scholarly journals Anti-Inflammatory Effects of Essential Oils from Rosmarinus officinalis and Populus alba on Experimental Models of Acute and Chronic Inflammation in Rats

2017 ◽  
Vol 51 (3s) ◽  
pp. s180-s184 ◽  
Author(s):  
Hamza Belkhodja ◽  
Boumediene Meddah ◽  
Sevgi Gezici
Keyword(s):  
Essential Oils ◽  
Chronic Inflammation ◽  
Experimental Models ◽  
Rosmarinus Officinalis ◽  
Populus Alba ◽  
Anti Inflammatory ◽  
Acute And Chronic Inflammation

scholarly journals Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mahaveer Golechha ◽  
Vikas Sarangal ◽  
Shreesh Ojha ◽  
Jagriti Bhatia ◽  
Dharmveer S. Arya
Keyword(s):  
Chronic Inflammation ◽  
Experimental Models ◽  
Inflammatory Activity ◽  
Prostaglandin E ◽  
Emblica Officinalis ◽  
Inflammatory Conditions ◽  
Rat Paw Edema ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Acute And Chronic Inflammation

Emblica officinalis, commonly known as amla in Ayurveda, is unarguably the most important medicinal plant for prevention and treatment of various ailments. The present study investigated the anti-inflammatory activity of hydroalcoholic extract ofEmblica officinalis(HAEEO). Acute inflammation in rats was induced by the subplantar injection of carrageenan, histamine, serotonin, and prostaglandin E2and chronic inflammation was induced by the cotton pellet granuloma. Intraperitoneal (i.p.) administration of HAEEO at all the tested doses (300, 500, and 700 mg/kg) significantly(P<0.001)inhibited rat paw edema against all phlogistic agents and also reduced granuloma formation. However, at the dose of 700 mg/kg, HAEEO exhibited maximum anti-inflammatory activity in all experimental models, and the effects were comparable to that of the standard anti-inflammatory drugs. Additionally, in paw tissue the antioxidant activity of HAEEO was also measured and it was found that HAEEO significantly(P<0.001)increased glutathione, superoxide dismutase, and catalase activity and subsequently reduced lipid peroxidation evidenced by reduced malondialdehyde. Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.

scholarly journals Farnesol-Loaded Liposomes Protect the Epidermis and Dermis from PM2.5-Induced Cutaneous Injury

2021 ◽  
Vol 22 (11) ◽  
pp. 6076
Author(s):  
Yu-Chiuan Wu ◽  
Wei-Yun Chen ◽  
Chun-Yin Chen ◽  
Sheng I. Lee ◽  
Yu-Wen Wang ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Water Solubility ◽  
Antibacterial Properties ◽  
Hair Follicles ◽  
Protective Effects ◽  
Cutaneous Injury ◽  
Anti Inflammatory ◽  
High Concentrations ◽  
Acute And Chronic Inflammation

Particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) increases oxidative stress through free radical generation and incomplete volatilization. In addition to affecting the respiratory system, PM2.5 causes aging- and inflammation-related damage to skin. Farnesol (Farn), a natural benzyl semiterpene, possesses anti-inflammatory, antioxidative, and antibacterial properties. However, because of its poor water solubility and cytotoxicity at high concentrations, the biomedical applications of Farn have been limited. This study examined the deleterious effects of PM2.5 on the epidermis and dermis. In addition, Farn-encapsulated liposomes (Lipo-Farn) and gelatin/HA/xanthan gel containing Lipo-Farn were prepared and applied in vivo to repair and alleviate PM2.5-induced damage and inflammation in skin. The prepared Lipo-Farn was 342 ± 90 nm in diameter with an encapsulation rate of 69%; the encapsulation significantly reduced the cytotoxicity of Farn. Lipo-Farn exhibited a slow-release rate of 35% after 192 h of incubation. The half-maximal inhibitory concentration of PM2.5 was approximately 850 μg/mL, and ≥400 μg/mL PM2.5 significantly increased IL-6 production in skin fibroblasts. Severe impairment in the epidermis and hair follicles and moderate impairment in the dermis were found in the groups treated with post-PM2.5 and continuous subcutaneous injection of PM2.5. Acute and chronic inflammation was observed in the skin in both experimental categories in vivo. Treatment with 4 mM Lipo-Farn largely repaired PM2.5-induced injury in the epidermis and dermis, restored injured hair follicles, and alleviated acute and chronic inflammation induced by PM2.5 in rat skin. In addition, treatment with 4 mM pure Farn and 2 mM Lipo-Farn exerted moderate reparative and anti-inflammatory effects on impaired skin. The findings of the current study indicate the therapeutic and protective effects of Lipo-Farn against various injuries caused by PM2.5 in the pilosebaceous units, epidermis, and dermis of skin.

