Neuroprotective Effect of Carica papaya Leaf Extract against Aluminium Toxicity: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Rats

The natural medicine has been known and used through out of the world. One of them is papaya. Efficacy papaya leave provide efficacy as fever, appetite enhancer, launsed menstruation and relieve pain. This study aims to determine whether the effect of aethanol extract of papaya leaf against power analgesic mefenamic acid on mice by using the method asetic acid induction. This study is an experimental study using twenty four mice. This animals were divided into six groups where each group consisting of four mice. Papaya leaves, mefenamic acid, and aquadest were give to each group as test substances and comparative solution. Observations were carried out for 10 minute using the method of asetic acid induction was a decreases of protection mechanism of the mice in of licking or stiff feet responses after the administration of test substances. There was a decrease of the response of mice to lick feet or stiff feet to the asetic acid induction were given after administration of papaya leaf extract. The extract of papaya leaves has an analgesic effect on mice.

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NEUROPROTECTIVE EFFECT OF ANACARDIUM OCCIDENTALE (CASHEW APPLE FRUIT) AGAINST ALUMINUM TOXICITY: AN EXPERIMENTAL STUDY ON COGNITIVE DYSFUNCTION AND BIOCHEMICAL ALTERATIONS IN RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i3.15937 ◽

2017 ◽

Vol 10 (3) ◽

pp. 164 ◽

Cited By ~ 1

Author(s):

Gade Kalyani ◽

Bhagyasree P

Keyword(s):

Cognitive Dysfunction ◽

Aluminum Toxicity ◽

Neuroprotective Effect ◽

Brain Homogenate ◽

Anacardium Occidentale ◽

Albino Rat ◽

Standard Drug ◽

Biochemical Alterations ◽

Group I ◽

Cashew Apple

ABSTRACTObjective: To study the protective role of fruit extract of Anacardium occidentale (cashew apple) in aluminum-induced cognitive dysfunction andoxidative damage in albino rat, and to explore the neuroprotective effect of A. occidentale represented by behavior and memory tests.Methods: Male Wistar rats (30) were divided into 5 groups of 6 rats each. Group I received normal saline. Group II was administered orally withaluminum chloride (100 mg/kg). Group III received rivastigmine 0.3 mg/kg body orally. Groups IV and V were administered with A. occidentale200 and 400 mg/kg along with aluminum chloride of 100 mg/kg orally after 1 hr interval. The study was carried out for 42 days (6 weeks). Thebehavioral assessment was performed using Rota-rod apparatus and Elevated plus maze and Biochemical parameters from brain homogenate such asacetylcholinesterase activity, total protein, lipid peroxidation malondialdehyde, superoxide dismutase (SOD), catalase, and glutathione reductase (GR)were estimated. All the data were analyzed using one-way analysis of variance followed by Tukey’s multiple comparison test.Results: The % reduction of acetylcholinesterase, GR observed in A.O (400 mg/kg) dose as compared with that of standard drug was found to be87.5% and 89%, respectively, whereas % reduction of catalase and SOD observed in A.O (400 mg/kg) dose as compared with that of standard drugwas found to be 97% and 99%, respectively.Conclusion: This study demonstrates A. occidentale fruit has a neuroprotective effect against aluminum-induced behavioral changes.Keywords: Occidentale, Neuroprotective, Alzheimer’s disease, Aluminum.

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Phytochemical, hematologic and anti-tumor activity evaluations of Carica papaya leaf extract

Journal of Translational Science ◽

10.15761/jts.1000185 ◽

2017 ◽

Vol 3 (3) ◽

Author(s):

Hoang Nguyen ◽

Joseph P Kitzmiller ◽

Pooja Khungar ◽

Narendra Dabbade ◽

Kieu Tho Nguyen ◽

...

Keyword(s):

Leaf Extract ◽

Carica Papaya ◽

Anti Tumor Activity

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Analgesic Effectivty Of Nanoparticles Chitosan-Ethanol Leaf Extract Papaya (Carica Papaya L.) In White Male Mice (Mus Mucculus)

JURNAL ILMU KEFARMASIAN INDONESIA ◽

10.35814/jifi.v15i2.524 ◽

2017 ◽

Vol 15 (2) ◽

pp. 228

Author(s):

Juliferd Gredi ◽

Wintari Taurina ◽

Mohamad Andrie

Keyword(s):

Leaf Extract ◽

Carica Papaya ◽

White Male ◽

Ethanol Extract ◽

Test Method ◽

Ionic Gelation ◽

Male Mice ◽

Writhing Test ◽

Effi Ciency ◽

Optimal Formula

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

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Curcumin Reduces Neuroinflammation and Improves the Impairments of Anesthetics on Learning and Memory by Regulating the Expression of miR-181a-5p

NeuroImmunoModulation ◽

10.1159/000514548 ◽

2021 ◽

pp. 1-9

Author(s):

Guizhen Liu ◽

Yuchuan Sun ◽

Fei Liu

Keyword(s):

Cognitive Impairment ◽

Protective Effect ◽

Learning And Memory ◽

Cognitive Dysfunction ◽

Inflammatory Cytokines ◽

Neuroprotective Effect ◽

Morris Water Maze Test ◽

Sprague Dawley ◽

Protein Levels ◽

Sprague Dawley Rats

Objective: The purpose of this study was to explore the role of curcumin (Cur) in isoflurane (ISO)-induced learning and memory dysfunction in Sprague-Dawley rats and further elucidate the mechanism of the protective effect produced by Cur. Methods: Rat models of cognitive impairment were established by inhaling 3% ISO. The Morris water maze test was used to assess the cognitive function of rats. ELISA and qRT-PCR were used to analyze the protein levels of pro-inflammatory cytokines and expression levels of miR-181a-5p, respectively. Results: Cur significantly improved the ISO-induced cognitive dysfunction in rats and alleviated the ISO-induced neuroinflammation. miR-181a-5p was overexpressed in ISO-induced rats, while Cur treatment significantly reduced the expression of miR-181a-5p. Overexpression of miR-181a-5p promoted the cognitive impairment and the release of inflammatory cytokines and reversed the neuroprotective effect of Cur. Conclusion: Cur has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p.

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