scholarly journals A Rare Disease in the Differential Diagnosis of MS: Granulomatosis with Polyangitis (GPA) (Wegener Granulomatosis)

2021 ◽  
Vol 35 (3) ◽  
pp. 0-0
Author(s):  
Alper Ayaslı ◽  
Ayhan Öztürk
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Wegener Granulomatosis

scholarly journals Primary breast tuberculosis: imaging findings of a rare disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ali H. Baykan ◽  
Hakan S. Sayiner ◽  
Ibrahim Inan ◽  
Elcin Aydin ◽  
Sukru M. Erturk
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Extrapulmonary Tuberculosis ◽  
Reproductive Age ◽  
Malignant Diseases ◽  
Imaging Findings ◽  
Granulomatous Mastitis ◽  
Rare Form ◽  
Breast Tuberculosis

AbstractBreast tuberculosis is a rare form of extrapulmonary tuberculosis which tends to affect females of reproductive age, and is much rarer in males, postmenopausal women, and pre-pubescent girls. It is difficult to diagnose because it can mimic benign conditions such as a fibroadenoma, as well as malignant diseases like a carcinoma. It is also particularly difficult to distinguish breast tuberculosis from granulomatous mastitis, so other possible diagnoses should be ruled out first. The diagnosis of breast tuberculosis has three essential pillars: clinical examination, radiological evaluations, and histopathological sampling. Radiological evaluations are not only critical in diagnosis but are also important in the planning of the treatment and during the follow-up. This paper aims to review the imaging findings and the differential diagnosis of breast tuberculosis.

scholarly journals Belated Diagnosis of a Primary Bone Lymphoma of the Elbow: A Rare Case and Review of the Literature

2020 ◽  
pp. 100-107
Author(s):  
Michele Boffano ◽  
Nicola Ratto ◽  
Martina Rezzoagli ◽  
Andrea Conti ◽  
Pietro Pellegrino ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Rare Case ◽  
Early Stage ◽  
Bone Lesions ◽  
Review Of The Literature ◽  
Primary Bone Lymphoma ◽  
Lytic Bone Lesions ◽  
Primary Bone ◽  
Bone Lymphoma

Primary non-Hodgkin bone lymphoma (PBL) is a rare disease that accounts for <2% of all lymphomas in adults. PBL can be monostotic or polyostotic, mainly causing destructive and lytic bone lesions frequently located in the femur, humerus, and pelvis. PBL is rarely considered a differential diagnosis of the osteolytic tumor. In addition, PBL is not uncommonly diagnosed with delay because patients do not experience symptoms nor show objective abnormalities in the early stage of disease. Here, we reported a 60-year-old woman with a PBL of the elbow.

scholarly journals Erythremic Myelosis (Di Guglielmo's Disease)

Blood ◽  
1952 ◽  
Vol 7 (8) ◽  
pp. 765-793 ◽  
Author(s):  
STEVEN O. SCHWARTZ ◽  
JOAN CRITCHLOW
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Historical Background ◽  
Unknown Etiology ◽  
Rare Syndrome

Abstract This article represents a critical attempt to survey the cumulative information of the rare syndrome ordinarily called Di Guglielmo’s disease. The historical background lies predominately in Europe, more particularly in Italy, where the recording of cases has been fairly extensive and where interpretation has been pioneered. The present study does not presume to be definitive. It attempts to trace the thinking that has gone before, and to define the terms of reference so as not to compound nosologic confusion. It presents examples of cases in the literature acceptable diagnostically by definition. Criteria for the differential diagnosis of acute and chronic erythremic myelosis and erythroleukemia are offered. These three conditions are regarded as variants of reticulo-endotheliosis. This conclusion is based on what is known of the pathogenesis, and on what has been observed clinically and hematologically. All evaluation is necessarily offered with the reservations that must be held regarding a rare disease of unknown etiology.

scholarly journals Deep vein thrombosis in children

2013 ◽  
Vol 5 (2) ◽  
pp. 12 ◽  
Author(s):  
Kanakkande Aabideen ◽  
Michael Ogendele ◽  
Ijaz Ahmad ◽  
Laweh Amegavie
Keyword(s):  
Differential Diagnosis ◽  
Deep Vein Thrombosis ◽  
Early Diagnosis ◽  
Rare Disease ◽  
Rare Case ◽  
Differential Diagnoses ◽  
Leg Pain ◽  
Vein Thrombosis ◽  
Deep Vein

We describe a rare case of deep vein thrombosis (DVT) in children, highlight the importance of early diagnosis of rare disease with potential complications. In a 5 year old boy presented with persistent leg pain without any obvious cause. Detailed investigation led to diagnosis of DVT. As there are common differential diagnoses for leg pain in children, pediatricians usually have a low index of suspicious of DVT in children. This case highlight that paediatricians must consider DVT in their differential diagnosis when children present with leg pain.

scholarly journals Syphilitic encephalitis - a rare disease and a possible differential diagnosis of herpetic encephalitis

2014 ◽  
Vol 14 (S7) ◽  
Author(s):  
Mihaela Ionică ◽  
Magdalena Vasile ◽  
Șerban Benea ◽  
Virgil Ionescu ◽  
Elisabeta Benea
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
Herpetic Encephalitis

Gastrointestinal bleeding due to suspected anisakiasis: challenging differential diagnosis for a rare disease

2011 ◽  
Vol 63 (3) ◽  
pp. 213-217 ◽  
Author(s):  
Marco Filauro ◽  
Gian Andrea Rollandi ◽  
Giovanni Cassola ◽  
Paolo Quilici ◽  
Giulio Angelini ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Bleeding ◽  
Rare Disease

scholarly journals Keratosis Lichenoides Chronica – a Case Report and Literature Review

