaufmann
Keyword(s):  
Sciatic Nerve ◽  
Maternal Smoking ◽  
Ultrastructural Level ◽  
Uranyl Acetate ◽  
Nerve Tissue ◽  
Ultrastructural Changes ◽  
Cacodylate Buffer ◽  
And Control ◽  
Spontaneous Delivery

Previous research has revealed that passive (involuntary inhalation) tobacco smoking during gestation can have adverse effects upon the developing fetus. These prior investigations did not concentrate on changes in fetal morphology. This study was undertaken to delineate fetal neural abnormalities at the ultrastructural level in mice pups exposed in utero to passive maternal smoking.Pregnant study animals, housed in a special chamber, were subjected to cigarette smoke daily from conception until delivery. Blood tests for determination of carbon monoxide levels were run at 15-18 days gestation. Sciatic nerve tissue from experimental and control animals were obtained following spontaneous delivery and fixed in 2.5% gluteraldehyde in 0.1M cacodylate buffer pH 7.3. The samples were post-fixed in osmium ferrocyanide (1:1 mixture of 1.5% aqueous OSO4 and 2.5% K4 Fe(CN)6). Following dehydration, the tissues were infiltrated with and embedded in Spurr. Sections were stained with uranyl acetate and lead citrate.

Functional enhancement of intrastriatal dopamine-containing grafts by the co-transplantation of sciatic nerve tissue in 6-hydroxydopamine-lesioned rats

1991 ◽  
Vol 113 (2) ◽  
pp. 143-154 ◽  
Author(s):  
Craig G. van Horne ◽  
Ingrid Strömberg ◽  
David Young ◽  
Lars Olson ◽  
Barry Hoffer
Keyword(s):  
Sciatic Nerve ◽  
Nerve Tissue ◽  
6 Hydroxydopamine

IL-6/STAT3 growth signalling induced by exercise conditioning promotes regeneration of injured rat sciatic nerve: return to an old cytokine

2017 ◽  
Vol 13 (1) ◽  
pp. 45-52
Author(s):  
H. Ashour ◽  
L.A. Rashed ◽  
M.M. Sabry
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Compound Muscle Action Potential ◽  
Tissue Expression ◽  
Sciatic Nerve Injury ◽  
Nerve Tissue ◽  
Injury Group ◽  
Growth Promoting ◽  
Nerve Muscle

The effects of interleukin-6 (IL-6), a growth promoting myokine through signal transduction, and activator of transcription 3 (STAT3), as a growth promoting signal, in peripheral nerve injury (PNI) are still unclear, including whether exercise pre- and/or post-conditioning are useful in nerve regeneration. Four groups were included in the study: sham for sciatic nerve injury (control), sciatic nerve injury group (SNI), exercise post-conditioning (SNI+Ex) and exercise pre- and post-conditioning (Ex+SNI+Ex). IL-6 levels were measured in serum, muscle, nerve and its surrounding fascia. Elevated levels of IL-6 in serum, nerve, muscle and fascia revealed that IL-6 induced in nerve by exercise were: (1) local nerve tissue expression; (2) serum diffused as a myokine from contracting muscle; and (3) diffused for surrounding peri-tendinous region. Evaluation of nerve functions shows that, exercise post-conditioning significantly improved (P<0.05) nerve functions in the form of nerve conduction velocity (NCV) (19.21±4.30 vs 10.96±3.08 m/s), compound muscle action potential amplitude (CMAP) (0.26±0.06 vs 0.18±0.06 mv), histologic improvement in myelination% (35.63±3.92 vs 21.13±4.26) and number of nerve fibres (181.75±9.6 vs 145.75±9.67). However, combined pre- and post-conditioning improved NCV (26.95±2.41 vs 19.21±4.30 m/s) and % myelination (43.50±3.16 vs 35.63±3.92) (P<0.05) when compared with the exercise post-conditioning group. In conclusion, IL-6 induced by exercise is valuable in nerve regeneration. The IL-6/STAT3 growth pathway could be a treatment target in clinical trials in PNI conditions.