scholarly journals Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Nguyen Hai Dang ◽  
Le Thi Van Anh ◽  
Nguyen Tien Dat
Keyword(s):  
Essential Oils ◽  
Chronic Inflammation ◽  
Raw264.7 Cells ◽  
Phytochemical Analysis ◽  
Cellular Injury ◽  
Volatile Oils ◽  
Physiologic Response ◽  
Proinflammatory Mediators ◽  
Anti Inflammatory ◽  
First Time

Inflammation is a vital physiologic response of cellular injury, infection, or autoimmune activation. Overproduction of proinflammatory mediators may result in the chronic inflammation that leads to many diseases such as rheumatoid arthritis, asthma, multiple sclerosis, and atherosclerosis. In this study, we assessed for the first time the anti-inflammatory effects of the essential oils of Amomum aromaticum fruits (AAE) in RAW264.7 murine macrophage model. As a result, AAE potently inhibited the production of nitric oxide in LPS-induced RAW264.7 cells with the IC50 value of 0.45 ± 0.11 μg/ml. AAE also dose-dependently reduced the expression of two proinflammatory proteins iNOS and COX-2 in the stimulated cells. Phytochemical analysis revealed that major compositions of the volatile oils including 1,8 cineole (48.22%), geranial (9.24%), neral (6.72%), α-pinene (2.43%), and α-terpineol (2.28%) may contribute greatly to the inhibition effects due to their anti-inflammatory properties. The results suggest for the potential uses of AAE in chronic inflammation prevention.

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

Fitoterapia ◽  
2010 ◽  
Vol 81 (7) ◽  
pp. 855-858 ◽  
Author(s):  
M.R. Sulaiman ◽  
E.K. Perimal ◽  
M.N. Akhtar ◽  
A.S. Mohamad ◽  
M.H. Khalid ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Anti Inflammatory ◽  
Acute And Chronic Inflammation ◽  
Inflammatory Effect

scholarly journals Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

2017 ◽  
Vol 23 (1) ◽  
pp. 12-17
Author(s):  
Hamza Belkhodja ◽  
Boumediene Meddah ◽  
Aicha Meddah TirTouil ◽  
Khaled Slimani ◽  
Abdenacer Tou
Keyword(s):  
Essential Oils ◽  
Rat Model ◽  
Rosmarinus Officinalis ◽  
Populus Alba ◽  
Histopathologic Analysis

scholarly journals Anti-inflammatory effect of hydroalcoholic extract of hibiscus rosa on acute and chronic inflammation

2016 ◽  
Vol 4 (2) ◽  
pp. 123
Author(s):  
Pankaj Verma ◽  
Swati Sharma ◽  
Vikas Kumar ◽  
Hema Chaudhary
Keyword(s):  
Chronic Inflammation ◽  
Soxhlet Extraction ◽  
Treated Group ◽  
Chronic Inflammatory Disease ◽  
Control Group ◽  
Hydroalcoholic Extract ◽  
Anti Inflammatory ◽  
Acute And Chronic Inflammation ◽  
Different Doses ◽  
Inflammatory Effect

Background: The present study was carried out to explore the efficiency of Indian herbal source from Hibiscus rosa against a chronic inflammatory disease. Hibiscus rosa belongs to Malvaceae, acts by suppression of inflammation mediators.Methods: Hydroalcoholic extract form Hibiscus rosa is prepared through soxhlet extraction and Diclofenac is used as the standard. Carrageenan and formaldehyde are administered to induce acute and chronic inflammation. Animals are divided into 6 groups with 6 animals each including Normal group, inflammatory control group, Diclofenac treated group and Hibiscus rosa treated group at different doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg.Results: Different concentrations of Hibiscus rosa treated groups i.e. 250 mg/kg (p<0.05), 500 mg/kg (p<0.05) and 1000 mg/kg (p<0.01) showed significant reduction in Paw edema as compared to controls. Significant reduction in Body weight was also observed in Hibiscus rosa treated groups. Hematological profiles of Hibiscus rosa treated group are satisfying and significant.Conclusion: Results showed significant anti-inflammatory effect of Hydroalcoholic extract of Hibiscus rosa and justifying its therapeutic role in inflammatory condition..

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