2014 ◽  
Vol 6 (3) ◽  
pp. 120-137
Author(s):  
Mirjana Paravina ◽  
Predrag Cvetanović ◽  
Miloš Kostov ◽  
Slađana Živković ◽  
Ivana Dimovski ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Literature Review ◽  
Rare Disease ◽  
Clinical Picture ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Poor Response ◽  
Unknown Etiology ◽  
Distinct Entity

Abstract Keratosis lichenoides chronica represents a distinct entity, a rare disease of unknown etiology and pathogenesis, with clinical manifestations which, although typical, require extensive differential diagnosis. The course of the disease is chronic, progressive, and it is resistant to various treatment options, so despite variations in the clinical picture it is really easier to diagnose than to treat. This is a case report of a male patient in whom the diagnosis of keratosis lichenoides chronica was based on typical clinical picture, repeated biopsies and histopathological findings, course of the disease and poor response to any therapy.

scholarly journals Kikuchi-Fujimoto disease: State of the art

2021 ◽  
Author(s):  
Katarzyna Lammek ◽  
Dmitry Tretiakow ◽  
Andrzej Skorek
Keyword(s):  
Differential Diagnosis ◽  
Rare Disease ◽  
State Of The Art ◽  
Cervical Lymphadenopathy ◽  
Asian Population ◽  
Family Doctors ◽  
Necrotizing Lymphadenitis ◽  
Inflammatory Drugs ◽  
Causal Theories

Introduction: Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare disease that occurs with swollen lymph nodes and associated fever. This disease occurs in both children and adults. Aim: The aim of our work was to review the literature and to remind family doctors, otolaryngologists, hematologists and rheumatologists about this rare disease that should be included in the differential diagnosis of long-term cervical lymphadenopathy. Material and methods: Current information on Kikuchi-Fujimoto disease was sought and presented based on literature that was published in reputable magazines in the period 2007–2020 in English. We searched for articles in the Medline, PubMed, and Scopus databases. Results and discussion: KFD occurs in both children and adults. This disease is found all over the world, most often in the Asian population. The etiology of Kikuchi-Fujimoto disease is not entirely known, however, two causal theories are suspected, which are discussed in detail in our article. The course of the disease is mild and usually disappears on its own. A biopsy of an involved lymph node presented as the standard for diagnosis. KFD treatment was causal – nonsteroidal anti-inflammatory drugs and/or glucocorticosteroids were used. Conclusions: There are few reports in the literature about Kikuchi-Fujimoto disease. KFD is associated with cervical lymphadenopathy and associated fever. If the diagnosis of the above-mentioned symptoms is not obvious, then in the differential diagnosis rarer diseases, such as KFD, should be included.

scholarly journals Sinonasal Involvement in Systemic Vasculitides and Cocaine-Induced Midline Destructive Lesions: Diagnostic Controversies

2013 ◽  
Vol 4 (2) ◽  
pp. ar.2013.4.0051 ◽  
Author(s):  
M. Armengot ◽  
A. Garćia-Lliberós ◽  
M. J. Gómez ◽  
A. Navarro ◽  
A. Martorell
Keyword(s):  
Differential Diagnosis ◽  
Clinical Manifestations ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Response To Treatment ◽  
Wegener Granulomatosis ◽  
Systemic Manifestations ◽  
Perinuclear Anca ◽  
Histological Results ◽  
Antibody Levels ◽  
Sinonasal Involvement

Multiple systemic diseases produce various clinical manifestations in the sinonasal area. They usually appear as difficult-to-diagnose disease processes with slow, atypical clinical courses. The aim of this study was to evaluate the sinonasal manifestations of systemic vasculitides, highlighting key points for diagnosis and differential diagnosis with other pathological entities, especially cocaine-induced midline destructive lesions (CIMDL). A retrospective study was performed of 10 patients treated in our hospital during the last 5 years with an initial diagnosis of systemic vasculitides with sinonasal involvement: eight patients with granulomatosis with polyangiitis (GPA; new nomenclature for Wegener granulomatosis) and two patients with Churg-Strauss syndrome (CSS). The study variables were clinical presentation, nasal endoscopy results, maxillofacial scan results, nasal biopsy results, erythrocyte sedimentation rate, and autoimmune antibody levels. The definitive diagnosis was GPA in six (60%) patients, CSS in two (20%) patients, and CIMDL in two (20%) patients. Nasal symptoms were similar in all patients, but nasal polyps were present in only one patient with CSS. Systemic manifestations were absent in patients with CIMDL. Likewise, peripheral eosinophilia was observed only in the two patients with CSS. Specific positive biopsy specimens were obtained in six patients (all six patients with GPA, one with CSS, and one with CIMDL). Antineutrophil cytoplasmic antibodies (ANCA) were positive in all patients with GPA (proteinase 3 antigen in five patients and myeloperoxidase in one patient), and perinuclear ANCA was positive in one patient with CIMDL; however, this patient showed an undefined pattern. Finally, the response to treatment was adequate in all patients excluding those with CIMDL. GPA and CIMDL syndromes pose a difficult differential diagnosis because they have common clinical, serological, and histological presentations. Negative histological results do not exclude the diagnosis of sinonasal vasculitides. The absence of systemic manifestations and the lack of response to treatment will lead to the confirmation of CIMDL syndrome in a cocaine user. Otolaryngologists play an important role in the early and differential diagnosis of these diseases.

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