Comparative study on biological material for molecular diagnosis of Gallid herpesvirus

2018 ◽  
Author(s):  
Venkataramireddy Balena ◽  
M R Reddy ◽  
Rajendra Singh
Keyword(s):  
Sciatic Nerve ◽  
Comparative Study ◽  
Molecular Diagnosis ◽  
False Negative ◽  
Marek's Disease ◽  
Nerve Tissue ◽  
Marek’S Disease ◽  
Chain Reaction ◽  
Tissue Samples ◽  
Positive Results

The present study was intended to investigate the sensitivity of different tissues of tumorous and non-tumorous birds to the polymerize chain reaction-baseddiagnosis of Marek’s disease. Tissue samples were collected from spleen, sciatic nerve, feather follicles and tumour parts (if any)of chickens during the routine necropsy examination. The presence of Marek’s disease virus was examined using primers for 132 bp repeats of BamHI-H regionand positive samples were sequenced for 132 bp repeats and Meq gene. In the birds showing tumours, various samples such as the spleen, feather pulp, sciatic nerve and tumour tissue yielded positive results in 92.31%, 88.46%, 100% and 100% cases respectively. Amongst non-tumorous birds, 11.53% spleen, 23.07% feather pulp and 11.53% sciatic nerve were found positive. This is the first comparative study between nerve and other organs samples for molecular diagnosis of Marek’s disease. Data generated shows that the probability of false negative in tumorous birds and false positive in non-tumorous birds was comparatively low while employing nerve tissue than spleen and feather follicles. Thus, it may be concluded from our study that nerves are a more reliable and robust diagnostic organ in comparison to the other organs used for conventional diagnosis.

scholarly journals Amino Acid Levelsin the Brain of Rats with Peripheral Nerve Constriction or Section

1997 ◽  
Vol 2 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Mauro Bianchi ◽  
Paolo Ferrario ◽  
Antonio Clavenna ◽  
Gabriele Biella ◽  
Maria Luisa Sotgiu
Keyword(s):  
Amino Acid ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
High Performance ◽  
Tissue Injury ◽  
Point Of View ◽  
Nerve Tissue ◽  
Gamma Aminobutyric Acid ◽  
Brain Areas ◽  
Amino Acid Levels

BACKGROUND: Both excitatory and inhibitory amino acids modulate central neuronal activity following peripheral nerve tissue injury.OBJECTIVE: To establish whether mononeuropathy induced by chronic constriction injury or by sectioning of the sciatic nerve affects neurotransmitter amino acid levels in the rat brain areas.METHODS: Glutamine, glutamic acid, gamma-aminobutyric acid (GABA) and aspartic acid in the hindbrain, midbrain and hypothalamus of rats were measured by high performance liquid chromatography 14 days after surgery.RESULTS: After monolateral nerve ligation an increase in glutamine and a decrease in GABA levels in all brain areas were observed, with no side preference. The section of the sciatic nerve did not cause any modification in amino acid levels.CONCLUSIONS: The results allow one to differentiate more clearly classic models of mononeuropathy from a biochemical point of view. Moreover, results indicate that continuous neuronal stimulation induced by nerve constriction is able to modify some amino acid pathways at a supraspinal level.

Comparative study on biological material for molecular diagnosis of Gallid herpesvirus 2

2018 ◽  
Author(s):  
Venkataramireddy Balena ◽  
M. R. Reddy ◽  
Rajendra Singh
Keyword(s):  
Sciatic Nerve ◽  
Comparative Study ◽  
Molecular Diagnosis ◽  
False Negative ◽  
Marek's Disease ◽  
Nerve Tissue ◽  
Marek’S Disease ◽  
Tissue Samples ◽  
Gallid Herpesvirus 2 ◽  
Positive Results

The present study was intended to investigate the sensitivity of different tissues of tumorous and non-tumorous birds to the polymerize chain reaction-baseddiagnosis of Marek’s disease. Tissue samples were collected from spleen, sciatic nerve, feather follicles and tumour parts (if any)of chickens during the routine necropsy examination. The presence of Marek’s disease virus was examined using primers for 132 bp repeats of BamHI-H regionand positive samples were sequenced for 132 bp repeats and Meq gene. In the birds showing tumours, various samples such as the spleen, feather pulp, sciatic nerve and tumour tissue yielded positive results in 92.31%, 88.46%, 100% and 100% cases respectively. Amongst non-tumorous birds, 11.53% spleen, 23.07% feather pulp and 11.53% sciatic nerve were found positive. This is the first comparative study between nerve and other organs samples for molecular diagnosis of Marek’s disease. Data generated shows that the probability of false negative in tumorous birds and false positive in non-tumorous birds was comparatively low while employing nerve tissue than spleen and feather follicles. Thus, it may be concluded from our study that nerves are a more reliable and robust diagnostic organ in comparison to the other organs used for conventional diagnosis.

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