scholarly journals Stem cell therapy in animal models of central nervous system (CNS) diseases: therapeutic role, challenges and perspectives

2014 ◽  
Vol 1 (3) ◽  
pp. 75
Author(s):  
Swapan Maiti ◽  
AR Ninu ◽  
V Remya ◽  
TB Sivanarayanan ◽  
Susan Cherian ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Therapeutic Role ◽  
Cns Diseases

scholarly journals Immunological Barriers to Stem Cell Therapy in the Central Nervous System

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Gregory E. Tullis ◽  
Kathleen Spears ◽  
Mark D. Kirk
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Brain Disorders ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Cell Transplants ◽  
The Central Nervous System

The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders. Although stem cell therapy has shown some promising results in animal models for many brain disorders it has yet to translate into the clinic. A major hurdle to the translation of stem cell therapy into the clinic is the immune response faced by stem cell transplants. Here, we focus on immunological and related hurdles to stem cell therapies for central nervous system disorders.

Regenerative medicine for central nervous system disorders: Role of therapeutic molecules in stem cell therapy

2015 ◽  
Vol 1 (2) ◽  
pp. 125 ◽  
Author(s):  
CesarioV Borlongan ◽  
Paola Suárez-Meade ◽  
HoracioG Carvajal ◽  
Takao Yasuhara ◽  
Naoki Tajiri ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Central Nervous System Disorders ◽  
Therapeutic Molecules

scholarly journals Advances in intranasal application of stem cells in the treatment of central nervous system diseases

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu-Ting Zhang ◽  
Kai-Jie He ◽  
Jin-Bao Zhang ◽  
Quan-Hong Ma ◽  
Fen Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cell Types ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Advantages And Disadvantages

AbstractStem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-entry routes of transnasal treatment, the cell types, and diseases involved in intranasal stem cell therapy, and discuss its advantages and disadvantages in the treatment of central nervous system diseases, to provide a reference for the application of intranasal stem cell therapy.

scholarly journals Stem cell therapies for ischemic stroke: current animal models, clinical trials and biomaterials

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18668-18680 ◽  
Author(s):  
Hugh H. Chan ◽  
Connor A. Wathen ◽  
Ming Ni ◽  
Shuangmu Zhuo
Keyword(s):  
Tissue Engineering ◽  
Clinical Trials ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Stem Cell Therapies ◽  
Cell Therapies

We report the facilitation of stem cell therapy in stroke by tissue engineering and applications of biomaterials.

scholarly journals Effect of Stem Cell Therapy on Bone Mineral Density: A Meta-Analysis of Preclinical Studies in Animal Models of Osteoporosis

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149400 ◽  
Author(s):  
Feng Li ◽  
Changlin Zhou ◽  
Liang Xu ◽  
Shuqing Tao ◽  
Jingyi Zhao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Bone Mineral ◽  
Stem Cell Therapy ◽  
Meta Analysis ◽  
Preclinical Studies ◽  
Mineral Density

scholarly journals Towards the standardization of stem cell therapy studies for ischemic heart diseases: Bridging the gap between animal models and the clinical setting

2017 ◽  
Vol 228 ◽  
pp. 465-480 ◽  
Author(s):  
Fábio Trindade ◽  
Adelino Leite-Moreira ◽  
João Ferreira-Martins ◽  
Rita Ferreira ◽  
Inês Falcão-Pires ◽  
...  
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Clinical Setting ◽  
Heart Diseases ◽  
Ischemic Heart ◽  
Ischemic Heart Diseases ◽  
Therapy Studies
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